Tools, techniques, organisation and culture of the CADD group at Sygnature Discovery
St-Gallay, Steve A., Sambrook-Smith, Colin P.
Published in Journal of computer-aided molecular design (01.03.2017)
Published in Journal of computer-aided molecular design (01.03.2017)
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Journal Article
Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3
Boyd, Scott, Brookfield, Joanna L, Critchlow, Susan E, Cumming, Iain A, Curtis, Nicola J, Debreczeni, Judit, Degorce, Sébastien L, Donald, Craig, Evans, Nicola J, Groombridge, Sam, Hopcroft, Philip, Jones, Neil P, Kettle, Jason G, Lamont, Scott, Lewis, Hilary J, MacFaull, Philip, McLoughlin, Sheila B, Rigoreau, Laurent J. M, Smith, James M, St-Gallay, Steve, Stock, Julie K, Turnbull, Andrew P, Wheatley, Edward R, Winter, Jon, Wingfield, Jonathan
Published in Journal of medicinal chemistry (23.04.2015)
Published in Journal of medicinal chemistry (23.04.2015)
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Journal Article
The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)
Cheshire, David R., Åberg, Anders, Andersson, Gunilla M.K., Andrews, Glen, Beaton, Haydn G., Birkinshaw, Timothy N., Boughton-Smith, Nigel, Connolly, Stephen, Cook, Tony R., Cooper, Anne, Cooper, Sally L., Cox, David, Dixon, John, Gensmantel, Nigel, Hamley, Peter J., Harrison, Richard, Hartopp, Paul, Käck, Helena, Leeson, Paul D., Luker, Timothy, Mete, Antonio, Millichip, Ian, Nicholls, David J., Pimm, Austen D., St-Gallay, Steve A., Wallace, Alan V.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Journal Article
Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors
Baxter, Andrew, Brough, Steve, Cooper, Anne, Floettmann, Eike, Foster, Steve, Harding, Christine, Kettle, Jason, McInally, Tom, Martin, Craig, Mobbs, Michelle, Needham, Maurice, Newham, Pete, Paine, Stuart, St-Gallay, Steve, Salter, Sylvia, Unitt, John, Xue, Yafeng
Published in Bioorganic & medicinal chemistry letters (07.06.2004)
Published in Bioorganic & medicinal chemistry letters (07.06.2004)
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Journal Article
ChemInform Abstract: An Efficient One-Pot Synthesis of 2-Bromo-6-aryl[5H]pyrrolo[2,3-b]pyrazines
Simpson, Iain, St-Gallay, Steve A., Stokes, Stephen, Whittaker, David T. E., Wiewiora, Rafal
Published in ChemInform (01.07.2015)
Published in ChemInform (01.07.2015)
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Journal Article
Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point
Ward, Richard A, Bethel, Paul, Cook, Calum, Davies, Emma, Debreczeni, Judit E, Fairley, Gary, Feron, Lyman, Flemington, Vikki, Graham, Mark A, Greenwood, Ryan, Griffin, Nicola, Hanson, Lyndsey, Hopcroft, Philip, Howard, Tina D, Hudson, Julian, James, Michael, Jones, Clifford D, Jones, Christopher R, Lamont, Scott, Lewis, Richard, Lindsay, Nicola, Roberts, Karen, Simpson, Iain, St-Gallay, Steve, Swallow, Steve, Tang, Jia, Tonge, Michael, Wang, Zhenhua, Zhai, Baochang
Published in Journal of medicinal chemistry (27.04.2017)
Published in Journal of medicinal chemistry (27.04.2017)
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Journal Article
RIPK1 NICOTINAMIDE RIPK1 INHIBITORS
HOEMANN MICHAEL ZELLER, OSMAN SAMI, ARGIRIADI MARIA ANASTASIA, STAMBULI JAMES PATRICK, KINSMAN DAVID ANDREW, CUSACK KEVIN PATRICK, FORDYCE EUAN, ST. GALLAY STEVE, O'REILLY CIARAN, DEXTER HANNAH
Year of Publication 10.09.2024
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Year of Publication 10.09.2024
Patent
A novel point-of-care diagnostic prototype system for the simultaneous electrochemiluminescent sensing of multiple traumatic brain injury biomarkers
Jovi, Milica, Prim, Denis, Righini, Ophélie, Tagan, David, Stäuble, Mélanie, Pignat, Marc, Gallay, Steve, Geiser, Martial, Pfeifer, Marc E
Published in Sensors & diagnostics (17.07.2023)
Published in Sensors & diagnostics (17.07.2023)
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Journal Article
