Multiplex Genome-Edited T-cell Manufacturing Platform for "Off-the-Shelf" Adoptive T-cell Immunotherapies
Poirot, Laurent, Philip, Brian, Schiffer-Mannioui, Cécile, Le Clerre, Diane, Chion-Sotinel, Isabelle, Derniame, Sophie, Potrel, Pierrick, Bas, Cécile, Lemaire, Laetitia, Galetto, Roman, Lebuhotel, Céline, Eyquem, Justin, Cheung, Gordon Weng-Kit, Duclert, Aymeric, Gouble, Agnès, Arnould, Sylvain, Peggs, Karl, Pule, Martin, Scharenberg, Andrew M, Smith, Julianne
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Published in Cancer research (Chicago, Ill.) (15.09.2015)
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Targeting CD123 in blastic plasmacytoid dendritic cell neoplasm using allogeneic anti-CD123 CAR T cells
Cai, Tianyu, Gouble, Agnès, Black, Kathryn L., Skwarska, Anna, Naqvi, Ammar S., Taylor, Deanne, Zhao, Ming, Yuan, Qi, Sugita, Mayumi, Zhang, Qi, Galetto, Roman, Filipe, Stéphanie, Cavazos, Antonio, Han, Lina, Kuruvilla, Vinitha, Ma, Helen, Weng, Connie, Liu, Chang-Gong, Liu, Xiuping, Konoplev, Sergej, Gu, Jun, Tang, Guilin, Su, Xiaoping, Al-Atrash, Gheath, Ciurea, Stefan, Neelapu, Sattva S., Lane, Andrew A., Kantarjian, Hagop, Guzman, Monica L., Pemmaraju, Naveen, Smith, Julianne, Thomas-Tikhonenko, Andrei, Konopleva, Marina
Published in Nature communications (28.04.2022)
Published in Nature communications (28.04.2022)
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Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia
Sugita, Mayumi, Galetto, Roman, Zong, Hongliang, Ewing-Crystal, Nathan, Trujillo-Alonso, Vicenta, Mencia-Trinchant, Nuria, Yip, Winnie, Filipe, Stephanie, Lebuhotel, Celine, Gouble, Agnès, Hassane, Duane C., Smith, Julianne, Roboz, Gail J., Guzman, Monica L.
Published in Nature communications (28.04.2022)
Published in Nature communications (28.04.2022)
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Gene editing of PKLR gene in human hematopoietic progenitors through 5' and 3' UTR modified TALEN mRNA
Quintana-Bustamante, Oscar, Fañanas-Baquero, Sara, Orman, Israel, Torres, Raul, Duchateau, Philippe, Poirot, Laurent, Gouble, Agnès, Bueren, Juan A, Segovia, Jose C
Published in PloS one (16.10.2019)
Published in PloS one (16.10.2019)
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Non-viral DNA delivery and TALEN editing correct the sickle cell mutation in hematopoietic stem cells
Moiani, Arianna, Letort, Gil, Lizot, Sabrina, Chalumeau, Anne, Foray, Chloe, Felix, Tristan, Le Clerre, Diane, Temburni-Blake, Sonal, Hong, Patrick, Leduc, Sophie, Pinard, Noemie, Marechal, Alan, Seclen, Eduardo, Boyne, Alex, Mayer, Louisa, Hong, Robert, Pulicani, Sylvain, Galetto, Roman, Gouble, Agnès, Cavazzana, Marina, Juillerat, Alexandre, Miccio, Annarita, Duclert, Aymeric, Duchateau, Philippe, Valton, Julien
Published in Nature communications (11.06.2024)
Published in Nature communications (11.06.2024)
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Targeted gene therapy of xeroderma pigmentosum cells using meganuclease and TALEN
Dupuy, Aurélie, Valton, Julien, Leduc, Sophie, Armier, Jacques, Galetto, Roman, Gouble, Agnès, Lebuhotel, Céline, Stary, Anne, Pâques, Frédéric, Duchateau, Philippe, Sarasin, Alain, Daboussi, Fayza
Published in PloS one (13.11.2013)
Published in PloS one (13.11.2013)
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Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases
