A First-in-Human Study of Novel Cereblon Modulator Avadomide (CC-122) in Advanced Malignancies
Rasco, Drew W, Papadopoulos, Kyriakos P, Pourdehnad, Michael, Gandhi, Anita K, Hagner, Patrick R, Li, Yan, Wei, Xin, Chopra, Rajesh, Hege, Kristen, DiMartino, Jorge, Shih, Kent
Published in Clinical cancer research (01.01.2019)
Published in Clinical cancer research (01.01.2019)
Get full text
Journal Article
Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.)
Gandhi, Anita K, Kang, Jian, Havens, Courtney G, Conklin, Thomas, Ning, Yuhong, Wu, Lei, Ito, Takumi, Ando, Hideki, Waldman, Michelle F, Thakurta, Anjan, Klippel, Anke, Handa, Hiroshi, Daniel, Thomas O, Schafer, Peter H, Chopra, Rajesh
Published in British journal of haematology (01.03.2014)
Published in British journal of haematology (01.03.2014)
Get full text
Journal Article
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS
Krönke, Jan, Fink, Emma C., Hollenbach, Paul W., MacBeth, Kyle J., Hurst, Slater N., Udeshi, Namrata D., Chamberlain, Philip P., Mani, D. R., Man, Hon Wah, Gandhi, Anita K., Svinkina, Tanya, Schneider, Rebekka K., McConkey, Marie, Järås, Marcus, Griffiths, Elizabeth, Wetzler, Meir, Bullinger, Lars, Cathers, Brian E., Carr, Steven A., Chopra, Rajesh, Ebert, Benjamin L.
Published in Nature (London) (09.07.2015)
Published in Nature (London) (09.07.2015)
Get full text
Journal Article
Follicular lymphoma dynamics
Milpied, Pierre, Gandhi, Anita K, Cartron, Guillaume, Pasqualucci, Laura, Tarte, Karin, Nadel, Bertrand, Roulland, Sandrine
Published in Advances in immunology (01.01.2021)
Published in Advances in immunology (01.01.2021)
Get full text
Journal Article
Avadomide monotherapy in relapsed/refractory DLBCL: safety, efficacy, and a predictive gene classifier
Carpio, Cecilia, Bouabdallah, Reda, Ysebaert, Loïc, Sancho, Juan-Manuel, Salles, Gilles, Cordoba, Raul, Pinto, Antonio, Gharibo, Mecide, Rasco, Drew, Panizo, Carlos, Lopez-Martin, Jose A., Santoro, Armando, Salar, Antonio, Damian, Silvia, Martin, Alejandro, Verhoef, Gregor, Van den Neste, Eric, Wang, Maria, Couto, Suzana, Carrancio, Soraya, Weng, Andrew, Wang, Xuehai, Schmitz, Frank, Wei, Xin, Hege, Kristen, Trotter, Matthew W.B., Risueño, Alberto, Buchholz, Tonia J., Hagner, Patrick R., Gandhi, Anita K., Pourdehnad, Michael, Ribrag, Vincent
Published in Blood (26.03.2020)
Published in Blood (26.03.2020)
Get full text
Journal Article
CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL
Hagner, Patrick R., Man, Hon-Wah, Fontanillo, Celia, Wang, Maria, Couto, Suzana, Breider, Mike, Bjorklund, Chad, Havens, Courtney G., Lu, Gang, Rychak, Emily, Raymon, Heather, Narla, Rama Krishna, Barnes, Leo, Khambatta, Gody, Chiu, Hsiling, Kosek, Jolanta, Kang, Jian, Amantangelo, Michael D., Waldman, Michelle, Lopez-Girona, Antonia, Cai, Ti, Pourdehnad, Michael, Trotter, Matthew, Daniel, Thomas O., Schafer, Peter H., Klippel, Anke, Thakurta, Anjan, Chopra, Rajesh, Gandhi, Anita K.
