Lithium Hexamethyldisilazide-Mediated Enolization of Highly Substituted Aryl Ketones: Structural and Mechanistic Basis of the E/Z Selectivities
Mack, Kyle A, McClory, Andrew, Zhang, Haiming, Gosselin, Francis, Collum, David B
Published in Journal of the American Chemical Society (06.09.2017)
Published in Journal of the American Chemical Society (06.09.2017)
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Journal Article
Highly Regioselective and Practical Synthesis of 5‑Bromo-4-chloro-3-nitro-7-azaindole
Han, Chong, Green, Keena, Pfeifer, Eugen, Gosselin, Francis
Published in Organic process research & development (21.04.2017)
Published in Organic process research & development (21.04.2017)
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Journal Article
Asymmetric Synthesis of Akt Kinase Inhibitor Ipatasertib
Han, Chong, Savage, Scott, Al-Sayah, Mohammad, Yajima, Herbert, Remarchuk, Travis, Reents, Reinhard, Wirz, Beat, Iding, Hans, Bachmann, Stephan, Fantasia, Serena M, Scalone, Michelangelo, Hell, André, Hidber, Pirmin, Gosselin, Francis
Published in Organic letters (15.09.2017)
Published in Organic letters (15.09.2017)
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Journal Article
Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin
Savage, Scott, McClory, Andrew, Zhang, Haiming, Cravillion, Theresa, Lim, Ngiap-Kie, Masui, Colin, Robinson, Sarah J, Han, Chong, Ochs, Christoph, Rege, Pankaj D, Gosselin, Francis
Published in Journal of organic chemistry (05.10.2018)
Published in Journal of organic chemistry (05.10.2018)
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Journal Article
Kumada–Corriu Heteroaryl Cross-Coupling for Synthesis of a Pharmaceutical Intermediate: Comparison of Batch Versus Continuous Reaction Modes
Linghu, Xin, Wong, Nicholas, Jost, Vera, Fantasia, Serena, Sowell, C. Gregory, Gosselin, Francis
Published in Organic process research & development (15.09.2017)
Published in Organic process research & development (15.09.2017)
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Journal Article
Highly regioselective synthesis of 1-aryl-3,4,5-substituted pyrazoles
Gosselin, Francis, O'Shea, Paul D., Webster, Robert A., Reamer, Robert A., Tillyer, Richard D., Grabowski, Edward J. J.
Published in Synlett (01.12.2006)
Published in Synlett (01.12.2006)
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Journal Article
Studies on Oxidopyrylium [5 + 2] Cycloadditions: Toward a General Synthetic Route to the C12-Hydroxy Daphnetoxins
Wender, Paul A, Bi, F. Christopher, Buschmann, Nicole, Gosselin, Francis, Kan, Cindy, Kee, Jung-Min, Ohmura, Hirofumi
Published in Organic letters (09.11.2006)
Published in Organic letters (09.11.2006)
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Journal Article
Unprecedented Catalytic Asymmetric Reduction of N−H Imines
Gosselin, Francis, O'Shea, Paul D, Roy, Stéphanie, Reamer, Robert A, Chen, Cheng-yi, Volante, Ralph P
Published in Organic letters (20.01.2005)
Published in Organic letters (20.01.2005)
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Journal Article
A Practical Synthesis of 5-Lipoxygenase Inhibitor MK-0633
Gosselin, Francis, Britton, Robert A, Davies, Ian W, Dolman, Sarah J, Gauvreau, Danny, Hoerrner, R. Scott, Hughes, Gregory, Janey, Jacob, Lau, Stephen, Molinaro, Carmela, Nadeau, Christian, O’Shea, Paul D, Palucki, Michael, Sidler, Rick
Published in Journal of organic chemistry (18.06.2010)
Published in Journal of organic chemistry (18.06.2010)
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Journal Article
Selective metal-halogen exchange of 4,4′-dibromobiphenyl mediated by lithium tributylmagnesiate
Dolman, Sarah J., Gosselin, Francis, O'Shea, Paul D., Davies, Ian W.
Published in Tetrahedron (22.05.2006)
Published in Tetrahedron (22.05.2006)
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Journal Article
Toward the ideal synthesis. New transition metal-catalyzed reactions inspired by novel medicinal leads
Wender, Paul A., Bi, F. Christopher, Gamber, Gabriel G., Gosselin, Francis, Hubbard, Robert D., Scanio, Marc J. C., Sun, Robert, Williams, Travis J., Zhang, Lei
Published in Pure and applied chemistry (01.01.2002)
Published in Pure and applied chemistry (01.01.2002)
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Journal Article
Asymmetric organozincate additions to ethyl 2,2,2-trifluoropyruvate
Gosselin, Francis, Britton, Robert A., Mowat, Jeffrey, O'Shea, Paul D., Davies, Ian W.
Published in Synlett (03.09.2007)
Published in Synlett (03.09.2007)
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Journal Article
Asymmetric Synthesis of N‑Alkyl Amino Acids through a Biocatalytic Dynamic Kinetic Resolution of PEGylated N‑Alkyl Amino Esters
Molinaro, Carmela, Kelly, Sean, Tang, Allison, Iding, Hans, Stocker, Patrik, Linghu, Xin, Gosselin, Francis
Published in Organic letters (15.12.2023)
Published in Organic letters (15.12.2023)
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Journal Article
Engineered Cytochrome P450-Catalyzed Oxidative Biaryl Coupling Reaction Provides a Scalable Entry into Arylomycin Antibiotics
Molinaro, Carmela, Kawasaki, Yukie, Wanyoike, George, Nishioka, Taiki, Yamamoto, Tsuyoshi, Snedecor, Brad, Robinson, Sarah J., Gosselin, Francis
Published in Journal of the American Chemical Society (17.08.2022)
Published in Journal of the American Chemical Society (17.08.2022)
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Journal Article
Development of a First-Generation Stereocontrolled Manufacturing Process of TRPA1 Inhibitor GDC-6599
Hong, Allen Y., Piechowicz, Katarzyna A., Timmerman, Jacob C., Zhang, Haiming, Molinaro, Carmela, Gosselin, Francis
Published in Organic process research & development (21.06.2024)
Published in Organic process research & development (21.06.2024)
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