Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides
Anderson, Brooke A, Freestone, Graeme C, Low, Audrey, De-Hoyos, Cheryl L, III, William J Drury, Østergaard, Michael E, Migawa, Michael T, Fazio, Michael, Wan, W Brad, Berdeja, Andres, Scandalis, Eli, Burel, Sebastien A, Vickers, Timothy A, Crooke, Stanley T, Swayze, Eric E, Liang, Xuehai, Seth, Punit P
Published in Nucleic acids research (20.09.2021)
Published in Nucleic acids research (20.09.2021)
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Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs
Vasquez, Guillermo, Freestone, Graeme C, Wan, W Brad, Low, Audrey, De Hoyos, Cheryl Li, Yu, Jinghua, Prakash, Thazha P, Ǿstergaard, Michael E, Liang, Xue-hai, Crooke, Stanley T, Swayze, Eric E, Migawa, Michael T, Seth, Punit P
Published in Nucleic acids research (26.02.2021)
Published in Nucleic acids research (26.02.2021)
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Towards combining backbone and sugar constraint in 3'-3' bis-phosphonate tethered 2'-4' bridged LNA oligonucleotide trimers
Duchamp, Edouard, Vasquez, Guillermo, Firoozi, Neda, Freestone, Graeme C, Oestergaard, Michael, Seth, Punit P, Hanessian, Stephen
Published in RSC advances (26.07.2024)
Published in RSC advances (26.07.2024)
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Systematic Investigation of Tether Length and Phosphorus Configuration in Backbone Constrained Macrocyclic Nucleic Acids to Modulate Binding Kinetics for RNA
Rajasekaran, Tamilselvan, Freestone, Graeme C., Galindo-Murillo, Rodrigo, Lugato, Barbara, Gaus, Hans, Migawa, Michael T., Swayze, Eric. E., Cheatham, Thomas E., Seth, Punit P., Hanessian, Stephen
Published in Journal of organic chemistry (17.03.2023)
Published in Journal of organic chemistry (17.03.2023)
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Backbone Hydrocarbon-Constrained Nucleic Acids Modulate Hybridization Kinetics for RNA
Rajasekaran, Tamilselvan, Freestone, Graeme C, Galindo-Murillo, Rodrigo, Lugato, Barbara, Rico, Lorena, Salinas, Juan C, Gaus, Hans, Migawa, Michael T, Swayze, Eric E, Cheatham, Thomas E, Hanessian, Stephen, Seth, Punit P
Published in Journal of the American Chemical Society (02.02.2022)
Published in Journal of the American Chemical Society (02.02.2022)
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Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders
Gomez, Laurent, Massari, Mark Eben, Vickers, Troy, Freestone, Graeme, Vernier, William, Ly, Kiev, Xu, Rui, McCarrick, Margaret, Marrone, Tami, Metz, Markus, Yan, Yingzhou G, Yoder, Zachary W, Lemus, Robert, Broadbent, Nicola J, Barido, Richard, Warren, Noelle, Schmelzer, Kara, Neul, David, Lee, Dong, Andersen, Carsten B, Sebring, Kristen, Aertgeerts, Kathleen, Zhou, Xianbo, Tabatabaei, Ali, Peters, Marco, Breitenbucher, J. Guy
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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Design and Synthesis of Novel and Selective Glycine Transporter‑1 (GlyT1) Inhibitors with Memory Enhancing Properties
Santora, Vincent J, Almos, Theresa A, Barido, Richard, Basinger, Jillian, Bellows, Chris L, Bookser, Brett C, Breitenbucher, J. Guy, Broadbent, Nicola J, Cabebe, Clifford, Chai, Chih-Kun, Chen, Mi, Chow, Stephine, Chung, De Michael, Crickard, Lindsay, Danks, Anne M, Freestone, Graeme C, Gitnick, Dany, Gupta, Varsha, Hoffmaster, Christine, Hudson, Andrew R, Kaplan, Alan P, Kennedy, Michael R, Lee, Dong, Limberis, James, Ly, Kiev, Mak, Chi Ching, Masatsugu, Brittany, Morse, Andrew C, Na, Jim, Neul, David, Nikpur, John, Peters, Marco, Petroski, Robert E, Renick, Joel, Sebring, Kristen, Sevidal, Samantha, Tabatabaei, Ali, Wen, Jenny, Yan, Yingzhuo, Yoder, Zachary W, Zook, Douglas
Published in Journal of medicinal chemistry (26.07.2018)
Published in Journal of medicinal chemistry (26.07.2018)
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Azetidine-based selective glycine transporter-1 (GlyT1) inhibitors with memory enhancing properties
Hudson, Andrew R., Santora, Vincent J., Petroski, Robert E., Almos, Theresa A., Anderson, Gary, Barido, Richard, Basinger, Jillian, Bellows, Chris L., Bookser, Brett C., Broadbent, Nicola J., Cabebe, Clifford, Chai, Chih-Kun, Chen, Mi, Chow, Stephine, Chung, De Michael, Heger, Lindsay, Danks, Anne M., Freestone, Graeme C., Gitnick, Dany, Gupta, Varsha, Hoffmaster, Christine, Kaplan, Alan P., Kennedy, Michael R., Lee, Dong, Limberis, James, Ly, Kiev, Mak, Chi Ching, Masatsugu, Brittany, Morse, Andrew C., Na, Jim, Neul, David, Nikpur, John, Renick, Joel, Sebring, Kristen, Sevidal, Samantha, Tabatabaei, Ali, Wen, Jenny, Xia, Shouzhen, Yan, Yingzhuo, Yoder, Zachary W., Zook, Douglas, Peters, Marco, Breitenbucher, J. Guy
Published in Bioorganic & medicinal chemistry letters (15.07.2020)
Published in Bioorganic & medicinal chemistry letters (15.07.2020)
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Synthesis of Highly Substituted N-Hydroxyindoles through 1,5-Addition of Carbon Nucleophiles to In Situ Generated Unsaturated Nitrones
Nicolaou, K. C., Estrada, Anthony A., Lee, Sang Hyup, Freestone, Graeme C.
Published in Angewandte Chemie (International ed.) (11.08.2006)
Published in Angewandte Chemie (International ed.) (11.08.2006)
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Synthesis of Enantiopure Dihydropyranones: Aldol-Based Ring Expansion of Dihydrofurans
Donohoe, Timothy J, Raoof, Ali, Freestone, Graeme C, Linney, Ian D, Cowley, Andrew, Helliwell, Madeleine
Published in Organic letters (05.09.2002)
Published in Organic letters (05.09.2002)
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