Ultra-fast microscale purification of chiral racemates and achiral pharmaceuticals with analytical supercritical fluid chromatography
Hayes, Michael, Hettiarachchi, Kanaka, Lang, Simon, Wang, Jun, Greshock, Thomas J.
Published in Journal of Chromatography A (22.02.2022)
Published in Journal of Chromatography A (22.02.2022)
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Isolation, Structure Elucidation, and Biomimetic Total Synthesis of Versicolamide B, and the Isolation of Antipodal (-)-Stephacidin A and (+)-Notoamide B from Aspergillus versicolor NRRL 35600
Greshock, Thomas J, Grubbs, Alan W, Jiao, Ping, Wicklow, Donald T, Gloer, James B, Williams, Robert M
Published in Angewandte Chemie (International ed.) (01.01.2008)
Published in Angewandte Chemie (International ed.) (01.01.2008)
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Microscale Purification with Direct Charged Aerosol Detector Quantitation Using Selective Online One- or Two-Dimensional Liquid Chromatography
Hettiarachchi, Kanaka, Streckfuss, Eric, Sanzone, Jillian R., Wang, Jun, Hayes, Michael, Kong, May, Greshock, Thomas J.
Published in Analytical chemistry (Washington) (14.06.2022)
Published in Analytical chemistry (Washington) (14.06.2022)
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Journal Article
Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench-Stable Organozinc Reagents
Greshock, Thomas J., Moore, Keith P., McClain, Ray T., Bellomo, Ana, Chung, Cheol K., Dreher, Spencer D., Kutchukian, Peter S., Peng, Zhengwei, Davies, Ian W., Vachal, Petr, Ellwart, Mario, Manolikakes, Sophia M., Knochel, Paul, Nantermet, Philippe G.
Published in Angewandte Chemie International Edition (24.10.2016)
Published in Angewandte Chemie International Edition (24.10.2016)
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Journal Article
Predictions of Chromatography Methods by Chemical Structure Similarity to Accelerate High-Throughput Medicinal Chemistry
Wang, Jun, Yen, Rose, Beck, Armen G., Aggarwal, Pankaj, Kong, May, Hayes, Michael, Jabri, Salman, Greshock, Thomas J., Hettiarachchi, Kanaka
Published in ACS medicinal chemistry letters (08.08.2024)
Published in ACS medicinal chemistry letters (08.08.2024)
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Discovery of a 3‑(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity
Scott, Jack D, DeMong, Duane E, Greshock, Thomas J, Basu, Kallol, Dai, Xing, Harris, Joel, Hruza, Alan, Li, Sarah W, Lin, Sue-Ing, Liu, Hong, Macala, Megan K, Hu, Zhiyong, Mei, Hong, Zhang, Honglu, Walsh, Paul, Poirier, Marc, Shi, Zhi-Cai, Xiao, Li, Agnihotri, Gautam, Baptista, Marco A. S, Columbus, John, Fell, Matthew J, Hyde, Lynn A, Kuvelkar, Reshma, Lin, Yinghui, Mirescu, Christian, Morrow, John A, Yin, Zhizhang, Zhang, Xiaoping, Zhou, Xiaoping, Chang, Ronald K, Embrey, Mark W, Sanders, John M, Tiscia, Heather E, Drolet, Robert E, Kern, Jonathan T, Sur, Sylvie M, Renger, John J, Bilodeau, Mark T, Kennedy, Matthew E, Parker, Eric M, Stamford, Andrew W, Nargund, Ravi, McCauley, John A, Miller, Michael W
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Journal Article
A Concise, Biomimetic Total Synthesis of Stephacidin A and Notoamide B
Greshock, Thomas J., Grubbs, Alan W., Tsukamoto, Sachiko, Williams, Robert M.
