Results From the First‐in‐Human Study With Ozanimod, a Novel, Selective Sphingosine‐1‐Phosphate Receptor Modulator
Tran, Jonathan Q., Hartung, Jeffrey P., Peach, Robert J., Boehm, Marcus F., Rosen, Hugh, Smith, Heather, Brooks, Jennifer L., Timony, Gregg A., Olson, Allan D., Gujrathi, Sheila, Frohna, Paul A.
Published in Journal of clinical pharmacology (01.08.2017)
Published in Journal of clinical pharmacology (01.08.2017)
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Cardiac Safety of Ozanimod, a Novel Sphingosine‐1‐Phosphate Receptor Modulator: Results of a Thorough QT/QTc Study
Tran, Jonathan Q., Hartung, Jeffrey P., Olson, Allan D., Mendzelevski, Boaz, Timony, Gregg A., Boehm, Marcus F., Peach, Robert J., Gujrathi, Sheila, Frohna, Paul A.
Published in Clinical pharmacology in drug development (01.03.2018)
Published in Clinical pharmacology in drug development (01.03.2018)
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Rationally Designed High-Affinity 2-Amino-6-halopurine Heat Shock Protein 90 Inhibitors That Exhibit Potent Antitumor Activity
Kasibhatla, Srinivas R, Hong, Kevin, Biamonte, Marco A, Busch, David J, Karjian, Patricia L, Sensintaffar, John L, Kamal, Adeela, Lough, Rachel E, Brekken, John, Lundgren, Karen, Grecko, Roy, Timony, Gregg A, Ran, Yingqing, Mansfield, Robert, Fritz, Lawrence C, Ulm, Edgar, Burrows, Francis J, Boehm, Marcus F
Published in Journal of medicinal chemistry (14.06.2007)
Published in Journal of medicinal chemistry (14.06.2007)
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7‘-Substituted Benzothiazolothio- and Pyridinothiazolothio-Purines as Potent Heat Shock Protein 90 Inhibitors
Zhang, Lin, Fan, Junhua, Vu, Khang, Hong, Kevin, Le Brazidec, Jean-Yves, Shi, Jiandong, Biamonte, Marco, Busch, David J, Lough, Rachel E, Grecko, Roy, Ran, Yingqing, Sensintaffar, John L, Kamal, Adeela, Lundgren, Karen, Burrows, Francis J, Mansfield, Robert, Timony, Gregg A, Ulm, Edgar H, Kasibhatla, Srinivas R, Boehm, Marcus F
Published in Journal of medicinal chemistry (24.08.2006)
Published in Journal of medicinal chemistry (24.08.2006)
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Orally Active Purine-Based Inhibitors of the Heat Shock Protein 90
Biamonte, Marco A, Shi, Jiandong, Hong, Kevin, Hurst, David C, Zhang, Lin, Fan, Junhua, Busch, David J, Karjian, Patricia L, Maldonado, Angelica A, Sensintaffar, John L, Yang, Yong-Ching, Kamal, Adeela, Lough, Rachel E, Lundgren, Karen, Burrows, Francis J, Timony, Gregg A, Boehm, Marcus F, Kasibhatla, Srinivas R
Published in Journal of medicinal chemistry (26.01.2006)
Published in Journal of medicinal chemistry (26.01.2006)
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Inhibition of mast cell degranulation by novel small molecule MRGPRX2 antagonists
Wollam, Joshua, Solomon, Michelle, Villescaz, Christiane, Lanier, Marion, Evans, Samantha, Bacon, Corinne, Freeman, David, Vasquez, Alexis, Vest, Alan, Napora, Jim, Charlot, Brittney, Cavarlez, Christine, Kim, Andrew, Dvorak, Lisa, Selfridge, Brandon, Huang, Liming, Nevarez, Andres, Dedman, Harry, Brooks, Jennifer, Frischbutter, Stefan, Metz, Martin, Serhan, Nadine, Gaudenzio, Nicolas, Timony, Gregg, Martinborough, Esther, Boehm, Marcus F., Viswanath, Veena
Published in Journal of allergy and clinical immunology (01.10.2024)
Published in Journal of allergy and clinical immunology (01.10.2024)
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MRGPRX2 Antagonist EP262 Potently Inhibits Agonist-Induced Mast Cell Degranulation In Vitro and In Vivo
Wollam, Joshua, Solomon, Michelle, Villescaz, Christiane, Lanier, Marion, Brooks, Jennifer, Kim, Andrew, Anderson, Samantha, Freeman, David, Vasquez, Alexis, Pisacane, Corinne, Charlot, Brittney, Vest, Alan, Napora, Jim, Cavarlez, Christine, Dvorak, Lisa, Selfridge, Brandon, Huang, Liming, Sainz, Marcos, Nevarez, Andres, Dedman, Harry, Timony, Gregg, Martinborough, Esther, Viswanath, Veena, Boehm, Marcus
Published in Journal of allergy and clinical immunology (01.02.2023)
Published in Journal of allergy and clinical immunology (01.02.2023)
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Sa1222 Results of a Safety and Tolerability Study of Rpc1063, a Novel Orally Administered Sphingosine-1-Phosphate Receptor 1 (S1p1r) Agonist, in Healthy Adult Volunteers
Olson, Allan, Timony, Gregg, Hartung, Jeffrey P, Smith, Heather, Peach, Robert J, Rosen, Hugh, Pan, Christine, Brooks, Jennifer, Boehm, Marcus, Gujrathi, Sheila
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2013)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2013)
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358 A Small Molecule S1P1 Receptor Agonist With Significant Efficacy in Animal Models of Inflammatory Bowel Disease (IBD)
Clemons, Bryan, Dedman, Harry, Powell, Rachel, Martinborough, Esther, Timony, Gregg, Peach, Robert J, Scott, Fiona L
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
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Sa1221 Rpc1063, a Potent, Selective S1P1 Receptor Modulator, Is Active in a Therapeutic IBD Model and Exhibits Favorable PK/PD Properties in Healthy Volunteers
Brooks, Jennifer, Peach, Robert J, Boehm, Marcus, Brahmachary, Enugurthi, Clemons, Bryan, Dedman, Harry, Desale, Hans, Gujrathi, Sheila, Huang, Liming, Hartung, Jeffrey P, Martinborough, Esther, Moorjani, Manisha, Powell, Rachel, Reinhart, Greg, Scott, Fiona L, Tamiya, Junko, Yeager, Adam, Rosen, Hugh, Timony, Gregg
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2013)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2013)
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Synthesis and Biological Evaluation of a New Class of Geldanamycin Derivatives as Potent Inhibitors of Hsp90
Le Brazidec, Jean-Yves, Kamal, Adeela, Busch, David, Thao, Lia, Zhang, Lin, Timony, Gregg, Grecko, Roy, Trent, Katy, Lough, Rachel, Salazar, Tim, Khan, Samina, Burrows, Francis, Boehm, Marcus F
Published in Journal of medicinal chemistry (15.07.2004)
Published in Journal of medicinal chemistry (15.07.2004)
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Dimeric ansamycins—A new class of antitumor Hsp90 modulators with prolonged inhibitory activity
Zhang, Hong, Yang, Yong‐Ching, Zhang, Lin, Fan, Junhua, Chung, Daun, Choi, Diana, Grecko, Roy, Timony, Gregg, Karjian, Patricia, Boehm, Marcus, Burrows, Francis
Published in International journal of cancer (15.02.2007)
Published in International journal of cancer (15.02.2007)
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