Pharmacophore-guided lead optimization: The rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease
Burnett, J.C., Wang, C., Nuss, J.E., Nguyen, T.L., Hermone, A.R., Schmidt, J.J., Gussio, R., Wipf, P., Bavari, S.
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Published in Bioorganic & medicinal chemistry letters (01.10.2009)
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Evaluation and Comparison of 3D-QSAR CoMSIA Models for CDK1, CDK5, and GSK-3 Inhibition by Paullones
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Published in Journal of medicinal chemistry (01.01.2004)
Published in Journal of medicinal chemistry (01.01.2004)
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A Posttranslational Modification of β-Actin Contributes to the Slow Dissociation of the Spectrin-Protein 4.1-Actin Complex of Irreversibly Sickled Cells
Shartava, Archil, Monteiro, Carlos A., Bencsath, F. Aladar, Schneider, Klaus, Chait, Brian T., Gussio, Rick, Casoria-Scott, Linda A., Shah, Arvind K., Heuerman, Christine A., Goodman, Steven R.
Published in The Journal of cell biology (01.03.1995)
Published in The Journal of cell biology (01.03.1995)
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A Common Pharmacophore for a Diverse Set of Colchicine Site Inhibitors Using a Structure-Based Approach
Nguyen, Tam Luong, McGrath, Connor, Hermone, Ann R, Burnett, James C, Zaharevitz, Daniel W, Day, Billy W, Wipf, Peter, Hamel, Ernest, Gussio, Rick
Published in Journal of medicinal chemistry (22.09.2005)
Published in Journal of medicinal chemistry (22.09.2005)
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A Common Pharmacophore for Epothilone and Taxanes: Molecular Basis for Drug Resistance Conferred by Tubulin Mutations in Human Cancer Cells
Giannakakou, P, Gussio, R, Nogales, E, Downing, K H, Zaharevitz, D, Bollbuck, B, Poy, G, Sackett, D, Nicolaou, K C, Fojo, T
Published in Proceedings of the National Academy of Sciences - PNAS (14.03.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (14.03.2000)
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Structural basis for the inhibition of botulinum neurotoxin serotype A by potent peptidomimetics
Zuniga, J., Hammill, J., Drory, O., Nuss, J., Burnett, J., Gussio, R., Wipf, P., Bavari, S., Brunger, A.T.
Published in Toxicon (Oxford) (15.06.2013)
Published in Toxicon (Oxford) (15.06.2013)
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Paullones, a Series of Cyclin-Dependent Kinase Inhibitors: Synthesis, Evaluation of CDK1/Cyclin B Inhibition, and in Vitro Antitumor Activity
Schultz, Christiane, Link, Andreas, Leost, Maryse, Zaharevitz, Daniel W, Gussio, Rick, Sausville, Edward A, Meijer, Laurent, Kunick, Conrad
Published in Journal of medicinal chemistry (29.07.1999)
Published in Journal of medicinal chemistry (29.07.1999)
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Chemical synthesis and biological properties of pyridine epothilones
Nicolaou, KC, Scarpelli, R, Bollbuck, B, Werschkun, B, Pereira, MMA, Wartmann, M, Altmann, K-H, Zaharevitz, D, Gussio, R, Giannakakou, P
Published in Chemistry & biology (01.08.2000)
Published in Chemistry & biology (01.08.2000)
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Identification of a Potent and Selective Pharmacophore for Cdc25 Dual Specificity Phosphatase Inhibitors
Lazo, John S, Nemoto, Kaoru, Pestell, Katharine E, Cooley, Kathleen, Southwick, Eileen C, Mitchell, Douglas A, Furey, William, Gussio, Rick, Zaharevitz, Daniel W, Joo, Beomjun, Wipf, Peter
Published in Molecular pharmacology (01.04.2002)
Published in Molecular pharmacology (01.04.2002)
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Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases
ZAHAREVITZ, D. W, GUSSIO, R, LEOST, M, SENDEROWICZ, A. M, LAHUSEN, T, KUNICK, C, MEIJER, L, SAUSVILLE, E. A
Published in Cancer research (Chicago, Ill.) (01.06.1999)
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Published in Cancer research (Chicago, Ill.) (01.06.1999)
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Identification of small molecule inhibitors of anthrax lethal factor
Panchal, Rekha G, Bavari, Sina, Hermone, Ann R, Nguyen, Tam Luong, Wong, Thiang Yian, Schwarzenbacher, Robert, Schmidt, James, Lane, Douglas, McGrath, Connor, Turk, Benjamin E, Burnett, James, Aman, M Javad, Little, Stephen, Sausville, Edward A, Zaharevitz, Daniel W, Cantley, Lewis C, Liddington, Robert C, Gussio, Rick
Published in Nature structural & molecular biology (01.01.2004)
Published in Nature structural & molecular biology (01.01.2004)
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Anthrax Biosensor, Protective Antigen Ion Channel Asymmetric Blockade
Halverson, Kelly M., Panchal, Rekha G., Nguyen, Tam L., Gussio, Rick, Little, Stephen F., Misakian, Martin, Bavari, Sina, Kasianowicz, John J.
Published in The Journal of biological chemistry (07.10.2005)
Published in The Journal of biological chemistry (07.10.2005)
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A Refined Pharmacophore Identifies Potent 4-Amino-7-chloroquinoline-Based Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease
Burnett, James C, Opsenica, Dejan, Sriraghavan, Kamaraj, Panchal, Rekha G, Ruthel, Gordon, Hermone, Ann R, Nguyen, Tam L, Kenny, Tara A, Lane, Douglas J, McGrath, Connor F, Schmidt, James J, Vennerstrom, Jonathan L, Gussio, Rick, Šolaja, Bogdan A, Bavari, Sina
Published in Journal of medicinal chemistry (03.05.2007)
Published in Journal of medicinal chemistry (03.05.2007)
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Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity
Burnett, James C, Schmidt, James J, Stafford, Robert G, Panchal, Rekha G, Nguyen, Tam L, Hermone, Ann R, Vennerstrom, Jonathan L, McGrath, Connor F, Lane, Douglas J, Sausville, Edward A, Zaharevitz, Daniel W, Gussio, Rick, Bavari, Sina
Published in Biochemical and biophysical research communications (10.10.2003)
Published in Biochemical and biophysical research communications (10.10.2003)
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A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype a Has a Very Different Conformation Than SNAP-25 Substrate
Zuniga, J.E., Schmidt, J.J., Fenn, T., Burnett, J.C., Arac, D., Gussio, R., Stafford, R.G., Badie, S.S., Bavari, S., Brunger, A.T.
Published in Structure (London) (28.05.2009)
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Published in Structure (London) (28.05.2009)
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Cyclostreptin (FR182877), an Antitumor Tubulin-Polymerizing Agent Deficient in Enhancing Tubulin Assembly Despite Its High Affinity for the Taxoid Site
Edler, Michael C, Buey, Rubén M, Gussio, Rick, Marcus, Adam I, Vanderwal, Christopher D, Sorensen, Erik J, Díaz, J. Fernando, Giannakakou, Paraskevi, Hamel, Ernest
Published in Biochemistry (Easton) (30.08.2005)
Published in Biochemistry (Easton) (30.08.2005)
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