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Published in Scientific reports (29.08.2022)
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Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor
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Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency
Edwards, Philip D, Albert, Jeffrey S, Sylvester, Mark, Aharony, David, Andisik, Donald, Callaghan, Owen, Campbell, James B, Carr, Robin A, Chessari, Gianni, Congreve, Miles, Frederickson, Martyn, Folmer, Rutger H. A, Geschwindner, Stefan, Koether, Gerard, Kolmodin, Karin, Krumrine, Jennifer, Mauger, Russell C, Murray, Christopher W, Olsson, Lise-Lotte, Patel, Sahil, Spear, Nate, Tian, Gaochao
Published in Journal of medicinal chemistry (29.11.2007)
Published in Journal of medicinal chemistry (29.11.2007)
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Biochemical characterization and in vitro activity of AZ513, a noncovalent, reversible, and noncompetitive inhibitor of fatty acid amide hydrolase
Scott, Clay W, Tian, Gaochao, Yu, Xiao Hong, Paschetto, Kathy A., Wilkins, Dee E., Meury, Luc, Cao, Chang Qing, Varnes, Jeffrey, Edwards, Philip D.
Published in European journal of pharmacology (30.09.2011)
Published in European journal of pharmacology (30.09.2011)
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Identification of N-(2-(azepan-1-yl)-2-phenylethyl)-benzenesulfonamides as novel inhibitors of GlyT1
Varnes, Jeffrey G., Forst, Janet M., Hoerter, Tiffany N., Holmquist, Christopher R., Wilkins, Deidre E., Tian, Gaochao, Jonak, Gerald, Wang, Xia, Potts, William M., Wood, Michael W., Alhambra, Cristóbal, Brugel, Todd A., Albert, Jeffrey S.
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
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Gut-Restricted Selective Cyclooxygenase‑2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer
Zhang, Zhuming, Ghosh, Avijit, Connolly, Peter J, King, Peter, Wilde, Thomas, Wang, Jianyao, Dong, Yawei, Li, Xueliang, Liao, Daohong, Chen, Hao, Tian, Gaochao, Suarez, Javier, Bonnette, William G, Pande, Vineet, Diloreto, Karen A, Shi, Yifan, Patel, Shefali, Pietrak, Beth, Szewczuk, Lawrence, Sensenhauser, Carlo, Dallas, Shannon, Edwards, James P, Bachman, Kurtis E, Evans, David C
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation
Babbe, Holger, Sundberg, Thomas B, Tichenor, Mark, Seierstad, Mark, Bacani, Genesis, Berstler, James, Chai, Wenying, Chang, Leon, Chung, De Michael, Coe, Kevin, Collins, Bernard, Finley, Michael, Guletsky, Alexander, Lemke, Christopher T, Mak, Puiying A, Mathur, Ashok, Mercado-Marin, Eduardo V, Metkar, Shailesh, Raymond, Donald D, Rives, Marie-Laure, Rizzolio, Michele, Shaffer, Paul L, Smith, Russell, Smith, Jacqueline, Steele, Ruth, Steffens, Helena, Suarez, Javier, Tian, Gaochao, Majewski, Nathan, Volak, Laurie P, Wei, Jianmei, Desai, Prerak T, Ong, Luvena L, Koudriakova, Tatiana, Goldberg, Steven D, Hirst, Gavin, Kaushik, Virendar K, Ort, Tatiana, Seth, Nilufer, Graham, Daniel B, Plevy, Scott, Venable, Jennifer D, Xavier, Ramnik J, Towne, Jennifer E
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2024)
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17β-(N-tert-butylcarbamoyl)-4-aza-5α-androstan-1-en-3-one is an active site-directed slow time-dependent inhibitor of human steroid 5α-reductase 1
GAOCHAO TIAN, STUART, J. D, FRYE, S. V, BATCHELOR, K. W, WISEMAN, J. S, MOSS, M. L, DOMANICO, P. L, BRAMSON, H. N, PATEL, I. R, KADWELL, S. H, OVERTON, L. K, KOST, T. A, MOOK, R. A
Published in Biochemistry (Easton) (01.03.1994)
Published in Biochemistry (Easton) (01.03.1994)
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Mechanism of Time-Dependent Inhibition of 5.alpha.-Reductases by .DELTA.1-4-Azasteroids: Toward Perfection of Rates of Time-Dependent Inhibition by Using Ligand-Binding Energies
Tian, Gaochao, Mook, Robert, Moss, Marcia L., Frye, Stephen V.
Published in Biochemistry (Easton) (17.10.1995)
Published in Biochemistry (Easton) (17.10.1995)
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Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1
Varnes, Jeffrey G., Xiong, Hui, Forst, Janet M., Holmquist, Christopher R., Ernst, Glen E., Frietze, William, Dembofsky, Bruce, Andisik, Don W., Palmer, William E., Hinkley, Lindsay, Steelman, Gary B., Wilkins, Deidre E., Tian, Gaochao, Jonak, Gerald, Potts, William M., Wang, Xia, Brugel, Todd A., Alhambra, Cristóbal, Wood, Michael W., Veale, Chris A., Albert, Jeffrey S.
Published in Bioorganic & medicinal chemistry letters (01.04.2018)
Published in Bioorganic & medicinal chemistry letters (01.04.2018)
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Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors
Varnes, Jeffrey G., Geschwindner, Stefan, Holmquist, Christopher R., Forst, Janet, Wang, Xia, Dekker, Niek, Scott, Clay W., Tian, Gaochao, Wood, Michael W., Albert, Jeffrey S.
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
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Mechanism of adenylate kinase. Are the essential lysines essential ?
GAOCHAO TIAN, HONGGAO YAN, RU-TAI JIANG, KISHI, F, NAKAZAWA, A, MING-DAW TSAI
Published in Biochemistry (Easton) (01.01.1990)
Published in Biochemistry (Easton) (01.01.1990)
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Mechanism of Inhibition of Fatty Acid Amide Hydrolase by Sulfonamide-Containing Benzothiazoles: Long Residence Time Derived from Increased Kinetic Barrier and Not Exclusively from Thermodynamic Potency
Tian, Gaochao, Paschetto, Kathy A, Gharahdaghi, Farzin, Gordon, Euan, Wilkins, Dee E, Luo, Xincai, Scott, Clay W
Published in Biochemistry (Easton) (16.08.2011)
Published in Biochemistry (Easton) (16.08.2011)
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