KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells
Metzger, Eric, Wang, Sheng, Urban, Sylvia, Willmann, Dominica, Schmidt, Andreas, Offermann, Anne, Allen, Anita, Sum, Manuela, Obier, Nadine, Cottard, Félicie, Ulferts, Svenja, Preca, Bogdan-Tiberius, Hermann, Bianca, Maurer, Jochen, Greschik, Holger, Hornung, Veit, Einsle, Oliver, Perner, Sven, Imhof, Axel, Jung, Manfred, Schüle, Roland
Published in Nature structural & molecular biology (01.05.2019)
Published in Nature structural & molecular biology (01.05.2019)
Get full text
Journal Article
Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity
Wang, Sheng, Klein, Sebastian O, Urban, Sylvia, Staudt, Maximilian, Barthes, Nicolas P F, Willmann, Dominica, Bacher, Johannes, Sum, Manuela, Bauer, Helena, Peng, Ling, Rennar, Georg A, Gratzke, Christian, Schüle, Katrin M, Zhang, Lin, Einsle, Oliver, Greschik, Holger, MacLeod, Calum, Thomson, Christopher G, Jung, Manfred, Metzger, Eric, Schüle, Roland
Published in Nature communications (02.01.2024)
Published in Nature communications (02.01.2024)
Get full text
Journal Article
Structure-Based Design, Docking and Binding Free Energy Calculations of A366 Derivatives as Spindlin1 Inhibitors
Luise, Chiara, Robaa, Dina, Regenass, Pierre, Maurer, David, Ostrovskyi, Dmytro, Seifert, Ludwig, Bacher, Johannes, Burgahn, Teresa, Wagner, Tobias, Seitz, Johannes, Greschik, Holger, Park, Kwang-Su, Xiong, Yan, Jin, Jian, Schüle, Roland, Breit, Bernhard, Jung, Manfred, Sippl, Wolfgang
Published in International journal of molecular sciences (31.05.2021)
Published in International journal of molecular sciences (31.05.2021)
Get full text
Journal Article
Lysine Methyltransferase 9 (KMT9) Is an Actionable Target in Muscle-Invasive Bladder Cancer
Totonji, Sainab, Ramos-Triguero, Anna, Willmann, Dominica, Sum, Manuela, Urban, Sylvia, Bauer, Helena, Rieder, Astrid, Wang, Sheng, Greschik, Holger, Metzger, Eric, Schüle, Roland
Published in Cancers (17.04.2024)
Published in Cancers (17.04.2024)
Get full text
Journal Article
LSD1 promotes oxidative metabolism of white adipose tissue
Duteil, Delphine, Metzger, Eric, Willmann, Dominica, Karagianni, Panagiota, Friedrichs, Nicolaus, Greschik, Holger, Günther, Thomas, Buettner, Reinhard, Talianidis, Iannis, Metzger, Daniel, Schüle, Roland
Published in Nature communications (10.06.2014)
Published in Nature communications (10.06.2014)
Get full text
Journal Article
Structural and Functional Evidence for Ligand-Independent Transcriptional Activation by the Estrogen-Related Receptor 3
Greschik, Holger, Wurtz, Jean-Marie, Sanglier, Sarah, Bourguet, William, van Dorsselaer, Alain, Moras, Dino, Renaud, Jean-Paul
Published in Molecular cell (01.02.2002)
Published in Molecular cell (01.02.2002)
Get full text
Journal Article
Differential Ligand-Dependent Protein-Protein Interactions between Nuclear Receptors and a Neuronal-Specific Cofactor
Greiner, Erich F., Kirfel, Jutta, Greschik, Holger, Huang, Dongya, Becker, Peter, Kapfhammer, Josef P., Schule, Roland
Published in Proceedings of the National Academy of Sciences - PNAS (20.06.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (20.06.2000)
Get full text
Journal Article
Characterization of the DNA-Binding and Dimerization Properties of the Nuclear Orphan Receptor Germ Cell Nuclear Factor
Greschik, Holger, Wurtz, Jean-Marie, Hublitz, Philip, Köhler, Fabian, Moras, Dino, Schüle, Roland
Published in Molecular and Cellular Biology (01.01.1999)
Published in Molecular and Cellular Biology (01.01.1999)
Get full text
Journal Article
Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4
Metzger, Eric, Imhof, Axel, Patel, Dharmeshkumar, Kahl, Philip, Hoffmeyer, Katrin, Friedrichs, Nicolaus, Müller, Judith M., Greschik, Holger, Kirfel, Jutta, Ji, Sujuan, Kunowska, Natalia, Beisenherz-Huss, Christian, Günther, Thomas, Buettner, Reinhard, Schüle, Roland
Published in Nature (London) (01.04.2010)
Published in Nature (London) (01.04.2010)
Get full text
Journal Article
