Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress
van der Reest, Jiska, Lilla, Sergio, Zheng, Liang, Zanivan, Sara, Gottlieb, Eyal
Published in Nature communications (20.04.2018)
Published in Nature communications (20.04.2018)
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Modeling cancer metabolism on a genome scale
Yizhak, Keren, Chaneton, Barbara, Gottlieb, Eyal, Ruppin, Eytan
Published in Molecular systems biology (01.06.2015)
Published in Molecular systems biology (01.06.2015)
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Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells
Kuntz, Elodie M, Baquero, Pablo, Michie, Alison M, Dunn, Karen, Tardito, Saverio, Holyoake, Tessa L, Helgason, G Vignir, Gottlieb, Eyal
Published in Nature medicine (01.10.2017)
Published in Nature medicine (01.10.2017)
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Cancer metabolism at a glance
Vazquez, Alexei, Kamphorst, Jurre J, Markert, Elke K, Schug, Zachary T, Tardito, Saverio, Gottlieb, Eyal
Published in Journal of cell science (15.09.2016)
Published in Journal of cell science (15.09.2016)
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Predicting selective drug targets in cancer through metabolic networks
Folger, Ori, Jerby, Livnat, Frezza, Christian, Gottlieb, Eyal, Ruppin, Eytan, Shlomi, Tomer
Published in Molecular systems biology (21.06.2011)
Published in Molecular systems biology (21.06.2011)
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Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
Mills, Evanna L., Kelly, Beth, Logan, Angela, Costa, Ana S.H., Varma, Mukund, Bryant, Clare E., Tourlomousis, Panagiotis, Däbritz, J. Henry M., Gottlieb, Eyal, Latorre, Isabel, Corr, Sinéad C., McManus, Gavin, Ryan, Dylan, Jacobs, Howard T., Szibor, Marten, Xavier, Ramnik J., Braun, Thomas, Frezza, Christian, Murphy, Michael P., O’Neill, Luke A.
Published in Cell (06.10.2016)
Published in Cell (06.10.2016)
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Glutaminolysis Activates Rag-mTORC1 Signaling
Durán, Raúl V., Oppliger, Wolfgang, Robitaille, Aaron M., Heiserich, Lisa, Skendaj, Roswitha, Gottlieb, Eyal, Hall, Michael N.
Published in Molecular cell (10.08.2012)
Published in Molecular cell (10.08.2012)
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A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
Kaplon, Joanna, Zheng, Liang, Meissl, Katrin, Chaneton, Barbara, Selivanov, Vitaly A., Mackay, Gillian, van der Burg, Sjoerd H., Verdegaal, Elizabeth M. E., Cascante, Marta, Shlomi, Tomer, Gottlieb, Eyal, Peeper, Daniel S.
Published in Nature (London) (06.06.2013)
Published in Nature (London) (06.06.2013)
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Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome
Rom, Oren, Liu, Yuhao, Liu, Zhipeng, Zhao, Ying, Wu, Jianfeng, Ghrayeb, Alia, Villacorta, Luis, Fan, Yanbo, Chang, Lin, Wang, Lu, Liu, Cai, Yang, Dongshan, Song, Jun, Rech, Jason C, Guo, Yanhong, Wang, Huilun, Zhao, Guizhen, Liang, Wenying, Koike, Yui, Lu, Haocheng, Koike, Tomonari, Hayek, Tony, Pennathur, Subramaniam, Xi, Chuanwu, Wen, Bo, Sun, Duxin, Garcia-Barrio, Minerva T, Aviram, Michael, Gottlieb, Eyal, Mor, Inbal, Liu, Wanqing, Zhang, Jifeng, Chen, Y Eugene
Published in Science translational medicine (02.12.2020)
Published in Science translational medicine (02.12.2020)
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Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic Lethality
Jerby-Arnon, Livnat, Pfetzer, Nadja, Waldman, Yedael Y., McGarry, Lynn, James, Daniel, Shanks, Emma, Seashore-Ludlow, Brinton, Weinstock, Adam, Geiger, Tamar, Clemons, Paul A., Gottlieb, Eyal, Ruppin, Eytan
Published in Cell (28.08.2014)
Published in Cell (28.08.2014)
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Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation
Bulusu, Vinay, Tumanov, Sergey, Michalopoulou, Evdokia, van den Broek, Niels J., MacKay, Gillian, Nixon, Colin, Dhayade, Sandeep, Schug, Zachary T., Vande Voorde, Johan, Blyth, Karen, Gottlieb, Eyal, Vazquez, Alexei, Kamphorst, Jurre J.
Published in Cell reports (Cambridge) (17.01.2017)
Published in Cell reports (Cambridge) (17.01.2017)
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Journal Article
Serine is a natural ligand and allosteric activator of pyruvate kinase M2
Chaneton, Barbara, Hillmann, Petra, Zheng, Liang, Martin, Agnès C. L., Maddocks, Oliver D. K., Chokkathukalam, Achuthanunni, Coyle, Joseph E., Jankevics, Andris, Holding, Finn P., Vousden, Karen H., Frezza, Christian, O’Reilly, Marc, Gottlieb, Eyal
Published in Nature (London) (15.11.2012)
Published in Nature (London) (15.11.2012)
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Journal Article
mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation
Morita, Masahiro, Gravel, Simon-Pierre, Chénard, Valérie, Sikström, Kristina, Zheng, Liang, Alain, Tommy, Gandin, Valentina, Avizonis, Daina, Arguello, Meztli, Zakaria, Chadi, McLaughlan, Shannon, Nouet, Yann, Pause, Arnim, Pollak, Michael, Gottlieb, Eyal, Larsson, Ola, St-Pierre, Julie, Topisirovic, Ivan, Sonenberg, Nahum
Published in Cell metabolism (05.11.2013)
Published in Cell metabolism (05.11.2013)
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Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis
Cardaci, Simone, Zheng, Liang, MacKay, Gillian, van den Broek, Niels J. F., MacKenzie, Elaine D., Nixon, Colin, Stevenson, David, Tumanov, Sergey, Bulusu, Vinay, Kamphorst, Jurre J., Vazquez, Alexei, Fleming, Stewart, Schiavi, Francesca, Kalna, Gabriela, Blyth, Karen, Strathdee, Douglas, Gottlieb, Eyal
Published in Nature cell biology (01.10.2015)
Published in Nature cell biology (01.10.2015)
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Analysis of Cell Metabolism Using LC-MS and Isotope Tracers
Mackay, Gillian M, Zheng, Liang, van den Broek, Niels J F, Gottlieb, Eyal
Published in Methods in enzymology (01.01.2015)
Published in Methods in enzymology (01.01.2015)
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