Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicious Use of Structure-Guided Design and Stucture−Activity Relationships
Charifson, Paul S, Grillot, Anne-Laure, Grossman, Trudy H, Parsons, Jonathan D, Badia, Michael, Bellon, Steve, Deininger, David D, Drumm, Joseph E, Gross, Christian H, LeTiran, Arnaud, Liao, Yusheng, Mani, Nagraj, Nicolau, David P, Perola, Emanuele, Ronkin, Steven, Shannon, Dean, Swenson, Lora L, Tang, Qing, Tessier, Pamela R, Tian, Ski-Kai, Trudeau, Martin, Wang, Tiansheng, Wei, Yunyi, Zhang, Hong, Stamos, Dean
Published in Journal of medicinal chemistry (11.09.2008)
Published in Journal of medicinal chemistry (11.09.2008)
Get full text
Journal Article
Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase
Ronkin, Steven M., Badia, Michael, Bellon, Steve, Grillot, Anne-Laure, Gross, Christian H., Grossman, Trudy H., Mani, Nagraj, Parsons, Jonathan D., Stamos, Dean, Trudeau, Martin, Wei, Yunyi, Charifson, Paul S.
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Get full text
Journal Article
Dual Targeting of GyrB and ParE by a Novel Aminobenzimidazole Class of Antibacterial Compounds
GROSSMAN, Trudy H, BARTELS, Douglas J, MANI, Nagraj, MULLIN, Steve, GROSS, Christian H, PARSONS, Jonathan D, YUSHENG LIAO, GRILLOT, Anne-Laure, STAMOS, Dean, OLSON, Eric R, CHARIFSON, Paul S
Published in Antimicrobial Agents and Chemotherapy (01.02.2007)
Published in Antimicrobial Agents and Chemotherapy (01.02.2007)
Get full text
Journal Article
In Vitro Characterization of the Antibacterial Spectrum of Novel Bacterial Type II Topoisomerase Inhibitors of the Aminobenzimidazole Class
MANI, Nagraj, GROSS, Christian H, GROSSMAN, Trudy H, PARSONS, Jonathan D, HANZELKA, Brian, MÜH, Ute, MULLIN, Steve, YUSHENG LIAO, GRILLOT, Anne-Laure, STAMOS, Dean, CHARIFSON, Paul S
Published in Antimicrobial Agents and Chemotherapy (01.04.2006)
Published in Antimicrobial Agents and Chemotherapy (01.04.2006)
Get full text
Journal Article
Second-Generation Antibacterial Benzimidazole Ureas: Discovery of a Preclinical Candidate with Reduced Metabolic Liability
Grillot, Anne-Laure, Tiran, Arnaud Le, Shannon, Dean, Krueger, Elaine, Liao, Yusheng, O’Dowd, Hardwin, Tang, Qing, Ronkin, Steve, Wang, Tiansheng, Waal, Nathan, Li, Pan, Lauffer, David, Sizensky, Emmanuelle, Tanoury, Jerry, Perola, Emanuele, Grossman, Trudy H, Doyle, Tim, Hanzelka, Brian, Jones, Steven, Dixit, Vaishali, Ewing, Nigel, Liao, Shengkai, Boucher, Brian, Jacobs, Marc, Bennani, Youssef, Charifson, Paul S
Published in Journal of medicinal chemistry (13.11.2014)
Published in Journal of medicinal chemistry (13.11.2014)
Get full text
Journal Article
Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores
Henderson, James A., Bilimoria, Darius, Bubenik, Monica, Cadilhac, Caroline, Cottrell, Kevin M., Denis, Francois, Dietrich, Evelyne, Ewing, Nigel, Falardeau, Guy, Giroux, Simon, L’Heureux, Lucille, Liu, Bingcan, Mani, Nagraj, Morris, Mark, Nicolas, Olivier, Pereira, Oswy Z., Poisson, Carl, Reddy, T. Jagadeeswar, Selliah, Subajini, Shawgo, Rebecca S., Vaillancourt, Louis, Wang, Jian, Xu, Jinwang, Chauret, Nathalie, Berlioz-Seux, Francoise, Chan, Laval C., Das, Sanjoy K., Grillot, Anne-Laure, Bennani, Youssef L., Maxwell, John P.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Get full text
Journal Article
Successful application of serum shift prediction models to the design of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV with improved in vivo efficacy
Perola, Emanuele, Stamos, Dean, Grillot, Anne-Laure, Ronkin, Steven, Wang, Tiansheng, LeTiran, Arnaud, Tang, Qing, Deininger, David D., Liao, Yusheng, Tian, Shi-Kai, Drumm, Joseph E., Nicolau, David P., Tessier, Pamela R., Mani, Nagraj, Grossman, Trudy H., Charifson, Paul S.
