Lipophilic Efficiency as an Important Metric in Drug Design
Johnson, Ted W, Gallego, Rebecca A, Edwards, Martin P
Published in Journal of medicinal chemistry (09.08.2018)
Published in Journal of medicinal chemistry (09.08.2018)
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An update on lipophilic efficiency as an important metric in drug design
Gallego, Rebecca A, Edwards, Martin P, Montgomery, T Patrick
Published in Expert opinion on drug discovery (02.08.2024)
Published in Expert opinion on drug discovery (02.08.2024)
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Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation
Johnson, Eric, McTigue, Michele, Gallego, Rebecca A., Johnson, Ted W., Timofeevski, Sergei, Maestre, Michael, Fisher, Timothy S., Kania, Robert, Sawasdikosol, Sansana, Burakoff, Steven, Cronin, Ciarán N.
Published in The Journal of biological chemistry (07.06.2019)
Published in The Journal of biological chemistry (07.06.2019)
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Design and Synthesis of Functionally Active 5‑Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1
Gallego, Rebecca A., Bernier, Louise, Chen, Hui, Cho-Schultz, Sujin, Chung, Loanne, Collins, Michael, Del Bel, Matthew, Elleraas, Jeff, Costa Jones, Cinthia, Cronin, Ciaran N., Edwards, Martin, Fang, Xu, Fisher, Timothy, He, Mingying, Hoffman, Jacqui, Huo, Ruiduan, Jalaie, Mehran, Johnson, Eric, Johnson, Ted W., Kania, Robert S., Kraus, Manfred, Lafontaine, Jennifer, Le, Phuong, Liu, Tongnan, Maestre, Michael, Matthews, Jean, McTigue, Michele, Miller, Nichol, Mu, Qiming, Qin, Xulong, Ren, Shijian, Richardson, Paul, Rohner, Allison, Sach, Neal, Shao, Li, Smith, Graham, Su, Ruirui, Sun, Bin, Timofeevski, Sergei, Tran, Phuong, Wang, Shuiwang, Wang, Wei, Zhou, Ru, Zhu, Jinjiang, Nair, Sajiv K.
Published in Journal of medicinal chemistry (13.04.2023)
Published in Journal of medicinal chemistry (13.04.2023)
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Discovery of Highly Selective Inhibitors of Microtubule-Associated Serine/Threonine Kinase-like (MASTL)
Gallego, Rebecca A., Scales, Stephanie, Toledo, Chad, Auth, Marin, Bernier, Louise, Berry, Madeline, Brun, Sonja, Chung, Loanne, Davis, Carl, Diehl, Wade, Dress, Klaus, Eisele, Koleen, Elleraas, Jeff, Ewanicki, Jason, Fobian, Yvette, Greasley, Samantha, Greenwald, Eric C., Johnson, Ted W., Khamphavong, Penney, Lafontaine, Jennifer, Li, Jian, Linton, Angelica, Maestre, Michael, Miller, Nichol, Murtaza, Anwar, Patman, Ryan L., Quinlan, Casey L., Ramms, Dana J., Richardson, Paul, Sach, Neal, Salomon-Ferrer, Romelia, Silva, Francisco, Timofeevski, Sergei, Tran, Phuong, Tran-Dubé, Michelle, Wang, Fen, Wang, Wei, Wythes, Martin, Yang, Shouliang, Zou, Aihua, VanArsdale, Todd, McAlpine, Indrawan
Published in Journal of medicinal chemistry (14.11.2024)
Published in Journal of medicinal chemistry (14.11.2024)
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Reviving B‑Factors: Retrospective Normalized B‑Factor Analysis of c‑ros Oncogene 1 Receptor Tyrosine Kinase and Anaplastic Lymphoma Kinase L1196M with Crizotinib and Lorlatinib
Johnson, Ted W, Gallego, Rebecca A, Brooun, Alexei, Gehlhaar, Dan, McTigue, Michele
Published in ACS medicinal chemistry letters (13.09.2018)
