A dideazatetrahydrofolate analog lacking a chiral center at C-6: N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5yl)ethyl[benzoyl]-L-glutamic acid is an inhibitor of thymidylate synthase
Taylor, Edward C, Kuhnt, Dietmar, Shih, Chuan, Rinzel, Sharon M, Grindey, Gerald B, Barredo, Julio, Jannatipour, Mehrdad, Moran, Richard G
Published in Journal of medicinal chemistry (01.11.1992)
Published in Journal of medicinal chemistry (01.11.1992)
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Sulfonylureas: a new class of cancer chemotherapeutic agents
Mohamadi, Fariborz, Spees, Michael M, Grindey, Gerald B
Published in Journal of medicinal chemistry (01.08.1992)
Published in Journal of medicinal chemistry (01.08.1992)
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Evaluation of the antitumor activity of gemcitabine (2',2'-difluoro-2'-deoxycytidine)
HERTEL, L. W, BODER, G. B, KROIN, J. S, RINZEL, S. M, POORE, G. A, TODD, G. C, GRINDEY, G. B
Published in Cancer research (Chicago, Ill.) (15.07.1990)
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Published in Cancer research (Chicago, Ill.) (15.07.1990)
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Cellular elimination of 2',2'-difluorodeoxycytidine 5'-triphosphate : a mechanism of self-potentiation
HEINEMAN, V, YI-ZHENG XU, CHUBB, S, SEN, A, HERTEL, L. W, GRINDEY, G. B, PLUNKETT, W
Published in Cancer research (Chicago, Ill.) (01.02.1992)
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Published in Cancer research (Chicago, Ill.) (01.02.1992)
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Synthesis and biological activity of acyclic analogs of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid
Shih, Chuan, Gossett, Lynn S, Worzalla, John F, Rinzel, Sharon M, Grindey, Gerald B, Harrington, Philip M, Taylor, Edward C
Published in Journal of medicinal chemistry (01.03.1992)
Published in Journal of medicinal chemistry (01.03.1992)
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A novel class of monoglutamated antifolates exhibits tight-binding inhibition of human glycinamide ribonucleotide formyltransferase and potent activity against solid tumors
Habeck, L L, Leitner, T A, Shackelford, K A, Gossett, L S, Schultz, R M, Andis, S L, Shih, C, Grindey, G B, Mendelsohn, L G
Published in Cancer research (Chicago, Ill.) (15.02.1994)
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Published in Cancer research (Chicago, Ill.) (15.02.1994)
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Sulfonimidamide Analogs of Oncolytic Sulfonylureas † ,1
Toth, John E, Grindey, Gerald B, Ehlhardt, William J, Ray, James E, Boder, George B, Bewley, Jesse R, Klingerman, Kim K, Gates, Susan B, Rinzel, Sharon M, Schultz, Richard M, Weir, Leonard C, Worzalla, John F
Published in Journal of medicinal chemistry (14.03.1997)
Published in Journal of medicinal chemistry (14.03.1997)
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N-(5-indanylsulfonyl)-N'-(4-chlorophenyl)urea, a novel agent equally cytotoxic to nonproliferating human colon adenocarcinoma cells
HOUGHTON, P. J, BAILEY, F. C, GERMAIN, G. S, GRINDEY, G. B, WITT, B. C, HOUGHTON, J. A
Published in Cancer research (Chicago, Ill.) (15.01.1990)
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Published in Cancer research (Chicago, Ill.) (15.01.1990)
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Comparison of metabolism and toxicity to the structure of the anticancer agent sulofenur and related sulfonylureas
Ehlhardt, William J, Woodland, Joseph M, Worzalla, John F, Bewley, Jesse R, Grindey, Gerald B, Todd, Glen C, Toth, John E, Howbert, J. Jeffry
Published in Chemical research in toxicology (01.09.1992)
Published in Chemical research in toxicology (01.09.1992)
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Action of 2',2'-difluorodeoxycytidine on DNA synthesis
PENG HUANG, CHUBB, S, HERTEL, L. W, GRINDEY, G. B, PLUNKETT, W
Published in Cancer research (Chicago, Ill.) (15.11.1991)
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Published in Cancer research (Chicago, Ill.) (15.11.1991)
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Synthesis and antitumor activity of 5-deaza-5,6,7,8-tetrahydrofolic acid and its N10-substituted analogs
Taylor, Edward C, Hamby, James M, Shih, Chuan, Grindey, Gerald B, Rinzel, Sharon M, Beardsley, G. Peter, Moran, Richard G
Published in Journal of medicinal chemistry (01.07.1989)
Published in Journal of medicinal chemistry (01.07.1989)
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