[¹⁸F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor
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Published in Proceedings of the National Academy of Sciences - PNAS (05.06.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (05.06.2007)
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Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors
Chu, Lin, Armstrong, Helen M., Chang, Linda L., Cheng, Amy F., Colwell, Lawrence, Cui, Jisong, Evans, Jilly, Galka, Amy, Goulet, Mark T., Hayes, Nancy, Lo, Jane, Menke, John, Ok, Hyun O., Ondeyka, Debra L., Patel, Minal, Quaker, Grace M., Sings, Heather, Witkin, Stephanie L., Zhao, Annie, Ujjainwalla, Feroze
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Published in Bioorganic & medicinal chemistry letters (15.06.2012)
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The role of melanocortins in body weight regulation: opportunities for the treatment of obesity
MacNeil, Douglas J., Howard, Andrew D., Guan, Xiaoming, Fong, Tung M., Nargund, Ravi P., Bednarek, Maria A., Goulet, Mark T., Weinberg, David H., Strack, Alison M., Marsh, Donald J., Chen, Howard Y., Shen, Chun-Pyn, Chen, Airu S., Rosenblum, Charles I., MacNeil, Tanya, Tota, Michael, MacIntyre, Euan D., Van der Ploeg, Lex H.T.
Published in European journal of pharmacology (16.08.2002)
Published in European journal of pharmacology (16.08.2002)
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The role of melanocortins in body weight regulation: opportunities for the treatment of obesity
MacNeil, Douglas J., Howard, Andrew D., Guan, Xiaoming, Fong, Tung M., Nargund, Ravi P., Bednarek, Maria A., Goulet, Mark T., Weinberg, David H., Strack, Alison M., Marsh, Donald J., Chen, Howard Y., Shen, Chun-Pyn, Chen, Airu S., Rosenblum, Charles I., MacNeil, Tanya, Tota, Michael, MacIntyre, Euan D., Van der Ploeg, Lex H.T.
Published in European journal of pharmacology (12.04.2002)
Published in European journal of pharmacology (12.04.2002)
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Initial structure–activity relationship of a novel class of nonpeptidyl GnRH receptor antagonists: 2-arylindoles
Chu, Lin, Hutchins, Jennifer E., Weber, Ann E., Lo, Jane-Ling, Yang, Yi-Tien, Cheng, Kang, Smith, Roy G., Fisher, Michael H., Wyvratt, Matthew J., Goulet, Mark T.
Published in Bioorganic & medicinal chemistry letters (26.02.2001)
Published in Bioorganic & medicinal chemistry letters (26.02.2001)
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Molecular Mechanism of Action of Pharmacoperone Rescue of Misrouted GPCR Mutants: The GnRH Receptor
Janovick, Jo Ann, Patny, Akshay, Mosley, Ralph, Goulet, Mark T, Altman, Michael D, Rush, Thomas S, Cornea, Anda, Conn, P. Michael
Published in Molecular endocrinology (Baltimore, Md.) (01.02.2009)
Published in Molecular endocrinology (Baltimore, Md.) (01.02.2009)
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Antiobesity Efficacy of a Novel Cannabinoid-1 Receptor Inverse Agonist, N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), in Rodents
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Published in The Journal of pharmacology and experimental therapeutics (01.06.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2007)
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Conformational Analysis and Receptor Docking of N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (Taranabant, MK-0364), a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist
Lin, Linus S, Ha, Sookhee, Ball, Richard G, Tsou, Nancy N, Castonguay, Laurie A, Doss, George A, Fong, Tung M, Shen, Chun-Pyn, Xiao, Jing Chen, Goulet, Mark T, Hagmann, William K
Published in Journal of medicinal chemistry (10.04.2008)
Published in Journal of medicinal chemistry (10.04.2008)
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Modification of the pyridine moiety of non-peptidyl indole GnRH receptor antagonists
Simeone, Joseph P, Bugianesi, Robert L, Ponpipom, Mitree M, Yang, Yi Tien, Lo, Jane-Ling, Yudkovitz, Joel B, Cui, Jisong, Mount, George R, Ren, Rena Ning, Creighton, Mellissa, Mao, An-Hua, Vincent, Stella H, Cheng, Kang, Goulet, Mark T
Published in Bioorganic & medicinal chemistry letters (18.11.2002)
Published in Bioorganic & medicinal chemistry letters (18.11.2002)
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Refolding of misfolded mutant GPCR: Post-translational pharmacoperone action in vitro
Janovick, Jo Ann, Brothers, Shaun P., Cornea, Anda, Bush, Eugene, Goulet, Mark T., Ashton, Wallace T., Sauer, Daryl R., Haviv, Fortuna, Greer, Jonathan, Michael Conn, P.
