Discovery of XL413, a potent and selective CDC7 inhibitor
Koltun, Elena S., Tsuhako, Amy Lew, Brown, David S., Aay, Naing, Arcalas, Arlyn, Chan, Vicky, Du, Hongwang, Engst, Stefan, Ferguson, Kim, Franzini, Maurizio, Galan, Adam, Holst, Charles R., Huang, Ping, Kane, Brian, Kim, Moon H., Li, Jia, Markby, David, Mohan, Manisha, Noson, Kevin, Plonowski, Arthur, Richards, Steven J., Robertson, Scott, Shaw, Kenneth, Stott, Gordon, Stout, Thomas J., Young, Jenny, Yu, Peiwen, Zaharia, Cristiana A., Zhang, Wentao, Zhou, Peiwen, Nuss, John M., Xu, Wei, Kearney, Patrick C.
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
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Journal Article
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors
Forsyth, Timothy, Kearney, Patrick C., Kim, Byung Gyu, Johnson, Henry W.B., Aay, Naing, Arcalas, Arlyn, Brown, David S., Chan, Vicky, Chen, Jeff, Du, Hongwang, Epshteyn, Sergey, Galan, Adam A., Huynh, Tai P., Ibrahim, Mohamed A., Kane, Brian, Koltun, Elena S., Mann, Grace, Meyr, Lisa E., Lee, Matthew S., Lewis, Gary L., Noguchi, Robin T., Pack, Michael, Ridgway, Brian H., Shi, Xian, Takeuchi, Craig S., Zu, Peiwen, Leahy, James W., Nuss, John M., Aoyama, Ron, Engst, Stefan, Gendreau, Steven B., Kassees, Robert, Li, Jia, Lin, Shwu-Hwa, Martini, Jean-Francois, Stout, Thomas, Tong, Philip, Woolfrey, John, Zhang, Wentao, Yu, Peiwen
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
Discovery of a new class of glucosylceramide synthase inhibitors
Koltun, Elena, Richards, Steven, Chan, Vicky, Nachtigall, Jason, Du, Hongwang, Noson, Kevin, Galan, Adam, Aay, Naing, Hanel, Art, Harrison, Amanda, Zhang, Jeff, Won, Kwang-Ai, Tam, Danny, Qian, Fawn, Wang, Tao, Finn, Patricia, Ogilvie, Kathleen, Rosen, Jon, Mohan, Raju, Larson, Christopher, Lamb, Peter, Nuss, John, Kearney, Patrick
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
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Journal Article
First-in-Class Mitogen-Activated Protein Kinase p38α: MAPK-Activated Protein Kinase-2 (MK2) Dual Signal Modulator with Anti-inflammatory and Endothelial-stabilizing Properties
Tulapurkar, Mohan E, Shirey, Kari Ann, Lugkey, Katerina N, Luo, Wendy, Lal, Ritu, Galan, Adam, Mahmoud, Omar, McClean, Nathaniel, Thangaraju, Kiruphagaran, Cericola, Daniel, Lewis, Daniel, Murphy, William A, Fletcher, Steven, MacKerell, Jr, Alexander D, Vogel, Stefanie N, Shapiro, Paul, Hasday, Jeffrey D
Published in The Journal of pharmacology and experimental therapeutics (16.09.2024)
Published in The Journal of pharmacology and experimental therapeutics (16.09.2024)
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Journal Article
Abstract 3897: Stability and safety evaluation of STRO-002, a site-specific anti-folate receptor alpha antibody-drug conjugate for the potential treatment of ovarian and endometrial cancers
Solis, Willy, Almeida, Venita De, Abrahams, Cristina, Li, Xiaofan, Heibeck, Tyler, Bruhns, Maureen, Galan, Adam, Hoffman, Heidi, Kiss, Robert, Hallam, Trevor, Lupher, Mark
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Inhibition of an HIV-1 Tat-derived peptide binding to TAR RNA by aminoglycoside antibiotics
Mei, Houng-Yau, Galan, Adam A., Halim, Nadia S., Mack, David P., Moreland, David W., Sanders, Kathryn B., Hoa N. Truong, Czarnik, Anthony W.
