Design and Optimization of Selective Protein Kinase C θ (PKCθ) Inhibitors for the Treatment of Autoimmune Diseases
Jimenez, Juan-Miguel, Boyall, Dean, Brenchley, Guy, Collier, Philip N, Davis, Christopher J, Fraysse, Damien, Keily, Shazia B, Henderson, Jaclyn, Miller, Andrew, Pierard, Francoise, Settimo, Luca, Twin, Heather C, Bolton, Claire M, Curnock, Adam P, Chiu, Peter, Tanner, Adam J, Young, Stephen
Published in Journal of medicinal chemistry (14.03.2013)
Published in Journal of medicinal chemistry (14.03.2013)
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Journal Article
Discovery of Selective, Orally Bioavailable Pyrazolopyridine Inhibitors of Protein Kinase Cθ (PKCθ) That Ameliorate Symptoms of Experimental Autoimmune Encephalomyelitis
Collier, Philip N, Twin, Heather C, Knegtel, Ronald M. A, Boyall, Dean, Brenchley, Guy, Davis, Christopher J, Keily, Shazia, Mak, Chau, Miller, Andrew, Pierard, Françoise, Settimo, Luca, Bolton, Clare M, Chiu, Peter, Curnock, Adam, Doyle, Elisabeth, Tanner, Adam J, Jimenez, Juan-Miguel
Published in ACS medicinal chemistry letters (08.08.2019)
Published in ACS medicinal chemistry letters (08.08.2019)
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Journal Article
Discovery and Structure−Activity Relationship of 3-Aminopyrid-2-ones as Potent and Selective Interleukin-2 Inducible T-Cell Kinase (Itk) Inhibitors
Charrier, Jean-Damien, Miller, Andrew, Kay, David P, Brenchley, Guy, Twin, Heather C, Collier, Philip N, Ramaya, Sharn, Keily, Shazia B, Durrant, Steven J, Knegtel, Ronald M. A, Tanner, Adam J, Brown, Kieron, Curnock, Adam P, Jimenez, Juan-Miguel
Published in Journal of medicinal chemistry (14.04.2011)
Published in Journal of medicinal chemistry (14.04.2011)
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Journal Article
Strategies for the modulation of phase II metabolism in a series of PKC epsilon inhibitors
Clemens, Jeremy J., Coon, Timothy, Busch, Brett B., Asgian, Juliana L., Hudson, Sarah, Termin, Andreas, Flores, Tina B., Tran, Dao, Chiang, Peggy, Sperry, Sam, Gross, Ray, Abt, Jeffrey, Heim, Roger, Lechner, Sandra, Twin, Heather, Studley, John, Brenchley, Guy, Collier, Philip N., Pierard, Francoise, Miller, Andrew, Mak, Chau, Dvornikovs, Vadims, Jimenez, Juan-Miguel, Stamos, Dean
Published in Bioorganic & medicinal chemistry letters (01.08.2014)
Published in Bioorganic & medicinal chemistry letters (01.08.2014)
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Journal Article
PYRAZOLOPYRIDINE KINASE INHIBITORS
BOYALL DEAN, SETTIMO LUCA, DAMIEN FRAYSSE, JIMENEZ JUAN-MIGUEL, GUY BRENCHLEY
Year of Publication 18.12.2014
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Year of Publication 18.12.2014
Patent
TRICYCLIC PYRAZOLO-PYRIDINE KINASE INHIBITOR
BOYALL DEAN, SETTIMO LUCA, DAMIEN FRAYSSE, JIMENEZ JUAN-MIGUEL, GUY BRENCHLEY
Year of Publication 06.11.2014
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Year of Publication 06.11.2014
Patent
TRICYCLIC PYRAZOLO-PYRIDINE KINASE INHIBITOR
PHILIP COLLIER, DAVIS CHRIS, BOYALL DEAN, MILLER ANDREW, SETTIMO LUCA, DAMIEN FRAYSSE, JOHN STUDLEY, JIMENEZ JUAN-MIGUEL, YOUNG STEVEN, KNEGTEL RONALD, GUY BRENCHLEY, HEATHER TWIN
Year of Publication 06.11.2014
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Year of Publication 06.11.2014
Patent
Synthesis of a stable pyridyl boronate and its reaction with aryl and heteroaryl halides
Durrant, Steven J., Pinder, Joanne L., Charrier, Jean-Damien, Jimenez, Juan-Miguel, Brenchley, Guy, Collier, Philip N., Kay, David, Miller, Andrew, Pierard, Francoise, Ramaya, Sharn, Sadiq, Shazia, Twin, Heather C.
Published in Heterocycles (31.12.2006)
Published in Heterocycles (31.12.2006)
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Journal Article
A new class of chiral phosphorus catalyst for asymmetric palladium catalysed allylic substitution reactions
Brenchley, Guy, Merifield, Eric, Wills, Martin, Fedouloff, Michael
Published in Tetrahedron letters (25.04.1994)
Published in Tetrahedron letters (25.04.1994)
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Journal Article
New ligands for asymmetric palladium catalysed allylic substitution reactions. X-ray crystal structures of two enantiomerically pure dihydrobenzazaphosphole-borane complexes
Brenchley, Guy, Fedouloff, Michael, Mahon, Mary F., Molloy, Kieran C., Wills, Martin
Published in Tetrahedron (18.09.1995)
Published in Tetrahedron (18.09.1995)
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Journal Article
inibidores de pirazolopiridina tricíclica cinase
Heather Twin, John Studley, Stephen Young, Andrew Miller, Ronald Knegtel, Chris David, Dean Bouyall, Juan-Miguel Jimenez, Guy Brenchley, Luca Settimo, Damien Fraysse, Phil Collier
Year of Publication 24.09.2019
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Year of Publication 24.09.2019
Patent