Published in Angewandte Chemie International Edition (01.01.2007)
Published in Angewandte Chemie International Edition (01.01.2007)
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Journal Article
Genome-Based Characterization of Two Prenylation Steps in the Assembly of the Stephacidin and Notoamide Anticancer Agents in a Marine-Derived Aspergillus sp
Ding, Yousong, Wet, Jeffrey R. de, Cavalcoli, James, Li, Shengying, Greshock, Thomas J, Miller, Kenneth A, Finefield, Jennifer M, Sunderhaus, James D, McAfoos, Timothy J, Tsukamoto, Sachiko, Williams, Robert M, Sherman, David H
Published in Journal of the American Chemical Society (15.09.2010)
Published in Journal of the American Chemical Society (15.09.2010)
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Journal Article
Synthesis and Conformation−Activity Relationships of the Peptide Isosteres of FK228 and Largazole
Bowers, Albert A, Greshock, Thomas J, West, Nathan, Estiu, Guillermina, Schreiber, Stuart L, Wiest, Olaf, Williams, Robert M, Bradner, James E
Published in Journal of the American Chemical Society (04.03.2009)
Published in Journal of the American Chemical Society (04.03.2009)
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Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α
Mak, Victor W., Patel, Akash M., Yen, Rose, Hanisak, Jennifer, Lim, Yeon-Hee, Bao, Jianming, Zheng, Rong, Seganish, W. Michael, Yu, Yang, Healy, David R., Ogawa, Aimie, Ren, Zhao, Soriano, Aileen, Ermakov, Grigori P., Beaumont, Maribel, Metwally, Essam, Cheng, Alan C., Verras, Andreas, Fischmann, Thierry, Zebisch, Matthias, Silvestre, H. Leonardo, McEwan, Paul A., Barker, John, Rearden, Paul, Greshock, Thomas J.
Published in Journal of medicinal chemistry (11.08.2022)
Published in Journal of medicinal chemistry (11.08.2022)
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Journal Article
Isolation of Notoamide E, a Key Precursor in the Biosynthesis of Prenylated Indole Alkaloids in a Marine-Derived Fungus, Aspergillus sp
Tsukamoto, Sachiko, Kato, Hikaru, Greshock, Thomas J, Hirota, Hiroshi, Ohta, Tomihisa, Williams, Robert M
Published in Journal of the American Chemical Society (25.03.2009)
Published in Journal of the American Chemical Society (25.03.2009)
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Journal Article
Rapid Affinity and Microsomal Stability Ranking of Crude Mixture Libraries of Histone Deacetylase Inhibitors
Tyagarajan, Sriram, Andrews, Christine L., Beshore, Douglas C., Buevich, Alexei V., Curran, Patrick J., Dandliker, Peter, Greshock, Thomas J., Hoar, Jason, Kim, Alex, Karnachi, Prabha, Knemeyer, Ian, Kozlowski, Joseph, Liu, Jian, Maletic, Milana, Myers, Robert, Rada, Vanessa, Sha, Deyou, Sauvagnat, Berengere, Vachal, Petr, Wolkenberg, Scott, Yu, Wensheng, Yu, Younong, Krska, Shane W.
Published in ACS medicinal chemistry letters (10.10.2024)
Published in ACS medicinal chemistry letters (10.10.2024)
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Journal Article
Discovery of a new class of integrin antibodies for fibrosis
Zhang, Ji, Wang, Tao, Saigal, Ashmita, Johnson, Josephine, Morrisson, Jennifer, Tabrizifard, Sahba, Hollingsworth, Scott A., Eddins, Michael J., Mao, Wenxian, O’Neill, Kim, Garcia-Calvo, Margarita, Carballo-Jane, Ester, Liu, DingGang, Ham, Taewon, Zhou, Qiong, Dong, Weifeng, Meng, Hsien-Wei, Hicks, Jacqueline, Cai, Tian-Quan, Akiyama, Taro, Pinto, Shirly, Cheng, Alan C., Greshock, Thomas, Marquis, John C., Ren, Zhao, Talukdar, Saswata, Shaheen, Hussam Hisham, Handa, Masahisa
Published in Scientific reports (22.01.2021)
Published in Scientific reports (22.01.2021)
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Journal Article
Improved Total Synthesis of the Potent HDAC Inhibitor FK228 (FR-901228)
Greshock, Thomas J, Johns, Deidre M, Noguchi, Yasuo, Williams, Robert M
Published in Organic letters (21.02.2008)
Published in Organic letters (21.02.2008)
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Journal Article
MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate
Beshore, Douglas C., N. Di Marco, Christina, Chang, Ronald K., Greshock, Thomas J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Fuerst, Joy, Hartman, George D., Bilodeau, Mark T., Ray, William J., Kuduk, Scott D.
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
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Na v 1.7 target modulation and efficacy can be measured in nonhuman primate assays
Kraus, Richard L, Zhao, Fuqiang, Pall, Parul S, Zhou, Dan, Vardigan, Joshua D, Danziger, Andrew, Li, Yuxing, Daley, Christopher, Ballard, Jeanine E, Clements, Michelle K, Klein, Rebecca M, Holahan, Marie A, Greshock, Thomas J, Kim, Ronald M, Layton, Mark E, Burgey, Christopher S, Serra, Jordi, Henze, Darrell A, Houghton, Andrea K
Published in Science translational medicine (19.05.2021)
Published in Science translational medicine (19.05.2021)
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