Concentration-dependent plasma protein binding of the novel dipeptidyl peptidase 4 inhibitor BI 1356 due to saturable binding to its target in plasma of mice, rats and humans
Fuchs, Holger, Tillement, Jean-Paul, Urien, Saik, Greischel, Andreas, Roth, Willy
Published in Journal of pharmacy and pharmacology (01.01.2009)
Published in Journal of pharmacy and pharmacology (01.01.2009)
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The dipeptidyl peptidase-4 inhibitor linagliptin exhibits time- and dose-dependent localization in kidney, liver, and intestine after intravenous dosing: results from high resolution autoradiography in rats
Greischel, Andreas, Binder, Rudolf, Baierl, Juergen
Published in Drug metabolism and disposition (01.09.2010)
Published in Drug metabolism and disposition (01.09.2010)
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Binding to dipeptidyl peptidase-4 determines the disposition of linagliptin (BI 1356) - investigations in DPP-4 deficient and wildtype rats
Retlich, Silke, Withopf, Barbara, Greischel, Andreas, Staab, Alexander, Jaehde, Ulrich, Fuchs, Holger
Published in Biopharmaceutics & drug disposition (01.11.2009)
Published in Biopharmaceutics & drug disposition (01.11.2009)
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Toxicity assessment of pramipexole in juvenile rhesus monkeys
Patterson, Tucker A, Li, Mi, Hotchkiss, Charlotte E, Mauz, Annerose, Eddie, Malcolm, Greischel, Andreas, Stierstorfer, Birgit, Deschl, Ulrich, Paule, Merle G
Published in Toxicology (Amsterdam) (29.10.2010)
Published in Toxicology (Amsterdam) (29.10.2010)
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Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice
Leusch, Andreas, Volz, Astrid, Müller, Gabriele, Wagner, Andrea, Sauer, Achim, Greischel, Andreas, Roth, Willy
Published in European journal of pharmaceutical sciences (01.08.2002)
Published in European journal of pharmaceutical sciences (01.08.2002)
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Altered drug disposition of the platelet activating factor antagonist apafant in mdrla knockout mice
LEUSCH, Andreas, VOLZ, Astrid, MÜLLER, Gabriele, WAGNER, Andrea, SAUER, Achim, GREISCHEL, Andreas, ROTH, Willy
Published in European journal of pharmaceutical sciences (2002)
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Published in European journal of pharmaceutical sciences (2002)
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Verwendung von (S)(+)-2-Äthoxy-4-[N-[1-(2-Piperidino-Phenyl)-3-Methyl-1-Butyl[Aminocarbonylmethyl]-Benzoesäure zur Herstellung eines Langzeitantidiabetikums
GREISCHEL ANDREAS, MARK MICHAEL, KNORR HANSJOERG, GRELL WOLFGANG, MUELLER UELRICH, ZAHN GABRIELE, RUPPRECHT ECKHARD
Year of Publication 08.01.2004
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Year of Publication 08.01.2004
Patent
(S)(+)-2-ETHOXY-4-(N-(1-(2-PIPERIDINOPHENYL)-3-METHYL-1-BUTYL)-AMINOCARBONYLMETHYL)BENZOIC ACID, MEDICINES CONTAINING THEM, THAT COMPOUND AND PROCESSES FOR THE PREPARATION THEREOF
WOLFGANG GRELL, MICHAEL MARK, ULRICH MUELLER, HANSJOERG KNORR, GABRIELE ZAHN, ECKHARD RUPPRECHT, ANDREAS GREISCHEL
Year of Publication 30.04.2001
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Year of Publication 30.04.2001
Patent
(S)(+)-2-ETHOXY-4-(N-(1-(2-PIPERIDINO-PHENYL)-3-METHYL-1- -BUTYL)AMINO-CARBONYLMETHYL) BENZOIC ACID, PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF, INTERMEDIATES FOR ITS PREPARATION, AND PROCESS FOR ITS PREPARATION
MULLER ULRICH, KNORR HANSJORG, GREISCHEL ANDREAS, MARK MICHAEL, RUPPRECH ECKHARD, GRELL WOLFGANG, ZAHN GABRIELE
Year of Publication 18.01.2001
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Year of Publication 18.01.2001
Patent
Benzoic Acid Derivative
WOLFGANG GRELL, MICHAEL MARK, HANSJORG KNORR, GABRIELE ZAHN, ULRICH MILLER, ECKHARD RUPPRECHT, ANDREAS GREISCHEL
Year of Publication 13.12.2000
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Year of Publication 13.12.2000
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Verwendung von (s)(+)-2-aethoxy-4- N- 1-(2piperidino-phenyl)-3-methyl-1-butyl aminocarbonylmethyl-Benzoesaeure zur Herstellung eines Langzeitantidiabetikums
GREISCHEL ANDREAS, MARK MICHAEL, KNORR HANSJOERG, GRELL WOLFGANG, MUELLER UELRICH, ZAHN GABRIELE, RUPPRECHT ECKHARD
Year of Publication 20.04.2000
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Year of Publication 20.04.2000
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USE OF (S)(+)-2-ETHOXY-4-[N-[1-(2-PIPERIDINOPHENYL)-3-METHYL-1-BUTYL]AMINOCARBONYLMETHYL]BENZOIC ACID FOR THE PREPARATION OF A LONGLASTING ANTIDIABETIC MEDICAMENT
RUPPRECHT, ECKHARD, MUELLER, UELRICH, MARK, MICHAEL, KNORR, HANSJOERG, GRELL, WOLFGANG, GREISCHEL, ANDREAS, ZAHN, GABRIELE
Year of Publication 29.02.2000
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Year of Publication 29.02.2000
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(S)(+)-2-ETHOXY-4-[N-{1-(2-PIPERIDINO-PHENYL) -3-METHYL-1-BUTYL]AMINOCARBONYLMETHYL]BENZOIC ACID
MARK, MICHAEL, KNORR, HANSJOERG, GRELL, WOLFGANG, GREISCHEL, ANDREAS, ZAHN, GABRIELE
Year of Publication 07.01.1993
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Year of Publication 07.01.1993
Patent