Toward Directing Opioid Receptor Signaling to Refine Opioid Therapeutics
Grim, Travis W., Acevedo-Canabal, Agnes, Bohn, Laura M.
Published in Biological psychiatry (1969) (01.01.2020)
Published in Biological psychiatry (1969) (01.01.2020)
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Journal Article
Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures
Hua, Tian, Li, Xiaoting, Wu, Lijie, Iliopoulos-Tsoutsouvas, Christos, Wang, Yuxia, Wu, Meng, Shen, Ling, Brust, Christina A., Nikas, Spyros P., Song, Feng, Song, Xiyong, Yuan, Shuguang, Sun, Qianqian, Wu, Yiran, Jiang, Shan, Grim, Travis W., Benchama, Othman, Stahl, Edward L., Zvonok, Nikolai, Zhao, Suwen, Bohn, Laura M., Makriyannis, Alexandros, Liu, Zhi-Jie
Published in Cell (20.02.2020)
Published in Cell (20.02.2020)
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Journal Article
G protein signaling–biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists
Stahl, Edward L., Schmid, Cullen L., Acevedo-Canabal, Agnes, Read, Cai, Grim, Travis W., Kennedy, Nicole M., Bannister, Thomas D., Bohn, Laura M.
Published in Proceedings of the National Academy of Sciences - PNAS (30.11.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (30.11.2021)
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Journal Article
Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain
Pantouli, Fani, Grim, Travis W., Schmid, Cullen L., Acevedo-Canabal, Agnes, Kennedy, Nicole M., Cameron, Michael D., Bannister, Thomas D., Bohn, Laura M.
Published in Neuropharmacology (01.03.2021)
Published in Neuropharmacology (01.03.2021)
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Journal Article
A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal
Grim, Travis W, Schmid, Cullen L, Stahl, Edward L, Pantouli, Fani, Ho, Jo-Hao, Acevedo-Canabal, Agnes, Kennedy, Nicole M, Cameron, Michael D, Bannister, Thomas D, Bohn, Laura M
Published in Neuropsychopharmacology (New York, N.Y.) (01.01.2020)
Published in Neuropsychopharmacology (New York, N.Y.) (01.01.2020)
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Journal Article
Effectiveness comparisons of G-protein biased and unbiased mu opioid receptor ligands in warm water tail-withdrawal and drug discrimination in male and female rats
Schwienteck, Kathryn L., Faunce, Kaycee E., Rice, Kenner C., Obeng, Samuel, Zhang, Yan, Blough, Bruce E., Grim, Travis W., Negus, S. Stevens, Banks, Matthew L.
Published in Neuropharmacology (15.05.2019)
Published in Neuropharmacology (15.05.2019)
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Journal Article
Investigation of Diacylglycerol Lipase Alpha Inhibition in the Mouse Lipopolysaccharide Inflammatory Pain Model
Wilkerson, Jenny L, Donvito, Giulia, Grim, Travis W, Abdullah, Rehab A, Ogasawara, Daisuke, Cravatt, Benjamin F, Lichtman, Aron H
Published in The Journal of pharmacology and experimental therapeutics (01.12.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2017)
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Journal Article
Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists
Jiang, Shan, Iliopoulos-Tsoutsouvas, Christos, Tong, Fei, Brust, Christina A, Keenan, Catherine M, Raghav, Jimit Girish, Hua, Tian, Wu, Simiao, Ho, Jo-Hao, Wu, Yiran, Grim, Travis W, Zvonok, Nikolai, Thakur, Ganesh A, Liu, Zhi-Jie, Sharkey, Keith A, Bohn, Laura M, Nikas, Spyros P, Makriyannis, Alexandros
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
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Journal Article
Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models
Grim, Travis W., Ghosh, Sudeshna, Hsu, Ku-Lung, Cravatt, Benjamin F., Kinsey, Steven G., Lichtman, Aron H.
Published in Pharmacology, biochemistry and behavior (01.09.2014)
Published in Pharmacology, biochemistry and behavior (01.09.2014)
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Journal Article
The effect of quinine in two bottle choice procedures in C57BL6 mice: Opioid preference, somatic withdrawal, and pharmacokinetic outcomes
Grim, Travis W., Park, Scarlet Jinhong, Schmid, Cullen L., Laprairie, Robert B., Cameron, Michael, Bohn, Laura M.