Published in Bioorganic & medicinal chemistry letters (16.11.1995)
Published in Bioorganic & medicinal chemistry letters (16.11.1995)
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Abstract 742: Nonclinical safety evaluation of STRO-001, a site-specific anti-CD74 antibody-drug conjugate for the potential treatment of B-cell malignancies
Solis, Willy, Almeida, Venita De, Yu, Abigail, Bruhns, Maureen, Zawada, James, Galan, Adam, Matheny, Shannon, Molina, Arturo, Hallam, Trevor, Lupher, Mark
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract NT-090: PRECLINICAL ACTIVITY AND SAFETY OF STRO-002, A NOVEL ADC TARGETING FOLATE RECEPTOR ALPHA FOR OVARIAN AND ENDOMETRIAL CANCER
Abrahams, Cristina, Krimm, Stellanie, Li, Xiaofan, Zhou, Sihong, Hanson, Jeffrey, Masikat, Mary Rose, Bajjuri, Krishna, Heibeck, Tyler, Kothari, Dharti, Yu, Abigail, Henningsen, Robert, Tran, Cuong, Yin, Gang, Zawada, James, Hang, Julie, Bruhns, Maureen, Solis, Willy, Steiner, Alexander, Galan, Adam, Kline, Toni, Stafford, Ryan, Yam, Alice, Almeida, Venita I. De, Lupher, Mark, Hallam, Trevor
Published in Clinical cancer research (15.11.2019)
Published in Clinical cancer research (15.11.2019)
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Abstract 1782: Discovery and activity of STRO-002, a novel ADC targeting folate receptor alpha for ovarian and endometrial cancer
Li, Xiaofan, Abrahams, Cristina, Zhou, Sihong, Krimm, Stellanie, Henningsen, Robert, Stephenson, Heather, Hanson, Jeffrey, Masikat, Mary Rose, Bajjuri, Krishna, Heibeck, Tyler, Tran, Cuong, Yin, Gang, Zawada, James, Sarma, Ganapathy, Chen, Joy, Bruhns, Maureen, Solis, Willy, Steiner, Alexander, Galan, Adam, Kline, Toni, Stafford, Ryan, Yam, Alice, Almeida, Venita I. De, Lupher, Mark, Hallam, Trevor
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Targeting CD74 with Novel Antibody Drug Conjugates (ADCs) for the Treatment of B-Cell Non-Hodgkin's Lymphoma (NHL)
Li, Xiaofan, Abrahams, Cristina, Embry, Millicent, Yu, Abigail, Kahana, Jason, Brown, Michael, Narla, Rama Krishna, Barnes, Leo, Schwartz, Eric, Boylan, John, Zawada, James, Stephenson, Heather, Bruhns, Maureen, Bussell, Stuart, Steiner, Alexander, Galan, Adam, Kline, Toni, Yam, Alice, Stafford, Ryan, Hoffmann, Heidi, Matheny, Shannon, DeAlmeida, Venita, Vasquez, Nicki, Heinsohn, Henry, Sato, Aaron, Molina, Arturo, Hallam, Trevor, Lupher, Mark
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Journal Article
Discovery and Preclinical Development of Novel CD74-Targeting Antibody-Drug Conjugates (ADCs) with Significant Activity in Multiple Myeloma (MM) Cell Lines and Xenograft Models
Abrahams, Cristina, Li, Xiaofan, Yu, Abigail, Krimm, Stellanie, Kahana, Jason, Narla, Rama Krishna, Schwartz, Eric, Boylan, John, Hoffmann, Heidi, Steiner, Alexander, Zawada, James, Stephenson, Heather, Bruhns, Maureen, DeAlmeida, Venita, Matheny, Shannon, Bussell, Stuart, Galan, Adam, Kline, Toni, Vasquez, Nicki, Yam, Alice, Stafford, Ryan, Heinsohn, Henry, Sato, Aaron, Molina, Arturo, Hallam, Trevor, Lupher, Mark
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Journal Article
The design, synthesis, and biological evaluation of PIM kinase inhibitors
Tsuhako, Amy Lew, Brown, David S., Koltun, Elena S., Aay, Naing, Arcalas, Arlyn, Chan, Vicky, Du, Hongwang, Engst, Stefan, Franzini, Maurizio, Galan, Adam, Huang, Ping, Johnston, Stuart, Kane, Brian, Kim, Moon H., Douglas Laird, A., Lin, Rui, Mock, Lillian, Ngan, Iris, Pack, Michael, Stott, Gordon, Stout, Thomas J., Yu, Peiwen, Zaharia, Cristiana, Zhang, Wentao, Zhou, Peiwen, Nuss, John M., Kearney, Patrick C., Xu, Wei
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
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Journal Article
Discovery and Characterization of an Inhibitor of Glucosylceramide Synthase
Richards, Steven, Larson, Christopher J, Koltun, Elena S, Hanel, Art, Chan, Vicky, Nachtigall, Jason, Harrison, Amanda, Aay, Naing, Du, Hongwang, Arcalas, Arlyn, Galan, Adam, Zhang, Jeff, Zhang, Wentao, Won, Kwang-Ai, Tam, Danny, Qian, Fawn, Wang, Tao, Finn, Patricia, Ogilvie, Kathy, Rosen, Jon, Aoyama, Ron, Plonowski, Artur, Cancilla, Belinda, Bentzien, Frauke, Yakes, Michael, Mohan, Raju, Lamb, Peter, Nuss, John, Kearney, Patrick
Published in Journal of medicinal chemistry (10.05.2012)
Published in Journal of medicinal chemistry (10.05.2012)
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