Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy
Gourley, Charlie, Balmaña, Judith, Ledermann, Jonathan A, Serra, Violeta, Dent, Rebecca, Loibl, Sibylle, Pujade-Lauraine, Eric, Boulton, Simon J
Published in Journal of clinical oncology (01.09.2019)
Published in Journal of clinical oncology (01.09.2019)
Get full text
Journal Article
Clear cell carcinoma of the ovary: a clinical and molecular perspective
Iida, Yasushi, Okamoto, Aikou, Hollis, Robert L, Gourley, Charlie, Herrington, C Simon
Published in International journal of gynecological cancer (01.04.2021)
Published in International journal of gynecological cancer (01.04.2021)
Get full text
Journal Article
Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial
Ledermann, Jonathan, Prof, Harter, Philipp, MD, Gourley, Charlie, Prof, Friedlander, Michael, Prof, Vergote, Ignace, Prof, Rustin, Gordon, Prof, Scott, Clare L, PhD, Meier, Werner, Prof, Shapira-Frommer, Ronnie, MD, Safra, Tamar, MD, Matei, Daniela, MD, Fielding, Anitra, MBChB, Spencer, Stuart, MSc, Dougherty, Brian, PhD, Orr, Maria, PhD, Hodgson, Darren, PhD, Barrett, J Carl, PhD, Matulonis, Ursula, MD
Published in The lancet oncology (01.07.2014)
Published in The lancet oncology (01.07.2014)
Get full text
Journal Article
Overall survival in patients with platinum-sensitive recurrent serous ovarian cancer receiving olaparib maintenance monotherapy: an updated analysis from a randomised, placebo-controlled, double-blind, phase 2 trial
Ledermann, Jonathan A, Prof, Harter, Philipp, MD, Gourley, Charlie, Prof, Friedlander, Michael, Prof, Vergote, Ignace, Prof, Rustin, Gordon, Prof, Scott, Clare, PhD, Meier, Werner, Prof, Shapira-Frommer, Ronnie, MD, Safra, Tamar, MD, Matei, Daniela, MD, Fielding, Anitra, MBChB, Spencer, Stuart, MSc, Rowe, Philip, MSc, Lowe, Elizabeth, MD, Hodgson, Darren, PhD, Sovak, Mika A, MD, Matulonis, Ursula, MD
Published in The lancet oncology (01.11.2016)
Published in The lancet oncology (01.11.2016)
Get full text
Journal Article
Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer
Ledermann, Jonathan, Harter, Philipp, Gourley, Charlie, Friedlander, Michael, Vergote, Ignace, Rustin, Gordon, Scott, Clare, Meier, Werner, Shapira-Frommer, Ronnie, Safra, Tamar, Matei, Daniela, Macpherson, Euan, Watkins, Claire, Carmichael, James, Matulonis, Ursula
Published in The New England journal of medicine (12.04.2012)
Published in The New England journal of medicine (12.04.2012)
Get full text
Journal Article
Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer
Bowtell, David D., Böhm, Steffen, Ahmed, Ahmed A., Aspuria, Paul-Joseph, Bast, Robert C., Beral, Valerie, Berek, Jonathan S., Birrer, Michael J., Blagden, Sarah, Bookman, Michael A., Brenton, James D., Chiappinelli, Katherine B., Martins, Filipe Correia, Coukos, George, Drapkin, Ronny, Edmondson, Richard, Fotopoulou, Christina, Gabra, Hani, Galon, Jérôme, Gourley, Charlie, Heong, Valerie, Huntsman, David G., Iwanicki, Marcin, Karlan, Beth Y., Kaye, Allyson, Lengyel, Ernst, Levine, Douglas A., Lu, Karen H., McNeish, Iain A., Menon, Usha, Narod, Steven A., Nelson, Brad H., Nephew, Kenneth P., Pharoah, Paul, Powell, Daniel J., Ramos, Pilar, Romero, Iris L., Scott, Clare L., Sood, Anil K., Stronach, Euan A., Balkwill, Frances R.
