The TLR4 antagonist Eritoran protects mice from lethal influenza infection
Shirey, Kari Ann, Lai, Wendy, Scott, Alison J., Lipsky, Michael, Mistry, Pragnesh, Pletneva, Lioubov M., Karp, Christopher L., McAlees, Jaclyn, Gioannini, Theresa L., Weiss, Jerrold, Chen, Wilbur H., Ernst, Robert K., Rossignol, Daniel P., Gusovsky, Fabian, Blanco, Jorge C. G., Vogel, Stefanie N.
Published in Nature (London) (23.05.2013)
Published in Nature (London) (23.05.2013)
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Vaccine-linked chemotherapy induces IL-17 production and reduces cardiac pathology during acute Trypanosoma cruzi infection
Cruz-Chan, Julio V., Villanueva-Lizama, Liliana E., Versteeg, Leroy, Damania, Ashish, Villar, Maria José, González-López, Cristina, Keegan, Brian, Pollet, Jeroen, Gusovsky, Fabian, Hotez, Peter J., Bottazzi, Maria Elena, Jones, Kathryn M.
Published in Scientific reports (05.02.2021)
Published in Scientific reports (05.02.2021)
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The impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection
Nguyen, Duc Minh, Poveda, Cristina, Pollet, Jeroen, Gusovsky, Fabian, Bottazzi, Maria Elena, Hotez, Peter J, Jones, Kathryn Marie
Published in PLoS neglected tropical diseases (21.11.2023)
Published in PLoS neglected tropical diseases (21.11.2023)
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Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase
Michalska, Karolina, Chang, Changsoo, Maltseva, Natalia I., Jedrzejczak, Robert, Robertson, Gregory T., Gusovsky, Fabian, McCarren, Patrick, Schreiber, Stuart L., Nag, Partha P., Joachimiak, Andrzej
Published in Protein science (01.03.2020)
Published in Protein science (01.03.2020)
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A therapeutic vaccine prototype induces protective immunity and reduces cardiac fibrosis in a mouse model of chronic Trypanosoma cruzi infection
Barry, Meagan A, Versteeg, Leroy, Wang, Qian, Pollet, Jeroen, Zhan, Bin, Gusovsky, Fabian, Bottazzi, Maria Elena, Hotez, Peter J, Jones, Kathryn M
Published in PLoS neglected tropical diseases (01.05.2019)
Published in PLoS neglected tropical diseases (01.05.2019)
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The Toll-Like Receptor 4 Antagonist Eritoran Protects Mice from Lethal Filovirus Challenge
Younan, Patrick, Ramanathan, Palaniappan, Graber, Jessica, Gusovsky, Fabian, Bukreyev, Alexander
Published in mBio (25.04.2017)
Published in mBio (25.04.2017)
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The Tuberculosis Drug Accelerator at year 10: what have we learned?
Aldridge, Bree B., Barros-Aguirre, David, Barry, Clifton E., Bates, Robert H., Berthel, Steven J., Boshoff, Helena I., Chibale, Kelly, Chu, Xin-Jie, Cooper, Christopher B., Dartois, Véronique, Duncan, Ken, Fotouhi, Nader, Gusovsky, Fabian, Hipskind, Philip A., Kempf, Dale J., Lelièvre, Joël, Lenaerts, Anne J., McNamara, Case W., Mizrahi, Valerie, Nathan, Carl, Olsen, David B., Parish, Tanya, Petrassi, H. Michael, Pym, Alexander, Rhee, Kyu Y., Robertson, Gregory T., Rock, Jeremy Michael, Rubin, Eric J., Russell, Betsy, Russell, David G., Sacchettini, James C., Schnappinger, Dirk, Schrimpf, Michael, Upton, Anna M., Warner, Peter, Wyatt, Paul Graham, Yuan, Ying
Published in Nature medicine (01.08.2021)
Published in Nature medicine (01.08.2021)
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Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo
Lamphier, Marc, Zheng, Wanjun, Latz, Eicke, Spyvee, Mark, Hansen, Hans, Rose, Jeffrey, Genest, Melinda, Yang, Hua, Shaffer, Christina, Zhao, Yan, Shen, Yongchun, Liu, Carrie, Liu, Diana, Mempel, Thorsten R, Rowbottom, Christopher, Chow, Jesse, Twine, Natalie C, Yu, Melvin, Gusovsky, Fabian, Ishizaka, Sally T
Published in Molecular pharmacology (01.03.2014)
Published in Molecular pharmacology (01.03.2014)
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Influenza "Trains" the Host for Enhanced Susceptibility to Secondary Bacterial Infection
Shirey, Kari Ann, Perkins, Darren J, Lai, Wendy, Zhang, Wei, Fernando, Lurds R, Gusovsky, Fabian, Blanco, Jorge C G, Vogel, Stefanie N
Published in mBio (07.05.2019)
Published in mBio (07.05.2019)
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Vaccine-linked chemotherapy with a low dose of benznidazole plus a bivalent recombinant protein vaccine prevents the development of cardiac fibrosis caused by Trypanosoma cruzi in chronically-infected BALB/c mice
Dzul-Huchim, Victor Manuel, Ramirez-Sierra, Maria Jesus, Martinez-Vega, Pedro Pablo, Rosado-Vallado, Miguel Enrique, Arana-Argaez, Victor Ermilo, Ortega-Lopez, Jaime, Gusovsky, Fabian, Dumonteil, Eric, Cruz-Chan, Julio Vladimir, Hotez, Peter, Bottazzi, María Elena, Villanueva-Lizama, Liliana Estefania
Published in PLoS neglected tropical diseases (12.09.2022)
Published in PLoS neglected tropical diseases (12.09.2022)
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Combinations of the azaquinazoline anti- Wolbachia agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis
