Loading…
Loading…
Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin
Wu, Meng-Ju, Chen, Yu-Syuan, Kim, Mi Ran, Chang, Chao-Ching, Gampala, Silpa, Zhang, Yingsheng, Wang, Yueyang, Chang, Chih-Yu, Yang, Jer-Yen, Chang, Chun-Ju
Published in Cell metabolism (02.04.2019)
Published in Cell metabolism (02.04.2019)
Get full text
Journal Article
Loading…
Loading…
New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types
Gampala, Silpa, Moon, Hye-ran, Wireman, Randall, Peil, Jacqueline, Kiran, Sonia, Mitchell, Dana K., Brewster, Kylee, Mang, Henry, Masters, Andi, Bach, Christine, Smith-Kinnamen, Whitney, Doud, Emma H., Rai, Ratan, Mosley, Amber L., Quinney, Sara K., Clapp, D. Wade, Hamdouchi, Chafiq, Wikel, James, Zhang, Chi, Han, Bumsoo, Georgiadis, Millie M., Kelley, Mark R., Fishel, Melissa L.
Published in Pharmacological research (01.03.2024)
Published in Pharmacological research (01.03.2024)
Get full text
Journal Article
Loading…
Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target
Gampala, Silpa, Shah, Fenil, Lu, Xiaoyu, Moon, Hye-ran, Babb, Olivia, Umesh Ganesh, Nikkitha, Sandusky, George, Hulsey, Emily, Armstrong, Lee, Mosely, Amber L., Han, Bumsoo, Ivan, Mircea, Yeh, Jing-Ruey Joanna, Kelley, Mark R., Zhang, Chi, Fishel, Melissa L.
Published in Journal of experimental & clinical cancer research (10.08.2021)
Published in Journal of experimental & clinical cancer research (10.08.2021)
Get full text
Journal Article
Loading…
RelA Is an Essential Target for Enhancing Cellular Responses to the DNA Repair/Ref-1 Redox Signaling Protein and Restoring Perturbated Cellular Redox Homeostasis in Mouse PDAC Cells
Mijit, Mahmut, Wireman, Randall, Armstrong, Lee, Gampala, Silpa, Hassan, Zonera, Schneeweis, Christian, Schneider, Guenter, Zhang, Chi, Fishel, Melissa L., Kelley, Mark R.
Published in Frontiers in oncology (24.03.2022)
Published in Frontiers in oncology (24.03.2022)
Get full text
Journal Article
Loading…
Activation of AMPK sensitizes medulloblastoma to Vismodegib and overcomes Vismodegib‐resistance
Gampala, Silpa, Zhang, GuangJun, Chang, Chun Ju, Yang, Jer‐Yen
Published in FASEB bioAdvances (01.06.2021)
Published in FASEB bioAdvances (01.06.2021)
Get full text
Journal Article
Loading…
Activation of the integrated stress response (ISR) pathways in response to Ref-1 inhibition in human pancreatic cancer and its tumor microenvironment
Mijit, Mahmut, Boner, Megan, Cordova, Ricardo A., Gampala, Silpa, Kpenu, Eyram, Klunk, Angela J., Zhang, Chi, Kelley, MarK R., Staschke, Kirk A., Fishel, Melissa L.
Published in Frontiers in medicine (27.04.2023)
Published in Frontiers in medicine (27.04.2023)
Get full text
Journal Article
Loading…
A graph neural network model to estimate cell-wise metabolic flux using single-cell RNA-seq data
Alghamdi, Norah, Chang, Wennan, Dang, Pengtao, Lu, Xiaoyu, Wan, Changlin, Gampala, Silpa, Huang, Zhi, Wang, Jiashi, Ma, Qin, Zang, Yong, Fishel, Melissa, Cao, Sha, Zhang, Chi
Published in Genome research (01.10.2021)
Published in Genome research (01.10.2021)
Get full text
Journal Article
Loading…
ROS associated ER-stress and intracellular Cysteine 65 in Ref-1 is essential for Ref-1 redox function and transcriptional regulation in human PDAC cells
Maihemuti, Mijiti, Gampala, Silpa, Wireman, Randall, Kpenu, Eryam, Georgiadis, Millie, Fishel, Melissa, Kelley, Mark
Published in Free radical biology & medicine (01.11.2022)
Published in Free radical biology & medicine (01.11.2022)
Get full text
Journal Article
Loading…
Abstract 5376: Unraveling the metabolic Achilles' heel of pancreatic ductal adenocarcinoma: targeting ref-1 and beyond
Gampala, Silpa, Peil, Jacqueline, Hayati, Sanya, Kiran, Sonia, Cheng, Caleb, Potchanant, Elizabeth A., Lyssiotis, Costas, Zhang, Chi, Cao, Sha, Kelley, Mark R., Fishel, Melissa L.
