Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer
Gross, Matt I, Demo, Susan D, Dennison, Jennifer B, Chen, Lijing, Chernov-Rogan, Tania, Goyal, Bindu, Janes, Julie R, Laidig, Guy J, Lewis, Evan R, Li, Jim, Mackinnon, Andrew L, Parlati, Francesco, Rodriguez, Mirna L M, Shwonek, Peter J, Sjogren, Eric B, Stanton, Timothy F, Wang, Taotao, Yang, Jinfu, Zhao, Frances, Bennett, Mark K
Published in Molecular cancer therapeutics (01.04.2014)
Published in Molecular cancer therapeutics (01.04.2014)
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Prodrugs of a 1′-CN-4-Aza-7,9-dideazaadenosine C‑Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV
Mackman, Richard L, Hui, Hon C, Perron, Michel, Murakami, Eisuke, Palmiotti, Christopher, Lee, Gary, Stray, Kirsten, Zhang, Lijun, Goyal, Bindu, Chun, Kwon, Byun, Daniel, Siegel, Dustin, Simonovich, Scott, Du Pont, Venice, Pitts, Jared, Babusis, Darius, Vijjapurapu, Arya, Lu, Xianghan, Kim, Cynthia, Zhao, Xiaofeng, Chan, Julie, Ma, Bin, Lye, Diane, Vandersteen, Adelle, Wortman, Sarah, Barrett, Kimberly T, Toteva, Maria, Jordan, Robert, Subramanian, Raju, Bilello, John P, Cihlar, Tomas
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Discovery of GS-7682, a Novel 4′-Cyano-Modified C‑Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys
Siegel, Dustin S., Hui, Hon C., Pitts, Jared, Vermillion, Meghan S., Ishida, Kazuya, Rautiola, Davin, Keeney, Michael, Irshad, Hammad, Zhang, Lijun, Chun, Kwon, Chin, Gregory, Goyal, Bindu, Doerffler, Edward, Yang, Hai, Clarke, Michael O., Palmiotti, Chris, Vijjapurapu, Arya, Riola, Nicholas C., Stray, Kirsten, Murakami, Eisuke, Ma, Bin, Wang, Ting, Zhao, Xiaofeng, Xu, Yili, Lee, Gary, Marchand, Bruno, Seung, Minji, Nayak, Arabinda, Tomkinson, Adrian, Kadrichu, Nani, Ellis, Scott, Barauskas, Ona, Feng, Joy Y., Perry, Jason K., Perron, Michel, Bilello, John P., Kuehl, Philip J., Subramanian, Raju, Cihlar, Tomas, Mackman, Richard L.
Published in Journal of medicinal chemistry (08.08.2024)
Published in Journal of medicinal chemistry (08.08.2024)
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CD73 화합물
CHIN GREGORY F, GOYAL BINDU, MISH MICHAEL R, ENSAN DEEBA, COSMAN ELLIS JENNIFER L, TAMSHEN KYLE C, HO STEPHEN, MACKMAN RICHARD L, SIEGEL DUSTIN S, CLARKE MICHAEL O, YANG HAI, BARTLETT MARK J
Year of Publication 27.06.2024
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Year of Publication 27.06.2024
Patent
Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition
Safina, Brian S, Baker, Stewart, Baumgardner, Matt, Blaney, Paul M, Chan, Bryan K, Chen, Yung-Hsiang, Cartwright, Matthew W, Castanedo, Georgette, Chabot, Christine, Cheguillaume, Arnaud J, Goldsmith, Paul, Goldstein, David M, Goyal, Bindu, Hancox, Timothy, Handa, Raj K, Iyer, Pravin S, Kaur, Jasmit, Kondru, Rama, Kenny, Jane R, Krintel, Sussie L, Li, Jun, Lesnick, John, Lucas, Matthew C, Lewis, Cristina, Mukadam, Sophie, Murray, Jeremy, Nadin, Alan J, Nonomiya, Jim, Padilla, Fernando, Palmer, Wylie S, Pang, Jodie, Pegg, Neil, Price, Steve, Reif, Karin, Salphati, Laurent, Savy, Pascal A, Seward, Eileen M, Shuttleworth, Stephen, Sohal, Sukhjit, Sweeney, Zachary K, Tay, Suzanne, Tivitmahaisoon, Parcharee, Waszkowycz, Bohdan, Wei, Binqing, Yue, Qin, Zhang, Chenghong, Sutherlin, Daniel P
Published in Journal of medicinal chemistry (28.06.2012)
Published in Journal of medicinal chemistry (28.06.2012)
