Zinc and the iron donor frataxin regulate oligomerization of the scaffold protein to form new Fe-S cluster assembly centers
Galeano, B K, Ranatunga, W, Gakh, O, Smith, D Y, Thompson, J R, Isaya, G
Published in Metallomics (21.06.2017)
Published in Metallomics (21.06.2017)
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Journal Article
Mammalian Pitrilysin: Substrate Specificity and Mitochondrial Targeting
Chow, K. Martin, Gakh, O, Payne, I. C, Juliano, Maria Aparecida, Juliano, Luiz, Isaya, G, Hersh, Louis B
Published in Biochemistry (Easton) (07.04.2009)
Published in Biochemistry (Easton) (07.04.2009)
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Journal Article
Functional studies of frataxin
Isaya, G, O'Neill, HA, Gakh, O, Park, S, Mantcheva, R, Mooney, SM
Published in Acta Paediatrica (01.04.2004)
Published in Acta Paediatrica (01.04.2004)
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Journal Article
Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity
Gakh, Oleksandr, Park, Sungjo, Liu, Gang, Macomber, Lee, Imlay, James A., Ferreira, Gloria C., Isaya, Grazia
Published in Human molecular genetics (01.02.2006)
Published in Human molecular genetics (01.02.2006)
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Journal Article
Yeast Frataxin Sequentially Chaperones and Stores Iron by Coupling Protein Assembly with Iron Oxidation
Park, Sungjo, Gakh, Oleksandr, O'Neill, Heather A., Mangravita, Arianna, Nichol, Helen, Ferreira, Gloria C., Isaya, Grazia
Published in The Journal of biological chemistry (15.08.2003)
Published in The Journal of biological chemistry (15.08.2003)
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Journal Article
The Structures of Frataxin Oligomers Reveal the Mechanism for the Delivery and Detoxification of Iron
Karlberg, Tobias, Schagerlöf, Ulrika, Gakh, Oleksandr, Park, Sungjo, Ryde, Ulf, Lindahl, Martin, Leath, Kirstin, Garman, Elspeth, Isaya, Grazia, Al-Karadaghi, Salam
Published in Structure (London) (01.10.2006)
Published in Structure (London) (01.10.2006)
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Journal Article
Assembly of Human Frataxin Is a Mechanism for Detoxifying Redox-Active Iron
O'Neill, Heather A, Gakh, Oleksandr, Park, Sungjo, Cui, Jin, Mooney, Steven M, Sampson, Matthew, Ferreira, Gloria C, Isaya, Grazia
Published in Biochemistry (Easton) (18.01.2005)
Published in Biochemistry (Easton) (18.01.2005)
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Journal Article
Cleavage Site Selection within a Folded Substrate by the ATP-dependent Lon Protease
Ondrovičová, Gabriela, Liu, Tong, Singh, Kamalendra, Tian, Bin, Li, Hong, Gakh, Oleksandr, Perečko, Dusan, Janata, Jiří, Granot, Zvi, Orly, Joseph, Kutejová, Eva, Suzuki, Carolyn K.
Published in The Journal of biological chemistry (01.07.2005)
Published in The Journal of biological chemistry (01.07.2005)
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Journal Article
Structural Basis of the Iron Storage Function of Frataxin from Single-Particle Reconstruction of the Iron-Loaded Oligomer
Schagerlöf, Ulrika, Elmlund, Hans, Gakh, Oleksandr, Nordlund, Gustav, Hebert, Hans, Lindahl, Martin, Isaya, Grazia, Al-Karadaghi, Salam
Published in Biochemistry (Easton) (29.04.2008)
Published in Biochemistry (Easton) (29.04.2008)
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Journal Article
Physical Evidence that Yeast Frataxin Is an Iron Storage Protein
Gakh, Oleksandr, Adamec, Jiri, Gacy, A. Marquis, Twesten, Ray D, Owen, Whyte G, Isaya, Grazia
Published in Biochemistry (Easton) (28.05.2002)
Published in Biochemistry (Easton) (28.05.2002)
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Journal Article
The Ferroxidase Activity of Yeast Frataxin
Park, Sungjo, Gakh, Oleksandr, Mooney, Steven M., Isaya, Grazia
Published in The Journal of biological chemistry (11.10.2002)
Published in The Journal of biological chemistry (11.10.2002)
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Journal Article
Structure of Frataxin Iron Cores: An X-ray Absorption Spectroscopic Study
Nichol, Helen, Gakh, Oleksandr, O'Neill, Heather A., Pickering, Ingrid J., Isaya, Grazia, George, Graham N.
Published in Biochemistry (Easton) (27.05.2003)
Published in Biochemistry (Easton) (27.05.2003)
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Journal Article
Substrate evokes translocation of both domains in the mitochondrial processing peptidase α-subunit during which the C-terminus acts as a stabilizing element
Janata, Jiřı́, Holá, Klára, Kubala, Martin, Gakh, Oleksandr, Parkhomenko, Natalya, Matušková, Anna, Kutejová, Eva, Amler, Evžen
Published in Biochemical and biophysical research communications (26.03.2004)
Published in Biochemical and biophysical research communications (26.03.2004)
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Journal Article
Towards the crystal structure of Saccharomyces cerevisiae frataxin
Karlberg, T., Gakh, O., Grazia, I., Al-Karadaghi, S.
Published in Acta crystallographica. Section A, Foundations of crystallography (23.08.2005)
Published in Acta crystallographica. Section A, Foundations of crystallography (23.08.2005)
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Journal Article
Substrate Binding Changes Conformation of the α-, but Not the β-Subunit of Mitochondrial Processing Peptidase
Gakh, Oleksandr, Obsil, Tomas, Adamec, Jiri, Spizek, Jaroslav, Amler, Evzen, Janata, Jiri, Kalousek, Frantisek
Published in Archives of biochemistry and biophysics (15.01.2001)
Published in Archives of biochemistry and biophysics (15.01.2001)
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Journal Article