니코틴아미드 RIPK1 억제제
HOEMANN MICHAEL ZELLER, OSMAN SAMI, ARGIRIADI MARIA ANASTASIA, STAMBULI JAMES PATRICK, KINSMAN DAVID ANDREW, CUSACK KEVIN PATRICK, FORDYCE EUAN, ST. GALLAY STEVE, O'REILLY CIARAN, DEXTER HANNAH
Year of Publication 30.11.2023
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Year of Publication 30.11.2023
Patent
Abstract 1647: Discovery of AZD0364, a potent and selective oral inhibitor of ERK1/2 that is efficacious in both monotherapy and combination therapy in models of NSCLC
Simpson, Iain, Anderton, Mark J., Andrews, David M., Breed, Jason, Davies, Emma, Debreczeni, Judit E., Flemington, Vikki, Gibbons, Francis D., Graham, Mark A., Hopcroft, Philip, Howard, Tina, Hudson, Julian, Jones, Clifford D., Jones, Christopher, Lindsay, Nicola, Pease, J Elizabeth, Rawlins, Philip, Roberts, Karen, Swallow, Steve, St-Gallay, Steve, Tonge, Michael E., Ward, Richard A.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
A signalome screening approach in the autoinflammatory disease TNF receptor associated periodic syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing
Todd, Ian, Negm, Ola H., Reps, Jenna, Radford, Paul, Figueredo, Grazziela, McDermott, Elizabeth M., Drewe, Elizabeth, Powell, Richard J., Bainbridge, Susan, Hamed, Mohamed, Crouch, Sharon, Garibaldi, Jon, St-Gallay, Steve, Fairclough, Lucy C., Tighe, Patrick J.
Published in Pharmacological research (01.11.2017)
Published in Pharmacological research (01.11.2017)
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Journal Article
An efficient one-pot synthesis of 2-bromo-6-aryl[5H]pyrrolo[2,3-b]pyrazines
Simpson, Iain, St-Gallay, Steve A., Stokes, Stephen, Whittaker, David T.E., Wiewiora, Rafal
Published in Tetrahedron letters (18.03.2015)
Published in Tetrahedron letters (18.03.2015)
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Journal Article
Structure-driven HtL: Design and synthesis of novel aminoindazole inhibitors of c-Jun N-terminal kinase activity
Stocks, Michael J., Barber, Simon, Ford, Rhonan, Leroux, Frederic, St-Gallay, Steve, Teague, Simon, Xue, Yafeng
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
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Journal Article
NICOTINAMIDE RIPK1 INHIBITORS
CUSACK, Kevin Patrick, HOEMANN, Michael Zeller, OSMAN, Sami, ARGIRIADI, Maria Anastasia, FORDYCE, Euan, KINSMAN, David Andrew, STAMBULI, James Patrick, O'REILLY, Ciaran, ST. GALLAY, Steve, DEXTER, Hannah
Year of Publication 28.08.2024
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Year of Publication 28.08.2024
Patent
Nicotinamide ripk1 inhibitors
ST. GALLAY Steve, FORDYCE Euan, O'REILLY Ciaran, OSMAN Sami, CUSACK Kevin Patrick, HOEMANN Michael Zeller, KINSMAN David Andrew, ARGIRIADI Maria Anastasia, DEXTER Hannah, STAMBULI James Patrick
Year of Publication 01.01.2024
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Year of Publication 01.01.2024
Patent
NICOTINAMIDE RIPK1 INHIBITORS
KINSMAN, David, HOEMANN, Michael, CUSACK, Kevin, OSMAN, Sami, FORDYCE, Euan, O'REILLY, Ciaran, ARGIRIADI, Maria, ST. GALLAY, Steve, DEXTER, Hannah, STAMBULI, James
Year of Publication 30.11.2023
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Year of Publication 30.11.2023
Patent
Nicotinamide RIPK1 inhibitors
Argiriadi, Maria Anastasia, O'Reilly, Ciaran, Cusack, Kevin Patrick, Dexter, Hannah, Hoemann, Michael Zeller, Fordyce, Euan, Osman, Sami, Kinsman, David Andrew, St. Gallay, Steve, Stambuli, James Patrick
Year of Publication 26.09.2023
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Year of Publication 26.09.2023
Patent
NICOTINAMIDE RIPK1 INHIBITORS
Argiriadi, Maria Anastasia, O'Reilly, Ciaran, Cusack, Kevin Patrick, Dexter, Hannah, Hoemann, Michael Zeller, Fordyce, Euan, Osman, Sami, Kinsman, David Andrew, St. Gallay, Steve, Stambuli, James Patrick
Year of Publication 27.04.2023
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Year of Publication 27.04.2023
Patent