A reversed sulfonamide series of selective RORc inverse agonists
van Niel, Monique B., Fauber, Benjamin P., Cartwright, Matthew, Gaines, Simon, Killen, Jonathan C., René, Olivier, Ward, Stuart I., de Leon Boenig, Gladys, Deng, Yuzhong, Eidenschenk, Céline, Everett, Christine, Gancia, Emanuela, Ganguli, Arunima, Gobbi, Alberto, Hawkins, Julie, Johnson, Adam R., Kiefer, James R., La, Hank, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, Qin, Ann, Wakes, Nicole, Waszkowycz, Bohdan, Wong, Harvey
Published in Bioorganic & medicinal chemistry letters (01.12.2014)
Published in Bioorganic & medicinal chemistry letters (01.12.2014)
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Mycobacterium tuberculosis Chaperonin 10 Is Secreted in the Macrophage Phagosome: Is Secretion Due to Dissociation and Adoption of a Partially Helical Structure at the Membrane?
Fossati, Gianluca, Izzo, Gaetano, Rizzi, Emanuele, Gancia, Emanuela, Modena, Daniela, Moras, Maria Luisa, Niccolai, Neri, Giannozzi, Elena, Spiga, Ottavia, Bono, Letizia, Marone, Piero, Leone, Eugenio, Mangili, Francesca, Harding, Stephen, Errington, Neil, Walters, Christopher, Henderson, Brian, Roberts, Michael M, Coates, Anthony R M, Casetta, Bruno, Mascagni, Paolo
Published in Journal of Bacteriology (01.07.2003)
Published in Journal of Bacteriology (01.07.2003)
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Discovery of LRRK2 inhibitors by using an ensemble of virtual screening methods
Gancia, Emanuela, De Groot, Marcel, Burton, Brenda, Clark, David E.
Published in Bioorganic & medicinal chemistry letters (01.06.2017)
Published in Bioorganic & medicinal chemistry letters (01.06.2017)
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The Rational Design of Selective Benzoxazepin Inhibitors of the α‑Isoform of Phosphoinositide 3‑Kinase Culminating in the Identification of (S)‑2-((2-(1-Isopropyl‑1H‑1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2‑d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)
Heffron, Timothy P, Heald, Robert A, Ndubaku, Chudi, Wei, BinQing, Augistin, Martin, Do, Steven, Edgar, Kyle, Eigenbrot, Charles, Friedman, Lori, Gancia, Emanuela, Jackson, Philip S, Jones, Graham, Kolesnikov, Aleksander, Lee, Leslie B, Lesnick, John D, Lewis, Cristina, McLean, Neville, Mörtl, Mario, Nonomiya, Jim, Pang, Jodie, Price, Steve, Prior, Wei Wei, Salphati, Laurent, Sideris, Steve, Staben, Steven T, Steinbacher, Stefan, Tsui, Vickie, Wallin, Jeffrey, Sampath, Deepak, Olivero, Alan G
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
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Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington’s Disease
Liu, Longbin, Malagu, Karine, Haughan, Alan F., Khetarpal, Vinod, Stott, Andrew J., Esmieu, William, Vater, Huw D., Webster, Stephen J., Van de Poël, Amanda J., Clissold, Cole, Cosgrove, Brett, Sutton, Benjamin, Spencer, Jonathan A., Breccia, Perla, Gancia, Emanuela, Bonomo, Silvia, Ladduwahetty, Tammy, Lazari, Ovadia, Patel, Hiral, Atton, Helen C., Clifton, Steve, Mota, Daniel M., Magnani, Dario, O’Neill, Amy, Stebbeds, Marta, Macabuag, Natsuko, Todd, Daniel, Herva, Maria E., Mitchell, Philip, Visser, Mijke, Compte Sancerni, Sara, Grand Moursel, Laure, da Silva, Marta, Kritikou, Eva, Heikkinen, Taneli T., Bolkvadze, Tamuna, Fodale, Valentina, Spadafora, Debora, Daldin, Manuel, Bresciani, Alberto, Mangette, John E., Doherty, Elizabeth M., Lee, Matthew R., Herbst, Todd, Monteagudo, Edith, Macdonald, Douglas, Plotnikov, Nikolay V., Chambers, Mark, McAllister, George, Muňoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (28.09.2023)
