IL-22 induces an acute-phase response
Liang, Spencer C, Nickerson-Nutter, Cheryl, Pittman, Debra D, Carrier, Yijun, Goodwin, Debra G, Shields, Kathleen M, Lambert, Andre-Jean, Schelling, Scott H, Medley, Quintus G, Ma, Hak-Ling, Collins, Mary, Dunussi-Joannopoulos, Kyriaki, Fouser, Lynette A
Published in The Journal of immunology (1950) (01.11.2010)
Published in The Journal of immunology (1950) (01.11.2010)
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Journal Article
Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α2α
Lee, Katherine L, Foley, Megan A, Chen, Lihren, Behnke, Mark L, Lovering, Frank E, Kirincich, Steven J, Wang, Weiheng, Shim, Jaechul, Tam, Steve, Shen, Marina W. H, Khor, SooPeang, Xu, Xin, Goodwin, Debra G, Ramarao, Manjunath K, Nickerson-Nutter, Cheryl, Donahue, Frances, Ku, M. Sherry, Clark, James D, McKew, John C
Published in Journal of medicinal chemistry (22.03.2007)
Published in Journal of medicinal chemistry (22.03.2007)
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Journal Article
Indole Cytosolic Phospholipase A2 α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic Acid, Efipladib
McKew, John C, Lee, Katherine L, Shen, Marina W. H, Thakker, Paresh, Foley, Megan A, Behnke, Mark L, Hu, Baihua, Sum, Fuk-Wah, Tam, Steve, Hu, Yonghan, Chen, Lihren, Kirincich, Steven J, Michalak, Ronald, Thomason, Jennifer, Ipek, Manus, Wu, Kun, Wooder, Lane, Ramarao, Manjunath K, Murphy, Elizabeth A, Goodwin, Debra G, Albert, Leo, Xu, Xin, Donahue, Frances, Ku, M. Sherry, Keith, James, Nickerson-Nutter, Cheryl L, Abraham, William M, Williams, Cara, Hegen, Martin, Clark, James D
Published in Journal of medicinal chemistry (26.06.2008)
Published in Journal of medicinal chemistry (26.06.2008)
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Journal Article
Discovery of ecopladib, an indole inhibitor of cytosolic phospholipase A2α
LEE, Katherine L, FOLEY, Megan A, KHOR, Soopeang, XIN XU, GOODWIN, Debra G, RAMARAO, Manjunath K, NICKERSON-NUTTER, Cheryl, DONAHUE, Frances, SHERRY KU, M, DARK, James D, MCKEW, John C, CHEN, Lihren, BEHNKE, Mark L, LOVERING, Frank E, KIRINCICH, Steven J, WEIHENG WANG, SHIM, Jaechul, TAM, Steve, SHEN, Marina W. H
Published in Journal of medicinal chemistry (22.03.2007)
Published in Journal of medicinal chemistry (22.03.2007)
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Journal Article
Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2α : Optimization of in vitro potency and rat pharmacokinetics for oral efficacy
LEE, Katherine L, BEHNKE, Mark L, SHEN, Marina W. H, RAMARAO, Manjunath K, GOODWIN, Debra G, NICKERSON-NUTTER, Cheryl L, ABRAHAM, William M, WILLIAMS, Cara, CLARK, James D, MCKEW, John C, FOLEY, Megan A, CHEN, Lihren, WEIHENG WANG, VARGAS, Richard, NUNEZ, Jill, TAM, Steve, MOLLOVA, Nevena, XIN XU
Published in Bioorganic & medicinal chemistry (01.02.2008)
Published in Bioorganic & medicinal chemistry (01.02.2008)
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Journal Article
Selective functional inhibition of JAK‐3 is sufficient for efficacy in collagen‐induced arthritis in mice
Lin, Tsung H., Hegen, Martin, Quadros, Elizabeth, Nickerson‐Nutter, Cheryl L., Appell, Kenneth C., Cole, Andrew G., Shao, Yuefei, Tam, Steve, Ohlmeyer, Michael, Wang, Bojing, Goodwin, Debra G., Kimble, Earl F., Quintero, Jorge, Gao, Min, Symanowicz, Peter, Wrocklage, Christopher, Lussier, Jennifer, Schelling, Scott H., Hewet, Amha G., Xuan, Dejun, Krykbaev, Rustem, Togias, Jenny, Xu, Xin, Harrison, Richard, Mansour, Tarek, Collins, Mary, Clark, James D., Webb, Maria L., Seidl, Katherine J.