Published in Drug and alcohol dependence (01.10.2018)
Published in Drug and alcohol dependence (01.10.2018)
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Journal Article
Hyperactivity in Mice Induced by Opioid Agonists with Partial Intrinsic Efficacy and Biased Agonism Administered Alone and in Combination with Morphine
Acevedo-Canabal, Agnes, Grim, Travis W, Schmid, Cullen L, McFague, Nina, Stahl, Edward L, Kennedy, Nicole M, Bannister, Thomas D, Bohn, Laura M
Published in Biomolecules (Basel, Switzerland) (01.06.2023)
Published in Biomolecules (Basel, Switzerland) (01.06.2023)
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Journal Article
The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model
Wilkerson, Jenny L, Niphakis, Micah J, Grim, Travis W, Mustafa, Mohammed A, Abdullah, Rehab A, Poklis, Justin L, Dewey, William L, Akbarali, Hamid, Banks, Matthew L, Wise, Laura E, Cravatt, Benjamin F, Lichtman, Aron H
Published in The Journal of pharmacology and experimental therapeutics (01.04.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2016)
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Journal Article
Probing the CB1 Cannabinoid Receptor Binding Pocket with AM6538, a High-Affinity Irreversible Antagonist
Laprairie, Robert B, Vemuri, Kiran, Stahl, Edward L, Korde, Anisha, Ho, Jo-Hao, Grim, Travis W, Hua, Tian, Wu, Yiran, Stevens, Raymond C, Liu, Zhi-Jie, Makriyannis, Alexandros, Bohn, Laura M
Published in Molecular pharmacology (01.11.2019)
Published in Molecular pharmacology (01.11.2019)
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Journal Article
Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice
Ghosh, Sudeshna, Kinsey, Steven G, Liu, Qing-Song, Hruba, Lenka, McMahon, Lance R, Grim, Travis W, Merritt, Christina R, Wise, Laura E, Abdullah, Rehab A, Selley, Dana E, Sim-Selley, Laura J, Cravatt, Benjamin F, Lichtman, Aron H
Published in The Journal of pharmacology and experimental therapeutics (01.08.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2015)
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Journal Article
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
Soethoudt, Marjolein, Grether, Uwe, Fingerle, Jürgen, Grim, Travis W., Fezza, Filomena, de Petrocellis, Luciano, Ullmer, Christoph, Rothenhäusler, Benno, Perret, Camille, van Gils, Noortje, Finlay, David, MacDonald, Christa, Chicca, Andrea, Gens, Marianela Dalghi, Stuart, Jordyn, de Vries, Henk, Mastrangelo, Nicolina, Xia, Lizi, Alachouzos, Georgios, Baggelaar, Marc P., Martella, Andrea, Mock, Elliot D., Deng, Hui, Heitman, Laura H., Connor, Mark, Di Marzo, Vincenzo, Gertsch, Jürg, Lichtman, Aron H., Maccarrone, Mauro, Pacher, Pal, Glass, Michelle, van der Stelt, Mario
Published in Nature communications (03.01.2017)
Published in Nature communications (03.01.2017)
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Journal Article
Probing the CB 1 Cannabinoid Receptor Binding Pocket with AM6538, a High-Affinity Irreversible Antagonist
Laprairie, Robert B, Vemuri, Kiran, Stahl, Edward L, Korde, Anisha, Ho, Jo-Hao, Grim, Travis W, Hua, Tian, Wu, Yiran, Stevens, Raymond C, Liu, Zhi-Jie, Makriyannis, Alexandros, Bohn, Laura M
Published in Molecular pharmacology (01.11.2019)
Published in Molecular pharmacology (01.11.2019)
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Journal Article
Pharmacological characterization of repeated administration of the first generation abused synthetic cannabinoid CP47,497
Grim, Travis W., Samano, Kimberly L., Ignatowska-Jankowska, Bogna, Tao, Qing, Sim-Selly, Laura J., Selley, Dana E., Wise, Laura E., Poklis, Alphonse, Lichtman, Aron H.
Published in Journal of basic and clinical physiology and pharmacology (01.05.2016)
Published in Journal of basic and clinical physiology and pharmacology (01.05.2016)
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Journal Article
Δ9-tetrahydrocannabinol and endocannabinoid degradative enzyme inhibitors attenuate intracranial self-stimulation in mice
Wiebelhaus, Jason M, Grim, Travis W, Owens, Robert A, Lazenka, Matthew F, Sim-Selley, Laura J, Abdullah, Rehab A, Niphakis, Micah J, Vann, Robert E, Cravatt, Benjamin F, Wiley, Jenny L, Negus, S Stevens, Lichtman, Aron H
Published in The Journal of pharmacology and experimental therapeutics (01.02.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2015)
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