Influenza Neuraminidase Inhibitors: Structure-Based Design of a Novel Inhibitor Series
Stoll, Vincent, Stewart, Kent D, Maring, Clarence J, Muchmore, Steven, Giranda, Vincent, Gu, Yu-gui Y, Wang, Gary, Chen, Yuanwei, Sun, Minghua, Zhao, Chen, Kennedy, April L, Madigan, Darold L, Xu, Yibo, Saldivar, Ayda, Kati, Warren, Laver, Graeme, Sowin, Thomas, Sham, Hing L, Greer, Jonathan, Kempf, Dale
Published in Biochemistry (Easton) (28.01.2003)
Published in Biochemistry (Easton) (28.01.2003)
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Structure-based Optimization of MurF Inhibitors
Stamper, Geoffrey F., Longenecker, Kenton L., Fry, Elizabeth H., Jakob, Clarissa G., Florjancic, Alan S., Gu, Yu-Gui, Anderson, David D., Cooper, Curt S., Zhang, Tianyuan, Clark, Richard F., Cia, Yingna, Black-Schaefer, Candace L., Owen McCall, J., Lerner, Claude G., Hajduk, Philip J., Beutel, Bruce A., Stoll, Vincent S.
Published in Chemical biology & drug design (01.01.2006)
Published in Chemical biology & drug design (01.01.2006)
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Design, synthesis and structure–activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae
Yong, Hong, Gui Gu, Yu, Clark, Richard F., Marron, Thomas, Ma, Zhenkun, Soni, Niru, Stone, Gregory G., Nilius, Angela M., Marsh, Kennan, Djuric, Stevan W.
Published in Bioorganic & medicinal chemistry letters (16.05.2005)
Published in Bioorganic & medicinal chemistry letters (16.05.2005)
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From Bacterial Genomes to Novel Antibacterial Agents: Discovery, Characterization, and Antibacterial Activity of Compounds that Bind to HI0065 (YjeE) from Haemophilus influenzae
Lerner, Claude G., Hajduk, Philip J., Wagner, Rolf, Wagenaar, Frank L., Woodall, Charlotte, Gu, Yu‐Gui, Searle, Xenia B., Florjancic, Alan S., Zhang, Tianyuan, Clark, Richard F., Cooper, Curt S., Mack, Jamey C., Yu, Liping, Cai, Mengli, Betz, Steven F., Chovan, Linda E., McCall, J. Owen, Black‐Schaefer, Candace L., Kakavas, Stephan J., Schurdak, Mark E., Comess, Kenneth M., Walter, Karl A., Edalji, Rohinton, Dorwin, Sarah A., Smith, Richard A., Hebert, Eric J., Harlan, John E., Metzger, Randy E., Merta, Philip J., Baranowski, John L., Coen, Michael L., Thornewell, Susan J., Shivakumar, Annapur G., Saiki, Anne Y., Soni, Niru, Bui, Mai, Balli, Darlene J., Sanders, William J., Nilius, Angela M., Holzman, Thomas F., Fesik, Stephen W., Beutel, Bruce A.
Published in Chemical biology & drug design (01.06.2007)
Published in Chemical biology & drug design (01.06.2007)
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An efficient chemical synthesis of carboxylate-isostere analogs of daptomycin
Yoganathan, Sabesan, Yin, Ning, He, Yong, Mesleh, Michael F., Gu, Yu Gui, Miller, Scott J.
Published in Organic & biomolecular chemistry (28.07.2013)
Published in Organic & biomolecular chemistry (28.07.2013)
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Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway
Waring, Jeffrey F, Yang, Yi, Healan-Greenberg, Christine H, Adler, Andrew L, Dickinson, Robert, McNally, Teresa, Wang, Xiaojun, Weitzberg, Moshe, Xu, Xiangdong, Lisowski, Andrew, Warder, Scott E, Gu, Yu Gui, Zinker, Bradley A, Blomme, Eric A, Camp, Heidi S
Published in The Journal of pharmacology and experimental therapeutics (01.02.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2008)
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Studies of mild dehydrogenations in heterocyclic systems
Williams, David R., Lowder, Patrick D., Gu, Yu-Gui, Brooks, Dawn A.
Published in Tetrahedron letters (20.01.1997)
Published in Tetrahedron letters (20.01.1997)
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Journal Article
Structure of MurF from Streptococcus pneumoniae co‐crystallized with a small molecule inhibitor exhibits interdomain closure
Longenecker, Kenton L., Stamper, Geoffrey F., Hajduk, Philip J., Fry, Elizabeth H., Jakob, Clarissa G., Harlan, John E., Edalji, Rohinton, Bartley, Diane M., Walter, Karl A., Solomon, Larry R., Holzman, Thomas F., Gu, Yu Gui, Lerner, Claude G., Beutel, Bruce A., Stoll, Vincent S.
