Structural basis for partial agonism in 5-HT3A receptors
Felt, Kevin, Stauffer, Madeleine, Salas-Estrada, Leslie, Guzzo, Peter R., Xie, Dejian, Huang, Jinkun, Filizola, Marta, Chakrapani, Sudha
Published in Nature structural & molecular biology (01.04.2024)
Published in Nature structural & molecular biology (01.04.2024)
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Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives
Nacro, Kassoum, Zha, Conxiang (Charles), Guzzo, Peter R., Jason Herr, R., Peace, Denise, Friedrich, Thomas D.
Published in Bioorganic & medicinal chemistry (15.06.2007)
Published in Bioorganic & medicinal chemistry (15.06.2007)
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Author Correction: Structural basis for partial agonism in 5-HT3A receptors
Felt, Kevin, Stauffer, Madeleine, Salas-Estrada, Leslie, Guzzo, Peter R., Xie, Dejian, Huang, Jinkun, Filizola, Marta, Chakrapani, Sudha
Published in Nature structural & molecular biology (01.04.2024)
Published in Nature structural & molecular biology (01.04.2024)
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Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity
Sebhat, Iyassu K, Franklin, Christopher, Lo, Michael M.-C, Chen, David, Jewell, James P, Miller, Randy, Pang, Jianmei, Palyha, Oksana, Kan, Yanqing, Kelly, Theresa M, Guan, Xiao-Ming, Marsh, Donald J, Kosinski, Jennifer A, Metzger, Joseph M, Lyons, Kathryn, Dragovic, Jasminka, Guzzo, Peter R, Henderson, Alan J, Reitman, Marc L, Nargund, Ravi P, Wyvratt, Matthew J, Lin, Linus S
Published in ACS medicinal chemistry letters (13.01.2011)
Published in ACS medicinal chemistry letters (13.01.2011)
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From preclinical to clinical development: The example of a novel treatment for obesity
Moore, Nicholas A, Sargent, Bruce J, Guzzo, Peter R, Surman, Matthew D
Published in Neurobiology of disease (01.01.2014)
Published in Neurobiology of disease (01.01.2014)
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CSTI-300 (SMP-100); a Novel 5-HT 3 Receptor Partial Agonist with Potential to Treat Patients with Irritable Bowel Syndrome or Carcinoid Syndrome
Roberts, Alexander, Grafton, Gillian, Powell, Andrew D, Brock, Kristian, Chen, Chunlin, Xie, Dejian, Huang, Jinkun, Liu, Shuang, Cooper, Alison J, Brady, Catherine A, Qureshi, Omar, Stamataki, Zania, Manning, David D, Moore, Nicholas A, Sargent, Bruce J, Guzzo, Peter R, Barnes, Nicholas M
Published in The Journal of pharmacology and experimental therapeutics (01.04.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2020)
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Bifidenone: Structure–Activity Relationship and Advanced Preclinical Candidate
Huang, Zhongping, Williams, Russell B, Martin, Steven M, Lawrence, Julie A, Norman, Vanessa L, O’Neil-Johnson, Mark, Harding, Jim, Mangette, John E, Liu, Shuang, Guzzo, Peter R, Starks, Courtney M, Eldridge, Gary R
Published in Journal of medicinal chemistry (09.08.2018)
Published in Journal of medicinal chemistry (09.08.2018)
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The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties
Guo, Cheng, Hu, Min, DeOrazio, Russell J., Usyatinsky, Alexander, Fitzpatrick, Kevin, Zhang, Zhenjun, Maeng, Jun-Ho, Kitchen, Douglas B., Tom, Susan, Luche, Michele, Khmelnitsky, Yuri, Mhyre, Andrew J., Guzzo, Peter R., Liu, Shuang
Published in Bioorganic & medicinal chemistry (01.07.2014)
Published in Bioorganic & medicinal chemistry (01.07.2014)
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Preparation of 8-Amido-2-dimethylamino-1,2,3,4-tetrahydro-2-dibenzofurans and Several Fluorinated Derivatives via [3,3]-Sigmatropic Rearrangement of O-Aryloximes
Guzzo, Peter R, Buckle, Ronald N, Chou, Ming, Dinn, Sean R, Flaugh, Michael E, Kiefer, Anton D, Ryter, Kendal T, Sampognaro, Anthony J, Tregay, Steven W, Xu, Yao-Chang
Published in Journal of organic chemistry (07.02.2003)
Published in Journal of organic chemistry (07.02.2003)
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Synthesis and Biological Evaluation of N‑((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter‑1
