Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3' Kinase Inhibitor GDC-0941 in Breast Cancer Preclinical Models
O'BRIEN, Carol, WALLIN, Jeffrey J, BEIVIN, Marcia, FRIEDMAN, Lori S, LACKNER, Mark R, SAMPATH, Deepak, GUHATHAKURTA, Debraj, SAVAGE, Heidi, PUNNOOSE, Elizabeth A, GUAN, Jane, BERRY, Leanne, PRIOR, Wei Wei, AMLER, Lukas C
Published in Clinical cancer research (15.07.2010)
Published in Clinical cancer research (15.07.2010)
Get full text
Journal Article
GDC-0941, a Novel Class I Selective PI3K Inhibitor, Enhances the Efficacy of Docetaxel in Human Breast Cancer Models by Increasing Cell Death In Vitro and In Vivo
WALLIN, Jeffrey J, GUAN, Jane, PRIOR, Wei Wei, LEE, Leslie B, BERRY, Leanne, BELMONT, Lisa D, KOEPPEN, Hartmut, BELVIN, Marcia, FRIEDMAN, Lori S, SAMPATH, Deepak
Published in Clinical cancer research (15.07.2012)
Published in Clinical cancer research (15.07.2012)
Get full text
Journal Article
Active PI3K pathway causes an invasive phenotype which can be reversed or promoted by blocking the pathway at divergent nodes
Wallin, Jeffrey J, Guan, Jane, Edgar, Kyle A, Zhou, Wei, Francis, Ross, Torres, Anthony C, Haverty, Peter M, Eastham-Anderson, Jeffrey, Arena, Sabrina, Bardelli, Alberto, Griffin, Sue, Goodall, John E, Grimshaw, Kyla M, Hoeflich, Klaus P, Torrance, Christopher, Belvin, Marcia, Friedman, Lori S
Published in PloS one (03.05.2012)
Published in PloS one (03.05.2012)
Get full text
Journal Article
Abstract C201: A novel potent and selective inhibitor of PI3K/mTOR, GDC-0980, currently in phase I clinical trials
Friedman, Lori S., Belvin, Marcia, Berry, Leanne, Berry, Megan, Castanedo, Georgette, Edgar, Kyle, Folkes, Adrian, Guan, Jane, Heffron, Tim, Lesnick, John, Lewis, Cris, Nonomiya, Jim, Olivero, Alan, Patel, Sonal, Pang, Jodie, Prior, Wei Wei, Salphati, Laurent, Sampath, Deepak, Sutherlin, Dan, Wallin, Jeff, Zhu, Bingyan
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
Get full text
Journal Article
Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility
Guan, Jane, Zhou, Wei, Hafner, Marc, Blake, Robert A., Chalouni, Cecile, Chen, Irene P., De Bruyn, Tom, Giltnane, Jennifer M., Hartman, Steven J., Heidersbach, Amy, Houtman, Rene, Ingalla, Ellen, Kategaya, Lorn, Kleinheinz, Tracy, Li, Jun, Martin, Scott E., Modrusan, Zora, Nannini, Michelle, Oeh, Jason, Ubhayakar, Savita, Wang, Xiaojing, Wertz, Ingrid E., Young, Amy, Yu, Mamie, Sampath, Deepak, Hager, Jeffrey H., Friedman, Lori S., Daemen, Anneleen, Metcalfe, Ciara
Published in Cell (08.08.2019)
Published in Cell (08.08.2019)
Get full text
Journal Article
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER plus Breast Cancer
Liang, Jun, Zbieg, Jason R., Blake, Robert A., Chang, Jae H., Daly, Stephen, DiPasquale, Antonio G., Friedman, Lori S., Gelzleichter, Thomas, Gill, Matthew, Giltnane, Jennifer M., Goodacre, Simon, Guan, Jane, Hartman, Steven J., Ingalla, Ellen Rei, Kategaya, Lorn, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada S., Lai, Tommy, Li, Jun, Liao, Jiangpeng, Liu, Zhiguo, Mody, Vidhi, McLean, Neville, Metcalfe, Ciara, Nannini, Michelle A., Oeh, Jason, O'Rourke, Martin G., Ortwine, Daniel F., Ran, Yingqing, Ray, Nicholas C., Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Schutt, Leah K., Vinogradova, Maia, Wai, John, Wang, Tao, Wertz, Ingrid E., White, Jonathan R., Yeap, Siew Kuen, Young, Amy, Zhang, Birong, Zheng, Xiaoping, Zhou, Wei, Zhong, Yu, Wang, Xiaojing
Published in Journal of medicinal chemistry (26.08.2021)
Published in Journal of medicinal chemistry (26.08.2021)
Get full text
Journal Article
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer
Liang, Jun, Zbieg, Jason R., Blake, Robert A., Chang, Jae H., Daly, Stephen, DiPasquale, Antonio G., Friedman, Lori S., Gelzleichter, Thomas, Gill, Matthew, Giltnane, Jennifer M., Goodacre, Simon, Guan, Jane, Hartman, Steven J., Ingalla, Ellen Rei, Kategaya, Lorn, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada S., Lai, Tommy, Li, Jun, Liao, Jiangpeng, Liu, Zhiguo, Mody, Vidhi, McLean, Neville, Metcalfe, Ciara, Nannini, Michelle A., Oeh, Jason, O’Rourke, Martin G., Ortwine, Daniel F., Ran, Yingqing, Ray, Nicholas C., Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Schutt, Leah K., Vinogradova, Maia, Wai, John, Wang, Tao, Wertz, Ingrid E., White, Jonathan R., Yeap, Siew Kuen, Young, Amy, Zhang, Birong, Zheng, Xiaoping, Zhou, Wei, Zhong, Yu, Wang, Xiaojing
Published in Journal of medicinal chemistry (26.08.2021)
Published in Journal of medicinal chemistry (26.08.2021)
Get full text
Journal Article
Abstract B36: Progesterone receptor signaling in estrogen receptor-positive breast cancer
Young, Amy, Guan, Jane, Daemen, Anneleen, Friedman, Lori, Lin, Kui
Published in Molecular cancer research (01.08.2018)
Published in Molecular cancer research (01.08.2018)
Get full text
Journal Article
Abstract 1004: Leveraging an expanding tool box for ER+ breast cancer: exploring breast cancer dependencies to support optimal therapeutic strategies
Zhou, Wei, Guan, Jane, Hatzivassiliou, Georgia, Daemen, Anneleen, Hafner, Marc, Metcalfe, Ciara
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Get full text
Journal Article
RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy
Song, Kyung W, Edgar, Kyle A, Hanan, Emily J, Hafner, Marc, Oeh, Jason, Merchant, Mark, Sampath, Deepak, Nannini, Michelle A, Hong, Rebecca, Phu, Lilian, Forrest, William F, Stawiski, Eric, Schmidt, Stephen, Endres, Nicholas, Guan, Jane, Wallin, Jeffrey J, Cheong, Jonathan, Plise, Emile G, Lewis Phillips, Gail D, Salphati, Laurent, Heffron, Timothy P, Olivero, Alan G, Malek, Shiva, Staben, Steven T, Kirkpatrick, Donald S, Dey, Anwesha, Friedman, Lori S
Published in Cancer discovery (01.01.2022)
Published in Cancer discovery (01.01.2022)
Get full text
Journal Article
GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway
Wallin, Jeffrey J, Edgar, Kyle A, Guan, Jane, Berry, Megan, Prior, Wei Wei, Lee, Leslie, Lesnick, John D, Lewis, Cristina, Nonomiya, Jim, Pang, Jodie, Salphati, Laurent, Olivero, Alan G, Sutherlin, Daniel P, O'Brien, Carol, Spoerke, Jill M, Patel, Sonal, Lensun, Letitia, Kassees, Robert, Ross, Leanne, Lackner, Mark R, Sampath, Deepak, Belvin, Marcia, Friedman, Lori S
Published in Molecular cancer therapeutics (01.12.2011)
Published in Molecular cancer therapeutics (01.12.2011)
Get full text
Journal Article
Abstract P2-24-04: The ER antagonist giredestrant induces profound chromatin remodeling including activation of cis-regulatory elements bound by FOXA1 and GATA3 in HR+ breast cancer models
Ahmed, Musaddeque, Guan, Jane, Zhou, Wei, Yao, Xiaosai, Metcalfe, Ciara, Hafner, Marc
Published in Cancer research (Chicago, Ill.) (01.03.2023)
Published in Cancer research (Chicago, Ill.) (01.03.2023)
Get full text
Journal Article
Abstract 3406: GDC-9545: A pure antiestrogen clinical candidate that immobilizes the estrogen receptor and profoundly alters chromatin accessibility in vivo
Metcalfe, Ciara, Zhou, Wei, Guan, Jane, Blake, Robert A., De Bruyn, Tom, Giltnane, Jennifer M., Ingalla, Ellen, Kleinheinz, Tracy, Liang, Jun, Mody, Vidhi, Oeh, Jason, Ubhayakar, Savita, Wertz, Ingrid, Young, Amy, Zbieg, Jason, Wang, Xiaojing, Hafner, Marc