Selective targeting of epigenetic reader domains
Greschik, Holger, Schüle, Roland, Günther, Thomas
Published in Expert opinion on drug discovery (04.05.2017)
Published in Expert opinion on drug discovery (04.05.2017)
Get more information
Journal Article
Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform
Wagner, Tobias, Greschik, Holger, Burgahn, Teresa, Schmidtkunz, Karin, Schott, Anne-Kathrin, McMillan, Joel, Baranauskienė, Lina, Xiong, Yan, Fedorov, Oleg, Jin, Jian, Oppermann, Udo, Matulis, Daumantas, Schüle, Roland, Jung, Manfred
Published in Nucleic acids research (19.05.2016)
Published in Nucleic acids research (19.05.2016)
Get full text
Journal Article
Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor
Xiong, Yan, Greschik, Holger, Johansson, Catrine, Seifert, Ludwig, Gamble, Vicki, Park, Kwang-su, Fagan, Vincent, Li, Fengling, Chau, Irene, Vedadi, Masoud, Arrowsmith, Cheryl H., Brennan, Paul, Fedorov, Oleg, Jung, Manfred, Farnie, Gillian, Liu, Jing, Oppermann, Udo, Schüle, Roland, Jin, Jian
Published in Journal of medicinal chemistry (11.04.2024)
Published in Journal of medicinal chemistry (11.04.2024)
Get full text
Journal Article
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression
Vogler, Christine, Metzger, Eric, Schneider, Robert, Schüle, Roland, Wissmann, Melanie, Yin, Na, Müller, Judith M, Fodor, Barna D, Jenuwein, Thomas, Buettner, Reinhard, Greschik, Holger, Günther, Thomas
Published in Nature cell biology (01.03.2007)
Published in Nature cell biology (01.03.2007)
Get full text
Journal Article
Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1)
Xiong, Yan, Greschik, Holger, Johansson, Catrine, Seifert, Ludwig, Bacher, Johannes, Park, Kwang-su, Babault, Nicolas, Martini, Michael, Fagan, Vincent, Li, Fengling, Chau, Irene, Christott, Thomas, Dilworth, David, Barsyte-Lovejoy, Dalia, Vedadi, Masoud, Arrowsmith, Cheryl H, Brennan, Paul, Fedorov, Oleg, Jung, Manfred, Farnie, Gillian, Liu, Jing, Oppermann, Udo, Schüle, Roland, Jin, Jian
Published in Journal of medicinal chemistry (24.10.2019)
Published in Journal of medicinal chemistry (24.10.2019)
Get full text
Journal Article
A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function
Fagan, Vincent, Johansson, Catrine, Gileadi, Carina, Monteiro, Octovia, Dunford, James E, Nibhani, Reshma, Philpott, Martin, Malzahn, Jessica, Wells, Graham, Faram, Ruth, Cribbs, Adam P, Halidi, Nadia, Li, Fengling, Chau, Irene, Greschik, Holger, Velupillai, Srikannathasan, Allali-Hassani, Abdellah, Bennett, James, Christott, Thomas, Giroud, Charline, Lewis, Andrew M, Huber, Kilian V. M, Athanasou, Nick, Bountra, Chas, Jung, Manfred, Schüle, Roland, Vedadi, Masoud, Arrowsmith, Cheryl, Xiong, Yan, Jin, Jian, Fedorov, Oleg, Farnie, Gillian, Brennan, Paul E, Oppermann, Udo
Published in Journal of medicinal chemistry (24.10.2019)
Published in Journal of medicinal chemistry (24.10.2019)
Get full text
Journal Article
The histone code reader SPIN1 controls RET signaling in liposarcoma
Franz, Henriette, Greschik, Holger, Willmann, Dominica, Ozretić, Luka, Jilg, Cordula Annette, Wardelmann, Eva, Jung, Manfred, Buettner, Reinhard, Schüle, Roland
Published in Oncotarget (10.03.2015)
Published in Oncotarget (10.03.2015)
Get full text
Journal Article
LSD1 promotes oxidative metabolism of white adipose tissue
Duteil, Delphine, Metzger, Eric, Willmann, Dominica, Karagianni, Panagiota, Friedrichs, Nicolaus, Greschik, Holger, Günther, Thomas, Buettner, Reinhard, Talianidis, Iannis, Metzger, Daniel, Schüle, Roland
Published in Nature communications (10.06.2014)
Published in Nature communications (10.06.2014)
Get full text
Journal Article
The histone code reader Spin1 controls skeletal muscle development
Greschik, Holger, Duteil, Delphine, Messaddeq, Nadia, Willmann, Dominica, Arrigoni, Laura, Sum, Manuela, Jung, Manfred, Metzger, Daniel, Manke, Thomas, Günther, Thomas, Schüle, Roland
Published in Cell death & disease (23.11.2017)
Published in Cell death & disease (23.11.2017)
Get full text
Journal Article