Published in Bioorganic & medicinal chemistry letters (01.05.2014)
Published in Bioorganic & medicinal chemistry letters (01.05.2014)
Get full text
Journal Article
Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C-2-Symmetric inhibitors with diyne and biphenyl linkers
Giroux, Simon, Bilimoria, Darius, Cadilhac, Caroline, Cottrell, Kevin M., Denis, Francois, Dietrich, Evelyne, Ewing, Nigel, Henderson, James A., L'Heureux, Lucille, Mani, Nagraj, Morris, Mark, Nicolas, Olivier, Reddy, T. Jagadeeswar, Selliah, Subajini, Shawgo, Rebecca S., Xu, Jinwang, Chauret, Nathalie, Berlioz-Seux, Francoise, Chan, Laval C., Das, Sanjoy K., Grillot, Anne-Laure, Bennani, Youssef L., Maxwell, John P.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Get full text
Journal Article
Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV
O’Dowd, Hardwin, Shannon, Dean E, Chandupatla, Kishan R, Dixit, Vaishali, Engtrakul, Juntyma J, Ye, Zhengqi, Jones, Steven M, O’Brien, Colleen F, Nicolau, David P, Tessier, Pamela R, Crandon, Jared L, Song, Bin, Macikenas, Dainius, Hanzelka, Brian L, Le Tiran, Arnaud, Bennani, Youssef L, Charifson, Paul S, Grillot, Anne-Laure
Published in ACS medicinal chemistry letters (09.07.2015)
Published in ACS medicinal chemistry letters (09.07.2015)
Get full text
Journal Article
Benzimidazole-containing HCV NS5A inhibitors: Effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency
Henderson, James A., Bilimoria, Darius, Bubenik, Monica, Cadilhac, Caroline, Cottrell, Kevin M., Dietrich, Evelyne, Denis, Francois, Ewing, Nigel, Falardeau, Guy, Giroux, Simon, Grey, Ronald, L’Heureux, Lucille, Liu, Bingcan, Mani, Nagraj, Morris, Mark, Nicolas, Olivier, Pereira, Oswy Z., Poisson, Carl, Govinda Rao, B., Reddy, T. Jagadeeswar, Selliah, Subajini, Shawgo, Rebecca S., Vaillancourt, Louis, Wang, Jian, Yannopoulos, Constantin G., Chauret, Nathalie, Berlioz-Seux, Francoise, Chan, Laval C., Das, Sanjoy K., Grillot, Anne-Laure, Bennani, Youssef L., Maxwell, John P.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Get full text
Journal Article
Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: Non-symmetric inhibitors with potent activity against genotype 1a and 1b
Giroux, Simon, Bilimoria, Darius, Cadilhac, Caroline, Cottrell, Kevin M., Denis, Francois, Dietrich, Evelyne, Ewing, Nigel, Henderson, James A., L’Heureux, Lucille, Mani, Nagraj, Morris, Mark, Nicolas, Olivier, Reddy, T. Jagadeeswar, Selliah, Subajini, Shawgo, Rebecca S., Xu, Jinwang, Chauret, Nathalie, Berlioz-Seux, Francoise, Chan, Laval C., Das, Sanjoy K., Grillot, Anne-Laure, Bennani, Youssef L., Maxwell, John P.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Get full text
Journal Article
Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-Symmetric inhibitors with diyne and biphenyl linkers