Daboussi, Fayza, Zaslavskiy, Mikhail, Poirot, Laurent, Loperfido, Mariana, Gouble, Agnès, Guyot, Valerie, Leduc, Sophie, Galetto, Roman, Grizot, Sylvestre, Oficjalska, Danusia, Perez, Christophe, Delacôte, Fabien, Dupuy, Aurélie, Chion-Sotinel, Isabelle, Le Clerre, Diane, Lebuhotel, Céline, Danos, Olivier, Lemaire, Frédéric, Oussedik, Kahina, Cédrone, Frédéric, Epinat, Jean-Charles, Smith, Julianne, Yáñez-Muñoz, Rafael J, Dickson, George, Popplewell, Linda, Koo, Taeyoung, VandenDriessche, Thierry, Chuah, Marinee K, Duclert, Aymeric, Duchateau, Philippe, Pâques, Frédéric
Published in Nucleic acids research (01.07.2012)
Published in Nucleic acids research (01.07.2012)
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Pre-TCRα supports CD3-dependent reactivation and expansion of TCRα-deficient primary human T-cells
Galetto, Román, Lebuhotel, Celine, Poirot, Laurent, Gouble, Agnès, Toribio, Maria L, Smith, Julianne, Scharenberg, Andrew
Published in Molecular therapy. Methods & clinical development (01.01.2014)
Published in Molecular therapy. Methods & clinical development (01.01.2014)
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megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
Boissel, Sandrine, Jarjour, Jordan, Astrakhan, Alexander, Adey, Andrew, Gouble, Agnès, Duchateau, Philippe, Shendure, Jay, Stoddard, Barry L, Certo, Michael T, Baker, David, Scharenberg, Andrew M
Published in Nucleic acids research (01.02.2014)
Published in Nucleic acids research (01.02.2014)
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Endowing universal CAR T-cell with immune-evasive properties using TALEN-gene editing
Jo, Sumin, Das, Shipra, Williams, Alan, Chretien, Anne-Sophie, Pagliardini, Thomas, Le Roy, Aude, Fernandez, Jorge Postigo, Le Clerre, Diane, Jahangiri, Billal, Chion-Sotinel, Isabelle, Rozlan, Sandra, Dessez, Emilie, Gouble, Agnes, Dusséaux, Mathilde, Galetto, Roman, Duclert, Aymeric, Marcenaro, Emanuela, Devillier, Raynier, Olive, Daniel, Duchateau, Philippe, Poirot, Laurent, Valton, Julien
Published in Nature communications (30.06.2022)
Published in Nature communications (30.06.2022)
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Factors affecting double-strand break-induced homologous recombination in mammalian cells
Perez, Christophe, Guyot, Valérie, Cabaniols, Jean-Pierre, Gouble, Agnès, Micheaux, Beatrice, Smith, Julie, Leduc, Sophie, Pâques, Frédéric, Duchateau, Philippe
Published in BioTechniques (01.07.2005)
Published in BioTechniques (01.07.2005)
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Gene correction of a duchenne muscular dystrophy mutation by meganuclease-enhanced exon knock-in
Popplewell, Linda, Koo, Taeyoung, Leclerc, Xavier, Duclert, Aymeric, Mamchaoui, Kamel, Gouble, Agnés, Mouly, Vincent, Voit, Thomas, Pâques, Frédéric, Cédrone, Frédéric, Isman, Olga, Yáñez-Muñoz, Rafael J, Dickson, George
Published in Human gene therapy (01.07.2013)
Published in Human gene therapy (01.07.2013)
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143 Mesothelin (MSLN) targeting allogeneic CAR T cells engineered to overcome tumor immunosuppressive microenvironment
Schiffer-Mannioui, Cecile, Leduc, Sophie, Chion-Sotinel, Isabelle, Clerre, Diane le, Guyot, Valérie, Rotondi, Marco, Galetto, Roman, Gouble, Agnès
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Preliminary Results of Balli-01: A Phase I Study of UCART22 (allogeneic engineered T-cells expressing anti-CD22 Chimeric Antigen Receptor) in Adult Patients with Relapsed or Refractory (R/R) CD22+ B-Cell Acute Lymphoblastic Leukemia (B-ALL)
Jain, Nitin, Roboz, Gail J., Konopleva, Marina, Liu, Hongtao, Jabbour, Elias, Poirot, Camille, Schiffer-Manniou, Cécile, Gouble, Agnès, Haider, Asifa, Zernovak, Oleg, Larson, Richard A.
