Pimelic Diphenylamide 106 Is a Slow, Tight-binding Inhibitor of Class I Histone Deacetylases
Chou, C. James, Herman, David, Gottesfeld, Joel M.
Published in The Journal of biological chemistry (19.12.2008)
Published in The Journal of biological chemistry (19.12.2008)
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Journal Article
RNA Toxicity and Missplicing in the Common Eye Disease Fuchs Endothelial Corneal Dystrophy
Du, Jintang, Aleff, Ross A., Soragni, Elisabetta, Kalari, Krishna, Nie, Jinfu, Tang, Xiaojia, Davila, Jaime, Kocher, Jean-Pierre, Patel, Sanjay V., Gottesfeld, Joel M., Baratz, Keith H., Wieben, Eric D.
Published in The Journal of biological chemistry (06.03.2015)
Published in The Journal of biological chemistry (06.03.2015)
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Journal Article
Repeat-Associated Non-ATG (RAN) Translation in Fuchs' Endothelial Corneal Dystrophy
Soragni, Elisabetta, Petrosyan, Lina, Rinkoski, Tommy A, Wieben, Eric D, Baratz, Keith H, Fautsch, Michael P, Gottesfeld, Joel M
Published in Investigative ophthalmology & visual science (01.04.2018)
Published in Investigative ophthalmology & visual science (01.04.2018)
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Journal Article
Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia
Gottesfeld, Joel M, Herman, David, Jenssen, Kai, Burnett, Ryan, Soragni, Elisabetta, Perlman, Susan L
Published in Nature chemical biology (01.10.2006)
Published in Nature chemical biology (01.10.2006)
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Journal Article
Epigenetic therapy for Friedreich ataxia
Soragni, Elisabetta, Miao, Wenyan, Iudicello, Marco, Jacoby, David, De Mercanti, Stefania, Clerico, Marinella, Longo, Filomena, Piga, Antonio, Ku, Sherman, Campau, Erica, Du, Jintang, Penalver, Pablo, Rai, Myriam, Madara, Joseph C., Nazor, Kristopher, O'Connor, Melinda, Maximov, Anton, Loring, Jeanne F., Pandolfo, Massimo, Durelli, Luca, Gottesfeld, Joel M., Rusche, James R.
Published in Annals of neurology (01.10.2014)
Published in Annals of neurology (01.10.2014)
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Journal Article
Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model
Rai, Myriam, Soragni, Elisabetta, Chou, C James, Barnes, Glenn, Jones, Steve, Rusche, James R, Gottesfeld, Joel M, Pandolfo, Massimo
Published in PloS one (21.01.2010)
Published in PloS one (21.01.2010)
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Journal Article
HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice
Thomas, Elizabeth A, Coppola, Giovanni, Desplats, Paula A, Tang, Bin, Soragni, Elisabetta, Burnett, Ryan, Gao, Fuying, Fitzgerald, Kelsey M, Borok, Jenna F, Herman, David, Geschwind, Daniel H, Gottesfeld, Joel M
Published in Proceedings of the National Academy of Sciences - PNAS (07.10.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (07.10.2008)
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Journal Article
Role of Mismatch Repair Enzymes in GAA·TTC Triplet-repeat Expansion in Friedreich Ataxia Induced Pluripotent Stem Cells
Du, Jintang, Campau, Erica, Soragni, Elisabetta, Ku, Sherman, Puckett, James W., Dervan, Peter B., Gottesfeld, Joel M.
Published in The Journal of biological chemistry (24.08.2012)
Published in The Journal of biological chemistry (24.08.2012)
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Journal Article
Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease
Jia, Haiqun, Pallos, Judit, Jacques, Vincent, Lau, Alice, Tang, Bin, Cooper, Andrew, Syed, Adeela, Purcell, Judith, Chen, Yi, Sharma, Shefali, Sangrey, Gavin R, Darnell, Shayna B, Plasterer, Heather, Sadri-Vakili, Ghazaleh, Gottesfeld, Joel M, Thompson, Leslie M, Rusche, James R, Marsh, J. Lawrence, Thomas, Elizabeth A
Published in Neurobiology of disease (01.05.2012)
Published in Neurobiology of disease (01.05.2012)
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Journal Article
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis
Balch, William E, Hutt, Darren M, Herman, David, Rodrigues, Ana P C, Noel, Sabrina, Pilewski, Joseph M, Matteson, Jeanne, Hoch, Ben, Kellner, Wendy, Kelly, Jeffery W, Schmidt, Andre, Thomas, Philip J, Matsumura, Yoshihiro, Skach, William R, Gentzsch, Martina, Riordan, John R, Sorscher, Eric J, Okiyoneda, Tsukasa, Yates, John R, Lukacs, Gergely L, Frizzell, Raymond A, Manning, Gerard, Gottesfeld, Joel M
Published in Nature chemical biology (01.01.2010)
Published in Nature chemical biology (01.01.2010)
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Journal Article
HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model
Rai, Myriam, Soragni, Elisabetta, Jenssen, Kai, Burnett, Ryan, Herman, David, Coppola, Giovanni, Geschwind, Daniel H, Gottesfeld, Joel M, Pandolfo, Massimo
Published in PloS one (09.04.2008)
Published in PloS one (09.04.2008)
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Journal Article
Prolonged treatment with pimelic o -aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model
Sandi, Chiranjeevi, Pinto, Ricardo Mouro, Al-Mahdawi, Sahar, Ezzatizadeh, Vahid, Barnes, Glenn, Jones, Steve, Rusche, James R, Gottesfeld, Joel M, Pook, Mark A
Published in Neurobiology of disease (01.06.2011)
Published in Neurobiology of disease (01.06.2011)
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Journal Article
Quantitative Proteomic Analysis Identifies Targets and Pathways of a 2‑Aminobenzamide HDAC Inhibitor in Friedreich’s Ataxia Patient iPSC-Derived Neural Stem Cells
Shan, Bing, Xu, Chunping, Zhang, Yaoyang, Xu, Tao, Gottesfeld, Joel M, Yates, John R
Published in Journal of proteome research (07.11.2014)
Published in Journal of proteome research (07.11.2014)
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Journal Article
A non-synonymous single nucleotide polymorphism in SIRT6 predicts neurological severity in Friedreich ataxia
Rodden, Layne N., Rummey, Christian, Dong, Yi Na, Lagedrost, Sarah, Regner, Sean, Brocht, Alicia, Bushara, Khalaf, Delatycki, Martin B., Gomez, Christopher M., Mathews, Katherine, Murray, Sarah, Perlman, Susan, Ravina, Bernard, Subramony, S. H., Wilmot, George, Zesiewicz, Theresa, Bolotta, Alessandra, Domissy, Alain, Jespersen, Christine, Ji, Baohu, Soragni, Elisabetta, Gottesfeld, Joel M., Lynch, David R.
Published in Frontiers in molecular biosciences (05.09.2022)
Published in Frontiers in molecular biosciences (05.09.2022)
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Journal Article
Chromatin structure determines accessibility of a hairpin polyamide–chlorambucil conjugate at histone H4 genes in pancreatic cancer cells
Jespersen, Christine, Soragni, Elisabetta, James Chou, C., Arora, Paramjit S., Dervan, Peter B., Gottesfeld, Joel M.
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
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Journal Article
Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin
Boger, Dale L, Trzupek, John D, Gottesfeld, Joel M
Published in Nature chemical biology (01.02.2006)
Published in Nature chemical biology (01.02.2006)
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