Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion
Cockerill, G. Stuart, Angell, Richard M, Bedernjak, Alexandre, Chuckowree, Irina, Fraser, Ian, Gascon-Simorte, Jose, Gilman, Morgan S. A, Good, James A. D, Harland, Rachel, Johnson, Sara M, Ludes-Meyers, John H, Littler, Edward, Lumley, James, Lunn, Graham, Mathews, Neil, McLellan, Jason S, Paradowski, Michael, Peeples, Mark E, Scott, Claire, Tait, Dereck, Taylor, Geraldine, Thom, Michelle, Thomas, Elaine, Villalonga Barber, Carol, Ward, Simon E, Watterson, Daniel, Williams, Gareth, Young, Paul, Powell, Kenneth
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
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Discovery and synthesis of a new class of opioid ligand having a 3-azabicyclo[3.1.0]hexane core. An example of a ‘magic methyl’ giving a 35-fold improvement in binding
Lunn, Graham, Banks, Bernard J., Crook, Robert, Feeder, Neil, Pettman, Alan, Sabnis, Yogesh
Published in Bioorganic & medicinal chemistry letters (01.08.2011)
Published in Bioorganic & medicinal chemistry letters (01.08.2011)
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Journal Article
Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain
Andrews, Mark D, af Forselles, Kerry, Beaumont, Kevin, Galan, Sébastien R. G, Glossop, Paul A, Grenie, Mathilde, Jessiman, Alan, Kenyon, Amy S, Lunn, Graham, Maw, Graham, Owen, Robert M, Pryde, David C, Roberts, Dannielle, Tran, Thien Duc
Published in ACS medicinal chemistry letters (09.04.2015)
Published in ACS medicinal chemistry letters (09.04.2015)
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Full efficacy with no CNS side-effects: unachievable panacea or reality? DMPK considerations in design of drugs with limited brain penetration
Cole, Susan, Bagal, Sharan, El-Kattan, Ayman, Fenner, Katherine, Hay, Tanya, Kempshall, Sarah, Lunn, Graham, Varma, Manthena, Stupple, Paul, Speed, William
Published in Xenobiotica (01.01.2012)
Published in Xenobiotica (01.01.2012)
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Journal Article
Use of libraries to access new chemical space: Applications to CRTH2
Abid Masood, M., Gardner, Mark, Dack, Kevin, Winpenny, David, Lunn, Graham
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
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Journal Article
SAR and biological evaluation of 3-azabicyclo[3.1.0]hexane derivatives as μ opioid ligands
Lunn, Graham, Roberts, Lee R., Content, Stephane, Critcher, Douglas J., Douglas, Sara, Fenwick, Ashley E., Gethin, David M., Goodwin, Graham, Greenway, David, Greenwood, Sean, Hall, Kim, Thomas, Martin, Thompson, Stephen, Williams, David, Wood, Gavin, Wylie, Andrew
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
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Optimized glucuronidation of dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD
Hilton, Laura, Osborne, Rachel, Kenyon, Amy S., Baldock, Helen, Bunnage, Mark E., Burrows, Jane, Clarke, Nick, Coghlan, Michele, Entwistle, David, Fairman, David, Feeder, Neil, James, Kim, Jones, Rhys M., Laouar, Nadia, Lunn, Graham, Marshall, Stuart, Newman, Sandra D., Patel, Sheena, Selby, Matthew D., Spence, Fiona, Stuart, Emilio F., Summerhill, Susan, Trevethick, Michael A., Wright, Karen N., Yeadon, Michael, Price, David A., Jones, Lyn H.
Published in MedChemComm (01.09.2011)
Published in MedChemComm (01.09.2011)
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