Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis
Desmet, Christophe J., Gallenne, Tristan, Prieur, Alexandre, Reyal, Fabien, Visser, Nils L., Wittner, Ben S., Smit, Marjon A., Geiger, Thomas R., Laoukili, Jamila, Iskit, Sedef, Rodenko, Boris, Zwart, Wilbert, Evers, Bastiaan, Horlings, Hugo, Ajouaou, Abderrahrim, Zevenhoven, John, van Vliet, Martin, Ramaswamy, Sridhar, Wessels, Lodewyk F. A., Peeper, Daniel S.
Published in Proceedings of the National Academy of Sciences - PNAS (26.03.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (26.03.2013)
Get full text
Journal Article
Web Resource
Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members
Gallenne, Tristan, Gautier, Fabien, Oliver, Lisa, Hervouet, Eric, Noël, Belinda, Hickman, John A, Geneste, Olivier, Cartron, Pierre-François, Vallette, François M, Manon, Stephen, Juin, Philippe
Published in The Journal of cell biology (20.04.2009)
Published in The Journal of cell biology (20.04.2009)
Get full text
Journal Article
Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade
Geuijen, Cecile A.W., De Nardis, Camilla, Maussang, David, Rovers, Eric, Gallenne, Tristan, Hendriks, Linda J.A., Visser, Therese, Nijhuis, Roy, Logtenberg, Ton, de Kruif, John, Gros, Piet, Throsby, Mark
Published in Cancer cell (14.05.2018)
Published in Cancer cell (14.05.2018)
Get full text
Journal Article
Abstract 957: Zenocutuzumab: An antibody that can overcome HER3 mediated HRG signalling in tumor cells by docking on HER2
Geuijen, Cecile, Maussang-Detaille, David, Gallenne, Tristan, Hendriks, Linda, Kramer, Arjen, Gerlach, Jan, Throsby, Mark, de Kruif, John
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Get full text
Journal Article
Abstract 952: The bispecific antibody MCLA-129 impairs NSCLC tumor growth by targeting EGFR and c-MET, inhibiting ligand-induced signaling and promoting ADCC and ADCP
de Gorter, David J., Deshiere, Alexandre, van Rosmalen, Martijn, Wohn, Christian, Eppink, Berina, Gallenne, Tristan, Klooster, Rinse, Mao, Li, Xu, Wenxin, Deng, Liang, Shu, Qingyu, Liu, Wei, de Kruif, John, Matteo, Mario Di, Mazzone, Massimiliano, Throsby, Mark, Geuijen, Cecile A.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Get full text
Journal Article
Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade
Geuijen, Cecile A.W., De Nardis, Camilla, Maussang, David, Rovers, Eric, Gallenne, Tristan, Hendriks, Linda J.A., Visser, Therese, Nijhuis, Roy, Logtenberg, Ton, de Kruif, John, Gros, Piet, Throsby, Mark
Published in Cancer cell (09.08.2021)
Published in Cancer cell (09.08.2021)
Get full text
Journal Article
Abstract LB-C07: Preclinical evaluation of MCLA-129: A bispecific antibody targeting c-MET and EGFR
Geuijen, Cecile, Matteo, Mario di, Gallenne, Tristan, Cafarello, Sarah Trusso, Nijhuis, Roy, Visser, Therese, Bartelink, Willem, Bartelink-Clements, Carina, Eppink, Berina, Klooster, Rinse, dekruif, John, Mazzone, Massimiliano, Throsby, Mark
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
Get full text
Journal Article
Systematic functional perturbations uncover a prognostic genetic network driving human breast cancer
Gallenne, Tristan, Ross, Kenneth N, Visser, Nils L, Salony, Desmet, Christophe J, Wittner, Ben S, Wessels, Lodewyk F A, Ramaswamy, Sridhar, Peeper, Daniel S
Published in Oncotarget (15.03.2017)
Published in Oncotarget (15.03.2017)
Get full text
Journal Article
Web Resource
The First α Helix of Bax Plays a Necessary Role in Its Ligand-Induced Activation by the BH3-Only Proteins Bid and PUMA
Cartron, Pierre-François, Gallenne, Tristan, Bougras, Gwenola, Gautier, Fabien, Manero, Florence, Vusio, Patricia, Meflah, Khaled, Vallette, François M., Juin, Philippe
Published in Molecular cell (03.12.2004)
Published in Molecular cell (03.12.2004)
Get full text
Journal Article
EGFR, HER2 및 HER3에 결합하는 결합 모이어티들의 병용물
GALLENNE TRISTAN LOUIS JEAN, GEUIJEN CECILIA ANNA WILHELMINA, THROSBY MARK, DE KRUIF CORNELIS ADRIAAN
