SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies
Barnes, Christopher O., Jette, Claudia A., Abernathy, Morgan E., Dam, Kim-Marie A., Esswein, Shannon R., Gristick, Harry B., Malyutin, Andrey G., Sharaf, Naima G., Huey-Tubman, Kathryn E., Lee, Yu E., Robbiani, Davide F., Nussenzweig, Michel C., West, Anthony P., Bjorkman, Pamela J.
Published in Nature (London) (24.12.2020)
Published in Nature (London) (24.12.2020)
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Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies
Barnes, Christopher O., West, Anthony P., Huey-Tubman, Kathryn E., Hoffmann, Magnus A.G., Sharaf, Naima G., Hoffman, Pauline R., Koranda, Nicholas, Gristick, Harry B., Gaebler, Christian, Muecksch, Frauke, Lorenzi, Julio C. Cetrulo, Finkin, Shlomo, Hägglöf, Thomas, Hurley, Arlene, Millard, Katrina G., Weisblum, Yiska, Schmidt, Fabian, Hatziioannou, Theodora, Bieniasz, Paul D., Caskey, Marina, Robbiani, Davide F., Nussenzweig, Michel C., Bjorkman, Pamela J.
Published in Cell (20.08.2020)
Published in Cell (20.08.2020)
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Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop
Wang, Haoqing, Cohen, Alexander A., Galimidi, Rachel P., Gristick, Harry B., Jensen, Grant J., Bjorkman, Pamela J.
Published in Proceedings of the National Academy of Sciences - PNAS (15.11.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (15.11.2016)
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Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody
Schommers, Philipp, Gruell, Henning, Abernathy, Morgan E., Tran, My-Kim, Dingens, Adam S., Gristick, Harry B., Barnes, Christopher O., Schoofs, Till, Schlotz, Maike, Vanshylla, Kanika, Kreer, Christoph, Weiland, Daniela, Holtick, Udo, Scheid, Christof, Valter, Markus M., van Gils, Marit J., Sanders, Rogier W., Vehreschild, Jörg J., Cornely, Oliver A., Lehmann, Clara, Fätkenheuer, Gerd, Seaman, Michael S., Bloom, Jesse D., Bjorkman, Pamela J., Klein, Florian
Published in Cell (06.02.2020)
Published in Cell (06.02.2020)
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Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site
Gristick, Harry B, von Boehmer, Lotta, West Jr, Anthony P, Schamber, Michael, Gazumyan, Anna, Golijanin, Jovana, Seaman, Michael S, Fätkenheuer, Gerd, Klein, Florian, Nussenzweig, Michel C, Bjorkman, Pamela J
Published in Nature structural & molecular biology (01.10.2016)
Published in Nature structural & molecular biology (01.10.2016)
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Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody
Yang, Zhi, Wang, Haoqing, Liu, Albert Z., Gristick, Harry B., Bjorkman, Pamela J.
Published in Nature structural & molecular biology (01.12.2019)
Published in Nature structural & molecular biology (01.12.2019)
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Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope
Barnes, Christopher O., Gristick, Harry B., Freund, Natalia T., Escolano, Amelia, Lyubimov, Artem Y., Hartweger, Harald, West, Anthony P., Cohen, Aina E., Nussenzweig, Michel C., Bjorkman, Pamela J.
Published in Nature communications (28.03.2018)
Published in Nature communications (28.03.2018)
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Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques
Escolano, Amelia, Gristick, Harry B., Abernathy, Morgan E., Merkenschlager, Julia, Gautam, Rajeev, Oliveira, Thiago Y., Pai, Joy, West, Anthony P., Barnes, Christopher O., Cohen, Alexander A., Wang, Haoqing, Golijanin, Jovana, Yost, Daniel, Keeffe, Jennifer R., Wang, Zijun, Zhao, Peng, Yao, Kai-Hui, Bauer, Jens, Nogueira, Lilian, Gao, Han, Voll, Alisa V., Montefiori, David C., Seaman, Michael S., Gazumyan, Anna, Silva, Murillo, McGuire, Andrew T., Stamatatos, Leonidas, Irvine, Darrell J., Wells, Lance, Martin, Malcolm A., Bjorkman, Pamela J., Nussenzweig, Michel C.