Published in Blood (06.08.2015)
Published in Blood (06.08.2015)
Get full text
Journal Article
SpatialSort: a Bayesian model for clustering and cell population annotation of spatial proteomics data
Lee, Eric, Chern, Kevin, Nissen, Michael, Wang, Xuehai, Huang, Chris, Gandhi, Anita K, Bouchard-Côté, Alexandre, Weng, Andrew P, Roth, Andrew
Published in Bioinformatics (Oxford, England) (30.06.2023)
Published in Bioinformatics (Oxford, England) (30.06.2023)
Get full text
Journal Article
Interactome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL
Hagner, Patrick R, Chiu, Hsiling, Chopra, Vivek S, Colombo, Martino, Patel, Nisha, Estevez, Maria Ortiz, Waldman, Michelle F, Loos, Remco, Towfic, Fadi, Gandhi, Anita K
Published in Clinical cancer research (02.08.2022)
Published in Clinical cancer research (02.08.2022)
Get full text
Journal Article
Follicular lymphoma comprises germinal center–like and memory-like molecular subtypes with prognostic significance
Laurent, Camille, Trisal, Preeti, Tesson, Bruno, Seth, Sahil, Beyou, Alicia, Roulland, Sandrine, Lesne, Bastien, Van Acker, Nathalie, Cerapio, Juan-Pablo, Chartier, Loic, Guille, Arnaud, Stokes, Matthew E., Huang, C. Chris, Huet, Sarah, Gandhi, Anita K., Morschhauser, Franck, Xerri, Luc
Published in Blood (07.10.2024)
Published in Blood (07.10.2024)
Get full text
Journal Article
Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity
Gandhi, Anita K., Mendy, Derek, Waldman, Michelle, Chen, Gengxin, Rychak, Emily, Miller, Karen, Gaidarova, Svetlana, Ren, Yan, Wang, Maria, Breider, Michael, Carmel, Gilles, Mahmoudi, Afshin, Jackson, Pilgrim, Abbasian, Mahan, Cathers, Brian E., Schafer, Peter H., Daniel, Tom O., Lopez‐Girona, Antonia, Thakurta, Anjan, Chopra, Rajesh
Published in British journal of haematology (01.01.2014)
Published in British journal of haematology (01.01.2014)
Get full text
Journal Article
Targeting of inflammatory pathways with R2CHOP in high-risk DLBCL
Hartert, Keenan T., Wenzl, Kerstin, Krull, Jordan E., Manske, Michelle, Sarangi, Vivekananda, Asmann, Yan, Larson, Melissa C., Maurer, Matthew J., Slager, Susan, Macon, William R., King, Rebecca L., Feldman, Andrew L., Gandhi, Anita K., Link, Brian K., Habermann, Thomas M., Yang, Zhi-Zhang, Ansell, Stephen M., Cerhan, James R., Witzig, Thomas E., Nowakowski, Grzegorz S., Novak, Anne J.
Published in Leukemia (01.02.2021)
Published in Leukemia (01.02.2021)
Get full text
Journal Article
Triggering interferon signaling in T cells with avadomide sensitizes CLL to anti-PD-L1/PD-1 immunotherapy
Ioannou, Nikolaos, Hagner, Patrick R., Stokes, Matt, Gandhi, Anita K., Apollonio, Benedetta, Fanous, Mariam, Papazoglou, Despoina, Sutton, Lesley-Ann, Rosenquist, Richard, Amini, Rose-Marie, Chiu, Hsiling, Lopez-Girona, Antonia, Janardhanan, Preethi, Awan, Farrukh T., Jones, Jeffrey, Kay, Neil E., Shanafelt, Tait D., Tallman, Martin S., Stamatopoulos, Kostas, Patten, Piers E.M., Vardi, Anna, Ramsay, Alan G.
Published in BLOOD (14.01.2021)
Published in BLOOD (14.01.2021)
Get full text
Journal Article
Conference Proceeding
High-plex imaging and cellular neighborhood spatial analysis reveals multiple immune escape and suppression patterns in diffuse large B-cell lymphoma
Reiss, David J., Nakayama, Yumi, Weng, Andrew P., Stokes, Matthew E., Sehn, Laurie, Steidl, Christian, Scott, David W., Huang, C. Chris, Gandhi, Anita K.
