Cariprazine (RGH-188), a Dopamine D 3 Receptor-Preferring, D 3 /D 2 Dopamine Receptor Antagonist–Partial Agonist Antipsychotic Candidate: In Vitro and Neurochemical Profile
Kiss, Béla, Horváth, Attila, Némethy, Zsolt, Schmidt, Éva, Laszlovszky, István, Bugovics, Gyula, Fazekas, Károly, Hornok, Katalin, Orosz, Szabolcs, Gyertyán, István, Ágai-Csongor, Éva, Domány, György, Tihanyi, Károly, Adham, Nika, Szombathelyi, Zsolt
Published in The Journal of pharmacology and experimental therapeutics (01.04.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2010)
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Journal Article
Cariprazine (RGH-188), a potent D 3/D 2 dopamine receptor partial agonist, binds to dopamine D 3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents
Gyertyán, István, Kiss, Béla, Sághy, Katalin, Laszy, Judit, Szabó, Györgyi, Szabados, Tamás, Gémesi, Larisza I., Pásztor, Gabriella, Zájer-Balázs, Mária, Kapás, Margit, Csongor, Éva Ágai, Domány, György, Tihanyi, Károly, Szombathelyi, Zsolt
Published in Neurochemistry international (01.11.2011)
Published in Neurochemistry international (01.11.2011)
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Journal Article
Discovery of 4-amino-3-arylsulfoquinolines, a novel non-acetylenic chemotype of metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulators
Galambos, János, Bielik, Attila, Wágner, Gábor, Domány, György, Kóti, János, Béni, Zoltán, Szigetvári, Áron, Sánta, Zsuzsanna, Orgován, Zoltán, Bobok, Amrita, Kiss, Béla, Mikó-Bakk, Mónika L., Vastag, Mónika, Sághy, Katalin, Krasavin, Mikhail, Gál, Krisztina, Greiner, István, Szombathelyi, Zsolt, Keserű, György M.
Published in European journal of medicinal chemistry (16.06.2017)
Published in European journal of medicinal chemistry (16.06.2017)
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Journal Article
4-Aryl-3-arylsulfonyl-quinolines as negative allosteric modulators of metabotropic GluR5 receptors: From HTS hit to development candidate
Galambos, János, Domány, György, Nógrádi, Katalin, Wágner, Gábor, Keserű, György M., Bobok, Amrita, Kolok, Sándor, Mikó-Bakk, Mónika L., Vastag, Mónika, Sághy, Katalin, Kóti, János, Szakács, Zoltán, Béni, Zoltán, Gál, Krisztina, Szombathelyi, Zsolt, Greiner, István
Published in Bioorganic & medicinal chemistry letters (15.02.2016)
Published in Bioorganic & medicinal chemistry letters (15.02.2016)
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Journal Article
The influence of 5-HT2A activity on a 5-HT2C specific in vivo assay used for early identification of multiple acting SERT and 5-HT2C receptor ligands
Éliás, Olivér, Nógrádi, Katalin, Domány, György, Szakács, Zoltán, Kóti, János, Szántay, Csaba, Tarcsay, Ákos, Keserű, György M., Gere, Anikó, Kiss, Béla, Kurkó, Dalma, Kolok, Sándor, Némethy, Zsolt, Kapui, Zoltán, Hellinger, Éva, Vastag, Mónika, Sághy, Katalin, Kedves, Rita, Gyertyán, István
Published in Bioorganic & medicinal chemistry letters (01.02.2016)
Published in Bioorganic & medicinal chemistry letters (01.02.2016)
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Journal Article
Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: Hit-to-lead optimization
Nógrádi, Katalin, Wágner, Gábor, Domány, György, Bobok, Amrita, Magdó, Ildikó, Kiss, Béla, Kolok, Sándor, Fónagy, Katalin, Gyertyán, István, Háda, Viktor, Kóti, János, Gál, Krisztina, Farkas, Sándor, Keserű, György M., Greiner, István, Szombathelyi, Zsolt
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
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Journal Article
Design of novel multiple-acting ligands towards SERT and 5-HT2C receptors
Éliás, Olivér, Ágai-Csongor, Éva, Domány, György, Keserű, György Miklós, Gere, Anikó, Kiss, Béla, Hellinger, Éva, Vastag, Mónika, Gyertyán, István
Published in Bioorganic & medicinal chemistry letters (01.05.2014)
Published in Bioorganic & medicinal chemistry letters (01.05.2014)
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Journal Article
Quinolinyl- and phenantridinyl-acetamides as bradykinin B1 receptor antagonists
Éles, János, Beke, Gyula, Vágó, István, Bozó, Éva, Huszár, József, Tarcsay, Ákos, Kolok, Sándor, Schmidt, Éva, Vastag, Mónika, Hornok, Katalin, Farkas, Sándor, Domány, György, Keserű, György M.
