Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects
Baquero, Juan Miguel, Benítez-Buelga, Carlos, Rajagopal, Varshni, Zhenjun, Zhao, Torres-Ruiz, Raúl, Müller, Sarah, Hanna, Bishoy M. F., Loseva, Olga, Wallner, Olov, Michel, Maurice, Rodríguez-Perales, Sandra, Gad, Helge, Visnes, Torkild, Helleday, Thomas, Benítez, Javier, Osorio, Ana
Published in Scientific reports (10.02.2021)
Published in Scientific reports (10.02.2021)
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Journal Article
AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma
Das, Ishani, Gad, Helge, Bräutigam, Lars, Pudelko, Linda, Tuominen, Rainer, Höiom, Veronica, Almlöf, Ingrid, Rajagopal, Varshni, Hansson, Johan, Helleday, Thomas, Egyházi Brage, Suzanne, Warpman Berglund, Ulrika
Published in Cell death and differentiation (01.07.2020)
Published in Cell death and differentiation (01.07.2020)
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Journal Article
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2
Carter, Megan, Jemth, Ann-Sofie, Hagenkort, Anna, Page, Brent D. G., Gustafsson, Robert, Griese, Julia J., Gad, Helge, Valerie, Nicholas C. K., Desroses, Matthieu, Boström, Johan, Warpman Berglund, Ulrika, Helleday, Thomas, Stenmark, Pål
Published in Nature communications (04.08.2015)
Published in Nature communications (04.08.2015)
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Journal Article
Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma
Oksvold, Morten P., Berglund, Ulrika Warpman, Gad, Helge, Bai, Baoyan, Stokke, Trond, Rein, Idun Dale, Pham, Therese, Sanjiv, Kumar, Øy, Geir Frode, Norum, Jens Henrik, Smeland, Erlend B., Myklebust, June H., Helleday, Thomas, Våtsveen, Thea Kristin
Published in Scientific reports (18.03.2021)
Published in Scientific reports (18.03.2021)
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Journal Article
Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition
Bräutigam, Lars, Pudelko, Linda, Jemth, Ann-Sofie, Gad, Helge, Narwal, Mohit, Gustafsson, Robert, Karsten, Stella, Carreras Puigvert, Jordi, Homan, Evert, Berndt, Carsten, Berglund, Ulrika Warpman, Stenmark, Pål, Helleday, Thomas
Published in Cancer research (Chicago, Ill.) (15.04.2016)
Published in Cancer research (Chicago, Ill.) (15.04.2016)
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Journal Article
Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway
Shen, Jianyu, Guillén Mancina, Emilio, Chen, Shenyu, Manolakou, Theodora, Gad, Helge, Warpman Berglund, Ulrika, Sanjiv, Kumar, Helleday, Thomas
Published in Oncogenesis (New York, NY) (25.05.2024)
Published in Oncogenesis (New York, NY) (25.05.2024)
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Journal Article
Karonudib is a promising anticancer therapy in hepatocellular carcinoma
Hua, Xiangwei, Sanjiv, Kumar, Gad, Helge, Pham, Therese, Gokturk, Camilla, Rasti, Azita, Zhao, Zhenjun, He, Kang, Feng, Mingxuan, Zang, Yunjin, Zhang, Jianjun, Xia, Qiang, Helleday, Thomas, Warpman Berglund, Ulrika
Published in Therapeutic advances in medical oncology (2019)
Published in Therapeutic advances in medical oncology (2019)
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Journal Article
Endophilin/SH3p4 Is Required for the Transition from Early to Late Stages in Clathrin-Mediated Synaptic Vesicle Endocytosis
Ringstad, Niels, Gad, Helge, Löw, Peter, Di Paolo, Gilbert, Brodin, Lennart, Shupliakov, Oleg, De Camilli, Pietro
Published in Neuron (Cambridge, Mass.) (01.09.1999)
Published in Neuron (Cambridge, Mass.) (01.09.1999)
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Journal Article
Role of epsin 1 in synaptic vesicle endocytosis
Jakobsson, Joel, Gad, Helge, Andersson, Fredrik, Löw, Peter, Shupliakov, Oleg, Brodin, Lennart
Published in Proceedings of the National Academy of Sciences - PNAS (29.04.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (29.04.2008)
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Journal Article
Key components of the fission machinery are interchangeable
Hsu, Victor W, Yang, Jia-Shu, Zhang, Leiliang, Lee, Stella Y, Gad, Helge, Luini, Alberto
Published in Nature cell biology (01.12.2006)
Published in Nature cell biology (01.12.2006)
