Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons
Silva, M Catarina, Nandi, Ghata A, Tentarelli, Sharon, Gurrell, Ian K, Jamier, Tanguy, Lucente, Diane, Dickerson, Bradford C, Brown, Dean G, Brandon, Nicholas J, Haggarty, Stephen J
Published in Nature communications (26.06.2020)
Published in Nature communications (26.06.2020)
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Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo
Schofield, Darren J., Irving, Lorraine, Calo, Laura, Bogstedt, Anna, Rees, Gareth, Nuccitelli, Annalisa, Narwal, Rajesh, Petrone, Marcella, Roberts, Jennifer, Brown, Lee, Cusdin, Fiona, Dosanjh, Bhupinder, Lloyd, Christopher, Dobson, Claire, Gurrell, Ian, Fraser, Graham, McFarlane, Mary, Rockenstein, Edward, Spencer, Brian, Masliah, Eliezer, Spillantini, Maria Grazia, Tan, Keith, Billinton, Andrew, Vaughan, Tris, Chessell, Iain, Perkinton, Michael S.
Published in Neurobiology of disease (01.12.2019)
Published in Neurobiology of disease (01.12.2019)
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A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model
Thom, George, Tian, Mei-Mei, Hatcher, Jon P, Rodrigo, Natalia, Burrell, Matthew, Gurrell, Ian, Vitalis, Timothy Z, Abraham, Thomas, Jefferies, Wilfred A, Webster, Carl I, Gabathuler, Reinhard
Published in Journal of cerebral blood flow and metabolism (01.10.2019)
Published in Journal of cerebral blood flow and metabolism (01.10.2019)
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Discovery of Clinical Candidate 4‑[2-(5-Amino‑1H‑pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro‑N‑1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7
Swain, Nigel. A, Batchelor, Dave, Beaudoin, Serge, Bechle, Bruce M, Bradley, Paul A, Brown, Alan D, Brown, Bruce, Butcher, Ken J, Butt, Richard P, Chapman, Mark L, Denton, Stephen, Ellis, David, Galan, Sebastien R. G, Gaulier, Steven M, Greener, Ben S, de Groot, Marcel J, Glossop, Mel S, Gurrell, Ian K, Hannam, Jo, Johnson, Matthew S, Lin, Zhixin, Markworth, Christopher J, Marron, Brian E, Millan, David S, Nakagawa, Shoko, Pike, Andy, Printzenhoff, David, Rawson, David J, Ransley, Sarah J, Reister, Steven M, Sasaki, Kosuke, Storer, R. Ian, Stupple, Paul A, West, Christopher W
Published in Journal of medicinal chemistry (24.08.2017)
Published in Journal of medicinal chemistry (24.08.2017)
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Toward β‑Secretase‑1 Inhibitors with Improved Isoform Selectivity
Johansson, Patrik, Kaspersson, Karin, Gurrell, Ian K, Bäck, Elisabeth, Eketjäll, Susanna, Scott, Clay W, Cebers, Gvido, Thorne, Philip, McKenzie, Michael J, Beaton, Haydn, Davey, Paul, Kolmodin, Karin, Holenz, Jörg, Duggan, Mark E, Budd Haeberlein, Samantha, Bürli, Roland W
Published in Journal of medicinal chemistry (26.04.2018)
Published in Journal of medicinal chemistry (26.04.2018)
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Antibody-oligonucleotide conjugate achieves CNS delivery in animal models for spinal muscular atrophy
Hammond, Suzan M, Abendroth, Frank, Goli, Larissa, Stoodley, Jessica, Burrell, Matthew, Thom, George, Gurrell, Ian, Ahlskog, Nina, Gait, Michael J, Wood, Matthew Ja, Webster, Carl I
Published in JCI insight (22.12.2022)
Published in JCI insight (22.12.2022)
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Journal Article
Application of PBPK modelling in drug discovery and development at Pfizer
Jones, Hannah M, Dickins, Maurice, Youdim, Kuresh, Gosset, James R, Attkins, Neil J, Hay, Tanya L, Gurrell, Ian K, Logan, Y Raj, Bungay, Peter J, Jones, Barry C, Gardner, Iain B
Published in Xenobiotica (01.01.2012)
Published in Xenobiotica (01.01.2012)
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Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice
Jarvis, Rebecca, Josephine Ng, Shu Fun, Nathanson, Anna J., Cardarelli, Ross A., Abiraman, Krithika, Wade, Fergus, Evans-Strong, Aidan, Fernandez-Campa, Marina P., Deeb, Tarek Z., Smalley, Joshua L., Jamier, Tanguy, Gurrell, Ian K., McWilliams, Lisa, Kawatkar, Aarti, Conway, Leslie C., Wang, Qi, Burli, Roland W., Brandon, Nicholas J., Chessell, Iain P., Goldman, Aaron J., Maguire, Jamie L., Moss, Stephen J.
