Engineering Regioselectivity of a P450 Monooxygenase Enables the Synthesis of Ursodeoxycholic Acid via 7β‐Hydroxylation of Lithocholic Acid
Grobe, Sascha, Badenhorst, Christoffel P. S., Bayer, Thomas, Hamnevik, Emil, Wu, Shuke, Grathwol, Christoph W., Link, Andreas, Koban, Sven, Brundiek, Henrike, Großjohann, Beatrice, Bornscheuer, Uwe T.
Published in Angewandte Chemie International Edition (11.01.2021)
Published in Angewandte Chemie International Edition (11.01.2021)
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Journal Article
Biosensor-Guided Engineering of a Baeyer-Villiger Monooxygenase for Aliphatic Ester Production
Sakoleva, Thaleia, Vesenmaier, Florian, Koch, Lena, Schunke, Jarne E, Novak, Kay D, Grobe, Sascha, Dörr, Mark, Bornscheuer, Uwe T, Bayer, Thomas
Published in Chembiochem : a European journal of chemical biology (25.09.2024)
Published in Chembiochem : a European journal of chemical biology (25.09.2024)
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Protein Engineering of the Progesterone Hydroxylating P450‐Monooxygenase CYP17A1 Alters Its Regioselectivity
Morlock, Lisa K., Grobe, Sascha, Balke, Kathleen, Mauersberger, Stephan, Böttcher, Dominique, Bornscheuer, Uwe T.
Published in Chembiochem : a European journal of chemical biology (17.09.2018)
Published in Chembiochem : a European journal of chemical biology (17.09.2018)
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Journal Article
Modifikation der Regioselektivität einer P450‐Monooxygenase ermöglicht die Synthese von Ursodeoxycholsäure durch die 7β‐Hydroxylierung von Lithocholsäure
Grobe, Sascha, Badenhorst, Christoffel P. S., Bayer, Thomas, Hamnevik, Emil, Wu, Shuke, Grathwol, Christoph W., Link, Andreas, Koban, Sven, Brundiek, Henrike, Großjohann, Beatrice, Bornscheuer, Uwe T.
Published in Angewandte Chemie (11.01.2021)
Published in Angewandte Chemie (11.01.2021)
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Journal Article
C-NUCLEOSIDE MONOPHOSPHATE SYNTHESIS
GROBE, Sascha, KARPUS, Laurynas, URBELIENĖ, Nina, KOPLŪNAITĖ, Martyna, IKASALAITĖ, Diana, MEŠKYS, Rolandas, RUGGIERI, Federica, ZAKRYS, Linas
Year of Publication 04.07.2024
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Year of Publication 04.07.2024
Patent
C-NUCLEOSIDE MONOPHOSPHATE SYNTHESIS
GROBE, Sascha, KARPUS, Laurynas, URBELIENĖ, Nina, KOPLŪNAITĖ, Martyna, IKASALAITĖ, Diana, MEŠKYS, Rolandas, RUGGIERI, Federica, ZAKRYS, Linas
Year of Publication 13.07.2023
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Year of Publication 13.07.2023
Patent
C-NUCLEOSIDE MONOPHOSPHATE SYNTHESIS
IKASALAITE, DIANA, URBELIENE, NINA, ZAKRYS, LINAS, GROBE, SASCHA, KOPLUNAITE, MARTYNA, RUGGIERI, FEDERICA, MESKYS, ROLANDAS, KARPUS, LAURYNAS
Year of Publication 13.07.2023
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Year of Publication 13.07.2023
Patent
PROCESS FOR 7-BETA-HYDROXYLATION OF BILE ACID DERIVATIVES
Bornscheuer, Uwe, Bayer, Thomas, Grobe, Sascha, Hannevik, Emil, Großjohann, Beatrice, Badenhorst, Christoffel, Brundiek, Henrike
Year of Publication 05.01.2022
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Year of Publication 05.01.2022
Patent