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항바이러스 화합물
CHIN GREGORY F, GOYAL BINDU, MISH MICHAEL R, JANSA PETR, MACKMAN RICHARD L, SIEGEL DUSTIN S, CLARKE MICHAEL O, BYUN DANIEL H
Year of Publication 24.10.2022
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Year of Publication 24.10.2022
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항바이러스 화합물
CHIN GREGORY F, GOYAL BINDU, HUI HON C, JANSA PETR, MACKMAN RICHARD L, SIEGEL DUSTIN S, CLARKE MICHAEL O, YANG HAI, CHUN BYOUNG KWON
Year of Publication 21.10.2022
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Year of Publication 21.10.2022
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항바이러스 화합물
CHIN GREGORY F, GOYAL BINDU, SIEGEL DUSTIN S, SPERANDIO DAVID, MISH MICHAEL R, ZHANG LIJUN, HUI HON C, JANSA PETR, MACKMAN RICHARD L, CLARKE MICHAEL O, YANG HAI, CHUN BYOUNG KWON, BYUN DANIEL H
Year of Publication 20.10.2022
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Year of Publication 20.10.2022
Patent
HETEROCYCLIC INHIBITORS OF GLUTAMINASE
STANTON TIMOTHY FRIEND, GOYAL BINDU, CHEN LIJING, LAIDIG GUY, SJOGREN ERIC BRIAN, LI JIM
Year of Publication 13.11.2019
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Year of Publication 13.11.2019
Patent
CD73를 억제하는 2,4-다이옥소피리미딘 화합물
CHIN GREGORY F, GOYAL BINDU, TANG DORIS T, ENSAN DEEBA, SCHROEDER SCOTT D, SIEGEL DUSTIN S, COSMAN JENNIFER L, MISH MICHAEL R, HO STEPHEN, HUI HON C, MACKMAN RICHARD L, CLARKE MICHAEL O, YANG HAI, BARTLETT MARK J, SHAPIRO NATHAN D
Year of Publication 11.01.2023
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Year of Publication 11.01.2023
Patent
Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): Optimization for JNK potency and physicochemical properties
Gong, Leyi, Han, Xiaochun, Silva, Tania, Tan, Yun-Chou, Goyal, Bindu, Tivitmahaisoon, Parch, Trejo, Alejandra, Palmer, Wylie, Hogg, Heather, Jahagir, Alam, Alam, Muzaffar, Wagner, Paul, Stein, Karin, Filonova, Lubov, Loe, Brad, Makra, Ferenc, Rotstein, David, Rapatova, Lubica, Dunn, James, Zuo, Fengrong, Porto, Joseph Dal, Wong, Brian, Jin, Sue, Chang, Alice, Tran, Patricia, Hsieh, Gary, Niu, Linghao, Shao, Ada, Reuter, Deborah, Hermann, Johaness, Kuglstatter, Andreas, Goldstein, David
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
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Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): Kinase profiling guided optimization of a 1,2,3-benzotriazole lead
Palmer, Wylie S., Alam, Muzaffar, Arzeno, Humberto B., Chang, Kung-Ching, Dunn, James P., Goldstein, David M., Gong, Leyi, Goyal, Bindu, Hermann, Johannes C., Hogg, J. Heather, Hsieh, Gary, Jahangir, Alam, Janson, Cheryl, Jin, Sue, Ursula Kammlott, R., Kuglstatter, Andreas, Lukacs, Christine, Michoud, Christophe, Niu, Linghao, Reuter, Deborah C., Shao, Ada, Silva, Tania, Trejo-Martin, Teresa A., Stein, Karin, Tan, Yun-Chou, Tivitmahaisoon, Parcharee, Tran, Patricia, Wagner, Paul, Weller, Paul, Wu, Shao-Yong
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
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Novel pyrrolo[2,1- f][1,2,4]triazin-4-amines: Dual inhibitors of EGFR and HER2 protein tyrosine kinases
Fink, Brian E., Norris, Derek, Mastalerz, Harold, Chen, Ping, Goyal, Bindu, Zhao, Yufen, Kim, Soong-Hoon, Vite, Gregory D., Lee, Francis Y., Zhang, Hongjian, Oppenheimer, Simone, Tokarski, John S., Wong, Tai W., Gavai, Ashvinikumar V.
