Structure and Inhibition of Plasmepsin II, a Hemoglobin-Degrading Enzyme from Plasmodium falciparum
Silva, A. M., Lee, A. Y., Gulnik, S. V., Majer, P., Collins, J., Bhat, T. N., Collins, P. J., Cachau, R. E., Luker, K. E., Gluzman, I. Y., Francis, S. E., Oksman, A., Goldberg, D. E., Erickson, J. W.
Published in Proceedings of the National Academy of Sciences - PNAS (17.09.1996)
Published in Proceedings of the National Academy of Sciences - PNAS (17.09.1996)
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Journal Article
Cyclopropane-Derived Peptidomimetics. Design, Synthesis, Evaluation, and Structure of Novel HIV-1 Protease Inhibitors
Martin, Stephen F, Dorsey, Gordon O, Gane, Todd, Hillier, Michael C, Kessler, Horst, Baur, Matthias, Mathä, Barbara, Erickson, John W, Bhat, T. Nagarajan, Munshi, Sanjeev, Gulnik, Sergei V, Topol, Igor A
Published in Journal of medicinal chemistry (07.05.1998)
Published in Journal of medicinal chemistry (07.05.1998)
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Journal Article
Conformational switching in an aspartic proteinase
Erickson, John W, Lee, Angela Y, Gulnik, Sergei V
Published in Nature structural biology (01.10.1998)
Published in Nature structural biology (01.10.1998)
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Structure‐based subsite specificity mapping of human cathepsin D using statine‐based inhibitors
Majer, Pavel, Collins, Jack R., Gulnik, Sergei V., Erickson, John W.
Published in Protein science (01.07.1997)
Published in Protein science (01.07.1997)
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Journal Article
Novel Uncomplexed and Complexed Structures of Plasmepsin II, an Aspartic Protease from Plasmodium falciparum
Asojo, Oluwatoyin A., Gulnik, Sergei V., Afonina, Elena, Yu, Betty, Ellman, Jonathan A., Haque, Tasir S., Silva, Abelardo M.
Published in Journal of molecular biology (14.03.2003)
Published in Journal of molecular biology (14.03.2003)
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A Potent Human Immunodeficiency Virus Type 1 Protease Inhibitor, UIC-94003 (TMC-126), and Selection of a Novel (A28S) Mutation in the Protease Active Site
Yoshimura, Kazuhisa, Kato, Ryohei, Kavlick, Mark F, Nguyen, Aline, Maroun, Victor, Maeda, Kenji, Hussain, Khaja A, Ghosh, Arun K, Gulnik, Sergei V, Erickson, John W, Mitsuya, Hiroaki
Published in Journal of Virology (01.02.2002)
Published in Journal of Virology (01.02.2002)
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Journal Article
Design, synthesis, and resistance patterns of MP-134 and MP-167, two novel inhibitors of HIV type 1 protease
Mo, H, Markowitz, M, Majer, P, Burt, S K, Gulnik, S V, Suvorov, L I, Erickson, J W, Ho, D D
Published in AIDS research and human retroviruses (01.01.1996)
Published in AIDS research and human retroviruses (01.01.1996)
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Kinetic Characterization and Cross-Resistance Patterns Of HIV-1 Protease Mutants Selected under Drug Pressure
Gulnik, Sergei V, Suvorov, Leonid I, Liu, Beishan, Yu, Betty, Anderson, Barry, Mitsuya, Hiroaki, Erickson, John W
Published in Biochemistry (Easton) (01.07.1995)
Published in Biochemistry (Easton) (01.07.1995)
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Journal Article
Unsymmetric nonpeptidic HIV protease inhibitors containing anthranilamide as a P2′ ligand
Randad, Ramnarayan S., Lubkowska, Lucyna, Eissenstat, Michael A., Gulnik, Sergei V., Yu, Betty, Narayana Bhat, T., Clanton, David J., House, Tyra, Stinson, Sherman F., Erickson, John W.
