1,4-Dihydroindeno[1,2-c]pyrazoles with Acetylenic Side Chains as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors with Low Affinity for the hERG Ion Channel
Dinges, Jürgen, Albert, Daniel H, Arnold, Lee D, Ashworth, Kimba L, Akritopoulou-Zanze, Irini, Bousquet, Peter F, Bouska, Jennifer J, Cunha, George A, Davidsen, Steven K, Diaz, Gilbert J, Djuric, Stevan W, Gasiecki, Alan F, Gintant, Gary A, Gracias, Vijaya J, Harris, Christopher M, Houseman, Kathryn A, Hutchins, Charles W, Johnson, Eric F, Li, Hu, Marcotte, Patrick A, Martin, Ruth L, Michaelides, Michael R, Nyein, Michelle, Sowin, Thomas J, Su, Zhi, Tapang, Paul H, Xia, Zhiren, Zhang, Henry Q
Published in Journal of medicinal chemistry (03.05.2007)
Published in Journal of medicinal chemistry (03.05.2007)
Get full text
Journal Article
1,4-Dihydroindeno[1,2- c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors
Dinges, Jürgen, Ashworth, Kimba L., Akritopolou-Zanze, Irini, Arnold, Lee D., Baumeister, Steven A., Bousquet, Peter F., Cunha, George A., Davidsen, Steven K., Djuric, Stevan W., Gracias, Vijaya J., Michaelides, Michael R., Rafferty, Paul, Sowin, Thomas J., Stewart, Kent D., Xia, Zhiren, Zhang, Henry Q.
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
Get full text
Journal Article
5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS
BAKKER MARGARETHA, LI BIQIN, MACK HELMUT, PATEL JYOTI R, JOHNSON ERIC F, KALVIN DOUGLAS M, LONG ANDREW J, FRANK KRISTINE, GRACIAS VIJAYA J, WAKEFIELD BRIAN D, ST. JOHN MOORE NIGEL, SARRIS KATHY, TURNER SEAN C, WANG LU, HOBSON ADRIAN, TEUSCH NICOLE, GASIECKI ALAN F, SHUAI QI, VASUDEVAN ANIL, MICHMERHUIZEN MELISSA J, AKRITOPOULOU ZANZE IRINI, GEORGE DAWN, KOVAR PETER J, DJURIC STEVAN W
Year of Publication 26.03.2010
Get full text
Year of Publication 26.03.2010
Patent
Corrigendum to “1,4-Dihydroindeno[1,2- c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors” [Bioorg. Med. Chem. Lett. 16 (2006) 4266–4271]
Dinges, Jürgen, Ashworth, Kimba L., Akritopoulou-Zanze, Irini, Arnold, Lee D., Baumeister, Steven A., Bousquet, Peter F., Cunha, George A., Davidsen, Steven K., Djuric, Stevan W., Gracias, Vijaya J., Michaelides, Michael R., Rafferty, Paul, Sowin, Thomas J., Stewart, Kent D., Xia, Zhiren, Zhang, Henry Q.
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
Get full text
Journal Article
TRICYCLIC PYRAZOLE KINASE INHIBITORS
ARNOLD, LEE, D, MAKOTO, AOYAMA, DIXON, RICHARD, W, GRACIAS, VIJAYA, J, AKRITOPOULOU-ZANZE, IRINI, MUCKEY, MELANIE, A, XIA, ZHIREN, DINGES, JÜRGEN, HOLMS, JAMES, H, STEINMAN, DOUGLAS, H, FISCHER, KIMBA, ERICSSON, ANNA, M, WADA, CAROL, K, RAFFERTY, PAUL, GASIECKI, ALAN, F, MICHAELIDES, MICHAEL, R, DJURIC, STEVAN, W, ZHANG, HENRY, Q
Year of Publication 19.08.2015
Get full text
Year of Publication 19.08.2015
Patent
5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS
BAKKER MARGARETHA, LI BIQIN, ST JOHN MOORE NIGEL, PATEL JYOTI R, MACK HELMUT, KALVIN DOUGLAS M, AKRITOPOULOU-ZANZE IRINI, LONG ANDREW J, FRANK KRISTINE, JOHNSON ERIC T, GRACIAS VIJAYA J, WAKEFIELD BRIAN D, SARRIS KATHY, HOBSON ADRIAN D, TURNER SEAN C, WANG LU, TEUSCH NICOLE, GASIECKI ALAN F, VASUDEVAN ANIL, SHUAI QI, MICHMERHUIZEN MELISSA J, GEORGE DAWN, KOVAR PETER J, DJURIC STEVAN W
Year of Publication 26.08.2015
Get full text
Year of Publication 26.08.2015
Patent
5-substituted indazoles as kinase inhibitors
BAKKER MARGARETHA H. M, PENNING THOMAS D, LI BIQIN, MACK HELMUT, KALVIN DOUGLAS M, GRACIAS VIJAYA J, HOBSON ADRIAN D, TEUSCH NICOLE, GASIECKI ALAN F, SHUAI QI, VASUDEVAN ANIL, GEORGE DAWN M, SARRIS KATHY A, PATEL JYOTI R, JOHNSON ERIC F, AKRITOPOULOU-ZANZE IRINI, LONG ANDREW J, WOODS KEITH W, WAKEFIELD BRIAN D, TURNER SEAN C, WANG LU, MOORE NIGEL S, SWANN, JR. STEVEN L, MICHMERHUIZEN MELISSA J, MIYASHIRO JULIE M, KOVAR PETER J, DJURIC STEVAN W