Published in Cancer research (Chicago, Ill.) (21.04.2025)
Published in Cancer research (Chicago, Ill.) (21.04.2025)
Get full text
Journal Article
Loading…
Abstract 2475: Differential sensitivity of mouse PDAC KrasG12D cells to Ref-1/APE1 redox signalling inhibitors: Role of NFkB as a primary target of Ref-1/APE1 in Kras driven pancreatic ductal adenocarcinoma
Caston, Rachel A., Wireman, Randy, Armstrong, Lee, Gampala, Silpa, Babb, Olivia, Chowdhury, Nayela, Hassan, Zonera, Schneeweis, Christian, Schneider, Gunter, Fishel, Melissa L., Kelley, Mark R.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Get full text
Journal Article
Loading…
Abstract C028: Challenging PDAC adaptability: Uncovering therapeutic vulnerabilities in APE1 DNA repair mechanisms
Kpenu, Eyram K, Wireman, Randall, Mijiti, Mahmut, Gampala, Silpa, Fishel, Melissa L, Kelley, Mark R
Published in Cancer research (Chicago, Ill.) (15.09.2024)
Published in Cancer research (Chicago, Ill.) (15.09.2024)
Get full text
Journal Article
Loading…
Abstract PO025: Ref-1 redox function identified as mitochondrial metabolic regulator in pancreatic cancer cells but not in CAFs
Gampala, Silpa, Shah, Fenil, Lu, Xiaoyu, Moon, Hye-ran, Sandusky, George E., Hulsey, Emily, Mosley, Amber L., Han, Bamsoo, Zhang, Chi, Kelley, Mark R., Fishel, Melissa L.
Published in Cancer research (Chicago, Ill.) (01.03.2021)
Published in Cancer research (Chicago, Ill.) (01.03.2021)
Get full text
Journal Article
Loading…
DLK1 Distinguishes Subsets of NF1-Associated Malignant Peripheral Nerve Sheath Tumors with Divergent Molecular Signatures
Mitchell, Dana K., Brewster, Kylee, Makri, Stavriani C., Khan, Jaffar, Albright, Eric A., Horvai, Andrew, Mang, Henry, Lu, Qingbo, Dixon, Shelley A.H., White, Emily, Saadatzadeh, Mohammad Reza, Bijangi-Vishehsaraei, Khadijeh, Gampala, Silpa, Hickey, Brooke E., Leffew, Hannah, Li, Xiaohong, Jiang, Li, Ciesielski, Marisa D., Bessler, Waylan K., Collier, Christopher D., Cohen-Gadol, Aaron, Fishel, Melissa L., Pratilas, Christine A., Pollok, Karen E., Angus, Steven P., Rhodes, Steven, Clapp, Wade
Published in Clinical cancer research (15.05.2025)
Published in Clinical cancer research (15.05.2025)
Get full text
Journal Article
Loading…
Loading…
Abstract 1452: Deciphering mechanisms of Ref-1 signaling and its inhibition in aggressive tumor-stroma PDAC models
Gampala, Silpa, Chowdhury, Nayela, Babb, Olivia, Caston, Rachel A., Wireman, Randall S., Moon, Hye-ran, Sandusky, George, Hulsey, Emily, Han, Bumsoo, Georgiadis, Millie M., Quinney, Sara K., Masters, Andi R., Wikel, James H., Kelley, Mark R., Fishel, Melissa L.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Get full text
Journal Article
Loading…
Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours
Gampala, Silpa, Shah, Fenil, Zhang, Chi, Rhodes, Steven D., Babb, Olivia, Grimard, Michelle, Wireman, Randall S., Rad, Ellie, Calver, Brian, Bai, Ren-Yuan, Staedtke, Verena, Hulsey, Emily L., Saadatzadeh, M. Reza, Pollok, Karen E., Tong, Yan, Smith, Abbi E., Clapp, D. Wade, Tee, Andrew R., Kelley, Mark R., Fishel, Melissa L.
Published in British journal of cancer (27.04.2021)
Published in British journal of cancer (27.04.2021)
Get full text
Journal Article
Loading…
Correction: Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours
Gampala, Silpa, Shah, Fenil, Zhang, Chi, Rhodes, Steven D., Babb, Olivia, Grimard, Michelle, Wireman, Randall S., Rad, Ellie, Calver, Brian, Bai, Ren-Yuan, Staedtke, Verena, Hulsey, Emily L., Saadatzadeh, M. Reza, Pollok, Karen E., Tong, Yan, Smith, Abbi E., Clapp, D. Wade, Tee, Andrew R., Kelley, Mark R., Fishel, Melissa L.
Published in British journal of cancer (19.10.2022)
Published in British journal of cancer (19.10.2022)
Get full text
Journal Article
Loading…
Abstract C017: Signaling through Ref-1 and STAT3 in soft tissue sarcoma (MPNST) and the effects of perturbing this pathway on tumor cell survival and gene expression
Shah, Fenil, Babb, Olivia, Zhang, Chi, Gampala, Silpa, Zhang, Emily, Rhodes, Steven D, Tee, Andrew R., Calver, Brian, Rad, Ellie, Staedtke, Verena, Pollok, Karen E, Clapp, D. Wade, Kelley, Mark R., Fishel, Melissa L.
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
Get full text
Journal Article