Year of Publication 20.10.2021
Get full text
Year of Publication 20.10.2021
Patent
Abstract 33: The binding mode of the bispecific anti-HER2xHER3 antibody MCLA-128 is responsible for its potent inhibition of HRG-driven tumorigenesis
Maussang-Detaille, David, Nardis, Camilla de, Hendriks, Linda, Bartelink-Clements, Carina, Rovers, Eric, Gallenne, Tristan, Doornbos, Robert, Bakker, Lex, Kruif, John de, Logtenberg, Ton, Gros, Piet, Geuijen, Cecile, Throsby, Mark
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Get full text
Journal Article
The small organic compound HA14-1 prevents Bcl-2 interaction with bax to sensitize malignant glioma cells to induction of cell death
MANERO, Florence, GAUTIER, Fabien, GALLENNE, Tristan, CAUQUIL, Nicolas, GREE, Danielle, CARTRON, Pierre-Francois, GENESTE, Olivier, GREE, René, VALLETTE, Francois M, JUIN, Philippe
Published in Cancer research (Chicago, Ill.) (01.03.2006)
Published in Cancer research (Chicago, Ill.) (01.03.2006)
Get full text
Journal Article
Abstract LB-261: Mechanism of action of MCLA-128, a humanized bispecific IgG1 antibody targeting the HER2:HER3 heterodimer
Geuijen, Cecile, Rovers, Eric, Gallenne, Tristan, Maussang-Detaille, David, Kramer, Arjen, Nieuwenhuizen, Nellie, Clements, Carina, van Zoest, Katinka, Nijhuis, Roy, Visser, Therese, Den Blanken-Smit, Renate, Bartelink, Willem, Zondag-van der Zande, Vanessa, Kaldenberg, Linda, van Loo, Pieter-Fokko, Roovers, Rob, Doornbos, Robert, Price, Leo, Braam, Stefan, van Driel, Setareh, Bakker, Lex, Logtenberg, Ton, de Kruif, John, Throsby, Mark
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Get full text
Journal Article
Preclinical activity of MCLA-128, an ADCC enhanced bispecific IgG1 antibody targeting the HER2:HER3 heterodimer
Geuijen, Cecile, Rovers, Eric, Nijhuis, Roy, den Blanken-Smit, Renate, Visser, Therese, Bartelink, Willem, Kramer, Arjen, Zondag-van der Zande, Vanessa, Clements, Carina, Kaldenberg, Linda, Nieuwenhuizen, Nellie, van Loo, Pieter Fokko, Roovers, Rob, Gallenne, Tristan, Price, Leo, Van Driel Shamsili, Setareh, Bakker, Lex, Logtenberg, Ton, de Kruif, John, Throsby, Mark
Published in Journal of clinical oncology (20.05.2014)
Published in Journal of clinical oncology (20.05.2014)
Get full text
Journal Article
Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members
Gallenne, Tristan, Gautier, Fabien, Oliver, Lisa, Hervouet, Eric, Noël, Belinda, Hickman, John A., Geneste, Olivier, Cartron, Pierre-François, Vallette, François M., Manon, Stephen, Juin, Philippe
Published in The Journal of experimental medicine (11.05.2009)
Published in The Journal of experimental medicine (11.05.2009)
Get full text
Journal Article
COMBINATIONS OF BINDING MOIETIES THAT BIND EGFR, HER2 AND HER3
GALLENNE, Tristan Louis Jean, THROSBY, Mark, GEUIJEN, Cecilia Anna Wilhelmina, DE KRUIF, Cornelis Adriaan
Year of Publication 28.04.2022
Get full text
Year of Publication 28.04.2022
Patent
COMBINATIONS OF BINDING MOIETIES THAT BIND EGFR, HER2 AND HER3
GALLENNE, Tristan Louis Jean, THROSBY, Mark, GEUIJEN, Cecilia Anna Wilhelmina, DE KRUIF, Cornelis Adriaan
Year of Publication 22.12.2021
Get full text
Year of Publication 22.12.2021
Patent
COMBINAISONS DE FRACTIONS DE LIAISON SE LIANT À EGFR, HER2 ET HER3
GALLENNE, Tristan Louis Jean, THROSBY, Mark, GEUIJEN, Cecilia Anna Wilhelmina, DE KRUIF, Cornelis Adriaan
Year of Publication 22.12.2021
Get full text
Year of Publication 22.12.2021
Patent
COMBINATIONS OF BINDING MOIETIES THAT BIND EGFR, HER2 AND HER3
GALLENNE, Tristan Louis Jean, THROSBY, Mark, GEUIJEN, Cecilia Anna Wilhelmina, DE KRUIF, Cornelis Adriaan
Year of Publication 29.09.2021
Get full text
Year of Publication 29.09.2021
Patent
Combinations of binding moieties that bind EGFR, HER2 and HER3
GALLENNE, Tristan Louis Jean, THROSBY, Mark, GEUIJEN, Cecilia Anna Wilhelmina, DE KRUIF, Cornelis Adriaan
Year of Publication 02.09.2021
Get full text
Year of Publication 02.09.2021
Patent