Fenfluramine for Treatment-Resistant Seizures in Patients With Dravet Syndrome Receiving Stiripentol-Inclusive Regimens: A Randomized Clinical Trial
Nabbout, Rima, Mistry, Arun, Zuberi, Sameer, Villeneuve, Nathalie, Gil-Nagel, Antonio, Sanchez-Carpintero, Rocio, Stephani, Ulrich, Laux, Linda, Wirrell, Elaine, Knupp, Kelly, Chiron, Catherine, Farfel, Gail, Galer, Bradley S, Morrison, Glenn, Lock, Michael, Agarwal, Anupam, Auvin, Stéphane
Published in Archives of neurology (Chicago) (01.03.2020)
Published in Archives of neurology (Chicago) (01.03.2020)
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Journal Article
Fenfluramine in the treatment of Dravet syndrome: Results of a third randomized, placebo-controlled clinical trial
Sullivan, Joseph, Lagae, Lieven, Cross, J Helen, Devinsky, Orrin, Guerrini, Renzo, Knupp, Kelly G, Laux, Linda, Nikanorova, Marina, Polster, Tilman, Talwar, Dinesh, Ceulemans, Berten, Nabbout, Rima, Farfel, Gail M, Galer, Bradley S, Gammaitoni, Arnold R, Lock, Michael, Agarwal, Anupam, Scheffer, Ingrid E
Published in Epilepsia (Copenhagen) (01.10.2023)
Published in Epilepsia (Copenhagen) (01.10.2023)
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Journal Article
A pilot, open‐label study of the effectiveness and tolerability of low‐dose ZX008 (fenfluramine HCl) in Lennox‐Gastaut syndrome
Lagae, Lieven, Schoonjans, An‐Sofie, Gammaitoni, Arnold R., Galer, Bradley S., Ceulemans, Berten
Published in Epilepsia (Copenhagen) (01.10.2018)
Published in Epilepsia (Copenhagen) (01.10.2018)
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Journal Article
Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial
Lagae, Lieven, Sullivan, Joseph, Knupp, Kelly, Laux, Linda, Polster, Tilman, Nikanorova, Marina, Devinsky, Orrin, Cross, J Helen, Guerrini, Renzo, Talwar, Dinesh, Miller, Ian, Farfel, Gail, Galer, Bradley S, Gammaitoni, Arnold, Mistry, Arun, Morrison, Glenn, Lock, Michael, Agarwal, Anupam, Lai, Wyman W, Ceulemans, Berten
Published in The Lancet (British edition) (21.12.2019)
Published in The Lancet (British edition) (21.12.2019)
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A phase I, randomized, open-label, single-dose, 3-period crossover study to evaluate the drug-drug interaction between ZX008 (fenfluramine HCl oral solution) and a regimen of stiripentol, clobazam, and valproate in healthy subjects
Boyd, Brooks, Smith, Steven, Gammaitoni, Arnold, Galer, Bradley S, Farfel, Gail M
Published in International journal of clinical pharmacology and therapeutics (01.01.2019)
Published in International journal of clinical pharmacology and therapeutics (01.01.2019)
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Journal Article
Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome: A Randomized Clinical Trial
Knupp, Kelly G, Scheffer, Ingrid E, Ceulemans, Berten, Sullivan, Joseph E, Nickels, Katherine C, Lagae, Lieven, Guerrini, Renzo, Zuberi, Sameer M, Nabbout, Rima, Riney, Kate, Shore, Svetlana, Agarwal, Anupam, Lock, Michael, Farfel, Gail M, Galer, Bradley S, Gammaitoni, Arnold R, Davis, Ronald, Gil-Nagel, Antonio
Published in Archives of neurology (Chicago) (01.06.2022)
Published in Archives of neurology (Chicago) (01.06.2022)
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Journal Article
Cardiovascular safety of fenfluramine in the treatment of Dravet syndrome: Analysis of an ongoing long‐term open‐label safety extension study
Lai, Wyman W., Galer, Bradley S., Wong, Pierre C., Farfel, Gail, Pringsheim, Milka, Keane, Martin G., Agarwal, Anupam
Published in Epilepsia (Copenhagen) (01.11.2020)
Published in Epilepsia (Copenhagen) (01.11.2020)
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Journal Article
An Emerging Role for Sigma-1 Receptors in the Treatment of Developmental and Epileptic Encephalopathies
Martin, Parthena, Reeder, Thadd, Sourbron, Jo, de Witte, Peter A M, Gammaitoni, Arnold R, Galer, Bradley S
Published in International journal of molecular sciences (05.08.2021)
Published in International journal of molecular sciences (05.08.2021)
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Journal Article
Fenfluramine significantly reduces day‐to‐day seizure burden by increasing number of seizure‐free days and time between seizures in patients with Dravet syndrome: A time‐to‐event analysis
Sullivan, Joseph, Specchio, Nicola, Devinsky, Orrin, Auvin, Stéphane, Perry, M. Scott, Strzelczyk, Adam, Gil‐Nagel, Antonio, Dai, David, Galer, Bradley S., Gammaitoni, Arnold R.