Giroux, Simon, Bilimoria, Darius, Cadilhac, Caroline, Cottrell, Kevin M., Denis, Francois, Dietrich, Evelyne, Ewing, Nigel, Henderson, James A., L’Heureux, Lucille, Mani, Nagraj, Morris, Mark, Nicolas, Olivier, Reddy, T. Jagadeeswar, Selliah, Subajini, Shawgo, Rebecca S., Xu, Jinwang, Chauret, Nathalie, Berlioz-Seux, Francoise, Chan, Laval C., Das, Sanjoy K., Grillot, Anne-Laure, Bennani, Youssef L., Maxwell, John P.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Get full text
Journal Article
Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors
Giroux, Simon, Xu, Jinwang, Reddy, T. Jagadeeswar, Morris, Mark, Cottrell, Kevin M, Cadilhac, Caroline, Henderson, James A, Nicolas, Oliver, Bilimoria, Darius, Denis, Francois, Mani, Nagraj, Ewing, Nigel, Shawgo, Rebecca, L’Heureux, Lucille, Selliah, Subajini, Chan, Laval, Chauret, Nathalie, Berlioz-Seux, Francoise, Namchuk, Mark N, Grillot, Anne-Laure, Bennani, Youssef L, Das, Sanjoy K, Maxwell, John P
Published in ACS medicinal chemistry letters (13.03.2014)
Published in ACS medicinal chemistry letters (13.03.2014)
Get full text
Journal Article
Facile preparation of fused ring azolylureas
Drumm, Joseph E., Deininger, David D., LeTiran, Arnaud, Wang, Tiansheng, Grillot, Anne-Laure, Liao, Yusheng, Ronkin, Steven M., Stamos, Dean P., Tang, Qing, Tian, Shi-Kai, Oliver-Shaffer, Patricia
Published in Tetrahedron letters (30.07.2007)
Published in Tetrahedron letters (30.07.2007)
Get full text
Journal Article
Synthetic Design for Combinatorial Chemistry. Solution and Polymer-Supported Synthesis of Polycyclic Lactams by Intramolecular Cyclization of Azomethine Ylides
Marx, Matthew A, Grillot, Anne-Laure, Louer, Christopher T, Beaver, Krista A, Bartlett, Paul A
Published in Journal of the American Chemical Society (02.07.1997)
Published in Journal of the American Chemical Society (02.07.1997)
Get full text
Journal Article
Discovery and Development of Telaprevir
Grillot, Anne‐Laure, Farmer, Luc J, Rao, B. Govinda, Taylor, William P, Weisberg, Ilan S, Jacobson, Ira M, Perni, Robert B, Kwong, Ann D
Published in Antiviral Drugs (08.08.2011)
Published in Antiviral Drugs (08.08.2011)
Get full text
Book Chapter
PHOSPHATE ESTERS OF GYRASE AND TOPOISOMERASE INHIBITORS
BENNANI YOUSSEF LAAFIRET, LETIRAN ARNAUD, CHARIFSON PAUL S, O'DOWD HARDWIN, GRILLOT ANNE LAURE
Year of Publication 04.04.2014
Get full text
Year of Publication 04.04.2014
Patent
PYRIMIDINE GYRASE AND TOPOISOMERASE IV INHIBITORS
BENNANI YOUSSEF LAAFIRET, PEROLA EMANUELE, LE TIRAN ARNAUD, CHARIFSON PAUL S, O'DOWD HARDWIN, GRILLOT ANNE LAURE
Year of Publication 26.03.2014
Get full text
Year of Publication 26.03.2014
Patent
ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE
LIAO YUSHENG, HENDERSON JAMES A, PIERCE ALBERT C, BANDARAGE UPUL K, CAO JINGRONG, COLLIER PHILIP N, DAVIES ROBERT J, WANG JIAN, ARONOV ALEX, NANTHAKUMAR SUGANTHINI, GREY RONALD, KRUEGER ELAINE, O'DOWD HARDWIN, COME JON H, GRILLOT ANNE LAURE, MESSERSMITH DAVID, TIRAN AMAUD LE
Year of Publication 03.09.2012
Get full text
Year of Publication 03.09.2012
Patent