Published in Cell reports. Medicine (21.03.2023)
Published in Cell reports. Medicine (21.03.2023)
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Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na V 1.7
Swain, Nigel A, Batchelor, Dave, Beaudoin, Serge, Bechle, Bruce M, Bradley, Paul A, Brown, Alan D, Brown, Bruce, Butcher, Ken J, Butt, Richard P, Chapman, Mark L, Denton, Stephen, Ellis, David, Galan, Sebastien R G, Gaulier, Steven M, Greener, Ben S, de Groot, Marcel J, Glossop, Mel S, Gurrell, Ian K, Hannam, Jo, Johnson, Matthew S, Lin, Zhixin, Markworth, Christopher J, Marron, Brian E, Millan, David S, Nakagawa, Shoko, Pike, Andy, Printzenhoff, David, Rawson, David J, Ransley, Sarah J, Reister, Steven M, Sasaki, Kosuke, Storer, R Ian, Stupple, Paul A, West, Christopher W
Published in Journal of medicinal chemistry (24.08.2017)
Published in Journal of medicinal chemistry (24.08.2017)
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Enhanced delivery of IL-1 receptor antagonist to the central nervous system as a novel anti-transferrin receptor-IL-1RA fusion reverses neuropathic mechanical hypersensitivity
Webster, Carl I, Hatcher, Jon, Burrell, Matthew, Thom, George, Thornton, Peter, Gurrell, Ian, Chessell, Iain
Published in Pain (Amsterdam) (01.04.2017)
Published in Pain (Amsterdam) (01.04.2017)
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Isolation of blood-brain barrier-crossing antibodies from a phage display library by competitive elution and their ability to penetrate the central nervous system
Thom, George, Hatcher, Jon, Hearn, Arron, Paterson, Judy, Rodrigo, Natalia, Beljean, Arthur, Gurrell, Ian, Webster, Carl
Published in mAbs (17.02.2018)
Published in mAbs (17.02.2018)
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Journal Article
Characterization and preclinical evaluation of a protease activated receptor 2 (PAR2) monoclonal antibody as a preventive therapy for migraine
Kopruszinski, Caroline M, Thornton, Peter, Arnold, Joanne, Newton, Philip, Lowne, David, Navratilova, Edita, Swiokla, Juliana, Dodick, David W, Dobson, Claire, Gurrell, Ian, Chessell, Iain Patrick, Porreca, Frank
Published in Cephalalgia (01.12.2020)
Published in Cephalalgia (01.12.2020)
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Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na(V)1.7
Swain, Nigel. A., Batchelor, Dave, Beaudoin, Serge, Bechle, Bruce M., Bradley, Paul A., Brown, Alan D., Brown, Bruce, Butcher, Kent J., Butt, Richard P., Chapman, Mark L., Denton, Stephen, Ellis, David, Galan, Sebastien R. G., Gaulier, Steven M., Greener, Ben S., de Groot, Marcel J., Glossop, Mel S., Gurrell, Ian K., Hannan, Jo, Johnson, Matthew S., Lin, Zhixin, Markworth, Christopher J., Marron, Brian E., Milan, David S., Nakaawa, Shoko, Pike, Andy, Printzephoff, David, Rawson, David J., Ransley, Sarah J., Reister, Steven M., Sasaki, Kosuke, Storer, R. Ian, Stupple, Paul A., West, Christopher W.
Published in Journal of medicinal chemistry (24.08.2017)
Published in Journal of medicinal chemistry (24.08.2017)
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Journal Article
Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels
Jones, Hannah M., Butt, Richard P., Webster, Rob W., Gurrell, Ian, Dzygiel, Pawel, Flanagan, Neil, Fraier, Daniela, Hay, Tanya, Iavarone, Laura Else, Luckwell, Jacquelynn, Pearce, Hannah, Phipps, Alex, Segelbacher, Jill, Speed, Bill, Beaumont, Kevin
Published in Clinical pharmacokinetics (01.07.2016)
Published in Clinical pharmacokinetics (01.07.2016)
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11. Orexin-1 Receptor Antagonists as Novel Smoking Cessation Agents
Kenny, Paul, Kamenecka, Theodore, Voren, George, Duncan, Alexander, Howe, Matthew, Hollander, Jonathan, Damez-Warno, Diane, Lu, Qun, Bali, Purva, Burli, Roland, Gurrell, Ian, Mather, Robert J., Brandon, Nicholas J.
Published in Biological psychiatry (1969) (01.05.2018)
Published in Biological psychiatry (1969) (01.05.2018)
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항-PAR2 항체 및 그의 용도
WILLIAMS RICHARD, NEWTON PHILIP, DOBSON CLAIRE, THORNTON PETER, GURRELL IAN, FAIRMAN DAVID, PODICHETTY SADHANA
Year of Publication 20.11.2019
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Year of Publication 20.11.2019
Patent
Case studies addressing human pharmacokinetic uncertainty using a combination of pharmacokinetic simulation and alternative first in human paradigms
Harrison, Anthony, Gardner, Iain, Hay, Tanya, Dickins, Maurice, Beaumont, Kevin, Phipps, Alex, Purkins, Lynn, Allan, Gill, Christian, Rachelle, Duckworth, Jonathan, Gurrell, Ian, Kempshall, Sarah, Savage, Mark, Seymour, Mark, Simpson, Marie, Taylor, Louise, Turnpenny, Paul
Published in Xenobiotica (01.01.2012)
Published in Xenobiotica (01.01.2012)
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N-Benzyl- N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors
Wakenhut, Florian, Fish, Paul V., Fray, M. Jonathan, Gurrell, Ian, Mills, James E., Stobie, Alan, Whitlock, Gavin A.
Published in Bioorganic & medicinal chemistry (01.08.2008)
Published in Bioorganic & medicinal chemistry (01.08.2008)
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ANTI-PAR2 ANTIBODIES AND USES THEREOF
DOBSON, Claire, WILLIAMS, Richard, GURRELL, Ian, FAIRMAN, David, PODICHETTY, Sadhana, THORNTON, Peter, NEWTON, Philip
Year of Publication 03.08.2023
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Year of Publication 03.08.2023
Patent
Anti-par2 antibodies and uses thereof
Newton, Philip, Gurrell, Ian, Fairman, David, Podichetty, Sadhana, Williams, Richard, Thornton, Peter, Dobson, Claire
Year of Publication 26.05.2023
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Year of Publication 26.05.2023
Patent