Published in Epilepsia (Copenhagen) (01.01.2022)
Published in Epilepsia (Copenhagen) (01.01.2022)
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Journal Article
Impact of fenfluramine on the expected SUDEP mortality rates in patients with Dravet syndrome
Cross, J. Helen, Galer, Bradley S., Gil-Nagel, Antonio, Devinsky, Orrin, Ceulemans, Berten, Lagae, Lieven, Schoonjans, An-Sofie, Donner, Elizabeth, Wirrell, Elaine, Kothare, Sanjeev, Agarwal, Anupam, Lock, Michael, Gammaitoni, Arnold R.
Published in Seizure (London, England) (01.12.2021)
Published in Seizure (London, England) (01.12.2021)
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Journal Article
Improved everyday executive functioning following profound reduction in seizure frequency with fenfluramine: Analysis from a phase 3 long-term extension study in children/young adults with Dravet syndrome
Bishop, Kim I., Isquith, Peter K., Gioia, Gerard A., Gammaitoni, Arnold R., Farfel, Gail, Galer, Bradley S., Nabbout, Rima, Wirrell, Elaine C., Polster, Tilman, Sullivan, Joseph
Published in Epilepsy & behavior (01.08.2021)
Published in Epilepsy & behavior (01.08.2021)
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Journal Article
Fenfluramine treatment is associated with improvement in everyday executive function in preschool-aged children (<5 years) with Dravet syndrome: A critical period for early neurodevelopment
Bishop, Kim I., Isquith, Peter K., Gioia, Gerard A., Knupp, Kelly G., Scheffer, Ingrid E., Nabbout, Rima, Specchio, Nicola, Sullivan, Joseph, Auvin, Stéphane, Helen Cross, J., Guerrini, Renzo, Farfel, Gail, Galer, Bradley S., Gammaitoni, Arnold R.
Published in Epilepsy & behavior (01.01.2023)
Published in Epilepsy & behavior (01.01.2023)
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Journal Article
Fenfluramine provides clinically meaningful reduction in frequency of drop seizures in patients with Lennox–Gastaut syndrome: Interim analysis of an open‐label extension study
Knupp, Kelly G., Scheffer, Ingrid E., Ceulemans, Berten, Sullivan, Joseph, Nickels, Katherine C., Lagae, Lieven, Guerrini, Renzo, Zuberi, Sameer M., Nabbout, Rima, Riney, Kate, Agarwal, Anupam, Lock, Michael, Dai, David, Farfel, Gail M., Galer, Bradley S., Gammaitoni, Arnold R., Polega, Shikha, Davis, Ronald, Gil‐Nagel, Antonio
Published in Epilepsia (Copenhagen) (01.01.2023)
Published in Epilepsia (Copenhagen) (01.01.2023)
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Journal Article
Life impact of caregiving for severe childhood epilepsy: Results of expert panels and caregiver focus groups
Jensen, Mark P., Liljenquist, Kendra S., Bocell, Fraser, Gammaitoni, Arnold R., Aron, Carey R., Galer, Bradley S., Amtmann, Dagmar
Published in Epilepsy & behavior (01.09.2017)
Published in Epilepsy & behavior (01.09.2017)
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Journal Article
The impact of TK2 deficiency syndrome and its treatment by nucleoside therapy on quality of life
Amtmann, Dagmar, Gammaitoni, Arnold R., Galer, Bradley S., Salem, Rana, Jensen, Mark P.
Published in Mitochondrion (01.01.2023)
Published in Mitochondrion (01.01.2023)
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Journal Article
Psychosocial impact on siblings of patients with developmental and epileptic encephalopathies
Bailey, Laurie D., Schwartz, Lauren, Dixon-Salazar, Tracy, Meskis, Mary Anne, Galer, Bradley S., Gammaitoni, Arnold R., Schad, Carla
Published in Epilepsy & behavior (01.11.2020)
Published in Epilepsy & behavior (01.11.2020)
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Journal Article
Long-term cardiovascular safety of fenfluramine in patients with Dravet syndrome treated for up to 3 years: Findings from serial echocardiographic assessments
Agarwal, Anupam, Farfel, Gail M., Gammaitoni, Arnold R., Wong, Pierre C., Pinto, Fausto J., Galer, Bradley S.
Published in European journal of paediatric neurology (01.07.2022)
Published in European journal of paediatric neurology (01.07.2022)
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Journal Article
The humanistic and economic burden of Dravet syndrome on caregivers and families: Implications for future research
Jensen, Mark P, Brunklaus, Andreas, Dorris, Liam, Zuberi, Sameer M, Knupp, Kelly G, Galer, Bradley S, Gammaitoni, Arnold R
Published in Epilepsy & behavior (01.05.2017)
Published in Epilepsy & behavior (01.05.2017)
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Journal Article