Hegde, Shrilakshmi, Marriott, Amy E, Pionnier, Nicolas, Steven, Andrew, Bulman, Christina, Gunderson, Emma, Vogel, Ian, Koschel, Marianne, Ehrens, Alexandra, Lustigman, Sara, Voronin, Denis, Tricoche, Nancy, Hoerauf, Achim, Hübner, Marc P, Sakanari, Judy, Aljayyoussi, Ghaith, Gusovsky, Fabian, Dagley, Jessica, Hong, David W, O'Neill, Paul, Ward, Steven A, Taylor, Mark J, Turner, Joseph D
Published in Frontiers in microbiology (01.02.2024)
Published in Frontiers in microbiology (01.02.2024)
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Vaccine-linked chemotherapy improves cardiac structure and function in a mouse model of chronic Chagas disease
Jones, Kathryn M, Mangin, Elise N, Reynolds, Corey L, Villanueva, Liliana E, Cruz, Julio Vladimir, Versteeg, Leroy, Keegan, Brian, Kendricks, April, Pollet, Jeroen, Gusovsky, Fabian, Bottazzi, Maria Elena, Hotez, Peter J
Published in Frontiers in cellular and infection microbiology (09.02.2023)
Published in Frontiers in cellular and infection microbiology (09.02.2023)
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Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria
Franklin, Bernardo S, Ishizaka, Sally T, Lamphier, Marc, Gusovsky, Fabian, Hansen, Hans, Rose, Jeffrey, Zheng, Wanjun, Ataíde, Marco Antônio, de Oliveira, Rosane B, Golenbock, Douglas T, Gazzinelli, Ricardo T
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2011)
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Combining SJ733, an oral ATP4 inhibitor of Plasmodium falciparum, with the pharmacokinetic enhancer cobicistat: An innovative approach in antimalarial drug development
Gaur, Aditya H., Panetta, John C., Smith, Amber M., Dallas, Ronald H., Freeman, Burgess B., Stewart, Tracy B., Tang, Li, John, Elizabeth, Branum, Kristen C., Patel, Nehali D., Ost, Shelley, Heine, Ryan N., Richardson, Julie L., Hammill, Jared T., Bebrevska, Lidiya, Gusovsky, Fabian, Maki, Noritsugu, Yanagi, Toshiharu, Flynn, Patricia M., McCarthy, James S., Chalon, Stephan, Guy, R. Kiplin
Published in EBioMedicine (01.06.2022)
Published in EBioMedicine (01.06.2022)
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Inhibition of Endotoxin Response by E5564, a Novel Toll-Like Receptor 4-Directed Endotoxin Antagonist
Mullarkey, Maureen, Rose, Jeffrey R, Bristol, John, Kawata, Tsutomu, Kimura, Akufumi, Kobayashi, Seiichi, Przetak, Melinda, Chow, Jesse, Gusovsky, Fabian, Christ, William J, Rossignol, Daniel P
Published in The Journal of pharmacology and experimental therapeutics (01.03.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2003)
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E6201 [(3S,4R,5Z,8S,9S,11E)-14-(Ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a Novel Kinase Inhibitor of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase (MEK)-1 and MEK Kinase-1: In Vitro Characterization of Its Anti-Inflammatory and Antihyperproliferative Activities
Goto, Masaki, Chow, Jesse, Muramoto, Kenzo, Chiba, Ken-ichi, Yamamoto, Satoshi, Fujita, Masanori, Obaishi, Hiroshi, Tai, Kenji, Mizui, Yoshiharu, Tanaka, Isao, Young, Donna, Yang, Hua, Wang, Yuan J, Shirota, Hiroshi, Gusovsky, Fabian
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
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Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2, III
Shen, Yongchun, Boivin, Roch, Yoneda, Naoki, Du, Hong, Schiller, Shawn, Matsushima, Tomohiro, Goto, Masaki, Shirota, Hiroshi, Gusovsky, Fabian, Lemelin, Charles, Jiang, Yimin, Zhang, Zhiyi, Pelletier, Robert, Ikemori-Kawada, Megumi, Kawakami, Yoshiyuki, Inoue, Atsushi, Schnaderbeck, Matthew, Wang, Yuan
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Drug Targeting Based on a New Concept-Targeting Against TLR4 as an Example
Maru, Yoshiro, Tomita, Takeshi, Deguchi, Atsuko, Ieguchi, Katsuaki, Takita, Morichika, Tsukahara, Fujiko, Takemura, Kazuhiro, Kitao, Akio, Gusovsky, Fabian
Published in Endocrine, metabolic & immune disorders drug targets (01.01.2015)
Published in Endocrine, metabolic & immune disorders drug targets (01.01.2015)
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Journal Article
Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction
Chow, J C, Young, D W, Golenbock, D T, Christ, W J, Gusovsky, F
Published in The Journal of biological chemistry (16.04.1999)
Published in The Journal of biological chemistry (16.04.1999)
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Discovery of an in vitro and in vivo potent resorcylic lactone analog of LL-Z1640-2 as anti-inflammatory lead, II
Shen, Yongchun, Du, Hong, Kotake, Makoto, Matsushima, Tomohiro, Goto, Masaki, Shirota, Hiroshi, Gusovsky, Fabian, Li, Xiangyi, Jiang, Yimin, Schiller, Shawn, Spyvee, Mark, Davis, Heather, Zhang, Zhiyi, Pelletier, Robert, Ikemori-Kawada, Megumi, Kawakami, Yoshiyuki, Inoue, Atsushi, Wang, Yuan
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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