Published in Nature (London) (01.06.2019)
Published in Nature (London) (01.06.2019)
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Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer
Yang, Zhi, Dam, Kim-Marie A., Bridges, Michael D., Hoffmann, Magnus A. G., DeLaitsch, Andrew T., Gristick, Harry B., Escolano, Amelia, Gautam, Rajeev, Martin, Malcolm A., Nussenzweig, Michel C., Hubbell, Wayne L., Bjorkman, Pamela J.
Published in Nature communications (08.02.2022)
Published in Nature communications (08.02.2022)
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HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design
Dam, Kim-Marie A., Barnes, Christopher O., Gristick, Harry B., Schoofs, Till, Gnanapragasam, Priyanthi N. P., Nussenzweig, Michel C., Bjorkman, Pamela J.
Published in Nature communications (17.10.2022)
Published in Nature communications (17.10.2022)
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Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller
Freund, Natalia T, Wang, Haoqing, Scharf, Louise, Nogueira, Lilian, Horwitz, Joshua A, Bar-On, Yotam, Golijanin, Jovana, Sievers, Stuart A, Sok, Devin, Cai, Hui, Cesar Lorenzi, Julio C, Halper-Stromberg, Ariel, Toth, Ildiko, Piechocka-Trocha, Alicja, Gristick, Harry B, van Gils, Marit J, Sanders, Rogier W, Wang, Lai-Xi, Seaman, Michael S, Burton, Dennis R, Gazumyan, Anna, Walker, Bruce D, West, Jr, Anthony P, Bjorkman, Pamela J, Nussenzweig, Michel C
Published in Science translational medicine (18.01.2017)
Published in Science translational medicine (18.01.2017)
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Short CDRL1 in intermediate VRC01-like mAbs is not sufficient to overcome key glycan barriers on HIV-1 Env
Agrawal, Parul, Knudsen, Maria L, MacCamy, Anna, Hurlburt, Nicholas K, Khechaduri, Arineh, Salladay, Kelsey R, Kher, Gargi M, Kallur Siddaramaiah, Latha, Stuart, Andrew B, Bontjer, Ilja, Shen, Xiaoying, Montefiori, David, Gristick, Harry B, Bjorkman, Pamela J, Sanders, Rogier W, Pancera, Marie, Stamatatos, Leonidas
Published in Journal of virology (06.09.2024)
Published in Journal of virology (06.09.2024)
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Nanoparticles presenting clusters of CD4 expose a universal vulnerability of HIV-1 by mimicking target cells
Hoffmann, Magnus A. G., Bar-On, Yotam, Yang, Zhi, Gristick, Harry B., Gnanapragasam, Priyanthi N. P., Vielmetter, Jost, Nussenzweig, Michel C., Bjorkman, Pamela J.
Published in Proceedings of the National Academy of Sciences - PNAS (04.08.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (04.08.2020)
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Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env
Escolano, Amelia, Gristick, Harry B, Gautam, Rajeev, DeLaitsch, Andrew T, Abernathy, Morgan E, Yang, Zhi, Wang, Haoqing, Hoffmann, Magnus A G, Nishimura, Yoshiaki, Wang, Zijun, Koranda, Nicholas, Kakutani, Leesa M, Gao, Han, Gnanapragasam, Priyanthi N P, Raina, Henna, Gazumyan, Ana, Cipolla, Melissa, Oliveira, Thiago Y, Ramos, Victor, Irvine, Darrell J, Silva, Murillo, West, Jr, Anthony P, Keeffe, Jennifer R, Barnes, Christopher O, Seaman, Michael S, Nussenzweig, Michel C, Martin, Malcolm A, Bjorkman, Pamela J
Published in Science translational medicine (24.11.2021)
Published in Science translational medicine (24.11.2021)
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Author Correction: SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies
Barnes, Christopher O., Jette, Claudia A., Abernathy, Morgan E., Dam, Kim-Marie A., Esswein, Shannon R., Gristick, Harry B., Malyutin, Andrey G., Sharaf, Naima G., Huey-Tubman, Kathryn E., Lee, Yu E., Robbiani, Davide F., Nussenzweig, Michel C., West, Anthony P., Bjorkman, Pamela J.
Published in Nature (London) (18.04.2024)
Published in Nature (London) (18.04.2024)
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Editorial: Novel Concepts in Using Broadly Neutralizing Antibodies for HIV-1 Treatment and Prevention
Wagh, Kshitij, van Gils, Marit J, Gristick, Harry, Schommers, Philipp
Published in Frontiers in immunology (21.12.2021)
Published in Frontiers in immunology (21.12.2021)
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