A model‐based analysis to guide gonadotropin‐releasing hormone receptor antagonist use for management of endometriosis
Pohl, Oliver, Baron, Kyle, Riggs, Matthew, French, Jonathan, Garcia, Ramon, Gotteland, Jean‐Pierre
Published in British journal of clinical pharmacology (01.05.2022)
Published in British journal of clinical pharmacology (01.05.2022)
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Journal Article
Pharmacokinetics, safety and tolerability of OBE022, a selective prostaglandin F2α receptor antagonist tocolytic: A first‐in‐human trial in healthy postmenopausal women
Pohl, Oliver, Marchand, Line, Gotteland, Jean‐Pierre, Coates, Simon, Täubel, Jörg, Lorch, Ulrike
Published in British journal of clinical pharmacology (01.08.2018)
Published in British journal of clinical pharmacology (01.08.2018)
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Journal Article
Coadministration of the prostaglandin F2α receptor antagonist preterm labour drug candidate OBE022 with magnesium sulfate, atosiban, nifedipine and betamethasone
Pohl, Oliver, Marchand, Line, Gotteland, Jean‐Pierre, Coates, Simon, Täubel, Jörg, Lorch, Ulrike
Published in British journal of clinical pharmacology (01.07.2019)
Published in British journal of clinical pharmacology (01.07.2019)
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Journal Article
Confirmation of the cardiac safety of nolasiban in a randomised cohort of healthy female volunteers
Täubel, Jörg, Lorch, Ulrike, Spencer, Christopher S., Freier, Anne, Camilleri, Dorothée, Djumanov, Dilshat, Ferber, Georg, Marchand, Line, Gotteland, Jean-Pierre, Pohl, Oliver
Published in Scientific reports (18.03.2021)
Published in Scientific reports (18.03.2021)
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Journal Article
c-Jun NH2 -terminal kinase inhibitor bentamapimod reduces induced endometriosis in baboons: an assessor-blind placebo-controlled randomized study
Hussein, Mostafa, M.D, Chai, Daniel C., D.V.M, Kyama, Cleophas M., Ph.D, Mwenda, Jason M., Ph.D, Palmer, Stephen S., Ph.D, Gotteland, Jean-Pierre, Ph.D, D'Hooghe, Thomas M., M.D
Published in Fertility and sterility (01.03.2016)
Published in Fertility and sterility (01.03.2016)
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Journal Article
Confirmation of the Cardiac Safety of PGF2α Receptor Antagonist OBE022 in a First‐in‐Human Study in Healthy Subjects, Using Intensive ECG Assessments
Täubel, Jörg, Lorch, Ulrike, Coates, Simon, Fernandes, Sara, Foley, Paul, Ferber, Georg, Gotteland, Jean‐Pierre, Pohl, Oliver
Published in Clinical pharmacology in drug development (01.11.2018)
Published in Clinical pharmacology in drug development (01.11.2018)
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Journal Article
Inhibition of c‐Jun N‐terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats
Ferrandi, Chiara, Ballerio, Rossana, Gaillard, Pascale, Giachetti, Claudio, Carboni, Sonia, Vitte, Pierre‐Alain, Gotteland, Jean‐Pierre, Cirillo, Rocco
Published in British journal of pharmacology (01.07.2004)
Published in British journal of pharmacology (01.07.2004)
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Journal Article
Design and Synthesis of the First Generation of Novel Potent, Selective, and in Vivo Active (Benzothiazol-2-yl)acetonitrile Inhibitors of the c-Jun N-Terminal Kinase
Gaillard, Pascale, Jeanclaude-Etter, Isabelle, Ardissone, Vittoria, Arkinstall, Steve, Cambet, Yves, Camps, Montserrat, Chabert, Christian, Church, Dennis, Cirillo, Rocco, Gretener, Denise, Halazy, Serge, Nichols, Anthony, Szyndralewiez, Cedric, Vitte, Pierre-Alain, Gotteland, Jean-Pierre
Published in Journal of medicinal chemistry (14.07.2005)
Published in Journal of medicinal chemistry (14.07.2005)
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Journal Article
Control of death receptor and mitochondrial‐dependent apoptosis by c‐Jun N‐terminal kinase in hippocampal CA1 neurones following global transient ischaemia
Carboni, Sonia, Antonsson, Bruno, Gaillard, Pascale, Gotteland, Jean‐Pierre, Gillon, Jean‐Yves, Vitte, Pierre‐Alain
Published in Journal of neurochemistry (01.03.2005)
Published in Journal of neurochemistry (01.03.2005)
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Journal Article
Treatment of endometriosis-associated pain with linzagolix, an oral gonadotropin-releasing hormone–antagonist: a randomized clinical trial