Year of Publication 20.10.2015
Get full text
Year of Publication 20.10.2015
Patent
5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS
ALAN F GASIECKI, BAKKER MARGARETHA, NICOLE TEUSCH, LI BIQIN, MACK HELMUT, PATEL JYOTI R, ANIL VASUDEVAN, DAWN GEORGE, KALVIN DOUGLAS M, GRACIAS VIJAYA J, WAKEFIELD BRIAN D, SARRIS KATHY, NIGEL ST JOHN MOORE, ADRIAN HOBSON, WANG LU, ERIC F JOHNSON, IRINI AKRITOPOULOU-ZANZE, SHUAI QI, MICHMERHUIZEN MELISSA J, ANDREW J LONG, SEAN C TURNER, KOVAR PETER J, KRISTINE FRANK, STEVAN W DJURIC
Year of Publication 24.04.2014
Get full text
Year of Publication 24.04.2014
Patent
5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS
PENNING THOMAS D, LI BIQIN, MACK HELMUT, KALVIN DOUGLAS M, GRACIAS VIJAYA J, HOBSON ADRIAN D, TEUSCH NICOLE, GASIECKI ALAN F, SHUAI QI, VASUDEVAN ANIL, GEORGE DAWN M, SARRIS KATHY A, PATEL JYOTI R, JOHNSON ERIC F, AKRITOPOULOU-ZANZE IRINI, LONG ANDREW J, WOODS KEITH W, WAKEFIELD BRIAN D, TURNER SEAN C, BAKKER MARGARETHA H.M, WANG LU, MOORE NIGEL S, SWANN, JR. STEVEN L, MICHMERHUIZEN MELISSA J, MIYASHIRO JULIE M, KOVAR PETER J, DJURIC STEVAN W
Year of Publication 20.11.2014
Get full text
Year of Publication 20.11.2014
Patent
5-heteroaryl substituted indazoles as kinase inhibitors
TEUSCH, NICOLE, AKRITOPOULOU-ZANZE, IRINI, SHUAI, QI, MACK, HELMUT, DJURIC, STEVAN W, GASIECKI, ALAN F, SARRIS, KATHY, KOVAR, PETER J, HOBSON, ADRIAN, TURNER, SEAN C, JOHNSON, ERIC F, WANG, LU, BAKKER, MARGARETHA, VASUDEVAN, ANIL, FRANK, KRISTINE, LONG, ANDREW J, MICHMERHUIZEN, MELISSA J, GRACIAS, VIJAYA J, PATEL, JYOTI R, WAKEFIELD, BRIAN D, MOORE, NIGEL ST. JOHN, LI, BIQIN, GEORGE, DAWN, KALVIN, DOUGLAS M
Year of Publication 17.10.2013
Get full text
Year of Publication 17.10.2013
Patent
5-substituted indazoles as kinase inhibitors
PENNING THOMAS D, BAKKER MARGARETHA, LI BIQIN, MACK HELMUT, KALVIN DOUGLAS M, GRACIAS VIJAYA J, HOBSON ADRIAN D, TEUSCH NICOLE, GASIECKI ALAN F, SHUAI QI, VASUDEVAN ANIL, SARRIS KATHY A, GEORGE DAWN, MOORE N. ST. JOHN, PATEL JYOTI R, JOHNSON ERIC F, AKRITOPOULOU-ZANZE IRINI, LONG ANDREW J, WOODS KEITH W, WAKEFIELD BRIAN D, TURNER SEAN C, WANG LU, SWANN, JR. STEVEN L, MICHMERHUIZEN MELISSA J, MIYASHIRO JULIE M, KOVAR PETER J, DJURIC STEVAN W
Year of Publication 11.02.2014
Get full text
Year of Publication 11.02.2014
Patent
5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS
TEUSCH, NICOLE, AKRITOPOULOU-ZANZE, IRINI, SHUAI, QI, MACK, HELMUT, DJURIC, STEVAN W, GASIECKI, ALAN F, SARRIS, KATHY, KOVAR, PETER J, HOBSON, ADRIAN, TURNER, SEAN C, BAKKER, MARGARETHA, WANG, LU, VASUDEVAN, ANIL, ST. JOHN MOORE, NIGEL, FRANK, KRISTINE, JOHNSON, ERIC T, MICHMERHUIZEN, MELISSA J, LONG, ANDREW J, GRACIAS, VIJAYA J, PATEL, JYOTI R, WAKEFIELD, BRIAN D, LI, BIQIN, GEORGE, DAWN, KALVIN, DOUGLAS M
Year of Publication 30.07.2012
Get full text
Year of Publication 30.07.2012
Patent
5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS
TEUSCH, NICOLE, AKRITOPOULOU-ZANZE, IRINI, SHUAI, QI, MACK, HELMUT, DJURIC, STEVAN W, GASIECKI, ALAN F, SARRIS, KATHY, KOVAR, PETER J, HOBSON, ADRIAN, TURNER, SEAN C, BAKKER, MARGARETHA, JOHNSON, ERIC F, VASUDEVAN, ANIL, ST. JOHN MOORE, NIGEL, MICHMERHUIZEN, MELISSA J, LONG, ANDREW J, GRACIAS, VIJAYA J, PATEL, JYOTI R, WAKEFIELD, BRIAN D, KALVIN, DOUGLAS M
Year of Publication 31.03.2010
Get full text
Year of Publication 31.03.2010
Patent