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Bypassing the Constraint for Chimeric Antigen Receptor (CAR) Development in T-Cells Expressing the Targeted Antigen: Improvement of Anti-CS1 CAR Activity in Allogenic TCRa/CS1 Double Knockout T-Cells for the Treatment of Multiple Myeloma (MM)
Galetto, Roman, Chion-Sotinel, Isabelle, Gouble, Agnès, Smith, Julianne
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Abstract 3763: UCART22: allogenic adoptive immunotherapy of leukemia by targeting CD22 with CAR T-cells
Gouble, Agnès, Schiffer-Mannioui, Cécile, Thomas, Severine, Gautron, Anne-Sophie, Poirot, Laurent, Smith, Julianne
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells
Garate, Zita, Quintana-Bustamante, Oscar, Crane, Ana M., Olivier, Emmanuel, Poirot, Laurent, Galetto, Roman, Kosinski, Penelope, Hill, Collin, Kung, Charles, Agirre, Xabi, Orman, Israel, Cerrato, Laura, Alberquilla, Omaira, Rodriguez-Fornes, Fatima, Fusaki, Noemi, Garcia-Sanchez, Felix, Maia, Tabita M., Ribeiro, Maria L., Sevilla, Julian, Prosper, Felipe, Jin, Shengfang, Mountford, Joanne, Guenechea, Guillermo, Gouble, Agnes, Bueren, Juan A., Davis, Brian R., Segovia, Jose C.
Published in Stem cell reports (08.12.2015)
Published in Stem cell reports (08.12.2015)
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419. Allogenic CAR T-Cells Targeting CD123 for Adoptive Immunotherapy of Acute Myeloid Leukemia (AML)
Galetto, Roman, Lebuhotel, Céline, Françon, Patricia, Gouble, Agnès, Smith, Julianne
Published in Molecular therapy (01.05.2015)
Published in Molecular therapy (01.05.2015)
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Pre-Clinical Development of a Highly Efficient TALEN ®-Based Correction of the β-Globin Gene in Patient-Derived Hematopoietic Stem and Progenitor Cells (HSPCs) to Treat Sickle Cell Disease
Moiani, Arianna, Hong, Patrick, Letort, Gil, Lizot, Sabrina, Chirinos, Alexa, Temburni-Blake, Sonal, Nik, Sara, Mayer, Louisa, Leduc, Sophie, Pinard, Noemie, Foray, Chloe, Boyne, Alex, Kazancioglu, Selena, Frati, Giacomo, Felix, Tristan, Chalumeau, Anne, Miccio, Annarita, Dusseaux, Mathilde, Gouble, Agnès, Frattini, Mark G., Brownstein, Carrie, Duclert, Aymeric, Shiffer-Mannoui, Cecile, Juillerat, Alexandre, Duchateau, Philippe, Valton, Julien
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Abstract 5681: Prediction of immunotherapy outcome by multimodal assessment of minimal residual disease and persistence of allogeneic anti-CD123 CAR T-cells (UCART123) in pre-clinical models of acute myeloid leukemia
Sugita, Mayumi, Mencia-Trinchant, Nuria, Ewing-Crystal, Nathan, Suppa, Gabrielle, Galetto, Roman, Gouble, Agnès, Smith, Julianne, Roboz, Gail J., Hassane, Duane C., Guzman, Monica L.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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