Published in ACS medicinal chemistry letters (13.09.2018)
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Reviving B‑Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase
Johnson, Ted W, Bolanos, Ben, Brooun, Alexei, Gallego, Rebecca A, Gehlhaar, Dan, Jalaie, Mehran, McTigue, Michele, Timofeevski, Sergei
Published in ACS medicinal chemistry letters (13.09.2018)
Published in ACS medicinal chemistry letters (13.09.2018)
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Journal Article
Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase
Johnson, Ted W., Bolanos, Ben, Brooun, Alexei, Gallego, Rebecca A., Gehlhaar, Dan, Jalaie, Mehran, McTigue, Michele, Timofeevski, Sergei
Published in ACS medicinal chemistry letters (09.08.2019)
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Published in ACS medicinal chemistry letters (09.08.2019)
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Abstract 5903: MASTL small-molecule inhibition to target mitosis for cancer therapy
Toledo, Chad M., Eisele, Koleen J., Kim, Dong Hyun, Mu, Xinmeng, Brun, Sonja, Davis, Carl, Greenwald, Eric C., Hui, Fion, He, Meilan, Yang, Yanling, Flores-Bojorquez, Ana, Li, Yuxin, Khamphavong, Penney L., Lee, Joseph H., Li, Jian, Ramms, Dana J., Jones, Greg, Auth, Marin, Painter, Cory L., Nager, Andrew, Oyer, Jon, Timofeevski, Sergei L., Pierceall, William E., Murtaza, Anwar, Heyen, Jonathan R., Gallego, Rebecca, Quinlan, Casey, McAlpine, Indrawan, VanArsdale, Todd L.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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HPK1 억제제로서의 아잘락탐 화합물
JALAIE MEHRAN, TUTTLE JAMISON BRYCE, ZHOU RU, GALLEGO REBECCA ANNE, BARBER JOYANN, DEL BEL MATTHEW L, SCHMITT ANNE MARIE DECHERT, KANIA ROBERT STEVEN, NAIR SAJIV KRISHNAN, HE MINGYING, CHO SCHULTZ SUJIN, MCTIGUE MICHELE ANN, ZHOU DAHUI
Year of Publication 05.01.2023
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Year of Publication 05.01.2023
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암의 치료를 위한 HPK1 억제제로서의 2,3-디히드로-1H-피롤로[3,4-C]피리딘-1-온 유도체
TUTTLE JAMISON BRYCE, JALAIE MEHRAN, ZHOU RU, GALLEGO REBECCA ANNE, AHMAD OMAR KHALED, DEL BEL MATTHEW L, SCHMITT ANNE MARIE DECHERT, KANIA ROBERT STEVEN, NAIR SAJIV KRISHNAN, HE MINGYING, JOHNSON TED WILLIAM, MCTIGUE MICHELE ANN, ZHOU DAHUI
Year of Publication 20.07.2021
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Year of Publication 20.07.2021
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Azalactam Compounds as HPK1 Inhibitors
Zhou, Ru, Zhou, Dahui, Gallego, Rebecca Anne, Del Bel, Matthew L, He, Mingying, Barber, Joyann, Tuttle, Jamison Bryce, Jalaie, Mehran, Nair, Sajiv Krishnan, Schmitt, Anne-Marie Dechert, Kania, Robert Steven, Cho-Schultz, Sujin, McTigue, Michele Ann
Year of Publication 20.06.2024
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Year of Publication 20.06.2024
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Azalactam compounds as HPK1 inhibitors
JALAIE, Mehran, ZHOU, Ru, BARBER, Joyann, MCTIGUE, Michele Ann, TUTTLE, Jamison Bryce, NAIR, Sajiv Krishnan, ZHOU, Dahui, SCHMITT, Anne-Marie Dechert, CHO-SCHULTZ, Sujin, HE, Mingying, DEL BEL, Matthew L, GALLEGO, Rebecca Anne, KANIA, Robert Steven
Year of Publication 28.03.2024
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Year of Publication 28.03.2024
