Therapeutic Manipulation of mtDNA Heteroplasmy: A Shifting Perspective
Jackson, Christopher B., Turnbull, Doug M., Minczuk, Michal, Gammage, Payam A.
Published in Trends in molecular medicine (01.07.2020)
Published in Trends in molecular medicine (01.07.2020)
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Journal Article
Linear mitochondrial DNA is rapidly degraded by components of the replication machinery
Peeva, Viktoriya, Blei, Daniel, Trombly, Genevieve, Corsi, Sarah, Szukszto, Maciej J, Rebelo-Guiomar, Pedro, Gammage, Payam A, Kudin, Alexei P, Becker, Christian, Altmüller, Janine, Minczuk, Michal, Zsurka, Gábor, Kunz, Wolfram S
Published in Nature communications (30.04.2018)
Published in Nature communications (30.04.2018)
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Journal Article
Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large‐scale deletions or point mutations
Gammage, Payam A, Rorbach, Joanna, Vincent, Anna I, Rebar, Edward J, Minczuk, Michal
Published in EMBO molecular medicine (01.04.2014)
Published in EMBO molecular medicine (01.04.2014)
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Journal Article
MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome
Rorbach, Joanna, Boesch, Pierre, Gammage, Payam A, Nicholls, Thomas J J, Pearce, Sarah F, Patel, Dipali, Hauser, Andreas, Perocchi, Fabiana, Minczuk, Michal
Published in Molecular biology of the cell (01.09.2014)
Published in Molecular biology of the cell (01.09.2014)
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Journal Article
Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila
Andreazza, Simonetta, Samstag, Colby L, Sanchez-Martinez, Alvaro, Fernandez-Vizarra, Erika, Gomez-Duran, Aurora, Lee, Juliette J, Tufi, Roberta, Hipp, Michael J, Schmidt, Elizabeth K, Nicholls, Thomas J, Gammage, Payam A, Chinnery, Patrick F, Minczuk, Michal, Pallanck, Leo J, Kennedy, Scott R, Whitworth, Alexander J
Published in Nature communications (23.07.2019)
Published in Nature communications (23.07.2019)
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Journal Article
Alternative translation initiation augments the human mitochondrial proteome
Kazak, Lawrence, Reyes, Aurelio, Duncan, Anna L, Rorbach, Joanna, Wood, Stuart R, Brea-Calvo, Gloria, Gammage, Payam A, Robinson, Alan J, Minczuk, Michal, Holt, Ian J
Published in Nucleic acids research (01.02.2013)
Published in Nucleic acids research (01.02.2013)
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Journal Article
NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction
Gaude, Edoardo, Schmidt, Christina, Gammage, Payam A., Dugourd, Aurelien, Blacker, Thomas, Chew, Sew Peak, Saez-Rodriguez, Julio, O’Neill, John S., Szabadkai, Gyorgy, Minczuk, Michal, Frezza, Christian
Published in Molecular cell (15.02.2018)
Published in Molecular cell (15.02.2018)
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Journal Article
Mitochondrial DNA is a major source of driver mutations in cancer
Kim, Minsoo, Mahmood, Mahnoor, Reznik, Ed, Gammage, Payam A
Published in Trends in cancer (01.12.2022)
Published in Trends in cancer (01.12.2022)
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Journal Article
Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs
Gammage, Payam A, Gaude, Edoardo, Van Haute, Lindsey, Rebelo-Guiomar, Pedro, Jackson, Christopher B, Rorbach, Joanna, Pekalski, Marcin L, Robinson, Alan J, Charpentier, Marine, Concordet, Jean-Paul, Frezza, Christian, Minczuk, Michal
Published in Nucleic acids research (19.09.2016)
Published in Nucleic acids research (19.09.2016)
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Journal Article
Single-cell mtDNA dynamics in tumors is driven by coregulation of nuclear and mitochondrial genomes
Kim, Minsoo, Gorelick, Alexander N, Vàzquez-García, Ignacio, Williams, Marc J, Salehi, Sohrab, Shi, Hongyu, Weiner, Adam C, Ceglia, Nick, Funnell, Tyler, Park, Tricia, Boscenco, Sonia, O'Flanagan, Ciara H, Jiang, Hui, Grewal, Diljot, Tang, Cerise, Rusk, Nicole, Gammage, Payam A, McPherson, Andrew, Aparicio, Sam, Shah, Sohrab P, Reznik, Ed
Published in Nature genetics (01.05.2024)
Published in Nature genetics (01.05.2024)
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Journal Article
Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA
Gorelick, Alexander N, Kim, Minsoo, Chatila, Walid K, La, Konnor, Hakimi, A Ari, Berger, Michael F, Taylor, Barry S, Gammage, Payam A, Reznik, Ed
Published in Nature metabolism (01.04.2021)
Published in Nature metabolism (01.04.2021)
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Journal Article
Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo
Gammage, Payam A, Viscomi, Carlo, Simard, Marie-Lune, Costa, Ana S H, Gaude, Edoardo, Powell, Christopher A, Van Haute, Lindsey, McCann, Beverly J, Rebelo-Guiomar, Pedro, Cerutti, Raffaele, Zhang, Lei, Rebar, Edward J, Zeviani, Massimo, Frezza, Christian, Stewart, James B, Minczuk, Michal
Published in Nature medicine (01.11.2018)
Published in Nature medicine (01.11.2018)
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Journal Article