Published in Arthritis and rheumatism (01.08.2010)
Published in Arthritis and rheumatism (01.08.2010)
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Journal Article
Indole cytosolic phospholipase A(2) alpha inhibitors: Discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib
McKew, John C., Lee, Katherine L., Shen, Marina W. H., Thakker, Paresh, Foley, Megan A., Behnke, Mark L., Hu, Baihua, Sum, Fuk-Wah, Tam, Steve, Hu, Yonghan, Chen, Lihren, Kirincich, Steven J., Michalak, Ronald, Thomason, Jennifer, Ipek, Manus, Wu, Kun, Wooder, Lane, Ramarao, Manjunath K., Murphy, Elizabeth A., Goodwin, Debra G., Albert, Leo, Xu, Xin, Donahue, Frances, Ku, M. Sherry, Keith, James, Nickerson-Nutter, Cheryl L., Abraham, William M., Williams, Cara, Hegen, Martin, Clark, James D.
Published in Journal of medicinal chemistry (26.06.2008)
Published in Journal of medicinal chemistry (26.06.2008)
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Journal Article
Discovery of ecopladib, an indole inhibitor of cytosolic phospholipase A(2)alpha
Lee, Katherine L., Foley, Megan A., Chen, Lihren, Behnke, Mark L., Lovering, Frank E., Kirincich, Steven J., Wang, Weiheng, Shim, Jaechul, Tam, Steve, Shen, Marina W. H., Khor, SooPeang, Xu, Xin, Goodwin, Debra G., Ramarao, Manjunath K., Nickerson-Nutter, Cheryl, Donahue, Frances, Ku, M. Sherry, Clark, James D., McKew, John C.
Published in Journal of medicinal chemistry (22.03.2007)
Published in Journal of medicinal chemistry (22.03.2007)
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Journal Article
Reactions of Functionalized Sulfonamides: Application to Lowering the Lipophilicity of Cytosolic Phospholipase A(2)alpha Inhibitors
Chen, Lihren, Wang, Weiheng, Lee, Katherine L., Shen, Marina W. H., Murphy, Elizabeth A., Zhang, Wen, Xu, Xin, Tam, Steve, Nickerson-Nutter, Cheryl, Goodwin, Debra G., Clark, James D., McKew, John C.
Published in Journal of medicinal chemistry (26.02.2009)
Published in Journal of medicinal chemistry (26.02.2009)
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Journal Article
Reactions of Functionalized Sulfonamides: Application to Lowering the Lipophilicity of Cytosolic Phospholipase A 2 α Inhibitors
Chen, Lihren, Wang, Weiheng, Lee, Katherine L., Shen, Marina W. H., Murphy, Elizabeth A., Zhang, Wen, Xu, Xin, Tam, Steve, Nickerson-Nutter, Cheryl, Goodwin, Debra G., Clark, James D., McKew, John C.
Published in Journal of medicinal chemistry (26.02.2009)
Published in Journal of medicinal chemistry (26.02.2009)
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Journal Article
Reactions of Functionalized Sulfonamides: Application to Lowering the Lipophilicity of Cytosolic Phospholipase A2α Inhibitors
Chen, Lihren, Wang, Weiheng, Lee, Katherine L, Shen, Marina W. H, Murphy, Elizabeth A, Zhang, Wen, Xu, Xin, Tam, Steve, Nickerson-Nutter, Cheryl, Goodwin, Debra G, Clark, James D, McKew, John C
Published in Journal of medicinal chemistry (26.02.2009)
Published in Journal of medicinal chemistry (26.02.2009)
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Journal Article
IL-22, A Th17 Cytokine, induces a systemic acute phase response
Liang, Spencer C., Pittman, Debra, Carrier, Yijun, Goodwin, Debra G., Shields, Kathleen, Lambert, Andre-Jean, Schelling, Scott H., Medley, Quint, Ma, Hak-Ling, Collins, Mary, Nickerson-Nutter, Cheryl, Dunussi-Joannopoulos, Kyriaki, Fouser, Lynette A.
Published in Cytokine (Philadelphia, Pa.) (01.10.2009)
Published in Cytokine (Philadelphia, Pa.) (01.10.2009)
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Journal Article
TRIL is a novel modulator of TLR4 with enriched expression in the brain
Carlson, Thaddeus, Carpenter, Susan, Gao, Ying, Percival, Karen, Schelling, Scott H., Hewet, Amha G., Kuang, Wen, Reddy, Padma, Goodwin, Debra G., Nickerson-Nutter, Cheryl, Senices, Mayra, Young, Deborah, Bradley, Leila, Lin, Lih-Ling, Clark, James D., Dunne, Aisling, O’Neill, Luke A.J., Collins, Mary, Seidl, Katherine J.
