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Published in Proceedings of the National Academy of Sciences - PNAS (03.11.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (03.11.2009)
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Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809
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Published in Proceedings of the National Academy of Sciences - PNAS (15.11.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (15.11.2011)
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PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
ROEPER STEFANIE, RYAN MICHAEL P, BOTFIELD MARTYN C, TRUDEAU MARTIN, KRUEGER BRIAN R, YAP DAHRIKA MILFRED LAO, ZLOKARNIK GREGOR, VAN GOOR FREDERICK F, DEMATTEI JOHN, LOOKER ADAM R, GROOTENHUIS PETER D.J, NEUBERT LANGILLE BOBBIANNA
Year of Publication 27.04.2018
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Year of Publication 27.04.2018
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Discovery of N‑(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, Ivacaftor), a Potent and Orally Bioavailable CFTR Potentiator
Hadida, Sabine, Van Goor, Fredrick, Zhou, Jinglan, Arumugam, Vijayalaksmi, McCartney, Jason, Hazlewood, Anna, Decker, Caroline, Negulescu, Paul, Grootenhuis, Peter D. J
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
ROEPER STEFANIE, RYAN MICHAEL P, BOTFIELD MARTYN C, TRUDEAU MARTIN, KRUEGER BRIAN R, YAP DAHRIKA MILFRED LAO, ZLOKARNIK GREGOR, VAN GOOR FREDERICK F, DEMATTEI JOHN, LOOKER ADAM R, GROOTENHUIS PETER D.J, NEUBERT LANGILLE BOBBIANNA
Year of Publication 19.04.2017
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Year of Publication 19.04.2017
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X-ray structure of antistasin at 1.9 Å resolution and its modelled complex with blood coagulation factor Xa
Lapatto, Risto, Krengel, Ute, Schreuder, Herman A., Arkema, Anita, de Boer, Bijtske, Kalk, Kor H., Hol, Wim G.J., Grootenhuis, Peter D.J., Mulders, John W.M., Dijkema, Rein, Theunissen, Henri J.M., Dijkstra, Bauke W.
Published in The EMBO journal (01.09.1997)
Published in The EMBO journal (01.09.1997)
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Rescue of ΔF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules
Van Goor, Fredrick, Straley, Kimberly S., Cao, Dong, González, Jesús, Hadida, Sabine, Hazlewood, Anna, Joubran, John, Knapp, Tom, Makings, Lewis R., Miller, Mark, Neuberger, Timothy, Olson, Eric, Panchenko, Victor, Rader, James, Singh, Ashvani, Stack, Jeffrey H., Tung, Roger, Grootenhuis, Peter D. J., Negulescu, Paul
Published in American journal of physiology. Lung cellular and molecular physiology (01.06.2006)
Published in American journal of physiology. Lung cellular and molecular physiology (01.06.2006)
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HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS
STAMOS DEAN, ANDERSON COREY DON, WHITNEY TARA, NUMA MEHDI MICHEL DJAMEL, GROOTENHUIS PETER D.J, ZIMMERMANN NICOLE
Year of Publication 11.03.2011
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Year of Publication 11.03.2011
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Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations
Capoferri, Luigi, Leth, Rasmus, ter Haar, Ernst, Mohanty, Arun K., Grootenhuis, Peter D. J., Vottero, Eduardo, Commandeur, Jan N. M., Vermeulen, Nico P. E., Jørgensen, Flemming Steen, Olsen, Lars, Geerke, Daan P.
Published in Proteins, structure, function, and bioinformatics (01.03.2016)
Published in Proteins, structure, function, and bioinformatics (01.03.2016)
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MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
ZHOU JINGLAN, MILLER MARK T, MCCARTNEY JASON, RUAH SARA S. HADIDA, VAN GOOR FREDRICK, BEAR BRIAN, NUMA MEHDI MICHEL DJAMEL, GROOTENHUIS PETER D.J
Year of Publication 04.08.2011
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Year of Publication 04.08.2011
Patent
PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
ROEPER STEFANIE, RYAN MICHAEL P, BOTFIELD MARTYN C, TRUDEAU MARTIN, KRUEGER BRIAN R, YAP DAHRIKA MILFRED LAO, ZLOKARNIK GREGOR, VAN GOOR FREDERICK F, DEMATTEI JOHN, LOOKER ADAM R, GROOTENHUIS PETER D.J, NEUBERT LANGILLE BOBBIANNA
Year of Publication 05.12.2011
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Year of Publication 05.12.2011
Patent
Efficient Screening of Cytochrome P450 BM3 Mutants for Their Metabolic Activity and Diversity toward a Wide Set of Drug-Like Molecules in Chemical Space
REINEN, Jelle, VAN LEEUWEN, Jolanda S, LI, Yongmin, SUN, Lifang, GROOTENHUIS, Peter D. J, DECKER, Caroline J, SAUNDERS, John, VERMEULEN, Nico P. E, COMMANDEUR, Jan N. M
Published in Drug metabolism and disposition (01.09.2011)
Published in Drug metabolism and disposition (01.09.2011)
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High throughput P450 inhibition screens in early drug discovery
Zlokarnik, Gregor, Grootenhuis, Peter D.J., Watson, John B.
Published in Drug discovery today (01.11.2005)
Published in Drug discovery today (01.11.2005)
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Performance of 3D-Database Molecular Docking Studies into Homology Models
Oshiro, Connie, Bradley, Erin K, Eksterowicz, John, Evensen, Erik, Lamb, Michelle L, Lanctot, J. Kevin, Putta, Santosh, Stanton, Robert, Grootenhuis, Peter D. J
Published in Journal of medicinal chemistry (29.01.2004)
Published in Journal of medicinal chemistry (29.01.2004)
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