A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation
Minutti, Carlos M., Modak, Rucha V., Macdonald, Felicity, Li, Fengqi, Smyth, Danielle J., Dorward, David A., Blair, Natalie, Husovsky, Connor, Muir, Andrew, Giampazolias, Evangelos, Dobie, Ross, Maizels, Rick M., Kendall, Timothy J., Griggs, David W., Kopf, Manfred, Henderson, Neil C., Zaiss, Dietmar M.
Published in Immunity (Cambridge, Mass.) (19.03.2019)
Published in Immunity (Cambridge, Mass.) (19.03.2019)
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Identification of potent and orally efficacious phosphodiesterase inhibitors in Cryptosporidium parvum-infected immunocompromised male mice
Ajiboye, Jubilee, Teixeira, José E., Gasonoo, Makafui, Mattice, Ethan B., Korwin-Mihavics, Bethany, Miller, Peter, Cameron, Alexandra C., Stebbins, Erin, Campbell, Scott D., Griggs, David W., Spangenberg, Thomas, Meyers, Marvin J., Huston, Christopher D.
Published in Nature communications (27.09.2024)
Published in Nature communications (27.09.2024)
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Clinical and microbiologic efficacy of the piperazine-based drug lead MMV665917 in the dairy calf cryptosporidiosis model
Stebbins, Erin, Jumani, Rajiv S, Klopfer, Connor, Barlow, John, Miller, Peter, Campbell, Mary A, Meyers, Marvin J, Griggs, David W, Huston, Christopher D
Published in PLoS neglected tropical diseases (01.01.2018)
Published in PLoS neglected tropical diseases (01.01.2018)
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Inhibition of αvβ3 Integrin Survival Signaling Enhances Antiangiogenic and Antitumor Effects of Radiotherapy
ABDOLLAHI, Amir, GRIGGS, David W, NIETHAMMER, Andreas G, HUBER, Peter E, ZIEHER, Heike, ROTH, Alexandra, LIPSON, Kenneth E, SAFFRICH, Rainer, GRONE, Hermann-Josef, HALLAHAN, Dennis E, REISFELD, Ralph A, DEBUS, Juergen
Published in Clinical cancer research (01.09.2005)
Published in Clinical cancer research (01.09.2005)
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An Inhibitor of Arginine‐Glycine‐Aspartate‐Binding Integrins Reverses Fibrosis in a Mouse Model of Nonalcoholic Steatohepatitis
Ulmasov, Barbara, Noritake, Hidenao, Carmichael, Peter, Oshima, Kiyoko, Griggs, David W., Neuschwander‐Tetri, Brent A.
Published in Hepatology communications (01.02.2019)
Published in Hepatology communications (01.02.2019)
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Proprotein convertase activation of aggrecanases in cartilage in situ
Malfait, Anne-Marie, Arner, Elizabeth C., Song, Ruo-Hua, Alston, James T., Markosyan, Stella, Staten, Nicholas, Yang, Zhiyong, Griggs, David W., Tortorella, Micky D.
Published in Archives of biochemistry and biophysics (01.10.2008)
Published in Archives of biochemistry and biophysics (01.10.2008)
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Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in Mice
Ulmasov, Barbara, Neuschwander-Tetri, Brent A, Lai, Jinping, Monastyrskiy, Vladimir, Bhat, Trisha, Yates, Matthew P, Oliva, Jonathan, Prinsen, Michael J, Ruminski, Peter G, Griggs, David W
Published in Cellular and molecular gastroenterology and hepatology (01.07.2016)
Published in Cellular and molecular gastroenterology and hepatology (01.07.2016)
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Journal Article
Combined application of biosponges and an antifibrotic agent for the treatment of volumetric muscle loss
West, Charles, Tobo, Connor, Au, Jeffrey, Johnson, David, Mottaleb, M Abdul, Robinson, Jessica, Shringarpure, Saloni, Griggs, David W, Garg, Koyal
Published in American Journal of Physiology: Cell Physiology (01.06.2023)
Published in American Journal of Physiology: Cell Physiology (01.06.2023)
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Journal Article
Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs
Henderson, Neil C, Arnold, Thomas D, Katamura, Yoshio, Giacomini, Marilyn M, Rodriguez, Juan D, McCarty, Joseph H, Pellicoro, Antonella, Raschperger, Elisabeth, Betsholtz, Christer, Ruminski, Peter G, Griggs, David W, Prinsen, Michael J, Maher, Jacquelyn J, Iredale, John P, Lacy-Hulbert, Adam, Adams, Ralf H, Sheppard, Dean
Published in Nature medicine (01.12.2013)
Published in Nature medicine (01.12.2013)
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Competition for Active TGFβ Cytokine Allows for Selective Retention of Antigen-Specific Tissue- Resident Memory T Cells in the Epidermal Niche
Hirai, Toshiro, Yang, Yi, Zenke, Yukari, Li, Haiyue, Chaudhri, Virendra K., De La Cruz Diaz, Jacinto S., Zhou, Paul Yifan, Nguyen, Breanna Anh-Thu, Bartholin, Laurent, Workman, Creg J., Griggs, David W., Vignali, Dario A.A., Singh, Harinder, Masopust, David, Kaplan, Daniel H.