Published in Bioorganic & medicinal chemistry letters (15.12.1998)
Published in Bioorganic & medicinal chemistry letters (15.12.1998)
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Journal Article
5,6-Dihydropyran-2-ones Possessing Various Sulfonyl Functionalities: Potent Nonpeptidic Inhibitors of HIV Protease
Boyer, Frederick E, Vara Prasad, J. V. N, Domagala, John M, Ellsworth, Edmund L, Gajda, Christopher, Hagen, Susan E, Markoski, Larry J, Tait, Bradley D, Lunney, Elizabeth A, Palovsky, Alexander, Ferguson, Donna, Graham, Neil, Holler, Tod, Hupe, Donald, Nouhan, Carolyn, Tummino, Peter J, Urumov, A, Zeikus, Eric, Zeikus, Greg, Gracheck, Stephen J, Sanders, James M, VanderRoest, Steven, Brodfuehrer, Joanne, Iyer, Krishna, Sinz, Michael, Gulnik, Sergei V, Erickson, John W
Published in Journal of medicinal chemistry (09.03.2000)
Published in Journal of medicinal chemistry (09.03.2000)
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Functional Characterization of the Protease of Human Endogenous Retrovirus, K10: Can It Complement HIV-1 Protease?
Towler, Eric M, Gulnik, Sergei V, Bhat, T. N, Xie, Dong, Gustschina, Elena, Sumpter, Terry R, Robertson, Nicole, Jones, Christopher, Sauter, Marlies, Mueller-Lantzsch, Nikolaus, Debouck, Christine, Erickson, John W
Published in Biochemistry (Easton) (08.12.1998)
Published in Biochemistry (Easton) (08.12.1998)
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Design of sensitive fluorogenic substrates for human cathepsin D
Gulnik, Sergei V., Suvorov, Leonid I., Majer, Pavel, Collins, Jack, Kane, Bradley P., Johnson, Donald G., Erickson, John W.
Published in FEBS letters (18.08.1997)
Published in FEBS letters (18.08.1997)
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Journal Article
Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390 : A lead HIV protease inhibitor
VARA PRASAD, J. V. N, BOYER, F. E, HUMBLET, C, LUNNEY, E. A, PAVLOVSKY, A, RUBIN, J. R, FERGUSON, D, GRAHAM, N, HOLLER, T, HUPE, D, NOUHAN, C, TUMMINO, P. J, DOMAGALA, J. M, URUMOV, A, ZEIKUS, E, ZEIKUS, G, GRACHECK, S. J, SAUNDERS, J. M, VANDERROEST, S, BRODFUEHRER, J, IYER, K, SINZ, M, GULNIK, S. V, ELLSWORTH, E. L, ERICKSON, J. W, GAJDA, C, HAMILTON, H. W, HAGEN, S. E, MARKOSKI, L. J, STEINBAUGH, B. A, TAIT, B. D
Published in Bioorganic & medicinal chemistry (01.12.1999)
Published in Bioorganic & medicinal chemistry (01.12.1999)
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Journal Article
4-Hydroxy-5,6-dihydropyrones. 2. Potent Non-Peptide Inhibitors of HIV Protease
Tait, Bradley D, Hagen, Susan, Domagala, John, Ellsworth, Edmund L, Gajda, Christopher, Hamilton, Harriet W, Vara Prasad, J. V. N, Ferguson, Donna, Graham, Neil, Hupe, Donald, Nouhan, Carolyn, Tummino, Peter J, Humblet, Christine, Lunney, Elizabeth A, Pavlovsky, Alexander, Rubin, John, Gracheck, Stephen J, Baldwin, Eric T, Bhat, T. N, Erickson, John W, Gulnik, Sergei V, Liu, Beishan
Published in Journal of medicinal chemistry (07.11.1997)
Published in Journal of medicinal chemistry (07.11.1997)
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Journal Article
Structure-based design of achiral, nonpeptidic hydroxybenzamide as a novel P2/P2′ replacement for the symmetry-based HIV protease inhibitors
Randad, Ramnarayan S., Lubkowska, Lucyna, Silva, Abelardo M., Guerin, Diego M.A., Gulnik, Sergei V., Yu, Betty, Erickson, John W.
Published in Bioorganic & medicinal chemistry (01.09.1996)
Published in Bioorganic & medicinal chemistry (01.09.1996)
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Journal Article
Escape mutants of HIV-1 proteinase: enzymic efficiency and susceptibility to inhibition
Wilson, Sara I, Phylip, Lowri H, Mills, John S, Gulnik, Sergei V, Erickson, John W, Dunn, Ben M, Kay, John
Published in Biochimica et biophysica acta (25.04.1997)
Published in Biochimica et biophysica acta (25.04.1997)
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The structure of Yersinia pestis dehydroquinase
Silva, A. M., Gabelli, S. B., Cao, W., Afonina, E., Erickson, J. W., Gulnik, S. V.
Published in Acta crystallographica. Section A, Foundations of crystallography (23.08.2005)
Published in Acta crystallographica. Section A, Foundations of crystallography (23.08.2005)
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