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
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Journal Article
Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluR5 NAMs
Wágner, Gábor, Wéber, Csaba, Nyéki, Olga, Nógrádi, Katalin, Bielik, Attila, Molnár, László, Bobok, Amrita, Horváth, Attila, Kiss, Béla, Kolok, Sándor, Nagy, József, Kurkó, Dalma, Gál, Krisztina, Greiner, István, Szombathelyi, Zsolt, Keserű, György M., Domány, György
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Journal Article
Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists
Galambos, János, Wágner, Gábor, Nógrádi, Katalin, Bielik, Attila, Molnár, László, Bobok, Amrita, Horváth, Attila, Kiss, Béla, Kolok, Sándor, Nagy, József, Kurkó, Dalma, Bakk, Mónika L., Vastag, Mónika, Sághy, Katalin, Gyertyán, István, Gál, Krisztina, Greiner, István, Szombathelyi, Zsolt, Keserű, György M., Domány, György
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Journal Article
Benzimidazole-2-carboxamides as novel NR2B selective NMDA receptor antagonists
Borza, István, Kolok, Sándor, Gere, Anikó, Nagy, József, Fodor, László, Galgóczy, Kornél, Fetter, József, Bertha, Ferenc, Ágai, Béla, Horváth, Csilla, Farkas, Sándor, Domány, György
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
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Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile
Ágai-Csongor, Éva, Nógrádi, Katalin, Galambos, János, Vágó, István, Bielik, Attila, Magdó, Ildikó, Ignácz-Szendrei, Györgyi, Keserű, György Miklós, Greiner, István, Laszlovszky, István, Béla Kiss, Éva Schmidt, Judit Laszy, Katalin Sághy, Gyertyán, István, Zájer-Balázs, Mária, Gémesi, Larisza, Domány, György
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
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Journal Article
PIPERAZINE SALTS AS D3/D2 ANTAGONISTS
AGAINE CSONGOR, Eva, DOMANY, Gyoergy, SEBOEK, Ferenc, CZIBULA, Laszlo, GREINER, Istvan
Year of Publication 28.03.2018
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Year of Publication 28.03.2018
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New piperazine salt and process for its preparation
dr. Greiner Istvan, Seboek Ferenc, dr. Domany Gyoergy, Againe Csongor Eva, dr. Czibula Laszlo
Year of Publication 28.02.2018
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Year of Publication 28.02.2018
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Process for the preparation of pyrimidinyl-piperazines
BARTANE SZALAI GIZELLA, DOBAY LASZLO, SZAVICSKO KRISZTINA, PAPP EVA, CZIBULA LASZLO, DOMANY GYOERGY
Year of Publication 28.04.2015
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Year of Publication 28.04.2015
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NOVOS SAIS DE PIPERAZINA COMO ANTAGONISTAS DE D3/D2
GYOERGY DOMANY, FERENC SEBOEK, LASZLO CZIBULA, EVA AGAINE CSONGOR, ISTVAN GREINER
Year of Publication 29.10.2014
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Year of Publication 29.10.2014
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Process for the preparation of pyrimidinyl-piperazines
BARTANE SZALAI GIZELLA, DOBAY LASZLO, SZAVICSKO KRISZTINA, PAPP EVA, CZIBULA LASZLO, DOMANY GYOERGY
Year of Publication 28.05.2014
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Year of Publication 28.05.2014
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NOVEL PIPERAZINE SALTS AS D3/D2 ANTAGONISTS
AGAINE CSONGOR, EVA, GREINER, ISTVAN, CZIBULA, LASZLO, DOMANY, GYOERGY, SEBOEK, FERENC
Year of Publication 28.02.2013
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Year of Publication 28.02.2013
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PIRIMIDINIL-PIPERAZINAS ÚTEIS COMO LIGANTES DO RECEPTOR D3/D2HU
GIZELLA BARTANE SZALAI, JUDIT LASZY, SANDOR FARKAS, GYOERGY DOMANY, EVA SCHMIDT, ISTVAN GYERTYAN, BELA KISS, EVA AGAINE CSONGOR, KATALIN SAGHY, ZSOLT KOMLODI
Year of Publication 11.11.2014
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Year of Publication 11.11.2014
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NOVEL PIPERAZINE SALTS AS D3/D2 ANTAGONISTS
AGAINE CSONGOR, EVA, GREINER, ISTVAN, CZIBULA, LASZLO, DOMANY, GYOERGY, SEBOEK, FERENC
Year of Publication 25.05.2012
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Year of Publication 25.05.2012
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