Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis
Ciccone, Lidia, Nencetti, Susanna, Tonali, Nicolo, Fruchart-Gaillard, Carole, Shepard, William, Nuti, Elisa, Camodeca, Caterina, Rossello, Armando, Orlandini, Elisabetta
Published in Bioorganic & medicinal chemistry (15.09.2020)
Published in Bioorganic & medicinal chemistry (15.09.2020)
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SKI-1/S1P Facilitates SARS-CoV-2 Spike Induced Cell-to-Cell Fusion via Activation of SREBP-2 and Metalloproteases, Whereas PCSK9 Enhances the Degradation of ACE2
Essalmani, Rachid, Andréo, Ursula, Evagelidis, Alexandra, Le Dévéhat, Maïlys, Pereira Ramos, Oscar Henrique, Fruchart Gaillard, Carole, Susan-Resiga, Delia, Cohen, Éric A, Seidah, Nabil G
Published in Viruses (27.01.2023)
Published in Viruses (27.01.2023)
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New Hybrid Compounds Incorporating Natural Products as Multifunctional Agents against Alzheimer's Disease
Ciccone, Lidia, Camodeca, Caterina, Tonali, Nicolò, Barlettani, Lucia, Rossello, Armando, Fruchart Gaillard, Carole, Kaffy, Julia, Petrarolo, Giovanni, La Motta, Concettina, Nencetti, Susanna, Orlandini, Elisabetta
Published in Pharmaceutics (22.09.2023)
Published in Pharmaceutics (22.09.2023)
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Journal Article
Molecular interactions of PCSK9 with an inhibitory nanobody, CAP1 and HLA-C: Functional regulation of LDLR levels
Fruchart Gaillard, Carole, Ouadda, Ali Ben Djoudi, Ciccone, Lidia, Girard, Emmanuelle, Mikaeeli, Sepideh, Evagelidis, Alexandra, Le Dévéhat, Maïlys, Susan-Resiga, Delia, Lajeunesse, Evelyne Cassar, Nozach, Hervé, Ramos, Oscar Henrique Pereira, Thureau, Aurélien, Legrand, Pierre, Prat, Annik, Dive, Vincent, Seidah, Nabil G.
Published in Molecular metabolism (Germany) (01.01.2023)
Published in Molecular metabolism (Germany) (01.01.2023)
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Ligand‐Directed Modification of Active Matrix Metalloproteases: Activity‐based Probes with no Photolabile Group
Kaminska, Monika, Bruyat, Pierrick, Malgorn, Carole, Doladilhe, Marion, Cassar‐Lajeunesse, Evelyne, Fruchart Gaillard, Carole, De Souza, Mélissa, Beau, Fabrice, Thai, Robert, Correia, Isabelle, Galat, Andrzej, Georgiadis, Dimitris, Lequin, Olivier, Dive, Vincent, Bregant, Sarah, Devel, Laurent
Published in Angewandte Chemie International Edition (09.08.2021)
Published in Angewandte Chemie International Edition (09.08.2021)
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Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases
Vadon-Le Goff, Sandrine, Tessier, Agnès, Napoli, Manon, Dieryckx, Cindy, Bauer, Julien, Dussoyer, Mélissa, Lagoutte, Priscillia, Peyronnel, Célian, Essayan, Lucie, Kleiser, Svenja, Tueni, Nicole, Bettler, Emmanuel, Mariano, Natacha, Errazuriz-Cerda, Elisabeth, Fruchart Gaillard, Carole, Ruggiero, Florence, Becker-Pauly, Christoph, Allain, Jean-Marc, Bruckner-Tuderman, Leena, Nyström, Alexander, Moali, Catherine
Published in Nature communications (04.12.2023)
Published in Nature communications (04.12.2023)
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Journal Article
Total Synthesis of Pinnatoxins A and G and Revision of the Mode of Action of Pinnatoxin A
Araoz, Romulo, Servent, Denis, Molgó, Jordi, Iorga, Bogdan I, Fruchart-Gaillard, Carole, Benoit, Evelyne, Gu, Zhenhua, Stivala, Craig, Zakarian, Armen
Published in Journal of the American Chemical Society (13.07.2011)
Published in Journal of the American Chemical Society (13.07.2011)
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The Repellent DEET Potentiates Carbamate Effects via Insect Muscarinic Receptor Interactions: An Alternative Strategy to Control Insect Vector-Borne Diseases
Abd-Ella, Aly, Stankiewicz, Maria, Mikulska, Karolina, Nowak, Wieslaw, Pennetier, Cédric, Goulu, Mathilde, Fruchart-Gaillard, Carole, Licznar, Patricia, Apaire-Marchais, Véronique, List, Olivier, Corbel, Vincent, Servent, Denis, Lapied, Bruno
Published in PloS one (11.05.2015)
Published in PloS one (11.05.2015)
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Nature-Inspired O -Benzyl Oxime-Based Derivatives as New Dual-Acting Agents Targeting Aldose Reductase and Oxidative Stress
Ciccone, Lidia, Petrarolo, Giovanni, Barsuglia, Francesca, Fruchart-Gaillard, Carole, Cassar Lajeunesse, Evelyne, Adewumi, Adeniyi T, Soliman, Mahmoud E S, La Motta, Concettina, Orlandini, Elisabetta, Nencetti, Susanna