Published in Journal of medicinal chemistry (28.09.2023)
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Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1)
Chan, Bryan K, Seward, Eileen, Lainchbury, Michael, Brewer, Thomas F, An, Le, Blench, Toby, Cartwright, Matthew W, Chan, Grace Ka Yan, Choo, Edna F, Drummond, Jason, Elliott, Richard L, Gancia, Emanuela, Gazzard, Lewis, Hu, Baihua, Jones, Graham E, Luo, Xifeng, Madin, Andrew, Malhotra, Sushant, Moffat, John G, Pang, Jodie, Salphati, Laurent, Sneeringer, Christopher J, Stivala, Craig E, Wei, Binqing, Wang, Weiru, Wu, Ping, Heffron, Timothy P
Published in ACS medicinal chemistry letters (13.01.2022)
Published in ACS medicinal chemistry letters (13.01.2022)
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Discovery of Novel Allosteric Mitogen-Activated Protein Kinase Kinase (MEK) 1,2 Inhibitors Possessing Bidentate Ser212 Interactions
Heald, Robert A, Jackson, Philip, Savy, Pascal, Jones, Mark, Gancia, Emanuela, Burton, Brenda, Newman, Richard, Boggs, Jason, Chan, Emily, Chan, Jocelyn, Choo, Edna, Merchant, Mark, Rudewicz, Patrick, Ultsch, Mark, Wiesmann, Christian, Yue, Qin, Belvin, Marcia, Price, Steve
Published in Journal of medicinal chemistry (24.05.2012)
Published in Journal of medicinal chemistry (24.05.2012)
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Estimation of pKa Using Semiempirical Molecular Orbital Methods. Part 1: Application to Phenols and Carboxylic Acids
Tehan, Benjamin G., Lloyd, Edward J., Wong, Margaret G., Pitt, Will R., Montana, John G., Manallack, David T., Gancia, Emanuela
Published in Quantitative structure-activity relationships (01.11.2002)
Published in Quantitative structure-activity relationships (01.11.2002)
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Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1
Gazzard, Lewis, Williams, Karen, Chen, Huifen, Axford, Lorraine, Blackwood, Elizabeth, Burton, Brenda, Chapman, Kerry, Crackett, Peter, Drobnick, Joy, Ellwood, Charles, Epler, Jennifer, Flagella, Michael, Gancia, Emanuela, Gill, Matthew, Goodacre, Simon, Halladay, Jason, Hewitt, Joanne, Hunt, Hazel, Kintz, Samuel, Lyssikatos, Joseph, Macleod, Calum, Major, Sarah, Médard, Guillaume, Narukulla, Raman, Ramiscal, Judi, Schmidt, Stephen, Seward, Eileen, Wiesmann, Christian, Wu, Ping, Yee, Sharon, Yen, Ivana, Malek, Shiva
Published in Journal of medicinal chemistry (25.06.2015)
Published in Journal of medicinal chemistry (25.06.2015)
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8-Fluoroimidazo[1,2-a]pyridine: Synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABAA receptor
Humphries, Alexander C., Gancia, Emanuela, Gilligan, Myra T., Goodacre, Simon, Hallett, David, Merchant, Kevin J., Thomas, Steve R.