Published in Immunity (Cambridge, Mass.) (12.01.2021)
Published in Immunity (Cambridge, Mass.) (12.01.2021)
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Journal Article
Piperazine-Derivative MMV665917: An Effective Drug in the Diarrheic Piglet Model of Cryptosporidium hominis
Lee, Sangun, Ginese, Melanie, Girouard, Don, Beamer, Gillian, Huston, Christopher D, Osbourn, Damon, Griggs, David W, Tzipori, Saul
Published in The Journal of infectious diseases (19.06.2019)
Published in The Journal of infectious diseases (19.06.2019)
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Journal Article
Structure–Activity Relationship Studies of the Aryl Acetamide Triazolopyridazines against Cryptosporidium Reveals Remarkable Role of Fluorine
Schubert, Tanner J., Oboh, Edmund, Peek, Hannah, Philo, Emily, Teixeira, José E., Stebbins, Erin E., Miller, Peter, Oliva, Jonathan, Sverdrup, Francis M., Griggs, David W., Huston, Christopher D., Meyers, Marvin J.
Published in Journal of medicinal chemistry (22.06.2023)
Published in Journal of medicinal chemistry (22.06.2023)
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Journal Article
CWHM-12, an Antagonist of Integrin-Mediated Transforming Growth Factor-Beta Activation Confers Protection During Early Mycobacterium tuberculosis Infection in Mice
Scott, Ninecia R, Thirunavukkarasu, Shyamala, Rangel-Moreno, Javier, Griggs, David W, Khader, Shabaana A
Published in Journal of interferon & cytokine research (01.08.2022)
Published in Journal of interferon & cytokine research (01.08.2022)
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Journal Article
Optimization of the Urea Linker of Triazolopyridazine MMV665917 Results in a New Anticryptosporidial Lead with Improved Potency and Predicted hERG Safety Margin
Oboh, Edmund, Schubert, Tanner J, Teixeira, Jose E, Stebbins, Erin E, Miller, Peter, Philo, Emily, Thakellapalli, Haresh, Campbell, Scott D, Griggs, David W, Huston, Christopher D, Meyers, Marvin J
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Journal Article
Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells
Karpova, Darja, Rettig, Michael P, Ritchey, Julie, Cancilla, Daniel, Christ, Stephanie, Gehrs, Leah, Chendamarai, Ezhilarasi, Evbuomwan, Moses O, Holt, Matthew, Zhang, Jingzhu, Abou-Ezzi, Grazia, Celik, Hamza, Wiercinska, Eliza, Yang, Wei, Gao, Feng, Eissenberg, Linda G, Heier, Richard F, Arnett, Stacy D, Meyers, Marvin J, Prinsen, Michael J, Griggs, David W, Trumpp, Andreas, Ruminski, Peter G, Morrow, Dwight M, Bonig, Halvard B, Link, Daniel C, DiPersio, John F
Published in The Journal of clinical investigation (01.07.2019)
Published in The Journal of clinical investigation (01.07.2019)
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Journal Article
Spontaneous Selection of Cryptosporidium Drug Resistance in a Calf Model of Infection
Hasan, Muhammad M, Stebbins, Erin E, Choy, Robert K M, Gillespie, J Robert, de Hostos, Eugenio L, Miller, Peter, Mushtaq, Aisha, Ranade, Ranae M, Teixeira, José E, Verlinde, Christophe L M J, Sateriale, Adam, Zhang, Zhongsheng, Osbourn, Damon M, Griggs, David W, Fan, Erkang, Buckner, Frederick S, Huston, Christopher D
Published in Antimicrobial agents and chemotherapy (18.05.2021)
Published in Antimicrobial agents and chemotherapy (18.05.2021)
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Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2
Zangi, Maryam, Donald, Katherine A., Casals, Andreu Gazquez, Franson, Abaigeal D., Yu, Alice J., Marker, Elise M., Woodson, Molly E., Campbell, Scott D., Mottaleb, M. Abdul, Narayana Hajay Kumar, Tanguturi Venkata, Reddy, Makala Shakar, Raghava Reddy, Lingala Vijaya, Sadhukhan, Subir Kumar, Griggs, David W., Morrison, Lynda A., Meyers, Marvin J.
Published in European journal of medicinal chemistry (05.08.2022)
Published in European journal of medicinal chemistry (05.08.2022)
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A novel CYR61-triggered 'CYR61-αvβ3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway
MENENDEZ, Javier A, VELLON, Luciano, MEHMI, Inderjit, TENG, Poh K, GRIGGS, David W, LUPU, Ruth
Published in Oncogene (27.01.2005)
Published in Oncogene (27.01.2005)
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