Published in Biomolecules (Basel, Switzerland) (14.03.2022)
Published in Biomolecules (Basel, Switzerland) (14.03.2022)
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Antioxidant Quercetin 3-O-Glycosylated Plant Flavonols Contribute to Transthyretin Stabilization
Ciccone, Lidia, Tonali, Nicolò, Fruchart-Gaillard, Carole, Barlettani, Lucia, Rossello, Armando, Braca, Alessandra, Orlandini, Elisabetta, Nencetti, Susanna
Published in Crystals (Basel) (29.04.2022)
Published in Crystals (Basel) (29.04.2022)
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Journal Article
Insights into PCSK9-LDLR Regulation and Trafficking via the Differential Functions of MHC-I Proteins HFE and HLA-C
Mikaeeli, Sepideh, Ben Djoudi Ouadda, Ali, Evagelidis, Alexandra, Essalmani, Rachid, Ramos, Oscar Henrique Pereira, Fruchart-Gaillard, Carole, Seidah, Nabil G
Published in Cells (Basel, Switzerland) (17.05.2024)
Published in Cells (Basel, Switzerland) (17.05.2024)
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Journal Article
Denmotoxin, a Three-finger Toxin from the Colubrid Snake Boiga dendrophila (Mangrove Catsnake) with Bird-specific Activity
Pawlak, Joanna, Mackessy, Stephen P., Fry, Bryan G., Bhatia, Madhav, Mourier, Gilles, Fruchart-Gaillard, Carole, Servent, Denis, Ménez, Renée, Stura, Enrico, Ménez, André, Kini, R. Manjunatha
Published in The Journal of biological chemistry (29.09.2006)
Published in The Journal of biological chemistry (29.09.2006)
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Journal Article
High throughput screening identifies disulfide isomerase DsbC as a very efficient partner for recombinant expression of small disulfide-rich proteins in E. coli
Nozach, Hervé, Fruchart-Gaillard, Carole, Fenaille, François, Beau, Fabrice, Ramos, Oscar Henrique Pereira, Douzi, Badreddine, Saez, Natalie J, Moutiez, Mireille, Servent, Denis, Gondry, Muriel, Thaï, Robert, Cuniasse, Philippe, Vincentelli, Renaud, Dive, Vincent
Published in Microbial cell factories (22.04.2013)
Published in Microbial cell factories (22.04.2013)
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Journal Article
Ligand‐Directed Modification of Active Matrix Metalloproteases: Activity‐based Probes with no Photolabile Group
Kaminska, Monika, Bruyat, Pierrick, Malgorn, Carole, Doladilhe, Marion, Cassar‐Lajeunesse, Evelyne, Fruchart Gaillard, Carole, De Souza, Mélissa, Beau, Fabrice, Thai, Robert, Correia, Isabelle, Galat, Andrzej, Georgiadis, Dimitris, Lequin, Olivier, Dive, Vincent, Bregant, Sarah, Devel, Laurent
Published in Angewandte Chemie (09.08.2021)
Published in Angewandte Chemie (09.08.2021)
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Journal Article
Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors
Fruchart-Gaillard, Carole, Mourier, Gilles, Blanchet, Guillaume, Vera, Laura, Gilles, Nicolas, Ménez, Renée, Marcon, Elodie, Stura, Enrico A, Servent, Denis
Published in PloS one (14.06.2012)
Published in PloS one (14.06.2012)
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Orthosteric binding of ρ-Da1a, a natural peptide of snake venom interacting selectively with the α1A-adrenoceptor
Maïga, Arhamatoulaye, Merlin, Jon, Marcon, Elodie, Rouget, Céline, Larregola, Maud, Gilquin, Bernard, Fruchart-Gaillard, Carole, Lajeunesse, Evelyne, Marchetti, Charles, Lorphelin, Alain, Bellanger, Laurent, Summers, Roger J, Hutchinson, Dana S, Evans, Bronwyn A, Servent, Denis, Gilles, Nicolas
Published in PloS one (25.07.2013)
Published in PloS one (25.07.2013)
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Journal Article
Experimentally Based Model of a Complex between a Snake Toxin and the α7 Nicotinic Receptor
Fruchart-Gaillard, Carole, Gilquin, Bernard, Antil-Delbeke, Stéphanie, Le Novère, Nicolas, Tamiya, Toru, Corringer, Pierre-Jean, Changeux, Jean-Pierre, Ménez, André, Servent, Denis
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2002)
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Journal Article
Different Interactions between MT7 Toxin and the Human Muscarinic M1 Receptor in Its Free and N-Methylscopolamine-Occupied States
Fruchart-Gaillard, Carole, Mourier, Gilles, Marquer, Catherine, Stura, Enrico, Birdsall, Nigel J M, Servent, Denis
Published in Molecular pharmacology (01.12.2008)
Published in Molecular pharmacology (01.12.2008)
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