Cioffi, Christopher L, Liu, Shuang, Wolf, Mark A, Guzzo, Peter R, Sadalapure, Kashinath, Parthasarathy, Visweswaran, Loong, David T. J, Maeng, Jun-Ho, Carulli, Edmund, Fang, Xiao, Karunakaran, Kalesh, Matta, Lakshman, Choo, Sok Hui, Panduga, Shailijia, Buckle, Ronald N, Davis, Randall N, Sakwa, Samuel A, Gupta, Priya, Sargent, Bruce J, Moore, Nicholas A, Luche, Michele M, Carr, Grant J, Khmelnitsky, Yuri L, Ismail, Jiffry, Chung, Mark, Bai, Mei, Leong, Wei Yee, Sachdev, Nidhi, Swaminathan, Srividya, Mhyre, Andrew J
Published in Journal of medicinal chemistry (22.09.2016)
Published in Journal of medicinal chemistry (22.09.2016)
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Initial Process Development and Scale-Up of the Synthesis of a Triple Reuptake Inhibitor ALB 109780
Yang, Qiang, Ulysse, Luckner G, McLaws, Mark D, Keefe, Daniel K, Haney, Brian P, Zha, Congxiang, Guzzo, Peter R, Liu, Shuang
Published in Organic process research & development (16.03.2012)
Published in Organic process research & development (16.03.2012)
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Partial Agonism of 5‑HT3 Receptors: A Novel Approach to the Symptomatic Treatment of IBS‑D
Moore, Nicholas A, Sargent, Bruce J, Manning, David D, Guzzo, Peter R
Published in ACS chemical neuroscience (16.01.2013)
Published in ACS chemical neuroscience (16.01.2013)
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Journal Article
The discovery of diazepinone-based 5-HT3 receptor partial agonists
Manning, David D., Guo, Cheng, Zhang, Zhenjun, Ryan, Kristen N., Naginskaya, Jennifer, Choo, Sok Hui, Masih, Liaqat, Earley, William G., Wierschke, Jonathan D., Newman, Amy S., Brady, Catherine A., Barnes, Nicholas M., Guzzo, Peter R.
Published in Bioorganic & medicinal chemistry letters (01.06.2014)
Published in Bioorganic & medicinal chemistry letters (01.06.2014)
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Epiminocyclohepta[b]indole analogs as 5-HT6 antagonists
Henderson, Alan J., Guzzo, Peter R., Ghosh, Animesh, Kaur, Jagjit, Koo, Jia-Man, Nacro, Kassoum, Panduga, Shailaja, Pathak, Rashmi, Shimpukade, Bharat, Tan, Valentina, Xiang, Kai, Wierschke, Jonathan D., Isherwood, Matthew L.
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Asymmetric Organic Synthesis. Radical Cyclizations of Chiral Enamides
Schultz, Arthur G, Guzzo, Peter R, Nowak, Deanne M
Published in Journal of organic chemistry (01.12.1995)
Published in Journal of organic chemistry (01.12.1995)
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Synthesis and SAR of 4-aryl-1-(indazol-5-yl)pyridin-2(1 H)ones as MCH-1 antagonists for the treatment of obesity
Hadden, Mark, Deering, Dustin M., Henderson, Alan J., Surman, Matthew D., Luche, Michele, Khmelnitsky, Yuri, Vickers, Steven, Viggers, Jean, Cheetham, Sharon, Guzzo, Peter R.
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
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Synthesis and Pharmacological Evaluation of Novel γ-Aminobutyric Acid Type B (GABAB) Receptor Agonists as Gastroesophageal Reflux Inhibitors
Alstermark, Christer, Amin, Kosrat, Dinn, Sean R, Elebring, Thomas, Fjellström, Ola, Fitzpatrick, Kevin, Geiss, William B, Gottfries, Johan, Guzzo, Peter R, Harding, James P, Holmén, Anders, Kothare, Mohit, Lehmann, Anders, Mattsson, Jan P, Nilsson, Karolina, Sundén, Gunnel, Swanson, Marianne, von Unge, Sverker, Woo, Alex M, Wyle, Michael J, Zheng, Xiaozhang
Published in Journal of medicinal chemistry (24.07.2008)
Published in Journal of medicinal chemistry (24.07.2008)
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Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1
Cioffi, Christopher L., Wolf, Mark A., Guzzo, Peter R., Sadalapure, Kashinath, Parthasarathy, Visweswaran, Dethe, Dattatraya, Maeng, Jun-Ho, Carulli, Edmund, Loong, David T.J., Fang, Xiao, Hu, Min, Gupta, Priya, Chung, Mark, Bai, Mei, Moore, Nick, Luche, Michele, Khmelnitsky, Yuri, Love, Patrick L., Watson, Megan A., Mhyre, Andrew J., Liu, Shuang
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
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The preparation of optically active alpha-amino 4H-[1,2,4]oxadiazol-5-ones from optically active alpha-amino acids
Mangette, John E., Johnson, Matthew R., Le, Van-Duc, Shenoy, Rajesh A., Roark, Howard, Stier, Michael, Belliotti, Thomas, Capiris, Thomas, Guzzo, Peter R.
Published in Tetrahedron (14.11.2009)
Published in Tetrahedron (14.11.2009)
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