Published in Molecular and cellular endocrinology (30.06.2007)
Published in Molecular and cellular endocrinology (30.06.2007)
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Furo[2,3- b]pyridine-based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation. Part 1
Debenham, John S., Madsen-Duggan, Christina B., Toupence, Richard B., Walsh, Thomas F., Wang, Junying, Tong, Xinchun, Kumar, Sanjeev, Lao, Julie, Fong, Tung M., Xiao, Jing Chen, Huang, Cathy R.-R.C., Shen, Chun-Pyn, Feng, Yue, Marsh, Donald J., Stribling, D. Sloan, Shearman, Lauren P., Strack, Alison M., Goulet, Mark T.
Published in Bioorganic & medicinal chemistry letters (15.02.2010)
Published in Bioorganic & medicinal chemistry letters (15.02.2010)
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3-Aryl-4-hydroxyquinolin-2(1 H)-one derivatives as type I fatty acid synthase inhibitors
Rivkin, Alexey, Kim, Yoona R., Goulet, Mark T., Bays, Nathan, Hill, Armetta D., Kariv, Ilona, Krauss, Stefan, Ginanni, Nicole, Strack, Peter R., Kohl, Nancy E., Chung, Christine C., Varnerin, Jeffrey P., Goudreau, Paul N., Chang, Amy, Tota, Michael R., Munoz, Benito
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
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Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant
Kopka, Ihor E., Lin, Linus S., Jewell, James P., Lanza, Thomas J., Fong, Tung M., Shen, Chun-Pyn, Lao, Zhege J., Ha, Sookhee, Castonguay, Laurie G., Van der Ploeg, Lex, Goulet, Mark T., Hagmann, William K.
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
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Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: Synthesis, SAR and biological evaluation
Madsen-Duggan, Christina B., Debenham, John S., Walsh, Thomas F., Yan, Lin, Huo, Pei, Wang, Junying, Tong, Xinchun, Lao, Julie, Fong, Tung M., Xiao, Jing Chen, Huang, Cathy R.-R.C., Shen, Chun-Pyn, Stribling, D.Sloan, Shearman, Lauren P., Strack, Alison M., Goulet, Mark T., Hale, Jeffrey J.
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity
Lin, Linus S, Lanza, Thomas J, Jewell, James P, Liu, Ping, Shah, Shrenik K, Qi, Hongbo, Tong, Xinchun, Wang, Junying, Xu, Suoyu S, Fong, Tung M, Shen, Chun-Pyn, Lao, Julie, Xiao, Jing Chen, Shearman, Lauren P, Stribling, D. Sloan, Rosko, Kimberly, Strack, Alison, Marsh, Donald J, Feng, Yue, Kumar, Sanjeev, Samuel, Koppara, Yin, Wenji, Van der Ploeg, Lex H. T, Goulet, Mark T, Hagmann, William K
Published in Journal of medicinal chemistry (28.12.2006)
Published in Journal of medicinal chemistry (28.12.2006)
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Discovery of N-{(1S,2S)-2-(3-Cyanophenyl)- 3-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylpropyl}- 2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide, a Cannabinoid-1 Receptor Positron Emission Tomography Tracer Suitable for Clinical Use
Liu, Ping, Lin, Linus S, Hamill, Terence G, Jewell, James P, Lanza, Thomas J, Gibson, Raymond E, Krause, Stephen M, Ryan, Christine, Eng, Waisi, Sanabria, Sandra, Tong, Xinchun, Wang, Junying, Levorse, Dorothy A, Owens, Karen A, Fong, Tung M, Shen, Chun-Pyn, Lao, Julie, Kumar, Sanjeev, Yin, Wenji, Payack, Joseph F, Springfield, Shawn A, Hargreaves, Richard, Burns, H. Donald, Goulet, Mark T, Hagmann, William K
Published in Journal of medicinal chemistry (26.07.2007)
Published in Journal of medicinal chemistry (26.07.2007)
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Application of the two-directional chain synthesis strategy to the first stereochemical assignment of structure to members of the skipped-polyol polyene macrolide class: mycoticin A and B
Schreiber, Stuart L, Goulet, Mark T
Published in Journal of the American Chemical Society (01.12.1987)
Published in Journal of the American Chemical Society (01.12.1987)
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2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists
Jiang, Jinlong, Hoang, Myle, Young, Jonathan R., Chaung, Danny, Eid, Ronsar, Turner, Cherilyn, Lin, Peter, Tong, Xinchun, Wang, Junying, Tan, Carina, Feighner, Scott, Palyha, Oksana, Hreniuk, Donna L., Pan, Jie, Sailer, Andreas W., MacNeil, Douglas J., Howard, Andrew, Shearman, Lauren, Stribling, Sloan, Camacho, Ramon, Strack, Alison, Van der Ploeg, Lex H.T., Goulet, Mark T., DeVita, Robert J.
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
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Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators
Guo, Liangqin, Ye, Zhixiong, Ujjainwalla, Feroze, Sings, Heather L., Sebhat, Iyassu K., Huber, John, Weinberg, David H., Tang, Rui, MacNeil, Tanya, Tamvakopoulos, Constantin, Peng, Qianping, MacIntyre, Euan, van der Ploeg, Lex H.T., Goulet, Mark T., Wyvratt, Matthew J., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
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