Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809
Van Goor, Fredrick, Hadida, Sabine, Grootenhuis, Peter D. J, Burton, Bill, Stack, Jeffrey H, Straley, Kimberly S, Decker, Caroline J, Miller, Mark, McCartney, Jason, Olson, Eric R, Wine, Jeffrey J, Frizzell, Ray A, Ashlock, Melissa, Negulescu, Paul A
Published in Proceedings of the National Academy of Sciences - PNAS (15.11.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (15.11.2011)
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Discovery of N‑(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, Ivacaftor), a Potent and Orally Bioavailable CFTR Potentiator
Hadida, Sabine, Van Goor, Fredrick, Zhou, Jinglan, Arumugam, Vijayalaksmi, McCartney, Jason, Hazlewood, Anna, Decker, Caroline, Negulescu, Paul, Grootenhuis, Peter D. J
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770
Van Goor, Fredrick, Hadida, Sabine, Grootenhuis, Peter D.J, Burton, Bill, Cao, Dong, Neuberger, Tim, Turnbull, Amanda, Singh, Ashvani, Joubran, John, Hazlewood, Anna, Zhou, Jinglan, McCartney, Jason, Arumugam, Vijayalaksmi, Decker, Caroline, Yang, Jennifer, Young, Chris, Olson, Eric R, Wine, Jeffery J, Frizzell, Raymond A, Ashlock, Melissa, Negulescu, Paul
Published in Proceedings of the National Academy of Sciences - PNAS (03.11.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (03.11.2009)
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Efficient Screening of Cytochrome P450 BM3 Mutants for Their Metabolic Activity and Diversity toward a Wide Set of Drug-Like Molecules in Chemical Space
REINEN, Jelle, VAN LEEUWEN, Jolanda S, LI, Yongmin, SUN, Lifang, GROOTENHUIS, Peter D. J, DECKER, Caroline J, SAUNDERS, John, VERMEULEN, Nico P. E, COMMANDEUR, Jan N. M
Published in Drug metabolism and disposition (01.09.2011)
Published in Drug metabolism and disposition (01.09.2011)
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Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations
Capoferri, Luigi, Leth, Rasmus, ter Haar, Ernst, Mohanty, Arun K., Grootenhuis, Peter D. J., Vottero, Eduardo, Commandeur, Jan N. M., Vermeulen, Nico P. E., Jørgensen, Flemming Steen, Olsen, Lars, Geerke, Daan P.
Published in Proteins, structure, function, and bioinformatics (01.03.2016)
Published in Proteins, structure, function, and bioinformatics (01.03.2016)
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Performance of 3D-Database Molecular Docking Studies into Homology Models
Oshiro, Connie, Bradley, Erin K, Eksterowicz, John, Evensen, Erik, Lamb, Michelle L, Lanctot, J. Kevin, Putta, Santosh, Stanton, Robert, Grootenhuis, Peter D. J
Published in Journal of medicinal chemistry (29.01.2004)
Published in Journal of medicinal chemistry (29.01.2004)
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Evaluation of a Novel Shape-Based Computational Filter for Lead Evolution: Application to Thrombin Inhibitors
Srinivasan, Jayashree, Castellino, Angelo, Bradley, Erin K, Eksterowicz, John E, Grootenhuis, Peter D. J, Putta, Santosh, Stanton, Robert V
Published in Journal of medicinal chemistry (06.06.2002)
Published in Journal of medicinal chemistry (06.06.2002)
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N-Phenylphenylglycines as Novel Corticotropin Releasing Factor Receptor Antagonists
Molteni, Valentina, Penzotti, Julie, Wilson, Dean M, Termin, Andreas P, Mao, Long, Crane, Christine M, Hassman, Fred, Wang, Tao, Wong, Harvey, Miller, Keith J, Grossman, Scott, Grootenhuis, Peter D. J
Published in Journal of medicinal chemistry (06.05.2004)
Published in Journal of medicinal chemistry (06.05.2004)
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Unique Overlap in the Prerequisites for Thrombin Inhibition and Oral Bioavailability Resulting in Potent Oral Antithrombotics
Adang, Anton E. P, de Man, Adrianus P. A, Vogel, Gerard M. T, Grootenhuis, Peter D. J, Smit, Martin J, Peters, Co A. M, Visser, Arie, Rewinkel, Jos B. M, van Dinther, Theo, Lucas, Hans, Kelder, Jan, van Aelst, Sjoerd, Meuleman, Dick G, van Boeckel, Constant A. A
Published in Journal of medicinal chemistry (26.09.2002)
Published in Journal of medicinal chemistry (26.09.2002)
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A Rapid Computational Method for Lead Evolution: Description and Application to α1-Adrenergic Antagonists
Bradley, Erin K, Beroza, Paul, Penzotti, Julie E, Grootenhuis, Peter D. J, Spellmeyer, David C, Miller, Jennifer L
Published in Journal of medicinal chemistry (13.07.2000)
Published in Journal of medicinal chemistry (13.07.2000)
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Arylamidrazones as Novel Corticotropin Releasing Factor Receptor Antagonists
Wilson, Dean M, Termin, Andreas P, Mao, Long, Ramirez-Weinhouse, Michele M, Molteni, Valentina, Grootenhuis, Peter D. J, Miller, Keith, Keim, Susan, Wise, Gwendolyn
Published in Journal of medicinal chemistry (23.05.2002)
Published in Journal of medicinal chemistry (23.05.2002)
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High throughput P450 inhibition screens in early drug discovery
Zlokarnik, Gregor, Grootenhuis, Peter D.J., Watson, John B.
Published in Drug discovery today (01.11.2005)
Published in Drug discovery today (01.11.2005)
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Pathways for Conformational Interconversion of Calix[4]arenes
Fischer, Stefan, Grootenhuis, Peter D. J, Groenen, Leo C, van Hoorn, Willem P, van Veggel, Frank C. J. M. vn, Reinhoudt, David N, Karplus, Martin
Published in Journal of the American Chemical Society (01.02.1995)
Published in Journal of the American Chemical Society (01.02.1995)
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PHARMACEUTICAL COMPOSITION AND ADMINISTRATIONS THEREOF
OVERHOFF KIRK, GROOTENHUIS PETER D. J, GROSSI ALFREDO, ROWE WILLIAM, HURTER PATRICIA, YOUNG CHRISTOPHER, DINEHART KIRK, VERWIJS MARINUS JACOBUS, BOTFIELD MARTYN
Year of Publication 14.05.2024
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Year of Publication 14.05.2024
Patent
Molecular mechanics and dynamics studies of crown ether - cation interactions: free energy calculations on the cation selectivity of dibenzo-18-crown-6 and dibenzo-30-crown-10
Grootenhuis, Peter D. J, Kollman, Peter A
Published in Journal of the American Chemical Society (01.03.1989)
Published in Journal of the American Chemical Society (01.03.1989)
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