Published in Bioorganic & medicinal chemistry letters (15.01.2011)
Published in Bioorganic & medicinal chemistry letters (15.01.2011)
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Discovery and Preclinical Evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic Acid, (3S)-3-Morpholinylmethyl Ester (BMS-599626), a Selective and Orally Efficacious Inhibitor of Human Epidermal Growth Factor Receptor 1 and 2 Kinases
Gavai, Ashvinikumar V, Fink, Brian E, Fairfax, David J, Martin, Gregory S, Rossiter, Lana M, Holst, Christian L, Kim, Soong-Hoon, Leavitt, Kenneth J, Mastalerz, Harold, Han, Wen-Ching, Norris, Derek, Goyal, Bindu, Swaminathan, Shankar, Patel, Bharat, Mathur, Arvind, Vyas, Dolatrai M, Tokarski, John S, Yu, Chiang, Oppenheimer, Simone, Zhang, Hongjian, Marathe, Punit, Fargnoli, Joseph, Lee, Francis Y, Wong, Tai W, Vite, Gregory D
Published in Journal of medicinal chemistry (12.11.2009)
Published in Journal of medicinal chemistry (12.11.2009)
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HETEROCYCLIC GLUTAMINASE INHIBITORS
STANTON TIMOTHY FRIEND, GOYAL BINDU, CHEN LIJING, LAIDIG GUY, SJOGREN ERIC BRIAN, LI JIM
Year of Publication 22.07.2015
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Year of Publication 22.07.2015
Patent
New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases
Mastalerz, Harold, Chang, Ming, Chen, Ping, Dextraze, Pierre, Fink, Brian E., Gavai, Ashvinikumar, Goyal, Bindu, Han, Wen-Ching, Johnson, Walter, Langley, David, Lee, Francis Y., Marathe, Punit, Mathur, Arvind, Oppenheimer, Simone, Ruediger, Edward, Tarrant, James, Tokarski, John S., Vite, Gregory D., Vyas, Dolatrai M., Wong, Henry, Wong, Tai W., Zhang, Hongjian, Zhang, Guifen
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
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Journal Article
HETEROCYCLIC INHIBITORS OF GLUTAMINASE
STANTON TIMOTHY FRIEND, GOYAL BINDU, CHEN LIJING, LAIDIG GUY, SJOGREN ERIC BRIAN, LI JIM
Year of Publication 05.01.2015
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Year of Publication 05.01.2015
Patent
Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17β-hydroxysteroid dehydrogenase type 3
Fink, Brian E., Gavai, Ashvinikumar V., Tokarski, John S., Goyal, Bindu, Misra, Raj, Xiao, Hai-Yun, Kimball, S. David, Han, Wen-Ching, Norris, Derek, Spires, Thomas E., You, Dan, Gottardis, Marco M., Lorenzi, Matthew V., Vite, Gregory D.
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
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TREATMENT OF CANCER WITH HETEROCYCLIC INHIBITORS OF GLUTAMINASE
STANTON TIMOTHY FRIEND, GOYAL BINDU, CHEN LIJING, LAIDIG GUY, BENNETT MARK K, BROMLEY SUSAN D, SJOGREN ERIC BRIAN, LI JIM, GROSS MATTHEW I
Year of Publication 10.08.2015
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Year of Publication 10.08.2015
Patent
Pyrimidine-based inhibitors of CaMKIIδ
Mavunkel, Babu, Xu, Yong-jin, Goyal, Bindu, Lim, Don, Lu, Qing, Chen, Zheng, Wang, Dan-Xiong, Higaki, Jeffrey, Chakraborty, Indrani, Liclican, Albert, Sideris, Steve, Laney, Maureen, Delling, Ulrike, Catalano, Rosanne, Higgins, Linda S., Wang, Hui, Wang, Jing, Feng, Ying, Dugar, Sundeep, Levy, Daniel E.
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
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