Discovery of BI-9787, a potent zwitterionic ketohexokinase inhibitor with oral bioavailability
Heine, Niklas, Weber, Alexander, Pautsch, Alexander, Gottschling, Dirk, Uphues, Ingo, Bauer, Margit, Ebenhoch, Rebecca, Magarkar, Aniket, Nosse, Bernd, Kley, Jörg Thomas
Published in Bioorganic & medicinal chemistry letters (01.11.2024)
Published in Bioorganic & medicinal chemistry letters (01.11.2024)
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Journal Article
Crystal structures of human and mouse ketohexokinase provide a structural basis for species‐ and isoform‐selective inhibitor design
Ebenhoch, Rebecca, Bauer, Margit, Romig, Helmut, Gottschling, Dirk, Kley, Jörg Thomas, Heine, Niklas, Weber, Alexander, Uphues, Ingo, Nar, Herbert, Pautsch, Alexander
Published in Acta crystallographica. Section D, Biological crystallography. (01.10.2023)
Published in Acta crystallographica. Section D, Biological crystallography. (01.10.2023)
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Journal Article
Epigenetic Modification 6‐Methyladenosine Can Impact the Potency and Specificity of siRNA
Rydzik, Anna M., Gottschling, Dirk, Simon, Eric, Skronska‐Wasek, Wioletta, Rippmann, Jörg F., Riether, Doris
Published in Chembiochem : a European journal of chemical biology (02.02.2021)
Published in Chembiochem : a European journal of chemical biology (02.02.2021)
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A Small-Molecule-Responsive Riboswitch Enables Conditional Induction of Viral Vector-Mediated Gene Expression in Mice
Strobel, Benjamin, Düchs, Matthias J, Blazevic, Dragica, Rechtsteiner, Philipp, Braun, Clemens, Baum-Kroker, Katja S, Schmid, Bernhard, Ciossek, Thomas, Gottschling, Dirk, Hartig, Jörg S, Kreuz, Sebastian
Published in ACS synthetic biology (19.06.2020)
Published in ACS synthetic biology (19.06.2020)
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Synthesis and Properties of 2′-Deoxycytidine Triphosphate Carrying C-Myc Tag Sequence
Hinz, Michael, Gottschling, Dirk, Eritja, Ramon, Seliger, Hartmut
Published in Nucleosides, nucleotides & nucleic acids (01.10.2000)
Published in Nucleosides, nucleotides & nucleic acids (01.10.2000)
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mARC1 in MASLD: Modulation of lipid accumulation in human hepatocytes and adipocytes
Jones, Amanda K, Bajrami, Besnik, Campbell, Morgan K, Erzurumluoglu, Abdullah Mesut, Guo, Qiusha, Chen, Hongxing, Zhang, Xiaomei, Zeveleva, Svetlana, Kvaskoff, David, Brunner, Andreas-David, Muller, Stefanie, Gathey, Vasudha, Dave, Rajvee M, Tanner, James W, Rixen, Sophia, Struwe, Michel A, Phoenix, Kathryn, Klumph, Kaitlyn J, Robinson, Heather, Veyel, Daniel, Muller, Annkatrin, Noyvert, Boris, Bartholdy, Boris Alexander, Steixner-Kumar, Agnes A, Stutzki, Jan, Drichel, Dmitriy, Omland, Steffen, Sheehan, Ryan, Hill, Jon, Bretschneider, Tom, Gottschling, Dirk, Scheidig, Axel J, Clement, Bernd, Giera, Martin, Ding, Zhihao, Broadwater, John, Warren, Curtis R
Published in Hepatology communications (01.05.2024)
Published in Hepatology communications (01.05.2024)
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Journal Article
TRPC6 Pyridine carbonyl derivatives and therapeutic uses thereof as TRPC6 inhibitors
HEINE NIKLAS, GOTTSCHLING DIRK, SURPRENANT SIMON, WU XINYUAN, SMITH KEENAN LANA LOUISE, LOWE MICHAEL D, SARKO CHRISTOPHER RONALD, BOUYSSOU THIERRY, TAKAHASHI HIDENORI, TURNER MICHAEL ROBERT, RAZAVI HOSSEIN
Year of Publication 04.11.2020
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Year of Publication 04.11.2020
Patent
피리딘 카보닐 유도체 및 TRPC6 억제제로서 이의 치료학적 용도
HEINE NIKLAS, GOTTSCHLING DIRK, SURPRENANT SIMON, WU XINYUAN, SMITH KEENAN LANA LOUISE, LOWE MICHAEL D, SARKO CHRISTOPHER RONALD, BOUYSSOU THIERRY, TAKAHASHI HIDENORI, TURNER MICHAEL ROBERT, RAZAVI HOSSEIN
Year of Publication 10.08.2020
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Year of Publication 10.08.2020
Patent
Design and Synthesis of Potent and Selective α4β7 Integrin Antagonists
Boer, Jürgen, Gottschling, Dirk, Schuster, Anja, Semmrich, Monika, Holzmann, Bernhard, Kessler, Horst
Published in Journal of medicinal chemistry (02.08.2001)
Published in Journal of medicinal chemistry (02.08.2001)
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Journal Article
NEW CYANOPYRIDINE KHK INHIBITOR COMPOUNDS
KLEY, Joerg, NOSSE, Bernd, WEBER, Alexander, GOTTSCHLING, Dirk, HEINE, Niklas, PAUTSCH, Alexander
Year of Publication 13.06.2024
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Year of Publication 13.06.2024
Patent