Difluoromethylbenzoxazole Pyrimidine Thioether Derivatives: A Novel Class of Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors
Boyer, Jérémie, Arnoult, Eric, Médebielle, Maurice, Guillemont, Jérôme, Unge, Johan, Jochmans, Dirk
Published in Journal of medicinal chemistry (08.12.2011)
Published in Journal of medicinal chemistry (08.12.2011)
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Journal Article
A new synthetic route towards multifunctionalized cyclic amidrazones for feeding chemical space
Leblanc, Johann, Boutin, Margaux, Vega, Clara, Mathé-Allainmat, Monique, Grosse, Sandrine, Guillemont, Jérôme, Lebreton, Jacques, Tessier, Arnaud
Published in Organic & biomolecular chemistry (20.03.2024)
Published in Organic & biomolecular chemistry (20.03.2024)
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Journal Article
Design, Synthesis, and Biological Evaluation of Novel Indoles Targeting the Influenza PB2 Cap Binding Region
McGowan, David C, Balemans, Wendy, Embrechts, Werner, Motte, Magali, Keown, Jeremy R, Buyck, Christophe, Corbera, Jordi, Funes, Mario, Moreno, Laura, Cooymans, Ludwig, Tahri, Abdellah, Eymard, Julien, Stoops, Bart, Strijbos, Rudy, Van den Berg, Joke, Fodor, Ervin, Grimes, Jonathan M, Koul, Anil, Jonckers, Tim H. M, Raboisson, Pierre, Guillemont, Jérôme
Published in Journal of medicinal chemistry (14.11.2019)
Published in Journal of medicinal chemistry (14.11.2019)
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Journal Article
Synthesis of 7’‐Substituted 2’‐O‐4’‐C‐Ethylene Bridged Nucleic Acid (ENA)‐Thymidine Monomers
Sunchu, Prabhakar, Gaurrand, Sandrine, Lambert, Émilie, Guillemont, Jérôme, Beigelman, Leonid, Brioche, Julien, Piettre, Serge R.
Published in European journal of organic chemistry (02.01.2024)
Published in European journal of organic chemistry (02.01.2024)
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Journal Article
New Advances in the Synthesis of Emerging Cyclic Amidrazones to Foster Bioisosterism of Azaheterocycles
Leblanc, Johann, Mathé‐Allainmat, Monique, Grosse, Sandrine, Guillemont, Jérôme, Tessier, Arnaud, Lebreton, Jacques
Published in European journal of organic chemistry (07.03.2023)
Published in European journal of organic chemistry (07.03.2023)
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Journal Article
A Fit-for-Purpose Synthesis of (R)‑2-Methylazepane
Guizzetti, Sylvain, Michaut, Antoine, Federspiel, Guillaume, Eymard, Julien, Caron, Isabelle, Quatrevaux, Sabrina, Daras, Etienne, Jolly, Sandrine, Guillemont, Jérôme, Lançois, David
Published in Organic process research & development (15.05.2020)
Published in Organic process research & development (15.05.2020)
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Journal Article
Novel Antibiotics Targeting Respiratory ATP Synthesis in Gram-Positive Pathogenic Bacteria
BALEMANS, Wendy, VRANCKX, Luc, BONROY, Kristien, LILL, Holger, ANDRIES, Koen, BALD, Dirk, KOUL, Anil, VERGAUWEN, Karen, LOUNIS, Nacer, POP, Ovidiu, GUILLEMONT, Jérôme, MOL, Selena, GILISSEN, Ron, MOTTE, Magali, LANCOIS, David, DE BOLLE, Miguel
Published in Antimicrobial Agents and Chemotherapy (01.08.2012)
Published in Antimicrobial Agents and Chemotherapy (01.08.2012)
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Journal Article
Use of 3-(Pentafluorosulfanyl)phenol to Access to Advanced Substituted Pentafluorosulfanylphenol/anisole: Application to the Synthesis of 2-(Arylpentafluorosulfanyl)indanedione
Michaut, Antoine, Quatrevaux, Sabrina, Queguiner, Laurence, Gaurrand, Sandrinc, Guillemont, Jerome
Published in Letters in organic chemistry (01.01.2022)
Published in Letters in organic chemistry (01.01.2022)
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Journal Article
A computational model of the inhibition of Mycobacterium tuberculosis ATPase by a new drug candidate R207910
de Jonge, Marc R., Koymans, Luc H.M., Guillemont, Jérôme E.G., Koul, Anil, Andries, Koen
Published in Proteins, structure, function, and bioinformatics (01.06.2007)
Published in Proteins, structure, function, and bioinformatics (01.06.2007)
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Journal Article
In Search of a Novel Anti-HIV Drug: Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, Rilpivirine)