Donnez, Jacques, Taylor, Hugh S., Taylor, Robert N., Akin, Mark D., Tatarchuk, Tatyana F., Wilk, Krzysztof, Gotteland, Jean-Pierre, Lecomte, Veronique, Bestel, Elke
Published in Fertility and sterility (01.07.2020)
Published in Fertility and sterility (01.07.2020)
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Journal Article
AS601245 (1,3-Benzothiazol-2-yl (2-{[2-(3-pyridinyl) ethyl] amino}-4 pyrimidinyl) Acetonitrile): A c-Jun NH2-Terminal Protein Kinase Inhibitor with Neuroprotective Properties
Carboni, Sonia, Hiver, Agnes, Szyndralewiez, Cedric, Gaillard, Pascale, Gotteland, Jean-Pierre, Vitte, Pierre-Alain
Published in The Journal of pharmacology and experimental therapeutics (01.07.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2004)
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Journal Article
Characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-Jun N-terminal kinase pathway biomarkers
Ferrandi, Chiara, Richard, Fabien, Tavano, Patrizia, Hauben, Ehud, Barbié, Valerie, Gotteland, Jean-Pierre, Greco, Beatrice, Fortunato, Mara, Mariani, Maurizio F, Furlan, Roberto, Comi, Giancarlo, Martino, Gianvito, Zaratin, Paola F
Published in Multiple sclerosis (01.01.2011)
Published in Multiple sclerosis (01.01.2011)
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Journal Article
Effects of combined GnRH receptor antagonist linzagolix and hormonal add-back therapy on vaginal bleeding—delayed add-back onset does not improve bleeding pattern
Pohl, Oliver, Marchand, Line, Bell, David, Gotteland, Jean-Pierre
Published in Reproductive sciences (Thousand Oaks, Calif.) (01.04.2020)
Published in Reproductive sciences (Thousand Oaks, Calif.) (01.04.2020)
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Journal Article
A 39-week oral toxicity study of ulipristal acetate in cynomolgus monkeys
Pohl, Oliver, Williams, Alistair R.W., Bergeron, Christine, Gotteland, Jean-Pierre
Published in Regulatory toxicology and pharmacology (01.06.2013)
Published in Regulatory toxicology and pharmacology (01.06.2013)
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Journal Article
Gonadotropin-Releasing Hormone Receptor Antagonist Mono- and Combination Therapy With Estradiol/Norethindrone Acetate Add-Back: Pharmacodynamics and Safety of OBE2109
Pohl, Oliver, Marchand, Line, Fawkes, Neil, Gotteland, Jean-Pierre, Loumaye, Ernest
Published in The journal of clinical endocrinology and metabolism (01.02.2018)
Published in The journal of clinical endocrinology and metabolism (01.02.2018)
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Journal Article
Bentamapimod (JNK Inhibitor AS602801) Induces Regression of Endometriotic Lesions in Animal Models
Palmer, Stephen S., Altan, Melis, Denis, Deborah, Tos, Enrico Gillio, Gotteland, Jean-Pierre, Osteen, Kevin G., Bruner-Tran, Kaylon L., Nataraja, Selvaraj G.
Published in Reproductive sciences (Thousand Oaks, Calif.) (01.01.2016)
Published in Reproductive sciences (Thousand Oaks, Calif.) (01.01.2016)
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Journal Article
Oxytocin Receptor Antagonists, Atosiban and Nolasiban, Inhibit Prostaglandin F 2α -induced Contractions and Inflammatory Responses in Human Myometrium
Kim, Sung Hye, Riaposova, Lucia, Ahmed, Hauwa, Pohl, Oliver, Chollet, André, Gotteland, Jean-Pierre, Hanyaloglu, Aylin, Bennett, Phillip R, Terzidou, Vasso
Published in Scientific reports (01.12.2019)
Published in Scientific reports (01.12.2019)
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Journal Article
Linzagolix with and without hormonal add-back therapy for the treatment of symptomatic uterine fibroids: two randomised, placebo-controlled, phase 3 trials
Donnez, Jacques, Taylor, Hugh S, Stewart, Elizabeth A, Bradley, Linda, Marsh, Erica, Archer, David, Al-Hendy, Ayman, Petraglia, Felice, Watts, Nelson, Gotteland, Jean-Pierre, Bestel, Elke, Terrill, Paul, Loumaye, Ernest, Humberstone, Andrew, Garner, Elizabeth
Published in The Lancet (British edition) (17.09.2022)
Published in The Lancet (British edition) (17.09.2022)
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Journal Article
The mechanism of action of oxytocin antagonist nolasiban in ART in healthy female volunteers
Pierzyński, Piotr, Pohl, Oliver, Marchand, Line, Mackens, Shari, Lorch, Ulrike, Gotteland, Jean-Pierre, Blockeel, Christophe
Published in Reproductive biomedicine online (01.08.2021)
Published in Reproductive biomedicine online (01.08.2021)
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Journal Article