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Get full text
Journal Article
Maternal help‐seeking for child developmental concerns: Associations with socio‐demographic factors
Eapen, Valsamma, Walter, Amelia, Guan, Jane, Descallar, Joseph, Axelsson, Emma, Einfeld, Stewart, Eastwood, John, Murphy, Elisabeth, Beasley, Deborah, Silove, Natalie, Dissanayake, Cheryl, Woolfenden, Sue, Williams, Katrina, Jalaludin, Bin, The ‘Watch Me Grow’ Study Group
Published in Journal of paediatrics and child health (01.10.2017)
Published in Journal of paediatrics and child health (01.10.2017)
Get full text
Journal Article
Abstract P2-11-05: ER pathway activity signature as a biomarker for endocrine agent GDC-9545
Daemen, Anneleen, Spoerke, Jill M, Zhou, Wei, Guan, Jane, Ingalla, Ellen, Young, Amy, Hafner, Marc, Aimi, Junko, Chang, Ching-Wei, Giltnane, Jennifer M, Gates, Mary, Mayer, Ingrid A, Azaro, Analia, Winer, Eric P, Loi, Sherene, Jhaveri, Komal, Lauchle, Jennifer, Gendreau, Steven, Humke, Eric W, Metcalfe, Ciara
Published in Cancer research (Chicago, Ill.) (15.02.2020)
Published in Cancer research (Chicago, Ill.) (15.02.2020)
Get full text
Journal Article
Abstract 5388: Triple-threat: Inavolisib and giredestrant combine with palbociclib to achieve sustained cell cycle arrest in ER-positive breast cancer models
Marohl, Taylor, Tan, Jenille, Zhou, Wei, Guan, Jane, Carlos, Sandra Melo, Xie, Shiqi, Hafner, Marc, Metcalfe, Ciara
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Get full text
Journal Article
Abstract NG05: Not all “SERDs” are equal: Context-independent ER degradation and full ER antagonism define the next generation of ER therapeutics
Guan, Jane, Zhou, Wei, Daemen, Anneleen, Hartman, Steven J., Blake, Robert A., Heidersbach, Amy, Yu, Mamie, Liang-Chu, May, Martin, Scott, Chalouni, Cecile, Chen, Irene, Friedman, Lori S., Wang, Xiaojing, Metcalfe, Ciara
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Nuclear phospho-Akt increase predicts synergy of PI3K inhibition and doxorubicin in breast and ovarian cancer
Wallin, Jeffrey J, Guan, Jane, Prior, Wei Wei, Edgar, Kyle A, Kassees, Robert, Sampath, Deepak, Belvin, Marcia, Friedman, Lori S
Published in Science translational medicine (08.09.2010)
Published in Science translational medicine (08.09.2010)
Get more information
Journal Article
Abstract 1648: Discovery and evolution of orally bioavailable selective estrogen receptor degraders for ER+ breast cancer: From GDC-0810 to GDC-0927
Kahraman, Mehmet, Govek, Steven P., Nagasawa, Johnny Y., Lai, Andiliy, Bonnefous, Celine, Douglas, Karensa, Sensintaffar, John, Lu, Nhin, Lee, KyoungJin, Aparicio, Anna, Kaufman, Josh, Qian, Jing, Shao, Gang, Prudente, Rene, Joseph, James D., Darimont, Beatrice, Brigham, Daniel, Heyman, Richard, Rix, Peter J., Hager, Jeffrey H., Smith, Nicholas D., Blake, Robert A., Chang, Jae, Choo, Edna, Daemen, Anneleen, Friedman, Lori S., Guan, Jane, Hartman, Steven, Ingalla, Ellen, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada, Metcalfe, Ciara, Mody, Vidhi, Nannini, Michelle, Sampath, Deepak, Young, Amy, Vinogradova, Maia, Zhou, Wei, Liang, Jun, Wang, Xiaojing
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Abstract 546: GDC-0032 PI3K inhibitor enhances the efficacy of endocrine therapies in breast cancer cells by differentially regulating the expression of ER-targeted genes and increasing apoptosis
Wallin, Jeffrey J., Guan, Jane, Hong, Rebecca, O'Brien, Carol, Wilson, Timothy, Nannini, Michelle, Sampath, Deepak, Belvin, Marcia, Friedman, Lori S.
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Get full text
Journal Article