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2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER
JALAIE, Mehran, ZHOU, Ru, TUTTLE, Jamison Bryce, MCTIGUE, Michele Ann, NAIR, Sajiv Krishnan, ZHOU, Dahui, SCHMITT, Anne-Marie Dechert, AHMAD, Omar Khaled, JOHNSON, Ted William, HE, Mingying, DEL BEL, Matthew L, GALLEGO, Rebecca Anne, KANIA, Robert Steven
Year of Publication 28.01.2024
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Year of Publication 28.01.2024
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2,7-NAPHTHYRIDINE COMPOUNDS AS MASTL INHIBITORS
MCALPINE, Indrawan James, BERRY, Madeline, WANG, Fen, YANG, Shouliang, SALOMON FERRER, Romelia Del Carmen, JOHNSON, Ted William, SCALES, Stephanie Anne, TRAN-DUBÉ, Michelle Bich, PATMAN, Ryan Lloyd, DRESS, Klaus Ruprecht, GALLEGO, Rebecca Anne, GREASLEY, Samantha Elizabeth
Year of Publication 04.01.2024
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Year of Publication 04.01.2024
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2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER
Zhou, Ru, Zhou, Dahui, Gallego, Rebecca Anne, Del Bel, Matthew L, He, Mingying, Ahmad, Omar Khaled, Tuttle, Jamison Bryce, Johnson, Ted William, Mctigue, Michele Ann, Nair, Sajiv Krishnan, Jalaie, Mehran, Schmitt, Anne-Marie Dechert, Kania, Robert Steven
Year of Publication 22.12.2023
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Year of Publication 22.12.2023
Patent
2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER
HE, MINGYING, KANIA, ROBERT STEVEN, MCTIGUE, MICHELE ANN, ZHOU, DAHUI, DEL BEL, MATTHEW L, AHMAD, OMAR KHALED, SCHMITT, ANNE-MARIE DECHERT, TUTTLE, JAMISON BRYCE, JALAIE, MEHRAN, GALLEGO, REBECCA ANNE, ZHOU, RU, NAIR, SAJIV KRISHNAN, JOHNSON, TED WILLIAM
Year of Publication 11.12.2023
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Year of Publication 11.12.2023
Patent
2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER
JALAIE, Mehran, ZHOU, Ru, TUTTLE, Jamison Bryce, MCTIGUE, Michele Ann, NAIR, Sajiv Krishnan, ZHOU, Dahui, SCHMITT, Anne-Marie Dechert, AHMAD, Omar Khaled, JOHNSON, Ted William, HE, Mingying, DEL BEL, Matthew L, GALLEGO, Rebecca Anne, KANIA, Robert Steven
Year of Publication 29.11.2023
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Year of Publication 29.11.2023
Patent
2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER
KANIA, ROBERT, STEVEN, HE, MINGYING, ZHOU, DAHUI, TUTTLE, JAMISON, BRYCE, GALLEGO, REBECCA, ANNE, JALAIE, MEHRAN, NAIR, SAJIV, KRISHNAN, ZHOU, RU, JOHNSON, TED, WILLIAM, SCHMITT, ANNE-MARIE, DECHERT, AHMAD, OMAR, KHALED, DEL, BEL, MATTHEW, L, MCTIGUE, MICHELE, ANN
Year of Publication 31.10.2023
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Year of Publication 31.10.2023
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2,3-DIHYDRO-1H-PYRROLO(3,4-C)PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER
NAIR Sajiv Krishnan, KANIA Robert Steven, HE Mingying, SCHMITT Anne-Marie Dechert, ZHOU Dahui, AHMAD Omar Khaled, JALAIE Mehran, TUTTLE Jamison Bryce, ZHOU Ru, MCTIGUE Michele Ann, DEL BEL Matthew L, JOHNSON Ted William, GALLEGO Rebecca Anne
Year of Publication 30.10.2023
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Year of Publication 30.10.2023
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