Published in Cytokine (Philadelphia, Pa.) (01.10.2009)
Published in Cytokine (Philadelphia, Pa.) (01.10.2009)
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Journal Article
The novel and selective JAK3 inhibitor WYE-152038 is highly efficacious in a mouse model of rheumatoid arthritis
Seidl, Katherine J., Lin, Tsung H., Hegen, Martin, Quadros, Elizabeth, Nickerson-Nutter, Cheryl L., Appell, Kenneth C., Cole, Andrew G., Shao, Yuefei, Tam, Steve, Ohlmeyer, Michael, Wang, Bojing, Goodwin, Debra G., Kimble, Earl F., Quintero, Jorge, Gao, Min, Symanowicz, Peter, Wrocklage, Christopher, Lussier, Jennifer, Schelling, Scott H., Hewet, Amha G., Xuan, Dejun, Krykbaev, Rustem, Togias, Jennifer, Harrison, Richard, Xu, Xin, Collins, Mary, Clark, James D., Webb, Maria L.
Published in Cytokine (Philadelphia, Pa.) (01.10.2009)
Published in Cytokine (Philadelphia, Pa.) (01.10.2009)
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Journal Article
Indole Cytosolic Phospholipase A 2 α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1 H -indol-3-yl]propyl}benzoic Acid, Efipladib
McKew, John C., Lee, Katherine L., Shen, Marina W. H., Thakker, Paresh, Foley, Megan A., Behnke, Mark L., Hu, Baihua, Sum, Fuk-Wah, Tam, Steve, Hu, Yonghan, Chen, Lihren, Kirincich, Steven J., Michalak, Ronald, Thomason, Jennifer, Ipek, Manus, Wu, Kun, Wooder, Lane, Ramarao, Manjunath K., Murphy, Elizabeth A., Goodwin, Debra G., Albert, Leo, Xu, Xin, Donahue, Frances, Ku, M. Sherry, Keith, James, Nickerson-Nutter, Cheryl L., Abraham, William M., Williams, Cara, Hegen, Martin, Clark, James D.
Published in Journal of medicinal chemistry (01.06.2008)
Published in Journal of medicinal chemistry (01.06.2008)
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Journal Article
Benzenesulfonamide indole inhibitors of cytosolic phospholipase A 2α: Optimization of in vitro potency and rat pharmacokinetics for oral efficacy
Lee, Katherine L., Behnke, Mark L., Foley, Megan A., Chen, Lihren, Wang, Weiheng, Vargas, Richard, Nunez, Jill, Tam, Steve, Mollova, Nevena, Xu, Xin, Shen, Marina W.H., Ramarao, Manjunath K., Goodwin, Debra G., Nickerson-Nutter, Cheryl L., Abraham, William M., Williams, Cara, Clark, James D., McKew, John C.
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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Journal Article
Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha
Lee, Katherine L, Foley, Megan A, Chen, Lihren, Behnke, Mark L, Lovering, Frank E, Kirincich, Steven J, Wang, Weiheng, Shim, Jaechul, Tam, Steve, Shen, Marina W H, Khor, Soopeang, Xu, Xin, Goodwin, Debra G, Ramarao, Manjunath K, Nickerson-Nutter, Cheryl, Donahue, Frances, Ku, M Sherry, Clark, James D, McKew, John C
Published in Journal of medicinal chemistry (22.03.2007)
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Published in Journal of medicinal chemistry (22.03.2007)
Journal Article
Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α 2 α
Lee, Katherine L., Foley, Megan A., Chen, Lihren, Behnke, Mark L., Lovering, Frank E., Kirincich, Steven J., Wang, Weiheng, Shim, Jaechul, Tam, Steve, Shen, Marina W. H., Khor, SooPeang, Xu, Xin, Goodwin, Debra G., Ramarao, Manjunath K., Nickerson-Nutter, Cheryl, Donahue, Frances, Ku, M. Sherry, Clark, James D., McKew, John C.
Published in Journal of medicinal chemistry (01.03.2007)
Published in Journal of medicinal chemistry (01.03.2007)
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Journal Article
Indole Cytosolic Phospholipase A2 α Inhibitors : Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-l-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic Acid, Efipladib
MCKEW, John C, LEE, Katherine L, CHEN, Lihren, KIRINCICH, Steven J, MICHALAK, Ronald, THOMASON, Jennifer, IPEK, Manus, KUN WU, WOODER, Lane, RAMARAO, Manjunath K, MURPHY, Elizabeth A, GOODWIN, Debra G, SHEN, Marina W. H, ALBERT, Leo, XIN XU, DONAHUE, Frances, SHERRY KU, M, KEITH, James, NICKERSON-NUTTER, Cheryl L, ABRAHAM, William M, WILLIAMS, Cara, HEGEN, Martin, CLARK, James D, THAKKER, Paresh, FOLEY, Megan A, BEHNKE, Mark L, BAIHUA HU, SUM, Fuk-Wah, TAM, Steve, YONGHAN HU
Published in Journal of medicinal chemistry (2008)
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Published in Journal of medicinal chemistry (2008)
Journal Article