Published in Protein science (01.12.2005)
Published in Protein science (01.12.2005)
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Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents
Clark, Richard F., Zhang, Tianyuan, Wang, Xiaojun, Wang, Rongqi, Zhang, Xiaolin, Camp, Heidi S., Beutel, Bruce A., Sham, Hing L., Gu, Yu Gui
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
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Synthesis and biological evaluation of 6,7-disubstituted 4-aminopyrido[2,3- d]pyrimidines as adenosine kinase inhibitors
Perner, Richard J., Lee, Chih-Hung, Jiang, Meiqun, Gu, Yu-Gui, DiDomenico, Stanley, Bayburt, Erol K., Alexander, Karen M., Kohlhaas, Kathy L., Jarvis, Michael F., Kowaluk, Elizabeth L., Bhagwat, Shripad S.
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
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Journal Article
Synthesis and Structure−Activity Relationships of N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy Derivatives as Selective Acetyl-CoA Carboxylase 2 Inhibitors
Gu, Yu Gui, Weitzberg, Moshe, Clark, Richard F, Xu, Xiangdong, Li, Qun, Zhang, Tianyuan, Hansen, T. Matthew, Liu, Gang, Xin, Zhili, Wang, Xiaojun, Wang, Rongqi, McNally, Teresa, Camp, Heidi, Beutel, Bruce A, Sham, Hing L
Published in Journal of medicinal chemistry (29.06.2006)
Published in Journal of medicinal chemistry (29.06.2006)
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Journal Article
Structure-Based Characterization and Optimization of Novel Hydrophobic Binding Interactions in a Series of Pyrrolidine Influenza Neuraminidase Inhibitors
Maring, Clarence J, Stoll, Vincent S, Zhao, Chen, Sun, Minghua, Krueger, Allan C, Stewart, Kent D, Madigan, Darold L, Kati, Warren M, Xu, Yibo, Carrick, Robert J, Montgomery, Debra A, Kempf-Grote, Anita, Marsh, Kennan C, Molla, Akhteruzzaman, Steffy, Kevin R, Sham, Hing L, Laver, W. Graeme, Gu, Yu-gui, Kempf, Dale J, Kohlbrenner, William E
Published in Journal of medicinal chemistry (16.06.2005)
Published in Journal of medicinal chemistry (16.06.2005)
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Journal Article
Synthesis and antibacterial activity of 5-methoxy- and 5-hydroxy-6-fluoro-1,8-naphthyridone-3-carboxylic acid derivatives
Matthew Hansen, T., Gu, Yu-Gui, Rehm, Tamara M., Dandliker, Peter J., Chovan, Linda E., Bui, Mai H., Nilius, Angela M., Beutel, Bruce A.
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
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Journal Article
N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy Derivatives as Acetyl-CoA Carboxylase InhibitorsImprovement of Cardiovascular and Neurological Liabilities via Structural Modifications
Gu, Yu Gui, Weitzberg, Moshe, Clark, Richard F, Xu, Xiangdong, Li, Qun, Lubbers, Nathan L, Yang, Yi, Beno, David W. A, Widomski, Deborah L, Zhang, Tianyuan, Hansen, T. Matthew, Keyes, Robert F, Waring, Jeffrey F, Carroll, Sherry L, Wang, Xiaojun, Wang, Rongqi, Healan-Greenberg, Christine H, Blomme, Eric A, Beutel, Bruce A, Sham, Hing L, Camp, Heidi S
Published in Journal of medicinal chemistry (08.03.2007)
Published in Journal of medicinal chemistry (08.03.2007)
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Journal Article
Novel inhibitors of bacterial protein synthesis: structure–activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants
Clark, Richard F., Wang, Sanyi, Ma, Zhenkun, Weitzberg, Moshe, Motter, Christopher, Tufano, Michael, Wagner, Rolf, Gu, Yu-Gui, Dandliker, Peter J., Lerner, Claude G., Chovan, Linda E., Cai, Yingna, Black-Schaefer, Candace L., Lynch, Linda, Kalvin, Douglas, Nilius, Angela M., Pratt, Steve D., Soni, Niru, Zhang, Tianyuan, Zhang, Xiaolin, Beutel, Bruce A.
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
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Journal Article
The synthesis and structure–activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: Polar region modifications
Xu, Xiangdong, Weitzberg, Moshe, Keyes, Robert F., Li, Qun, Wang, Rongqi, Wang, Xiaojun, Zhang, Xiaolin, Frevert, Ernst U., Camp, Heidi S., Beutel, Bruce A., Sham, Hing L., Gu, Yu Gui
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
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Journal Article
Discovery of 4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine, an Orally Active, Non-Nucleoside Adenosine Kinase Inhibitor
Lee, Chih-Hung, Jiang, Meiqun, Cowart, Marlon, Gfesser, Greg, Perner, Richard, Kim, Ki Hwan, Gu, Yu Gui, Williams, Michael, Jarvis, Michael F, Kowaluk, Elizabeth A, Stewart, Andrew O, Bhagwat, Shripad S
Published in Journal of medicinal chemistry (21.06.2001)
Published in Journal of medicinal chemistry (21.06.2001)
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