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Journal Article
A role for BARS at the fission step of COPI vesicle formation from Golgi membrane
Yang, Jia-Shu, Lee, Stella Y, Spanò, Stefania, Gad, Helge, Zhang, Leiliang, Nie, Zhongzhen, Bonazzi, Matteo, Corda, Daniela, Luini, Alberto, Hsu, Victor W
Published in The EMBO journal (07.12.2005)
Published in The EMBO journal (07.12.2005)
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Journal Article
Synaptic Vesicle Endocytosis Impaired by Disruption of Dynamin-SH3 Domain Interactions
Shupliakov, Oleg, Löw, Peter, Grabs, Detlev, Gad, Helge, Chen, Hong, David, Carol, Takei, Kohji, de Camilli, Pietro, Brodin, Lennart
Published in Science (American Association for the Advancement of Science) (11.04.1997)
Published in Science (American Association for the Advancement of Science) (11.04.1997)
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Journal Article
Amphiphysin is a Component of Clathrin Coats Formed During Synaptic Vesicle Recycling at the Lamprey Giant Synapse
Evergren, Emma, Marcucci, Melissa, Tomilin, Nikolay, Löw, Peter, Slepnev, Vladimir, Andersson, Fredrik, Gad, Helge, Brodin, Lennart, De Camilli, Pietro, Shupliakov, Oleg
Published in Traffic (Copenhagen, Denmark) (01.07.2004)
Published in Traffic (Copenhagen, Denmark) (01.07.2004)
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Journal Article
NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis
Zhao, Zhenjun, Gad, Helge, Benitez-Buelga, Carlos, Sanjiv, Kumar, Xiangwei, Hua, Kang, He, Feng, Mingxuan, Zhao, Zhicong, Berglund, Ulrika Warpman, Xia, Qiang, Helleday, Thomas
Published in Cancer research (Chicago, Ill.) (01.08.2021)
Published in Cancer research (Chicago, Ill.) (01.08.2021)
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Journal Article
MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG
Rudd, Sean G, Gad, Helge, Sanjiv, Kumar, Amaral, Nuno, Hagenkort, Anna, Groth, Petra, Ström, Cecilia E, Mortusewicz, Oliver, Berglund, Ulrika Warpman, Helleday, Thomas
Published in Cancer research (Chicago, Ill.) (01.09.2020)
Published in Cancer research (Chicago, Ill.) (01.09.2020)
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Journal Article
MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
Sanjiv, Kumar, Calderón-Montaño, José Manuel, Pham, Therese M, Erkers, Tom, Tsuber, Viktoriia, Almlöf, Ingrid, Höglund, Andreas, Heshmati, Yaser, Seashore-Ludlow, Brinton, Nagesh Danda, Akhilesh, Gad, Helge, Wiita, Elisee, Göktürk, Camilla, Rasti, Azita, Friedrich, Stefanie, Centio, Anders, Estruch, Montserrat, Våtsveen, Thea Kristin, Struyf, Nona, Visnes, Torkild, Scobie, Martin, Koolmeister, Tobias, Henriksson, Martin, Wallner, Olov, Sandvall, Teresa, Lehmann, Sören, Theilgaard-Mönch, Kim, Garnett, Mathew J, Östling, Päivi, Walfridsson, Julian, Helleday, Thomas, Warpman Berglund, Ulrika
Published in Cancer research (Chicago, Ill.) (2021)
Published in Cancer research (Chicago, Ill.) (2021)
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Journal Article
Abstract 1569: OXC-101 kills cancer by disturbing microtubule polymerization and inhibiting MTH1
Berglund, Ulrika Warpman, Gad, Helge, Sanjiv, Kumar, Jemth, Ann-Sofie, Mortusewics, Oliver, Brautigam, Lars, Rantala, Juha, Helleday, Thomas
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance
Hsu, Victor W, Yang, Jia-Shu, Gad, Helge, Lee, Stella Y, Mironov, Alexander, Zhang, Leiliang, Beznoussenko, Galina V, Valente, Carmen, Turacchio, Gabriele, Bonsra, Akua N, Du, Guangwei, Baldanzi, Gianluca, Graziani, Andrea, Bourgoin, Sylvain, Frohman, Michael A, Luini, Alberto
Published in Nature cell biology (01.10.2008)
Published in Nature cell biology (01.10.2008)
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Journal Article
Karonudib Has Potent Anti-Tumor Effects in Preclinical Models of B-Cell Lymphoma
Oksvold, Morten P, Warpman Berglund, Ulrika, Gad, Helge, Bai, Baoyan, Stokke, Trond, Rein, Idun D, Pham, Therese, Sanjiv, Kumar, Øy, Geir Frode, Norum, Jens Henrik, Smeland, Erlend B., Myklebust, June Helen, Helleday, Thomas, Våtsveen, Thea Kristin
Published in BLOOD (05.11.2020)
Published in BLOOD (05.11.2020)
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