The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
Firestein, Ron, Blander, Gil, Michan, Shaday, Oberdoerffer, Philipp, Ogino, Shuji, Campbell, Jennifer, Bhimavarapu, Anupama, Luikenhuis, Sandra, de Cabo, Rafael, Fuchs, Charles, Hahn, William C, Guarente, Leonard P, Sinclair, David A
Published in PloS one (16.04.2008)
Published in PloS one (16.04.2008)
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Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
Cohen, Dena E, Supinski, Andrea M, Bonkowski, Michael S, Donmez, Gizem, Guarente, Leonard P
Published in Genes & development (15.12.2009)
Published in Genes & development (15.12.2009)
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Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation
Lombard, David B., Alt, Frederick W., Cheng, Hwei-Ling, Bunkenborg, Jakob, Streeper, Ryan S., Mostoslavsky, Raul, Kim, Jennifer, Yancopoulos, George, Valenzuela, David, Murphy, Andrew, Yang, Yinhua, Chen, Yaohui, Hirschey, Matthew D., Bronson, Roderick T., Haigis, Marcia, Guarente, Leonard P., Farese, Robert V., Weissman, Sherman, Verdin, Eric, Schwer, Bjoern
Published in Molecular and Cellular Biology (01.12.2007)
Published in Molecular and Cellular Biology (01.12.2007)
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Nicotinamide riboside with pterostilbene (NRPT) increases NAD + in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI
Simic, Petra, Vela Parada, Xavier Fernando, Parikh, Samir M, Dellinger, Ryan, Guarente, Leonard P, Rhee, Eugene P
Published in BMC nephrology (13.08.2020)
Published in BMC nephrology (13.08.2020)
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Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice
Hayashi, Hideki, Cherpokova, Deya, Martinod, Kimberly, Witsch, Thilo, Wong, Siu Ling, Gallant, Maureen, Cifuni, Stephen M, Guarente, Leonard P, Wagner, Denisa D
Published in PloS one (13.12.2017)
Published in PloS one (13.12.2017)
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Dietary Restriction: Standing Up for Sirtuins [With Response]
BAUR, JOEPH A., CHEN, DANICA, CHINI, EDUARDO N., CHUA, KATRIN, COHEN, HAIM Y., DE CABO, RAFAEL, DENG, CHUXIA, DIMMELER, STEFANIE, GIUS, DAVID, GUARENTE, LEONARD P., HELFAND, STEPHEN L., IMAI, SHIN-ICHIRO, ITOH, HIROSHI, KADOWAKI, TAKASHI, KOYA, DAISUKE, LEEUWENBURGH, CHRISTIAAN, MCBURNEY, MICHAEL, NABESHIMA, YO-ICHI, NERI, CHRISTIAN, OBERDOERFFER, PHILIPP, PESTELL, RICHARD G., ROGINA, BLANKA, SADOSHIMA, JUNICHI, SARTORELLI, VITTORIO, SERRANO, MANUEL, SINCLAIR, DAVID A., STEEGBORN, CLEMENS, TATAR, MARC, TISSENBAUM, HEIDI A., TONG, QIANG, TSUBOTA, KAZUO, VAQUERO, ALEJANDRO, VERDIN, ERIC, FONTANA, LUIGI, PARTRIDGE, LINDA, LONGO, VALTER D.
Published in Science (American Association for the Advancement of Science) (27.08.2010)
Published in Science (American Association for the Advancement of Science) (27.08.2010)
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The NAD +-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control
Nakahata, Yasukazu, Kaluzova, Milota, Grimaldi, Benedetto, Sahar, Saurabh, Hirayama, Jun, Chen, Danica, Guarente, Leonard P., Sassone-Corsi, Paolo
Published in Cell (25.07.2008)
Published in Cell (25.07.2008)
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SIRT1 deacetylase in aging‐induced neuromuscular degeneration and amyotrophic lateral sclerosis
Herskovits, Adrianna Z., Hunter, Tegan A., Maxwell, Nicholas, Pereira, Katherine, Whittaker, Charles A., Valdez, Gregorio, Guarente, Leonard P.
Published in Aging cell (01.12.2018)
Published in Aging cell (01.12.2018)
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Correction: The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth
Firestein, Ron, Blander, Gil, Michan, Shaday, Oberdoerffer, Philipp, Ogino, Shuji, Campbell, Jennifer, Bhimavarapu, Anupama, Luikenhuis, Sandra, de Cabo, Rafael, Fuchs, Charles, Hahn, William C, Guarente, Leonard P, Sinclair, David A
Published in PloS one (06.06.2024)
Published in PloS one (06.06.2024)
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Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers
Gage, Fred H, Guarente, Leonard P, Wagers, Amy J
Published in Trends in molecular medicine (01.08.2016)
Published in Trends in molecular medicine (01.08.2016)
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Nicotinamide Riboside with Pterostilbene Increases NAD+ in Patients with AKI: A Randomized, Double-Blind, Placebo-Controlled, Stepwise Safety Study of NRPT in Patients with AKI: FR-OR05
Simic, Petra, Parada, Xavier F., Parikh, Samir M., Dellinger, Ryan, Guarente, Leonard P., Rhee, Eugene P.
Published in Journal of the American Society of Nephrology (01.10.2020)
Published in Journal of the American Society of Nephrology (01.10.2020)
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Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
Jeong, Hyunkyung, Cohen, Dena E, Cui, Libin, Supinski, Andrea, Savas, Jeffrey N, Mazzulli, Joseph R, Yates, John R, Bordone, Laura, Guarente, Leonard, Krainc, Dimitri
Published in Nature medicine (01.01.2012)
Published in Nature medicine (01.01.2012)
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Voices: The Future of Metabolism
Published in Cell metabolism
(07.01.2020)
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NAD+ Metabolism and Signaling
Published in Cell metabolism
(02.07.2019)
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Journal Article
Nicotinamide riboside with pterostilbene : a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI
Simic, Petra, Vela Parada, Xavier Fernando, Parikh, Samir M, Dellinger, Ryan, Guarente, Leonard P, Rhee, Eugene P
Published in BMC nephrology (13.08.2020)
Published in BMC nephrology (13.08.2020)
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