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Published in The Journal of biological chemistry (29.03.1996)
Published in The Journal of biological chemistry (29.03.1996)
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Effect of Gas6 on secretory phospholipase A2-IIA-induced apoptosis in cortical neurons
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Published in Brain research (26.09.2003)
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Published in Neurobiology of disease (01.08.2004)
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Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor
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Published in Neuro-degenerative diseases (01.01.2009)
Published in Neuro-degenerative diseases (01.01.2009)
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BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild‐type mice2
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Published in Journal of neurochemistry (01.12.2006)
Published in Journal of neurochemistry (01.12.2006)
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Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β‑Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial
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Published in Journal of medicinal chemistry (25.02.2021)
Published in Journal of medicinal chemistry (25.02.2021)
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Porcine pancreatic group IB secretory phospholipase A2potentiates Ca2+ influx through L-type voltage-sensitive Ca2+ channels
YAGAMI, Tatsurou, UEDA, Keiichi, ASAKURA, Kenji, SAKAEDA, Toshiyuki, HATA, Satoshi, KURODA, Takayuki, SAKAGUCHI, Gaku, ITOH, Naohiro, HASHIMOTO, Yutaka, HORI, Yozo
Published in Brain research (2003)
Published in Brain research (2003)
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P2-049 Neuroprotective effects of 2-(2-hydroxylphenyl)benzoxazol derivatives via induction of brain-derived neurotrophic factor synthesis
Hisanori Ito, Gaku Sakaguchi, Toshinaga Tsuji, Tsuyoshi Kihara, Shoei Furukawa, Norihiko Tanimoto, Akira Kato
Published in Journal of Pharmacological Sciences (2007)
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Published in Journal of Pharmacological Sciences (2007)
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O2G1-3 Involvement of amyloid-β in retinal cell death
Masamitsu Shimazawa, Yuta Inokuchi, Gaku Sakaguchi, Akira Kato, Takashi Kudo, Masatoshi Takeda, Hideaki Hara
Published in Journal of Pharmacological Sciences (2007)
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Published in Journal of Pharmacological Sciences (2007)
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Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis
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Published in Pain (Amsterdam) (01.05.2018)
Published in Pain (Amsterdam) (01.05.2018)
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Human group IIA secretory phospholipase A2 potentiates Ca2+ influx through L‐type voltage‐sensitive Ca2+ channels in cultured rat cortical neurons
Yagami, Tatsurou, Ueda, Keiichi, Asakura, Kenji, Nakazato, Hitoshi, Hata, Satoshi, Kuroda, Takayuki, Sakaeda, Toshiyuki, Sakaguchi, Gaku, Itoh, Naohiro, Hashimoto, Yutaka, Hori, Yozo
Published in Journal of neurochemistry (01.05.2003)
Published in Journal of neurochemistry (01.05.2003)
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Heterogeneous effects of antiepileptic drugs in an in vitro epilepsy model - a functional multineuron calcium imaging study
Hongo, Yoshie, Takasu, Keiko, Ikegaya, Yuji, Hasegawa, Minoru, Sakaguchi, Gaku, Ogawa, Koichi
Published in The European journal of neuroscience (01.07.2015)
Published in The European journal of neuroscience (01.07.2015)
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Discovery of Potent and Centrally Active 6‑Substituted 5‑Fluoro-1,3-dihydro-oxazine β‑Secretase (BACE1) Inhibitors via Active Conformation Stabilization
Nakahara, Kenji, Fuchino, Kouki, Komano, Kazuo, Asada, Naoya, Tadano, Genta, Hasegawa, Tsuyoshi, Yamamoto, Takahiko, Sako, Yusuke, Ogawa, Masayoshi, Unemura, Chie, Hosono, Motoko, Ito, Hisanori, Sakaguchi, Gaku, Ando, Shigeru, Ohnishi, Shuichi, Kido, Yasuto, Fukushima, Tamio, Dhuyvetter, Deborah, Borghys, Herman, Gijsen, Harrie J. M, Yamano, Yoshinori, Iso, Yasuyoshi, Kusakabe, Ken-ichi
Published in Journal of medicinal chemistry (12.07.2018)
Published in Journal of medicinal chemistry (12.07.2018)
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Rational Design of Novel 1,3-Oxazine Based β‑Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P‑gp Efflux Leading to Robust Aβ Reduction in the Brain
Fuchino, Kouki, Mitsuoka, Yasunori, Masui, Moriyasu, Kurose, Noriyuki, Yoshida, Shuhei, Komano, Kazuo, Yamamoto, Takahiko, Ogawa, Masayoshi, Unemura, Chie, Hosono, Motoko, Ito, Hisanori, Sakaguchi, Gaku, Ando, Shigeru, Ohnishi, Shuichi, Kido, Yasuto, Fukushima, Tamio, Miyajima, Hirofumi, Hiroyama, Shuichi, Koyabu, Kiyotaka, Dhuyvetter, Deborah, Borghys, Herman, Gijsen, Harrie J. M, Yamano, Yoshinori, Iso, Yasuyoshi, Kusakabe, Ken-ichi
Published in Journal of medicinal chemistry (28.06.2018)
Published in Journal of medicinal chemistry (28.06.2018)
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Mice deficient in protein tyrosine phosphatase receptor type Z
Fujikawa, Akihiro, Noda, Yukihiro, Yamamoto, Hideko, Tanga, Naomi, Sakaguchi, Gaku, Hattori, Satoko, Song, Wen-Jie, Sora, Ichiro, Nabeshima, Toshitaka, Katsuura, Goro, Noda, Masaharu
Published in PloS one (20.08.2019)
Published in PloS one (20.08.2019)
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Sp1 Family Proteins Recognize the U5 Repressive Element of the Long Terminal Repeat of Human T Cell Leukemia Virus Type I through Binding to the CACCC Core Motif
Okumura, K, Sakaguchi, G, Takagi, S, Naito, K, Mimori, T, Igarashi, H
Published in The Journal of biological chemistry (31.05.1996)
Published in The Journal of biological chemistry (31.05.1996)
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P3-012 BACE1 inhibition reduces endogenous Aβ and alters APP processing in wild-type mice
Kouhei Nishitomi, Gaku Sakaguchi, Yuko Horikoshi, Motoko Hosono, Isako Sakaguchi, Yoshihiro Nakajima, Chie Takeyama, Tsuyoshi Kihara, Paul S.Aisen, Noriaki Kinoshita, Yasuji Matsuoka, Akira Kato
Published in Journal of Pharmacological Sciences (2007)
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Published in Journal of Pharmacological Sciences (2007)
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The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between β-amyloid production and tau phosphorylation in Alzheimer disease
Kimura, Ryo, Kamino, Kouzin, Yamamoto, Mitsuko, Nuripa, Aidaralieva, Kida, Tomoyuki, Kazui, Hiroaki, Hashimoto, Ryota, Tanaka, Toshihisa, Kudo, Takashi, Yamagata, Hidehisa, Tabara, Yasuharu, Miki, Tetsuro, Akatsu, Hiroyasu, Kosaka, Kenji, Funakoshi, Eishi, Nishitomi, Kouhei, Sakaguchi, Gaku, Kato, Akira, Hattori, Hideyuki, Uema, Takeshi, Takeda, Masatoshi
Published in Human molecular genetics (01.01.2007)
Published in Human molecular genetics (01.01.2007)
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