Published in Leukemia (01.05.2024)
Published in Leukemia (01.05.2024)
Get full text
Journal Article
Activity of lenalidomide in mantle cell lymphoma can be explained by NK cell‐mediated cytotoxicity
Hagner, Patrick R., Chiu, Hsiling, Ortiz, Maria, Apollonio, Benedetta, Wang, Maria, Couto, Suzana, Waldman, Michelle F., Flynt, Erin, Ramsay, Alan G., Trotter, Matthew, Gandhi, Anita K., Chopra, Rajesh, Thakurta, Anjan
Published in British journal of haematology (01.11.2017)
Published in British journal of haematology (01.11.2017)
Get full text
Journal Article
Transcriptomic classification of diffuse large B-cell lymphoma identifies a high-risk activated B-cell-like subpopulation with targetable MYC dysregulation
Stokes, Matthew E., Wenzl, Kerstin, Huang, C. Chris, Ortiz, María, Hsu, Chih-Chao, Maurer, Matthew J., Stong, Nicholas, Nakayama, Yumi, Wu, Lei, Chiu, Hsiling, Polonskaia, Ann, Danziger, Samuel A., Towfic, Fadi, Parker, Joel, King, Rebecca L., Link, Brian K., Slager, Susan L., Sarangi, Vivekananda, Asmann, Yan W., Novak, Joseph P., Sudhindra, Akshay, Ansell, Stephen M., Habermann, Thomas M., Hagner, Patrick R., Nowakowski, Grzegorz S., Cerhan, James R., Novak, Anne J., Gandhi, Anita K.
Published in Nature communications (08.08.2024)
Published in Nature communications (08.08.2024)
Get full text
Journal Article
Combination lenalidomide‐rituximab immunotherapy activates anti‐tumour immunity and induces tumour cell death by complementary mechanisms of action in follicular lymphoma
Chiu, Hsiling, Trisal, Preeti, Bjorklund, Chad, Carrancio, Soraya, Toraño, Estela G., Guarinos, Carla, Papazoglou, Despoina, Hagner, Patrick R., Beldi‐Ferchiou, Asma, Tarte, Karin, Delfau‐Larue, Marie‐Hélène, Morschhauser, Franck, Ramsay, Alan G., Gandhi, Anita K.
Published in British journal of haematology (01.04.2019)
Published in British journal of haematology (01.04.2019)
Get full text
Journal Article
Immunomodulatory effects in a phase II study of lenalidomide combined with cetuximab in refractory KRAS-mutant metastatic colorectal cancer patients
Gandhi, Anita K, Shi, Tao, Li, Mingyu, Jungnelius, Ulf, Romano, Alfredo, Tabernero, Josep, Siena, Salvatore, Schafer, Peter H, Chopra, Rajesh
Published in PloS one (11.11.2013)
Published in PloS one (11.11.2013)
Get full text
Journal Article
Leveraging gene expression subgroups to classify DLBCL patients and select for clinical benefit from a novel agent
Risueño, Alberto, Hagner, Patrick R., Towfic, Fadi, Fontanillo, Celia, Djebbari, Amira, Parker, Joel S., Drew, Clifton P., Nowakowski, Grzegorz S., Maurer, Matthew J., Cerhan, James R., Wei, Xin, Ren, Yan, Lee, Chung-Wein, Couto, Suzana, Wang, Maria, Pourdehnad, Michael, Gandhi, Anita K., Trotter, Matthew W.B.
Published in Blood (26.03.2020)
Published in Blood (26.03.2020)
Get full text
Journal Article
Extended exposure to low doses of azacitidine induces differentiation of leukemic stem cells through activation of myeloperoxidase
Jeyaraju, Danny V, Alapa, Maryam, Polonskaia, Ann, Risueño, Alberto, Subramanyam, Prakash, Anand, Amit, Ghosh, Kaushik, Kyriakopoulos, Charalampos, Hemerich, Daiane, Hurren, Rose, Wang, Xiaoming, Gronda, Marcela, Ahsan, Aarif, Chiu, Hsiling, Thomas, Geethu, Lind, Evan F, Menezes, Daniel L, Schimmer, Aaron D, Hagner, Patrick R, Gandhi, Anita, Thakurta, Anjan G
Published in Haematologica (Roma) (01.04.2024)
Published in Haematologica (Roma) (01.04.2024)
Get full text
Journal Article
Pomalidomide in combination with dexamethasone results in synergistic anti‐tumour responses in pre‐clinical models of lenalidomide‐resistant multiple myeloma
Rychak, Emily, Mendy, Derek, Shi, Tao, Ning, Yuhong, Leisten, Jim, Lu, Ling, Miller, Karen, Narla, Rama K., Orlowski, Robert Z., Raymon, Heather K., Bjorklund, Chad C., Thakurta, Anjan, Gandhi, Anita K., Cathers, Brian E., Chopra, Rajesh, Daniel, Thomas O., Lopez‐Girona, Antonia
Published in British journal of haematology (01.03.2016)
Published in British journal of haematology (01.03.2016)
Get full text
Journal Article