Janssen, Paul A. J, Lewi, Paul J, Arnold, Eddy, Daeyaert, Frits, de Jonge, Marc, Heeres, Jan, Koymans, Luc, Vinkers, Maarten, Guillemont, Jérôme, Pasquier, Elisabeth, Kukla, Mike, Ludovici, Don, Andries, Koen, de Béthune, Marie-Pierre, Pauwels, Rudi, Das, Kalyan, Clark, Art D, Frenkel, Yulia Volovik, Hughes, Stephen H, Medaer, Bart, De Knaep, Fons, Bohets, Hilde, De Clerck, Fred, Lampo, Ann, Williams, Peter, Stoffels, Paul
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Journal Article
Ion mobility-mass spectrometry analysis of diarylquinoline diastereomers: Drugs used for tuberculosis treatment
Domalain, Virginie, Hubert-Roux, Marie, Quéguiner, Laurence, Fouque, Dany Jd, Arnoult, Eric, Speybrouck, David, Guillemont, Jérôme, Afonso, Carlos
Published in European journal of mass spectrometry (Chichester, England) (01.06.2019)
Published in European journal of mass spectrometry (Chichester, England) (01.06.2019)
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Journal Article
Selection of a Respiratory Syncytial Virus Fusion Inhibitor Clinical Candidate, Part 1: Improving the Pharmacokinetic Profile Using the Structure−Property Relationship
Bonfanti, Jean-François, Doublet, Frédéric, Fortin, Jérôme, Lacrampe, Jean, Guillemont, Jérôme, Muller, Philippe, Queguiner, Laurence, Arnoult, Eric, Gevers, Tom, Janssens, Peggy, Szel, Heidi, Willebrords, Rudy, Timmerman, Philip, Wuyts, Koen, Janssens, Frans, Sommen, Cois, Wigerinck, Piet, Andries, Koen
Published in Journal of medicinal chemistry (20.09.2007)
Published in Journal of medicinal chemistry (20.09.2007)
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Journal Article
A novel route to 2,4-dianilino-substituted pyrimidines
Leenders, Ruben, Heeres, Jan, Guillemont, Jérôme, Lewi, Paul
Published in Tetrahedron letters (20.01.2010)
Published in Tetrahedron letters (20.01.2010)
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Journal Article
Crystal Structures for HIV-1 Reverse Transcriptase in Complexes with Three Pyridinone Derivatives: A New Class of Non-Nucleoside Inhibitors Effective against a Broad Range of Drug-Resistant Strains
Himmel, Daniel M, Das, Kalyan, Clark, Arthur D, Hughes, Stephen H, Benjahad, Abdellah, Oumouch, Said, Guillemont, Jérôme, Coupa, Sophie, Poncelet, Alain, Csoka, Imre, Meyer, Christophe, Andries, Koen, Nguyen, Chi Hung, Grierson, David S, Arnold, Eddy
Published in Journal of medicinal chemistry (01.12.2005)
Published in Journal of medicinal chemistry (01.12.2005)
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Journal Article
Synthesis and Biological Evaluation of C-5 Methyl Substituted 4-Arylthio and 4-Aryloxy-3-Iodopyridin-2(1H)-one Type Anti-HIV Agents
Guillemont, Jérôme, Benjahad, Abdellah, Oumouch, Said, Decrane, Laurence, Palandjian, Patrice, Vernier, Daniel, Queguiner, Laurence, Andries, Koen, de Béthune, Marie-Pierre, Hertogs, Kurt, Grierson, David S, Nguyen, Chi Hung
Published in Journal of medicinal chemistry (10.12.2009)
Published in Journal of medicinal chemistry (10.12.2009)
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Journal Article
The challenge of new drug discovery for tuberculosis
Koul, Anil, Arnoult, Eric, Lounis, Nacer, Guillemont, Jerome, Andries, Koen
Published in Nature (London) (27.01.2011)
Published in Nature (London) (27.01.2011)
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Journal Article
3-(Arylamino)-1,2,4-triazin-5-one: A Novel Synthesis and Its Use
Leenders, Ruben, Heeres, Jan, Vandenput, Dirk, Zijlmans, Remco, Guillemont, Jérôme, Lewi, Paul
Published in European Journal of Organic Chemistry (01.05.2010)
Published in European Journal of Organic Chemistry (01.05.2010)
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Book Review
Journal Article
Conformational Analysis of R207910, a New Drug Candidate for the Treatment of Tuberculosis, by a Combined NMR and Molecular Modeling Approach
Gaurrand, Sandrine, Desjardins, Stéphanie, Meyer, Christophe, Bonnet, Pascal, Argoullon, Jean-Michel, Oulyadi, Hassan, Guillemont, Jérôme
Published in Chemical biology & drug design (01.08.2006)
Published in Chemical biology & drug design (01.08.2006)
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Journal Article