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
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A reversed sulfonamide series of selective RORc inverse agonists
van Niel, Monique B., Fauber, Benjamin P., Cartwright, Matthew, Gaines, Simon, Killen, Jonathan C., Rene, Olivier, Ward, Stuart I., Boenig, Gladys de Leon, Deng, Yuzhong, Eidenschenk, Celine, Everett, Christine, Gancia, Emanuela, Ganguli, Arunima, Gobbi, Alberto, Hawkins, Julie, Johnson, Adam R., Kiefer, James R., La, Hank, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, Qin, Ann, Wakes, Nicole, Waszkowycz, Bohdan, Wong, Harvey
Published in Bioorganic & medicinal chemistry letters (15.12.2014)
Published in Bioorganic & medicinal chemistry letters (15.12.2014)
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Year of Publication 26.04.2022
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Year of Publication 26.04.2022
Patent
8-Fluoroimidazo[1,2-a]pyridine: synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABA A receptor
Humphries, Alexander C, Gancia, Emanuela, Gilligan, Myra T, Goodacre, Simon, Hallett, David, Merchant, Kevin J, Thomas, Steve R
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
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Year of Publication 25.04.2022
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Year of Publication 25.04.2022
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HODGSON SIMON TEANBY, EVANS DAVID MICHAEL, HAMBLIN JULIE NICOLE, CRIDLAND ANDREW PETER, PANCHAL TERENCE AARON, EDWARDS HANNAH JOY, MARSH SALLY LOUISE, MAZZACANI ALESSANDRO, DAVIE REBECCA LOUISE, ROOKER DAVID PHILIP, HINCHLIFFE PAUL STUART, GANCIA EMANUELA, STOCKS MICHAEL JOHN, MILLER IAIN ROBERT, LEVANTO STEFANO
Year of Publication 25.04.2022
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Year of Publication 25.04.2022
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Estimation of pKa Using Semiempirical Molecular Orbital Methods. Part 2: Application to Amines, Anilines and Various Nitrogen Containing Heterocyclic Compounds
Tehan, Benjamin G., Lloyd, Edward J., Wong, Margaret G., Pitt, Will R., Gancia, Emanuela, Manallack, David T.
Published in Quantitative structure-activity relationships (01.11.2002)
Published in Quantitative structure-activity relationships (01.11.2002)
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RORc 조절제로서의 피리다진 유도체
RENE OLIVIER, WARD STUART, FAUBER BENJAMIN, HURLEY CHRISTOPHER, KILLEN JONATHAN, CYR PATRICK, WINSHIP PAUL, LEE WENDY, VAN NIEL MONIQUE BODIL, GANCIA EMANUELA, CRIDLAND ANDREW, BRONNER SARAH M, CRAWFORD JAMES J, GOBBI ALBERTO, ZBIEG JASON
Year of Publication 21.06.2019
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Year of Publication 21.06.2019
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HPK1 억제제로서의 나프티리딘
CHAN BRYAN, WEI BINQING, LU AIJUN, WANG WEIRU, CARTWRIGHT MATTHEW W, LIANG JUN, HEFFRON TIMOTHY, FAVOR DAVID, DANIELS BLAKE, MADIN ANDREW, HU YONGHAN, MALHOTRA SUSHANT, ZHOU AIHE, GOOD ANDREW, TELLIS JOHN, DROBNICK JOY, SEWARD EILEEN, LAINCHBURY MICHAEL, HUESTIS MALCOLM, JONES GRAHAM, FONG KIN CHIU, SIU MICHAEL, RAJAPAKSA NAOMI, HU BAIHUA, GANCIA EMANUELA, MENDONCA ROHAN, STIVALA CRAIG, GAZZARD LEWIS
Year of Publication 09.12.2019
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Year of Publication 09.12.2019
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HPK1의 억제제인 이소퀴놀린
GOOD ANDREW, TELLIS JOHN, CHAN BRYAN, DROBNICK JOY, WEI BINQING, WANG WEIRU, SEWARD EILEEN, LAINCHBURY MICHAEL, CARTWRIGHT MATTHEW W, LIANG JUN, FONG KIN CHIU, HEFFRON TIMOTHY, FAVOR DAVID, RAJAPAKSA NAOMI, GANCIA EMANUELA, MENDONCA ROHAN, MADIN ANDREW, HU YONGHAN, MALHOTRA SUSHANT, STIVALA CRAIG, ZHOU AIHE, GAZZARD LEWIS
Year of Publication 05.12.2019
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Year of Publication 05.12.2019
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DIAZACARBAZOLES AND METHODS OF USE
GOODACRE SIMON CHARLES, GANCIA EMANUELA, MACLEOD CALUM, LYSSIKATOS JOSEPH P, CHEN HUIFEN, DYKE HAZEL JOAN, WILLIAMS KAREN, GAZZARD LEWIS J
Year of Publication 28.06.2016
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Year of Publication 28.06.2016
Patent