Published in Nature reviews. Cancer (01.11.2015)
Published in Nature reviews. Cancer (01.11.2015)
Get full text
Journal Article
Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes
Hodgson, Darren R., Dougherty, Brian A., Lai, Zhongwu, Fielding, Anitra, Grinsted, Lynda, Spencer, Stuart, O’Connor, Mark J., Ho, Tony W., Robertson, Jane D., Lanchbury, Jerry S., Timms, Kirsten M., Gutin, Alexander, Orr, Maria, Jones, Helen, Gilks, Blake, Womack, Chris, Gourley, Charlie, Ledermann, Jonathan, Barrett, J. Carl
Published in British journal of cancer (27.11.2018)
Published in British journal of cancer (27.11.2018)
Get full text
Journal Article
Integrated collaborative care for comorbid major depression in patients with cancer (SMaRT Oncology-2): a multicentre randomised controlled effectiveness trial
Sharpe, Michael, Prof, Walker, Jane, PhD, Hansen, Christian Holm, PhD, Martin, Paul, MSc, Symeonides, Stefan, PhD, Gourley, Charlie, Prof, Wall, Lucy, MD, Weller, David, Prof, Murray, Gordon, Prof
Published in The Lancet (British edition) (20.09.2014)
Published in The Lancet (British edition) (20.09.2014)
Get full text
Journal Article
Molecular stratification of endometrioid ovarian carcinoma predicts clinical outcome
Hollis, Robert L., Thomson, John P., Stanley, Barbara, Churchman, Michael, Meynert, Alison M., Rye, Tzyvia, Bartos, Clare, Iida, Yasushi, Croy, Ian, Mackean, Melanie, Nussey, Fiona, Okamoto, Aikou, Semple, Colin A., Gourley, Charlie, Herrington, C. Simon
Published in Nature communications (05.10.2020)
Published in Nature communications (05.10.2020)
Get full text
Journal Article
Estrogen Signaling and Its Potential as a Target for Therapy in Ovarian Cancer
Langdon, Simon P., Herrington, C. Simon, Hollis, Robert L., Gourley, Charlie
Published in Cancers (22.06.2020)
Published in Cancers (22.06.2020)
Get full text
Journal Article
The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin
Wang, Yifan, Bernhardy, Andrea J, Cruz, Cristina, Krais, John J, Nacson, Joseph, Nicolas, Emmanuelle, Peri, Suraj, van der Gulden, Hanneke, van der Heijden, Ingrid, O'Brien, Shane W, Zhang, Yong, Harrell, Maribel I, Johnson, Shawn F, Candido Dos Reis, Francisco J, Pharoah, Paul D P, Karlan, Beth, Gourley, Charlie, Lambrechts, Diether, Chenevix-Trench, Georgia, Olsson, Håkan, Benitez, Javier J, Greene, Mark H, Gore, Martin, Nussbaum, Robert, Sadetzki, Siegal, Gayther, Simon A, Kjaer, Susanne K, D'Andrea, Alan D, Shapiro, Geoffrey I, Wiest, David L, Connolly, Denise C, Daly, Mary B, Swisher, Elizabeth M, Bouwman, Peter, Jonkers, Jos, Balmaña, Judith, Serra, Violeta, Johnson, Neil
Published in Cancer research (Chicago, Ill.) (01.05.2016)
Published in Cancer research (Chicago, Ill.) (01.05.2016)
Get full text
Journal Article
Expression of glycolytic enzymes in ovarian cancers and evaluation of the glycolytic pathway as a strategy for ovarian cancer treatment
Xintaropoulou, Chrysi, Ward, Carol, Wise, Alan, Queckborner, Suzanna, Turnbull, Arran, Michie, Caroline O, Williams, Alistair R W, Rye, Tzyvia, Gourley, Charlie, Langdon, Simon P
Published in BMC cancer (05.06.2018)
Published in BMC cancer (05.06.2018)
Get full text
Journal Article
Phase II, Open-Label, Randomized, Multicenter Study Comparing the Efficacy and Safety of Olaparib, a Poly (ADP-Ribose) Polymerase Inhibitor, and Pegylated Liposomal Doxorubicin in Patients With BRCA1 or BRCA2 Mutations and Recurrent Ovarian Cancer
KAYE, Stan B, LUBINSKI, Jan, SAFRA, Tamar, VERGOTE, Ignace, WICKENS, Mark, LOWE, Elizabeth S, CARMICHAEL, James, KAUFMAN, Bella, MATULONIS, Ursula, ERN ANG, Joo, GOURLEY, Charlie, KARLAN, Beth Y, AMNON, Amit, BELL-MCGUINN, Katherine M, CHEN, Lee-May, FRIEDLANDER, Michael
Published in Journal of clinical oncology (01.02.2012)
Published in Journal of clinical oncology (01.02.2012)
Get full text
Journal Article
Integrated collaborative care for major depression comorbid with a poor prognosis cancer (SMaRT Oncology-3): a multicentre randomised controlled trial in patients with lung cancer
Walker, Jane, Dr, Hansen, Christian Holm, PhD, Martin, Paul, MSc, Symeonides, Stefan, PhD, Gourley, Charlie, Prof, Wall, Lucy, MD, Weller, David, Prof, Murray, Gordon, Prof, Sharpe, Michael, Prof
Published in The lancet oncology (01.09.2014)
Published in The lancet oncology (01.09.2014)
Get full text
Journal Article
Poly(ADP)-Ribose Polymerase Inhibition: Frequent Durable Responses in BRCA Carrier Ovarian Cancer Correlating With Platinum-Free Interval
FONG, Peter C, YAP, Timothy A, A'HERN, Roger, TUTT, Andrew, ASHWORTH, Alan, STONE, John, CARMICHAEL, James, SCHELLENS, Jan H. M, DE BONO, Johann S, KAYE, Stan B, BOSS, David S, CARDEN, Craig P, MERGUI-ROELVINK, Marja, GOURLEY, Charlie, DE GREVE, Jacques, LUBINSKI, Jan, SHANLEY, Susan, MESSIOU, Christina
Published in Journal of clinical oncology (20.05.2010)
Published in Journal of clinical oncology (20.05.2010)
Get full text
Journal Article
Long-Term Responders on Olaparib Maintenance in High-Grade Serous Ovarian Cancer: Clinical and Molecular Characterization
Lheureux, Stephanie, Lai, Zhongwu, Dougherty, Brian A, Runswick, Sarah, Hodgson, Darren R, Timms, Kirsten M, Lanchbury, Jerry S, Kaye, Stan, Gourley, Charlie, Bowtell, David, Kohn, Elise C, Scott, Claire, Matulonis, Ursula, Panzarella, Tony, Karakasis, Katherine, Burnier, Julia V, Gilks, C Blake, O'Connor, Mark J, Robertson, Jane D, Ledermann, Jonathan, Barrett, J Carl, Ho, Tony W, Oza, Amit M
Published in Clinical cancer research (01.08.2017)
Published in Clinical cancer research (01.08.2017)
Get full text
Journal Article